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The Efficacy and Safety of Integrated Chinese Plus Western Medicine Compared with Western Medicine Alone in the Treatment for Purpuric Nephritis: A Meta-Aalysis

Received: Jan. 09, 2020    Accepted: Jan. 27, 2020    Published: Mar. 10, 2020
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Abstract

Objective: This research is aimed to systematically evaluate the efficacy and safety of Chinese plus Western Medicine treatment for Childhood purpuric nephritis by Meta-analysis, in order to improve the cure rate and reduce adverse reactions of this disease, then provide guidance for clinical medication. Methods: There are six major databases including CNKI, Pubmed, Embase, World Wide Database, Web of science and Science Direct retrieved through the Internet, and the randomized-controlled trials of the combined therapy for Childhood purpuric nephritis published both in Chinese and English from the 1999 to October 2019 were collected. Meta-analysis by R software 3.5.0 was adopted to analyze the effective index and adverse effect. Results: In total 92 papers of randomized-controlled clinical studies were enrolled. HSPN children treated with combined therapy demonstrated a significant increase in total effective rate (RR=1.19; 95%CI (1.16–1.21), P<0.001) when compared with Western medicine alone. Our study also found that Chinese plus Western medicine had an advantage on decreasing 24-hour urine protein (WMD=-0.47; 95%CI (-0.53,-0.41); p<0.001) and urine erythrocyte count (WMD=-8.88; 95%CI (-9.80,-7.96); p<0.001) when compared with Western medicine. Children seemed to benefit more from combined treatment in the adverse effect (RR=0.64; 95%CI (0.46, 0.87); p<0.01). Conclusions: Integrated Chinese plus Western medicine treatment was effective for Childhood purpuric nephritis, which may be a superior alternative for HSPN. Nevertheless, long-term, high-quality and multicenter RCTs are required to make the results more convincing.

DOI 10.11648/j.sjph.20200802.11
Published in Science Journal of Public Health ( Volume 8, Issue 2, March 2020 )
Page(s) 19-35
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Chinese Plus Western Medicine, Childhood Purpuric Nephritis, Efficacy and Safety, Randomized-Controlled Trials, Meta-Analysis

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    Changchun Shi, Meng Peng, Yingying Du, Wenxing Li, Yonghan Hu, et al. (2020). The Efficacy and Safety of Integrated Chinese Plus Western Medicine Compared with Western Medicine Alone in the Treatment for Purpuric Nephritis: A Meta-Aalysis. Science Journal of Public Health, 8(2), 19-35. https://doi.org/10.11648/j.sjph.20200802.11

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    ACS Style

    Changchun Shi; Meng Peng; Yingying Du; Wenxing Li; Yonghan Hu, et al. The Efficacy and Safety of Integrated Chinese Plus Western Medicine Compared with Western Medicine Alone in the Treatment for Purpuric Nephritis: A Meta-Aalysis. Sci. J. Public Health 2020, 8(2), 19-35. doi: 10.11648/j.sjph.20200802.11

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    AMA Style

    Changchun Shi, Meng Peng, Yingying Du, Wenxing Li, Yonghan Hu, et al. The Efficacy and Safety of Integrated Chinese Plus Western Medicine Compared with Western Medicine Alone in the Treatment for Purpuric Nephritis: A Meta-Aalysis. Sci J Public Health. 2020;8(2):19-35. doi: 10.11648/j.sjph.20200802.11

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  • @article{10.11648/j.sjph.20200802.11,
      author = {Changchun Shi and Meng Peng and Yingying Du and Wenxing Li and Yonghan Hu and Tingting Wu},
      title = {The Efficacy and Safety of Integrated Chinese Plus Western Medicine Compared with Western Medicine Alone in the Treatment for Purpuric Nephritis: A Meta-Aalysis},
      journal = {Science Journal of Public Health},
      volume = {8},
      number = {2},
      pages = {19-35},
      doi = {10.11648/j.sjph.20200802.11},
      url = {https://doi.org/10.11648/j.sjph.20200802.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.sjph.20200802.11},
      abstract = {Objective: This research is aimed to systematically evaluate the efficacy and safety of Chinese plus Western Medicine treatment for Childhood purpuric nephritis by Meta-analysis, in order to improve the cure rate and reduce adverse reactions of this disease, then provide guidance for clinical medication. Methods: There are six major databases including CNKI, Pubmed, Embase, World Wide Database, Web of science and Science Direct retrieved through the Internet, and the randomized-controlled trials of the combined therapy for Childhood purpuric nephritis published both in Chinese and English from the 1999 to October 2019 were collected. Meta-analysis by R software 3.5.0 was adopted to analyze the effective index and adverse effect. Results: In total 92 papers of randomized-controlled clinical studies were enrolled. HSPN children treated with combined therapy demonstrated a significant increase in total effective rate (RR=1.19; 95%CI (1.16–1.21), PConclusions: Integrated Chinese plus Western medicine treatment was effective for Childhood purpuric nephritis, which may be a superior alternative for HSPN. Nevertheless, long-term, high-quality and multicenter RCTs are required to make the results more convincing.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - The Efficacy and Safety of Integrated Chinese Plus Western Medicine Compared with Western Medicine Alone in the Treatment for Purpuric Nephritis: A Meta-Aalysis
    AU  - Changchun Shi
    AU  - Meng Peng
    AU  - Yingying Du
    AU  - Wenxing Li
    AU  - Yonghan Hu
    AU  - Tingting Wu
    Y1  - 2020/03/10
    PY  - 2020
    N1  - https://doi.org/10.11648/j.sjph.20200802.11
    DO  - 10.11648/j.sjph.20200802.11
    T2  - Science Journal of Public Health
    JF  - Science Journal of Public Health
    JO  - Science Journal of Public Health
    SP  - 19
    EP  - 35
    PB  - Science Publishing Group
    SN  - 2328-7950
    UR  - https://doi.org/10.11648/j.sjph.20200802.11
    AB  - Objective: This research is aimed to systematically evaluate the efficacy and safety of Chinese plus Western Medicine treatment for Childhood purpuric nephritis by Meta-analysis, in order to improve the cure rate and reduce adverse reactions of this disease, then provide guidance for clinical medication. Methods: There are six major databases including CNKI, Pubmed, Embase, World Wide Database, Web of science and Science Direct retrieved through the Internet, and the randomized-controlled trials of the combined therapy for Childhood purpuric nephritis published both in Chinese and English from the 1999 to October 2019 were collected. Meta-analysis by R software 3.5.0 was adopted to analyze the effective index and adverse effect. Results: In total 92 papers of randomized-controlled clinical studies were enrolled. HSPN children treated with combined therapy demonstrated a significant increase in total effective rate (RR=1.19; 95%CI (1.16–1.21), PConclusions: Integrated Chinese plus Western medicine treatment was effective for Childhood purpuric nephritis, which may be a superior alternative for HSPN. Nevertheless, long-term, high-quality and multicenter RCTs are required to make the results more convincing.
    VL  - 8
    IS  - 2
    ER  - 

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Author Information
  • Department of Health Management, Medical College of Hangzhou Normal University, Hangzhou city, China

  • Department of Health Management, Medical College of Hangzhou Normal University, Hangzhou city, China

  • Department of Health Management, Medical College of Hangzhou Normal University, Hangzhou city, China

  • Department of Health Management, Medical College of Hangzhou Normal University, Hangzhou city, China

  • Department of Health Management, Medical College of Hangzhou Normal University, Hangzhou city, China

  • Department of Health Management, Medical College of Hangzhou Normal University, Hangzhou city, China

  • Section