Oncological Outcomes and Morbidity of Radical Cystectomy for Bladder Cancer: Experience of a Senegalese Centre

Aboubacar Traore; Cyrille Ze Ondo; Alioune Sarr; Babacar Sine; Modou Ndiaye; Abdoulaye Ndiath; Yaya Sow; Boubacar Fall; Babacar Diao; Pape Ameth Fall; Alain Khassim Ndoye; Mamadou Ba

doi:doi:10.11648/j.ijcu.20200401.14

Oncological Outcomes and Morbidity of Radical Cystectomy for Bladder Cancer: Experience of a Senegalese Centre

Aboubacar Traore, Cyrille Ze Ondo, Alioune Sarr, Babacar Sine, Modou Ndiaye, Abdoulaye Ndiath, Yaya Sow, Boubacar Fall, Babacar Diao, Pape Ameth Fall, Alain Khassim Ndoye, Mamadou Ba

Published in International Journal of Clinical Urology (Volume 4, Issue 1)

Received: 5 February 2020 Accepted: 28 February 2020 Published: 10 March 2020

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Abstract

The purpose of this paperwork is to assess the oncological findings and the morbidity rate after complete cystectomy in our department. Patients and methods: We conducted a backward and descriptive study during a 80-month-period range from September 2011 to May 2018, in the Urology Department of Aristide Le Dantec Teaching Hospital standing as a referral structure in our country (Senegal). Results: Nineteen patients were included accounting for 13 men and 6 women corresponding to a sex ratio of 2. The mean age was at 58 years old (extremes range from 32 to 77 years old). Radical cystectomy consisted of an anterior pelvectomy and transileal cutaneous ureterostomy by Bricker approach in 6 women, a radical cystoprostatectomy with transileal cutaneous ureterostomy by Bricker approach in 12 men and a radical cystoprostatectomy followed by Studer orthotopic neobladder in 1 patient. Early post-operative morbidity consisted of one case of parietal suppuration (grade I), two cases of evisceration (grade IIIb), one case of digestive fistula (grade IIIb), and uroperitoneal peritonitis (grade IIIb) secondary to suture loosening of the uretero-ileal anastomosis (which occurred in the patient who had Studer neobladder). This patient died in resuscitation ward after surgical repair of the uretero-iliary anastomosis. Late complications were a case of acute pyelonephritis three months after cystectomy and a case of flanged occlusion. Two patients with urothelial carcinoma had received adjuvant chemotherapy using the M-VAC protocol. After an average follow-up of 15 months we recorded 13 deaths, three patients were lost of sight and three others respectively lived 4 years and 2 months, 5years and 8 months and 6years and 8 months after radical cystectomy. Mean overall survival was 15 months (4.2 to 25.8 months) with a median survival of 6 months. The only patient who had Studer neobladder died one week after cystectomy. The mean overall survival after previous pelvectomy was 17.2 months and that after cystoprostatectomy was 15.18 months. Conclusion: This work highlights the very poor prognosis of bladder cancers in our context linked to the advanced stage of tumours at the time of diagnosis, the rarity of endoscopic equipment essential for the diagnosis, treatment and monitoring of bladder cancers, the frequency of radiochemically resistant squamous cell carcinoma, the unavailability of chemotherapy in urothelial carcinoma to enable multimodal treatment, and the heaviness and complexity of radical cystectomy.

Published in	International Journal of Clinical Urology (Volume 4, Issue 1)
DOI	10.11648/j.ijcu.20200401.14
Page(s)	17-20
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Bladder Cancer, Cystectomy, Morbidity, Oncological Outcomes

