Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics

Gábor Ternák

doi:doi:10.11648/j.bio.20190702.12

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Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics

Gábor Ternák

Published in American Journal of Bioscience and Bioengineering (Volume 7, Issue 2)

Received: 5 March 2019 Accepted: 11 April 2019 Published: 9 May 2019

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Abstract

The rapid, pandemic-like, spread of certain noncontagious diseases (NCDs), like (childhood) obesity, type2 diabetes mellitus, particularly in children, autism, Alzheimer diseases, etc. prompted the researches to try to find appropriate explanation for this phenomenon. The well-known association between antibiotic enriched fodder and the weight gain of food animals, through the modification of the gut flora, clearly raises the possibility of similar relationship in human beings as well, which was described in several publications. The role of obesity in the development of diabetes is a well-known also. The antibiotic consumption pattern in the World clearly demonstrated the extensive utilization of the broad spectrum antibiotics, starting about three decades ago, and the appearance of still active degradation products in the environment, which might reenter into humans and animals again, and as the result of the alteration of human microbiome, could induce the pandemic-like NCDs. The yet to be explained rapid increase of prevalence of autism and Alzheimer diseases observed in the past three decades is alarming. According to a CDC survey, the prevalence of autism in the surveyed population was estimated as 16.8 per 1,000 (one in 59) children aged 8 years, which is considered as a 150% increase from the year 2000. The prevalence of Alzheimer’s disease in Europe was estimated at 5.05% (95% CI, 4.73-5.39). Microbiome alterations were observed in both cases and obesity is present in the 30% of autism as well. Putting together the mosaics from relevant publications, it might be concluded that we face the long term side effects of antibiotic consumption/pollution manifesting, through the alteration of microbioms as the pandemic appearance of certain NCDs. The restoration of the “normal” gut flora by fecal microbiota transfer (FMT) might be an option to influence those conditions.

Published in	American Journal of Bioscience and Bioengineering (Volume 7, Issue 2)
DOI	10.11648/j.bio.20190702.12
Page(s)	34-39
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Antibiotics, Microbiome, Type 2 Diabetes Mellitus (T2D), Obesity, Autism, Alzheimer Disease, Antibiotic Pollution, Fecal Microbiota Transfer (FMT)

