Antimicrobial activities of Carica papaya, Azadirachta indica and Moringa oleifera on Helicobacter pylori isolated from ulcer patients in Ondo State, Nigeria were investigated. Hot water, cold water and two organic solvents (Pet ether and Ethanol) were used for the extraction with the highest yield being the ethanolic extracts of Carica papaya with 17.2%, while cold water extract of both Carica papaya and Azadirachta indica (Neem) extracts had 15.6% and 11.6% respectively. The result shows that the Carica papaya, Azadirachta indica and Moringa oleifera leaves extract had antimicrobial effect on the H. pylori isolated from ulcer patients in Ondo State, Nigeria. Moringa oleifera leaves showed some remarkable effect on H. pylori with the ethanolic extract of Carica papaya being the most potent. In comparison, the ethanolic extract had the highest level of antimicrobial activity than pet ether, cold and hot water extracts. The results of this study showed that leaf extracts of C. papaya, A. indica and M. oleifera had a very high microbial action on the isolates. The results of this study clearly suggest that leaf extracts of C. papaya, A. indica and M. oleifera leaves act as potent growth inhibitor of H. pylori. The emergence of resistance of microorganism to current first line therapy required vigorous research for substitute antimicrobial. The plants used in this study could serve as qualified plants in drug production. There is need for vigorous research to be done on the purification of these crude extracts for the development of new antibiotics to combat the infections caused by these resistant strains.
| DOI | 10.11648/j.ijbmr.20190701.18 |
| Published in | International Journal of Biomedical Materials Research (Volume 7, Issue 1, June 2019) |
| Page(s) | 61-66 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Antimicrobial, Carica Papaya, Azadirachta Indica, Moringa Oleifera, Helicobacter Pylori, Ulcer
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APA Style
Morufu Adesina Bakare, Anthony Kayode Onifade. (2019). Evaluation of Antimicrobial Activities of Carica papaya, Azadirachta indica and Moringa oleifera on Helicobacter Pylori Isolated from Ulcer Patients in Ondo State, Nigeria. International Journal of Biomedical Materials Research, 7(1), 61-66. https://doi.org/10.11648/j.ijbmr.20190701.18
ACS Style
Morufu Adesina Bakare; Anthony Kayode Onifade. Evaluation of Antimicrobial Activities of Carica papaya, Azadirachta indica and Moringa oleifera on Helicobacter Pylori Isolated from Ulcer Patients in Ondo State, Nigeria. Int. J. Biomed. Mater. Res. 2019, 7(1), 61-66. doi: 10.11648/j.ijbmr.20190701.18
AMA Style
Morufu Adesina Bakare, Anthony Kayode Onifade. Evaluation of Antimicrobial Activities of Carica papaya, Azadirachta indica and Moringa oleifera on Helicobacter Pylori Isolated from Ulcer Patients in Ondo State, Nigeria. Int J Biomed Mater Res. 2019;7(1):61-66. doi: 10.11648/j.ijbmr.20190701.18
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Download@article{10.11648/j.ijbmr.20190701.18,
author = {Morufu Adesina Bakare and Anthony Kayode Onifade},
title = {Evaluation of Antimicrobial Activities of Carica papaya, Azadirachta indica and Moringa oleifera on Helicobacter Pylori Isolated from Ulcer Patients in Ondo State, Nigeria},
journal = {International Journal of Biomedical Materials Research},
volume = {7},
number = {1},
pages = {61-66},
doi = {10.11648/j.ijbmr.20190701.18},
url = {https://doi.org/10.11648/j.ijbmr.20190701.18},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbmr.20190701.18},
abstract = {Antimicrobial activities of Carica papaya, Azadirachta indica and Moringa oleifera on Helicobacter pylori isolated from ulcer patients in Ondo State, Nigeria were investigated. Hot water, cold water and two organic solvents (Pet ether and Ethanol) were used for the extraction with the highest yield being the ethanolic extracts of Carica papaya with 17.2%, while cold water extract of both Carica papaya and Azadirachta indica (Neem) extracts had 15.6% and 11.6% respectively. The result shows that the Carica papaya, Azadirachta indica and Moringa oleifera leaves extract had antimicrobial effect on the H. pylori isolated from ulcer patients in Ondo State, Nigeria. Moringa oleifera leaves showed some remarkable effect on H. pylori with the ethanolic extract of Carica papaya being the most potent. In comparison, the ethanolic extract had the highest level of antimicrobial activity than pet ether, cold and hot water extracts. The results of this study showed that leaf extracts of C. papaya, A. indica and M. oleifera had a very high microbial action on the isolates. The results of this study clearly suggest that leaf extracts of C. papaya, A. indica and M. oleifera leaves act as potent growth inhibitor of H. pylori. The emergence of resistance of microorganism to current first line therapy required vigorous research for substitute antimicrobial. The plants used in this study could serve as qualified plants in drug production. There is need for vigorous research to be done on the purification of these crude extracts for the development of new antibiotics to combat the infections caused by these resistant strains.},
year = {2019}
}
TY - JOUR T1 - Evaluation of Antimicrobial Activities of Carica papaya, Azadirachta indica and Moringa oleifera on Helicobacter Pylori Isolated from Ulcer Patients in Ondo State, Nigeria AU - Morufu Adesina Bakare AU - Anthony Kayode Onifade Y1 - 2019/05/23 PY - 2019 N1 - https://doi.org/10.11648/j.ijbmr.20190701.18 DO - 10.11648/j.ijbmr.20190701.18 T2 - International Journal of Biomedical Materials Research JF - International Journal of Biomedical Materials Research JO - International Journal of Biomedical Materials Research SP - 61 EP - 66 PB - Science Publishing Group SN - 2330-7579 UR - https://doi.org/10.11648/j.ijbmr.20190701.18 AB - Antimicrobial activities of Carica papaya, Azadirachta indica and Moringa oleifera on Helicobacter pylori isolated from ulcer patients in Ondo State, Nigeria were investigated. Hot water, cold water and two organic solvents (Pet ether and Ethanol) were used for the extraction with the highest yield being the ethanolic extracts of Carica papaya with 17.2%, while cold water extract of both Carica papaya and Azadirachta indica (Neem) extracts had 15.6% and 11.6% respectively. The result shows that the Carica papaya, Azadirachta indica and Moringa oleifera leaves extract had antimicrobial effect on the H. pylori isolated from ulcer patients in Ondo State, Nigeria. Moringa oleifera leaves showed some remarkable effect on H. pylori with the ethanolic extract of Carica papaya being the most potent. In comparison, the ethanolic extract had the highest level of antimicrobial activity than pet ether, cold and hot water extracts. The results of this study showed that leaf extracts of C. papaya, A. indica and M. oleifera had a very high microbial action on the isolates. The results of this study clearly suggest that leaf extracts of C. papaya, A. indica and M. oleifera leaves act as potent growth inhibitor of H. pylori. The emergence of resistance of microorganism to current first line therapy required vigorous research for substitute antimicrobial. The plants used in this study could serve as qualified plants in drug production. There is need for vigorous research to be done on the purification of these crude extracts for the development of new antibiotics to combat the infections caused by these resistant strains. VL - 7 IS - 1 ER -
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