References

[1]	Rouprêt M, Neuzillet Y, Masson-Lecomte A. et al. Recommandations en onco-urologie 2016-2018 du CCAFU: Tumeurs de la vessie Prog Urol 2016; 27: Suppl. 1 S67-S92.
[2]	Diao B, Thiam A, Fall B, et al. Les cancers de vessie au Sénégal: particularités Épidémiologiques, cliniques et histologiques. Prog Urol 2008; 18: 445-558.
[3]	Boucher A. Anatomie topographique descriptive et fonctionnelle; Tome 4. L’abdomen, la région rétro-péritonéale, le petit bassin, le périnée, 1991.
[4]	. Benoit G, Giuiliano F. Anatomie chirurgicale et voies d’abords de la vessie –Editions techniques. EMC techniques chirurgicales –urologie-gynécologie. 41160, 1991, 9p.
[5]	Dandekar NP, Tonggaonkar HB, Dalal AV, et al. Partial cystectomy for invasive bladder cancer. J Surg Oncol 1995; 60 (1): 24-29.
[6]	Malavaud B. Complications for Radical Cystectomy. Impact of the American Society of Anesthesiologists Score. Eur Urol 2001; 39: 79-84.
[7]	Cherif M, Chakroun M, Bouzouita A, et al. Caractéristiques épidémiologiques du cancer de la vessie chez la femme en Tunisie. Afr J Urol 2016; 22: 71-75.
[8]	Mitropoulos D, Artibani W, Graefen M, Remzi M, Rouprêt M, Truss M. Reporting and grading of complications after urologic surgical procedures: an ad hoc EAU guidelines panel assessment and recommendations. Eur Urol 2012; 61: 341-349.
[9]	Irani J. Tumeurs urothéliales: épidémiologie du cancer de vessie. Prog Urol 2003; 13: 1207-1208.
[10]	Botto H. Remplacement de vessie après cystectomie radicale pour cancer: expérience de l'hôpital Foch. Mémoires de l'Académie Nationale de Chirurgie 2003; 2 (4): 14-19.
[11]	Lebret T, Herve JM, Lugagne PM, et al. Incidence et prise en charge des complications non urologiques après cystectomie pour cancer. Congrès de l'association française de l'urologie AFU 2001 (référence incomplète).
[12]	Zerbib M, Slama J, Bouchot O. Les dérivations urinaires, techniques chirurgicales 2^ème partie. Prog Urol 2002; 12: 874-890.
[13]	Benchekroun A, El Alj HA, Essayegh H, et al. Tumeurs infiltrantes de vessie: étude rétrospective à propos de 225 cas. Ann Urol 2003; 37: 279-28.
[14]	Lebret T, Hervé JM, Yonneau L, et al. Etude de la survie après cystectomie pour cancer de vessie. A propos de 504 cas. Prog Urol 2000; 10: 553-560.
[15]	Frazier HA, Robertson JE, Dodger RK et al. The value of pathologic factors in predicting cancer-specific survival among patients treated with radical cystectomy for transitional cell carcinoma of the bladder and prostate. Cancer 1993 jun 15; 71 (12): 3993-4001.

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Aboubacar Traore, Cyrille Ze Ondo, Alioune Sarr, Babacar Sine, Modou Ndiaye, et al. (2020). Oncological Outcomes and Morbidity of Radical Cystectomy for Bladder Cancer: Experience of a Senegalese Centre. International Journal of Clinical Urology, 4(1), 17-20. https://doi.org/10.11648/j.ijcu.20200401.14

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ACS Style

Aboubacar Traore; Cyrille Ze Ondo; Alioune Sarr; Babacar Sine; Modou Ndiaye, et al. Oncological Outcomes and Morbidity of Radical Cystectomy for Bladder Cancer: Experience of a Senegalese Centre. Int. J. Clin. Urol. 2020, 4(1), 17-20. doi: 10.11648/j.ijcu.20200401.14

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AMA Style

Aboubacar Traore, Cyrille Ze Ondo, Alioune Sarr, Babacar Sine, Modou Ndiaye, et al. Oncological Outcomes and Morbidity of Radical Cystectomy for Bladder Cancer: Experience of a Senegalese Centre. Int J Clin Urol. 2020;4(1):17-20. doi: 10.11648/j.ijcu.20200401.14

