| Peer-Reviewed

Clinical Study of Quyuhuazhuo on Reducing Blood Hypercoagulability of Malignant Tumors

Received: 28 August 2019    Accepted: 16 September 2019    Published: 27 September 2019
Views:       Downloads:
Abstract

Objective: To investigate the clinical significance of Quyuhuazhuo on reducing blood stasis syndrome of malignant tumors (hypercoagulable state of blood). Methods: 60 malignant tumor patients with hypercoagulable state were randomly divided into treatment group and control group. In treatment group, 30 patients were treated with Quyuhuazhuo combined with chemotherapy. In control group, the other 30 patients received chemotherapy only. The clinical symptoms were observed. The changes of PLT (platelet), FIB (fibrinogen), PT (prothrombin time), APTT (activated partial thromboplastin time) and D-dimer were monitored dynamically before and after treatment. Result: The time of PT and APTT was prolonged significantly in treatment group compared with control group (P<0.05), and the value of PLT, FIB and D-dimer decreased significantly (P<0.05). Conclusion: The combined treatment of chemotherapy with Quyuhuazhuo can reduce the hypercoagulable state in malignant tumor patients.

Published in Cancer Research Journal (Volume 7, Issue 4)
DOI 10.11648/j.crj.20190704.11
Page(s) 125-128
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Quyuhuazhuo, Malignant TUmor, Blood Hypercoagulability, Blood Stasis

References
[1] Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018, 68 (6): 394-424.
[2] Blane DN, Lewandowska M. Living with cancer and multimorbidity: the role of primary care. Curr Opin Support Palliat Care. 2019, 13 (3): 213-219.
[3] Al-Samkari H, Connors JM. Dual anticoagulation with fondaparinux and dabigatran for treatment of cancer-associated hypercoagulability. Am J Hematol. 2018, 93 (6): E156-E158.
[4] Normile D. DRUG DISCOVERY. Nobel for antimalarial drug highlights East West divide. Science. 2015, 350 (6258): 265.
[5] Araújo A. [Cancer and deep venous thrombosis: the purpose of the CATCH clinical trial]. Acta Med Port. 2013, 26 (2): 83-85.
[6] Scărlătescu E, Lancé MD, White NJ, Aramă SS, Tomescu DR. Effects of malignancy on blood coagulation in septic intensive care patients. Blood Coagul Fibrinolysis. 2018, 29 (1): 92-96.
[7] Ay C, Pabinger I, Cohen AT. Cancer-associated venous thromboembolism: burden, mechanisms, and management. Thromb Haemost. 2017, 117: 219–230.
[8] Wang S, Long S, Wu W. Application of Traditional Chinese Medicines as Personalized Therapy in Human Cancers. Am J Chin Med. 2018, 46 (5): 953-970.
[9] Al-Samkari, H; Connors, JM; Dual anticoagulation with fondaparinux and dabigatran for treatment of cancer-associated hypercoagulability. Am J Hematol. 2018, 93 (6): E156-E158.
[10] Hsu JY, Liu AB. Anticoagulants for cancer-associated ischemic stroke. Ci Ji Yi Xue Za Zhi. 2019, 31 (3): 144-148.
[11] Ling CQ, Yue XQ, Ling C. Three advantages of using traditional Chinese medicine to prevent and treat tumor. J Integr Med. 2014, 12 (4): 331-335.
[12] Xi SY, Minuk GY. Role of traditional Chinese medicine in the management of patients with hepatocellular carcinoma. World J Hepatol. 2018, 10 (11): 799-806.
[13] Kang XJ, Wang HY, Peng HG, Chen BF, Zhang WY, Wu AH, Xu Q, Huang YZ. Codelivery of dihydroartemisinin and doxorubicin in mannosylated liposomes for drug-resistant colon cancer therapy. Acta Pharmacol Sin. 2017, 38 (6): 885-896.
[14] Zang W, Bian H, Huang X, Yin G, Zhang C, Han LI, Hao P, Ding S, Sun YU, Yang Z, Hoffman RM, Tang D. Traditional Chinese Medicine (TCM) Astragalus Membranaceus and Curcuma Wenyujin Promote Vascular Normalization in Tumor-derived Endothelial Cells of Human Hepatocellular Carcinoma. Anticancer Res. 2019, 39 (6): 2739-2747.
[15] Campello E, Ilich A, Simioni P, Key NS. The relationship between pancreatic cancer and hypercoagulability: a comprehensive review on epidemiological and biological issues. Br J Cancer. 2019 Jul 22. doi: 10.1038/s41416-019-0510-x. [Epub ahead of print]
Cite This Article
  • APA Style