References

[1]	Eili Y Klein, Elena Martinez, Suraj Pant, Sumanth Gandra, Simon A. Levin, Herman Goossens, et al (2018). Global increase and geographic convergence in antibiotic consumption between 2000 and 2015, Proceedings of the National Academy of Sciences, March 2018 DOI: 10.1073/pnas.1717295115.
[2]	Van Boeckel TP, Glennon EE, Chen D, Gilbert M, Robinson TP, Grenfell BT, et al (2017). Reducing antimicrobial use in food animals, Science Vol. 357, Issue 6358, pp. 1350-1352, DOI: 10.1126/. science.aao1495.
[3]	Grave K, Torren-Edo J, Mackay D (2010). Comparison of the sales of veterinary antibacterial agents between 10 European countries. J Antimicrob Chemother, 65: 2037-2040.
[4]	Andrade MJ1, Jayaprakash C, Bhat S, Evangelatos N, Brand A, Satyamoorthy K. (2017). Antibiotics- Induced Obesity: A Mitochondrial Perspective, Public Health Genomics, 20. 257–273.
[5]	L. Charles Bailey, Christopher B. Forrest, Thomas ichards, Alice Livshits, Patricia DeRusso (2014): Association of Antibiotics in Infancy With Early Childhood Obesity, JAMA Pediatr. 168, 1063–1069. doi: 10.1001/jamapediatrics.2014. 1539
[6]	Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, et al (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 1761-72.
[7]	Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57, 1470-8.
[8]	Del Fiol FS, Balcão VM, Barberato-Fillho S, Lopes LC, Bergamaschi CC (2018). Obesity: A New Adverse Effect of Antibiotics?, Front. Pharmacol. 9: 1408. doi: 10.3389/fphar.2018.01408).
[9]	Larsson DG, de Pedro C, Paxeus N. (2007): Effluent from drug manufactures contains extremely high levels of pharmaceuticals. J Hazard Mater. 30, 148(3): 751-5.
[10]	Wang J, Mao D, Mu Q, Luo Y (2015). Fate and proliferation of typical antibiotic resistance genes in five full-scale pharmaceutical wastewater treatment plants, Science of the Total Environment 526, 366–373.
[11]	Livermore, D. M. (2005), Minimizing antibiotic resistance. Lancet Infect. Dis. 5, 450-459.
[12]	Teuber, M., (2001). Veterinary use and antibiotic resistance. Curr. Opin. Microbiol. 4, 493-499.
[13]	Junjie Qin, Ruiqiang Li, Jeroen Raes, Manimozhiyan Arumugam, Kristoffer Solvsten Burgdorf, Chaysavanh Manichanh, et al (2010). A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 59-65.
[14]	Paul B. Eckburg, Elisabeth M. Bik, Charles N. Bernstein, Elizabeth Purdom, Les Dethlefsen, Michael Sargent et al (2015). Diversity of the human intestinal microbial flora. Science 308, 1635-1638.
[15]	Goodrich, Julia K., Waters, Jillian L., Poole, Angela C., Sutter, Jessica L., Koren, Omry, Blekhman, Ran; et al. (2014). Human genetics shape the gut microbiome. Cell 159, 789 -799.
[16]	Tanya Yatsunenko, Federico E. Rey, Mark J. Manary, Indi Trehan, Maria Gloria Dominguez- Bello, et al (2012). Human gut microbiome viewed across age and geography. Nature 486, 222-227.
[17]	Clemente JC, Ursell LK, Parfrey LW, Knight R.(2012). The impact of the gut microbiota on human health: an integrative view. Cell 148, 1258-1270.
[18]	Hedvig E Jakobsson, Ana M Rodríguez-Piñeiro, André Schütte, Anna Ermund, Preben Boysen, Mats Bemark, et al (2015). The composition of the gut microbiota shapes the colon mucus barrier. EMBO Rep.16, 164-177, 2016.
[19]	Jakobsson HE, Jernberg C, Andersson AF, Sjölund-Karlsson M, Jansson JK, Engstrand L. (2010). Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome. PLoS One 5, e9836.2010.
[20]	Fouhy F, Guinane CM, Hussey S, Wall R, Ryan CA, Dempsey EM, et al (2012). High-throughput sequencing reveals the incomplete, short-term recovery of infant gut microbiota following parenteral antibiotic treatment with ampicillin and gentamicin. Antimicrob. Agents Chemother. 56, 5811-5820.
[21]	Bajaj JS, Heuman DM, Hylemon PB, Sanyal AJ, White MB, Monteith P, et al (2014). Altered profile of human gut microbiome is associated with cirrhosis and its complications. J. Hepatol. 60, 940-947.
[22]	Bajaj JS, Heuman DM, Sanyal AJ, Hylemon PB, Sterling RK, Stravitz RT, et al (2013). Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy. PLoS One 8, e60042.
[23]	Lisowska, A., Wojtowicz, J., Walkowiak, J. (2009). Small intestine bacterial overgrowth is frequent in cystic fibrosis: combined hydrogen and methane measurements are required for its detection. Acta Biochim. Pol. 56, 631e634.
[24]	Shannon L. Russell, Matthew J. Gold, Lisa A. Reynolds, Benjamin P. Willing, Pedro Dimitriu, Lisa Thosrson , et al (2015). Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases. J. Allergy Clin. Immunol. 135, 100-109.
[25]	Jo Inchley, Dorothy Currie, Taryn Young, Oddrun Samdal, Torbjørn Torsheim, Lise Augustson, et al (2016). Growing up unequal. HBSC 2016 study http://www.euro.who.int/en/health-topics/Life- stages/child-and-adolescent-health/health-behaviour-in-school-aged-children-hbsc/hbsc-international-reports/growing-up-unequal.-hbsc-2016-study-20132014-survey.