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@article{10.11648/j.ijcu.20200401.14,
  author = {Aboubacar Traore and Cyrille Ze Ondo and Alioune Sarr and Babacar Sine and Modou Ndiaye and Abdoulaye Ndiath and Yaya Sow and Boubacar Fall and Babacar Diao and Pape Ameth Fall and Alain Khassim Ndoye and Mamadou Ba},
  title = {Oncological Outcomes and Morbidity of Radical Cystectomy for Bladder Cancer: Experience of a Senegalese Centre},
  journal = {International Journal of Clinical Urology},
  volume = {4},
  number = {1},
  pages = {17-20},
  doi = {10.11648/j.ijcu.20200401.14},
  url = {https://doi.org/10.11648/j.ijcu.20200401.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcu.20200401.14},
  abstract = {The purpose of this paperwork is to assess the oncological findings and the morbidity rate after complete cystectomy in our department. Patients and methods: We conducted a backward and descriptive study during a 80-month-period range from September 2011 to May 2018, in the Urology Department of Aristide Le Dantec Teaching Hospital standing as a referral structure in our country (Senegal). Results: Nineteen patients were included accounting for 13 men and 6 women corresponding to a sex ratio of 2. The mean age was at 58 years old (extremes range from 32 to 77 years old). Radical cystectomy consisted of an anterior pelvectomy and transileal cutaneous ureterostomy by Bricker approach in 6 women, a radical cystoprostatectomy with transileal cutaneous ureterostomy by Bricker approach in 12 men and a radical cystoprostatectomy followed by Studer orthotopic neobladder in 1 patient. Early post-operative morbidity consisted of one case of parietal suppuration (grade I), two cases of evisceration (grade IIIb), one case of digestive fistula (grade IIIb), and uroperitoneal peritonitis (grade IIIb) secondary to suture loosening of the uretero-ileal anastomosis (which occurred in the patient who had Studer neobladder). This patient died in resuscitation ward after surgical repair of the uretero-iliary anastomosis. Late complications were a case of acute pyelonephritis three months after cystectomy and a case of flanged occlusion. Two patients with urothelial carcinoma had received adjuvant chemotherapy using the M-VAC protocol. After an average follow-up of 15 months we recorded 13 deaths, three patients were lost of sight and three others respectively lived 4 years and 2 months, 5years and 8 months and 6years and 8 months after radical cystectomy. Mean overall survival was 15 months (4.2 to 25.8 months) with a median survival of 6 months. The only patient who had Studer neobladder died one week after cystectomy. The mean overall survival after previous pelvectomy was 17.2 months and that after cystoprostatectomy was 15.18 months. Conclusion: This work highlights the very poor prognosis of bladder cancers in our context linked to the advanced stage of tumours at the time of diagnosis, the rarity of endoscopic equipment essential for the diagnosis, treatment and monitoring of bladder cancers, the frequency of radiochemically resistant squamous cell carcinoma, the unavailability of chemotherapy in urothelial carcinoma to enable multimodal treatment, and the heaviness and complexity of radical cystectomy.},
 year = {2020}
}