    Aixia Sui, Wenhua Xu, Huayue Cong, Huiling Song, Yong Liu, et al. (2019). Clinical Study of Quyuhuazhuo on Reducing Blood Hypercoagulability of Malignant Tumors. Cancer Research Journal, 7(4), 125-128. https://doi.org/10.11648/j.crj.20190704.11

    Copy | Download

    ACS Style

    Aixia Sui; Wenhua Xu; Huayue Cong; Huiling Song; Yong Liu, et al. Clinical Study of Quyuhuazhuo on Reducing Blood Hypercoagulability of Malignant Tumors. Cancer Res. J. 2019, 7(4), 125-128. doi: 10.11648/j.crj.20190704.11

    Copy | Download

    AMA Style

    Aixia Sui, Wenhua Xu, Huayue Cong, Huiling Song, Yong Liu, et al. Clinical Study of Quyuhuazhuo on Reducing Blood Hypercoagulability of Malignant Tumors. Cancer Res J. 2019;7(4):125-128. doi: 10.11648/j.crj.20190704.11

    Copy | Download

  • @article{10.11648/j.crj.20190704.11,
      author = {Aixia Sui and Wenhua Xu and Huayue Cong and Huiling Song and Yong Liu and Haibo Jia and Yongqing Shen},
      title = {Clinical Study of Quyuhuazhuo on Reducing Blood Hypercoagulability of Malignant Tumors},
      journal = {Cancer Research Journal},
      volume = {7},
      number = {4},
      pages = {125-128},
      doi = {10.11648/j.crj.20190704.11},
      url = {https://doi.org/10.11648/j.crj.20190704.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20190704.11},
      abstract = {Objective: To investigate the clinical significance of Quyuhuazhuo on reducing blood stasis syndrome of malignant tumors (hypercoagulable state of blood). Methods: 60 malignant tumor patients with hypercoagulable state were randomly divided into treatment group and control group. In treatment group, 30 patients were treated with Quyuhuazhuo combined with chemotherapy. In control group, the other 30 patients received chemotherapy only. The clinical symptoms were observed. The changes of PLT (platelet), FIB (fibrinogen), PT (prothrombin time), APTT (activated partial thromboplastin time) and D-dimer were monitored dynamically before and after treatment. Result: The time of PT and APTT was prolonged significantly in treatment group compared with control group (PP<0.05). Conclusion: The combined treatment of chemotherapy with Quyuhuazhuo can reduce the hypercoagulable state in malignant tumor patients.},
     year = {2019}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Clinical Study of Quyuhuazhuo on Reducing Blood Hypercoagulability of Malignant Tumors
    AU  - Aixia Sui
    AU  - Wenhua Xu
    AU  - Huayue Cong
    AU  - Huiling Song
    AU  - Yong Liu
    AU  - Haibo Jia
    AU  - Yongqing Shen
    Y1  - 2019/09/27
    PY  - 2019
    N1  - https://doi.org/10.11648/j.crj.20190704.11
    DO  - 10.11648/j.crj.20190704.11
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 125
    EP  - 128
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20190704.11
    AB  - Objective: To investigate the clinical significance of Quyuhuazhuo on reducing blood stasis syndrome of malignant tumors (hypercoagulable state of blood). Methods: 60 malignant tumor patients with hypercoagulable state were randomly divided into treatment group and control group. In treatment group, 30 patients were treated with Quyuhuazhuo combined with chemotherapy. In control group, the other 30 patients received chemotherapy only. The clinical symptoms were observed. The changes of PLT (platelet), FIB (fibrinogen), PT (prothrombin time), APTT (activated partial thromboplastin time) and D-dimer were monitored dynamically before and after treatment. Result: The time of PT and APTT was prolonged significantly in treatment group compared with control group (PP<0.05). Conclusion: The combined treatment of chemotherapy with Quyuhuazhuo can reduce the hypercoagulable state in malignant tumor patients.
    VL  - 7
    IS  - 4
    ER  - 

    Copy | Download

Author Information
  • Department of Oncology, Hebei General Hospital, Shijiazhuang, China

  • College of Nursing, Hebei University of Chinese Medicine, Shijiazhuang, China

  • Department of Oncology, Hebei General Hospital, Shijiazhuang, China

  • Department of Oncology, Hebei General Hospital, Shijiazhuang, China

  • Department of Oncology, Baoding First Central Hospital, Baoding, China

  • Department of Traditional Chinese Medicine, Hebei General Hospital, Shijiazhuang, China

  • College of Nursing, Hebei University of Chinese Medicine, Shijiazhuang, China

  • Sections