[26]	http://www.czechcompete.cz/economic-policy/health-care/oecd-obesity-update-2017-obesity- rates- are- expected-to-increase-further.
[27]	https://www.forbes.com/sites/brucelee/2017/06/13/global-obesity-epidemic-new-study- shows-how-big-a-problem-its-become/#342ef0b72a2c.
[28]	Gabor Ternak, Zs Edel, Zs Feiszt, J. Szekeres, B. Visegrady, I. Wittmann (2015). Selective Association between Cephalosporin, Quinolone, Macrolide, and Penicillin Antibiotic Consumption and Childhood Obesity in Europe, Health, 7, 1306-1314.
[29]	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068646/.
[30]	Ranjit Unnikrishnan1, Rajendra Pradeepa1, Shashank R. Joshi and Viswanathan Mohan (2017). Type 2 Diabetes: Demystifying the Global Epidemic, Diabetes 66(6), 1432-1442.
[31]	http://www.diabetesatlas.org/resources/2017-atlas.html.
[32]	Anjana RM, Pradeep R, Deepa M, Datta, Sudha V, Unnikrishnan R, Bhansali A, et al (2011). ICMR–INDIAB Collaborative Study Group Prevalence of diabetes and prediabetes (impaired fasting glucose and/or impaired glucose tolerance) in urban and rural India: phase I results of the Indian Council of Medical Research-INdia DIABetes (ICMR-INDIAB) study. Diabetologia 54, 3022– 3027pmid: 21959957.
[33]	Zabetian A, Sanchez IM, Narayan KM, Hwang CK, Ali MK (2014). Global rural diabetes prevalence: a systematic review and meta-analysis covering 1990–2012. Diabetes Res Clin Pract 104: 206–213pmid: 24507869.
[34]	José F. Cara, The Epidemic of Type 2 Diabetes Mellitus in Children, https://www.medscape.org/viewarticle/447138.
[35]	Jon Baio, Lisa Wiggins, Deborah L., Christensen Matthew J Maenner, Julie Daniels, Zachary Warren, et al (2018). Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014, MMVR Surveillance Summaries / April 27, 2018 / 67(6); 1–23.
[36]	Meng-Chuan Lai, Michael V Lombardo, Simon Baron-Cohen (2014). Autism, Lancet, Volume 383, Issue 9920, 8–14 March 2014, Pages 896-910.
[37]	Lord C, Elsabbagh M, Baird G, Veenstra-Vanderweele J (2018). Autism spectrum disorder, Lancet. 2018 Aug 11; 392 (10146): 508-520. doi: 10.1016/S0140-6736(18)31129-2. Epub 2018 Aug 2.
[38]	Bjørklund G, Skalny AV, Rahman MM, Dadar M, Yassa HA, Aaseth J, et al (2018). Toxic metal (loid)-based pollutants and their possible role in autism spectrum disorder, Environmental Research Volume 166, 234-250.
[39]	Guo Z, Xie HQ, Zhang P, Luo Y, Xu T, Liu Y, et al (2018), Dioxins as potential risk factors for autism spectrum disorder, Envionment International, 121, 906-915.
[40]	Pequegnat B, Sagermann M, Valliani M, Toh M, Chow H, et al. (2013). A vaccine and diagnostic target for Clostridium bolteae, an autism associated bacterium, Vaccine 31, 2787-2790.
[41]	James B Adams, Leah J Johansen,, Linda D Powell, David Quig and Robert A Rubin (2011). Gastrointestinal flora and gastrointestinal status in children with autism; comparisons to typical children and correlation with autism severity, BMC Gastroenterology 11, 2. http://www.biomedcentral.com/1471-230X/11/22,
[42]	Heberling CA1, Dhurjati PS, Sasser M.. (2013). Hypothesis for a systems connectivity model of autism spectrum disorder pathogenesis: Links to gut bacteria, oxidative stress, and intestinal permeability. Medical Hypotheses 80 264-270.
[43]	Amar Sarkar, Siobhán Harty, Soili M Lehto, Andrew H. Moeller, Timithy G. Dinan, Robin I. M. Dunbar, et al (2018). The Microbiome in Physiology and Cognitive Neuroscence, Trends in Cognitive Science, Vol. 22, No. 7. https://doi.org/10.1016/j.tics.2018.04.006 611 ©.
[44]	https://www.alz.org/media/Documents/alzheimers-facts-and-figures-infographic.pdf.
[45]	H. Niua, I. Álvarez-Álvarez F. Guillén-Grimaa, I. Aguinaga-Ontosoa (2017). Prevalencia e incidencia de la enfermedadde Alzheimer en Europa: metaanálisis. Neurología. 32, 523—532.
[46]	Morley, JE., Farr, SA., Nguyen, AD. (2018): Alzheimer Disease, Clin Geriatr Med 34 591–601.
[47]	Miho Uematsu, Ayako Nakamura, Momoko Ebashi, Katsuiku Hirokawa, Ryosuke Takahashi, and Toshiki Uchihara (2018) Brain stem tau pathology in Alzheimer’s disease is characterized by increase of three repeat tau and independent of amyloid b. Acta Neuropathol Commun 6, 1.
[48]	Hao K, Di Narzo AF, Ho L, Luo W, Li S, Chen R, et al (2015): Shared genetic etiology underlying Alzheimer's disease and type 2 diabetes, Molecular Aspects of Medicine, Volumes 43–44, 66-76.
[49]	Mancuso, C., Santangelo, R. (2018). Alzheimer’s disease and gut microbiota modifications: The long way between preclinical studies and clinical evidence, Pharmacological Research, Volume 129, 329-336.
[50]	Ternak, G. (2005). Antibiotics may act as growth/obesity promoters in Humans as an inadvertent result of antibiotic pollution ? Medical Hypotheses, Volume 64, Issue 1, 14-16.
[51]	Hani Sbahi, Jack A Di Palma (2016). Faecal microbiota transplantation: applications and limitations in treating gastrointestinal disorders, BMJ Open Gastro2016; 3:e000087. doi:10.1136/bmjgast-2016- 000087.