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TY  - JOUR
T1  - Oncological Outcomes and Morbidity of Radical Cystectomy for Bladder Cancer: Experience of a Senegalese Centre
AU  - Aboubacar Traore
AU  - Cyrille Ze Ondo
AU  - Alioune Sarr
AU  - Babacar Sine
AU  - Modou Ndiaye
AU  - Abdoulaye Ndiath
AU  - Yaya Sow
AU  - Boubacar Fall
AU  - Babacar Diao
AU  - Pape Ameth Fall
AU  - Alain Khassim Ndoye
AU  - Mamadou Ba
Y1  - 2020/03/10
PY  - 2020
N1  - https://doi.org/10.11648/j.ijcu.20200401.14
DO  - 10.11648/j.ijcu.20200401.14
T2  - International Journal of Clinical Urology
JF  - International Journal of Clinical Urology
JO  - International Journal of Clinical Urology
SP  - 17
EP  - 20
PB  - Science Publishing Group
SN  - 2640-1355
UR  - https://doi.org/10.11648/j.ijcu.20200401.14
AB  - The purpose of this paperwork is to assess the oncological findings and the morbidity rate after complete cystectomy in our department. Patients and methods: We conducted a backward and descriptive study during a 80-month-period range from September 2011 to May 2018, in the Urology Department of Aristide Le Dantec Teaching Hospital standing as a referral structure in our country (Senegal). Results: Nineteen patients were included accounting for 13 men and 6 women corresponding to a sex ratio of 2. The mean age was at 58 years old (extremes range from 32 to 77 years old). Radical cystectomy consisted of an anterior pelvectomy and transileal cutaneous ureterostomy by Bricker approach in 6 women, a radical cystoprostatectomy with transileal cutaneous ureterostomy by Bricker approach in 12 men and a radical cystoprostatectomy followed by Studer orthotopic neobladder in 1 patient. Early post-operative morbidity consisted of one case of parietal suppuration (grade I), two cases of evisceration (grade IIIb), one case of digestive fistula (grade IIIb), and uroperitoneal peritonitis (grade IIIb) secondary to suture loosening of the uretero-ileal anastomosis (which occurred in the patient who had Studer neobladder). This patient died in resuscitation ward after surgical repair of the uretero-iliary anastomosis. Late complications were a case of acute pyelonephritis three months after cystectomy and a case of flanged occlusion. Two patients with urothelial carcinoma had received adjuvant chemotherapy using the M-VAC protocol. After an average follow-up of 15 months we recorded 13 deaths, three patients were lost of sight and three others respectively lived 4 years and 2 months, 5years and 8 months and 6years and 8 months after radical cystectomy. Mean overall survival was 15 months (4.2 to 25.8 months) with a median survival of 6 months. The only patient who had Studer neobladder died one week after cystectomy. The mean overall survival after previous pelvectomy was 17.2 months and that after cystoprostatectomy was 15.18 months. Conclusion: This work highlights the very poor prognosis of bladder cancers in our context linked to the advanced stage of tumours at the time of diagnosis, the rarity of endoscopic equipment essential for the diagnosis, treatment and monitoring of bladder cancers, the frequency of radiochemically resistant squamous cell carcinoma, the unavailability of chemotherapy in urothelial carcinoma to enable multimodal treatment, and the heaviness and complexity of radical cystectomy.
VL  - 4
IS  - 1
ER  -

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Author Information

Aboubacar Traore

Urology-Andrology Department, De la Paix Hospital, Ziguinchor, Senegal
Cyrille Ze Ondo

Urology-Andrology Department, Aristide Le-Dantec Hospital, Dakar, Senegal
Alioune Sarr

Urology-Andrology Department, Aristide Le-Dantec Hospital, Dakar, Senegal
Babacar Sine

Urology-Andrology Department, Aristide Le-Dantec Hospital, Dakar, Senegal
Modou Ndiaye

Urology-Andrology Department, Aristide Le-Dantec Hospital, Dakar, Senegal
Abdoulaye Ndiath

Urology-Andrology Department, Aristide Le-Dantec Hospital, Dakar, Senegal
Yaya Sow

Urology-Andrology Department, Regional Hospital, Saint Louis, Senegal
Boubacar Fall

Urology-Andrology Department, De la Paix Hospital, Ziguinchor, Senegal
Babacar Diao

Urology-Andrology Department, Aristide Le-Dantec Hospital, Dakar, Senegal
Pape Ameth Fall

Urology-Andrology Department, Aristide Le-Dantec Hospital, Dakar, Senegal
Alain Khassim Ndoye

Urology-Andrology Department, Aristide Le-Dantec Hospital, Dakar, Senegal
Mamadou Ba