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Gábor Ternák. (2019). Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics. American Journal of Bioscience and Bioengineering, 7(2), 34-39. https://doi.org/10.11648/j.bio.20190702.12

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Gábor Ternák. Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics. Am. J. BioSci. Bioeng. 2019, 7(2), 34-39. doi: 10.11648/j.bio.20190702.12

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Gábor Ternák. Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics. Am J BioSci Bioeng. 2019;7(2):34-39. doi: 10.11648/j.bio.20190702.12

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@article{10.11648/j.bio.20190702.12,
  author = {Gábor Ternák},
  title = {Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {7},
  number = {2},
  pages = {34-39},
  doi = {10.11648/j.bio.20190702.12},
  url = {https://doi.org/10.11648/j.bio.20190702.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20190702.12},
  abstract = {The rapid, pandemic-like, spread of certain noncontagious diseases (NCDs), like (childhood) obesity, type2 diabetes mellitus, particularly in children, autism, Alzheimer diseases, etc. prompted the researches to try to find appropriate explanation for this phenomenon. The well-known association between antibiotic enriched fodder and the weight gain of food animals, through the modification of the gut flora, clearly raises the possibility of similar relationship in human beings as well, which was described in several publications. The role of obesity in the development of diabetes is a well-known also. The antibiotic consumption pattern in the World clearly demonstrated the extensive utilization of the broad spectrum antibiotics, starting about three decades ago, and the appearance of still active degradation products in the environment, which might reenter into humans and animals again, and as the result of the alteration of human microbiome, could induce the pandemic-like NCDs. The yet to be explained rapid increase of prevalence of autism and Alzheimer diseases observed in the past three decades is alarming. According to a CDC survey, the prevalence of autism in the surveyed population was estimated as 16.8 per 1,000 (one in 59) children aged 8 years, which is considered as a 150% increase from the year 2000. The prevalence of Alzheimer’s disease in Europe was estimated at 5.05% (95% CI, 4.73-5.39). Microbiome alterations were observed in both cases and obesity is present in the 30% of autism as well. Putting together the mosaics from relevant publications, it might be concluded that we face the long term side effects of antibiotic consumption/pollution manifesting, through the alteration of microbioms as the pandemic appearance of certain NCDs. The restoration of the “normal” gut flora by fecal microbiota transfer (FMT) might be an option to influence those conditions.},
 year = {2019}
}

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TY  - JOUR
T1  - Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics
AU  - Gábor Ternák
Y1  - 2019/05/09
PY  - 2019
N1  - https://doi.org/10.11648/j.bio.20190702.12
DO  - 10.11648/j.bio.20190702.12
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
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PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.20190702.12
AB  - The rapid, pandemic-like, spread of certain noncontagious diseases (NCDs), like (childhood) obesity, type2 diabetes mellitus, particularly in children, autism, Alzheimer diseases, etc. prompted the researches to try to find appropriate explanation for this phenomenon. The well-known association between antibiotic enriched fodder and the weight gain of food animals, through the modification of the gut flora, clearly raises the possibility of similar relationship in human beings as well, which was described in several publications. The role of obesity in the development of diabetes is a well-known also. The antibiotic consumption pattern in the World clearly demonstrated the extensive utilization of the broad spectrum antibiotics, starting about three decades ago, and the appearance of still active degradation products in the environment, which might reenter into humans and animals again, and as the result of the alteration of human microbiome, could induce the pandemic-like NCDs. The yet to be explained rapid increase of prevalence of autism and Alzheimer diseases observed in the past three decades is alarming. According to a CDC survey, the prevalence of autism in the surveyed population was estimated as 16.8 per 1,000 (one in 59) children aged 8 years, which is considered as a 150% increase from the year 2000. The prevalence of Alzheimer’s disease in Europe was estimated at 5.05% (95% CI, 4.73-5.39). Microbiome alterations were observed in both cases and obesity is present in the 30% of autism as well. Putting together the mosaics from relevant publications, it might be concluded that we face the long term side effects of antibiotic consumption/pollution manifesting, through the alteration of microbioms as the pandemic appearance of certain NCDs. The restoration of the “normal” gut flora by fecal microbiota transfer (FMT) might be an option to influence those conditions.
VL  - 7
IS  - 2
ER  -

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Gábor Ternák

Chair of Migration Health, Faculty of Medicine, University of Pécs, Pécs, Hungary

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Gábor Ternák. (2019). Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics. American Journal of Bioscience and Bioengineering, 7(2), 34-39. https://doi.org/10.11648/j.bio.20190702.12

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Gábor Ternák. Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics. Am. J. BioSci. Bioeng. 2019, 7(2), 34-39. doi: 10.11648/j.bio.20190702.12

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AMA Style

Gábor Ternák. Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics. Am J BioSci Bioeng. 2019;7(2):34-39. doi: 10.11648/j.bio.20190702.12

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@article{10.11648/j.bio.20190702.12,
  author = {Gábor Ternák},
  title = {Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {7},
  number = {2},
  pages = {34-39},
  doi = {10.11648/j.bio.20190702.12},
  url = {https://doi.org/10.11648/j.bio.20190702.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20190702.12},
  abstract = {The rapid, pandemic-like, spread of certain noncontagious diseases (NCDs), like (childhood) obesity, type2 diabetes mellitus, particularly in children, autism, Alzheimer diseases, etc. prompted the researches to try to find appropriate explanation for this phenomenon. The well-known association between antibiotic enriched fodder and the weight gain of food animals, through the modification of the gut flora, clearly raises the possibility of similar relationship in human beings as well, which was described in several publications. The role of obesity in the development of diabetes is a well-known also. The antibiotic consumption pattern in the World clearly demonstrated the extensive utilization of the broad spectrum antibiotics, starting about three decades ago, and the appearance of still active degradation products in the environment, which might reenter into humans and animals again, and as the result of the alteration of human microbiome, could induce the pandemic-like NCDs. The yet to be explained rapid increase of prevalence of autism and Alzheimer diseases observed in the past three decades is alarming. According to a CDC survey, the prevalence of autism in the surveyed population was estimated as 16.8 per 1,000 (one in 59) children aged 8 years, which is considered as a 150% increase from the year 2000. The prevalence of Alzheimer’s disease in Europe was estimated at 5.05% (95% CI, 4.73-5.39). Microbiome alterations were observed in both cases and obesity is present in the 30% of autism as well. Putting together the mosaics from relevant publications, it might be concluded that we face the long term side effects of antibiotic consumption/pollution manifesting, through the alteration of microbioms as the pandemic appearance of certain NCDs. The restoration of the “normal” gut flora by fecal microbiota transfer (FMT) might be an option to influence those conditions.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics
AU  - Gábor Ternák
Y1  - 2019/05/09
PY  - 2019
N1  - https://doi.org/10.11648/j.bio.20190702.12
DO  - 10.11648/j.bio.20190702.12
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
SP  - 34
EP  - 39
PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.20190702.12
AB  - The rapid, pandemic-like, spread of certain noncontagious diseases (NCDs), like (childhood) obesity, type2 diabetes mellitus, particularly in children, autism, Alzheimer diseases, etc. prompted the researches to try to find appropriate explanation for this phenomenon. The well-known association between antibiotic enriched fodder and the weight gain of food animals, through the modification of the gut flora, clearly raises the possibility of similar relationship in human beings as well, which was described in several publications. The role of obesity in the development of diabetes is a well-known also. The antibiotic consumption pattern in the World clearly demonstrated the extensive utilization of the broad spectrum antibiotics, starting about three decades ago, and the appearance of still active degradation products in the environment, which might reenter into humans and animals again, and as the result of the alteration of human microbiome, could induce the pandemic-like NCDs. The yet to be explained rapid increase of prevalence of autism and Alzheimer diseases observed in the past three decades is alarming. According to a CDC survey, the prevalence of autism in the surveyed population was estimated as 16.8 per 1,000 (one in 59) children aged 8 years, which is considered as a 150% increase from the year 2000. The prevalence of Alzheimer’s disease in Europe was estimated at 5.05% (95% CI, 4.73-5.39). Microbiome alterations were observed in both cases and obesity is present in the 30% of autism as well. Putting together the mosaics from relevant publications, it might be concluded that we face the long term side effects of antibiotic consumption/pollution manifesting, through the alteration of microbioms as the pandemic appearance of certain NCDs. The restoration of the “normal” gut flora by fecal microbiota transfer (FMT) might be an option to influence those conditions.
VL  - 7
IS  - 2
ER  -

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