Urology-Andrology Department, Aristide Le-Dantec Hospital, Dakar, Senegal

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Aboubacar Traore, Cyrille Ze Ondo, Alioune Sarr, Babacar Sine, Modou Ndiaye, et al. (2020). Oncological Outcomes and Morbidity of Radical Cystectomy for Bladder Cancer: Experience of a Senegalese Centre. International Journal of Clinical Urology, 4(1), 17-20. https://doi.org/10.11648/j.ijcu.20200401.14

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ACS Style

Aboubacar Traore; Cyrille Ze Ondo; Alioune Sarr; Babacar Sine; Modou Ndiaye, et al. Oncological Outcomes and Morbidity of Radical Cystectomy for Bladder Cancer: Experience of a Senegalese Centre. Int. J. Clin. Urol. 2020, 4(1), 17-20. doi: 10.11648/j.ijcu.20200401.14

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AMA Style

Aboubacar Traore, Cyrille Ze Ondo, Alioune Sarr, Babacar Sine, Modou Ndiaye, et al. Oncological Outcomes and Morbidity of Radical Cystectomy for Bladder Cancer: Experience of a Senegalese Centre. Int J Clin Urol. 2020;4(1):17-20. doi: 10.11648/j.ijcu.20200401.14

Copy | Download

@article{10.11648/j.ijcu.20200401.14,
  author = {Aboubacar Traore and Cyrille Ze Ondo and Alioune Sarr and Babacar Sine and Modou Ndiaye and Abdoulaye Ndiath and Yaya Sow and Boubacar Fall and Babacar Diao and Pape Ameth Fall and Alain Khassim Ndoye and Mamadou Ba},
  title = {Oncological Outcomes and Morbidity of Radical Cystectomy for Bladder Cancer: Experience of a Senegalese Centre},
  journal = {International Journal of Clinical Urology},
  volume = {4},
  number = {1},
  pages = {17-20},
  doi = {10.11648/j.ijcu.20200401.14},
  url = {https://doi.org/10.11648/j.ijcu.20200401.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcu.20200401.14},
  abstract = {The purpose of this paperwork is to assess the oncological findings and the morbidity rate after complete cystectomy in our department. Patients and methods: We conducted a backward and descriptive study during a 80-month-period range from September 2011 to May 2018, in the Urology Department of Aristide Le Dantec Teaching Hospital standing as a referral structure in our country (Senegal). Results: Nineteen patients were included accounting for 13 men and 6 women corresponding to a sex ratio of 2. The mean age was at 58 years old (extremes range from 32 to 77 years old). Radical cystectomy consisted of an anterior pelvectomy and transileal cutaneous ureterostomy by Bricker approach in 6 women, a radical cystoprostatectomy with transileal cutaneous ureterostomy by Bricker approach in 12 men and a radical cystoprostatectomy followed by Studer orthotopic neobladder in 1 patient. Early post-operative morbidity consisted of one case of parietal suppuration (grade I), two cases of evisceration (grade IIIb), one case of digestive fistula (grade IIIb), and uroperitoneal peritonitis (grade IIIb) secondary to suture loosening of the uretero-ileal anastomosis (which occurred in the patient who had Studer neobladder). This patient died in resuscitation ward after surgical repair of the uretero-iliary anastomosis. Late complications were a case of acute pyelonephritis three months after cystectomy and a case of flanged occlusion. Two patients with urothelial carcinoma had received adjuvant chemotherapy using the M-VAC protocol. After an average follow-up of 15 months we recorded 13 deaths, three patients were lost of sight and three others respectively lived 4 years and 2 months, 5years and 8 months and 6years and 8 months after radical cystectomy. Mean overall survival was 15 months (4.2 to 25.8 months) with a median survival of 6 months. The only patient who had Studer neobladder died one week after cystectomy. The mean overall survival after previous pelvectomy was 17.2 months and that after cystoprostatectomy was 15.18 months. Conclusion: This work highlights the very poor prognosis of bladder cancers in our context linked to the advanced stage of tumours at the time of diagnosis, the rarity of endoscopic equipment essential for the diagnosis, treatment and monitoring of bladder cancers, the frequency of radiochemically resistant squamous cell carcinoma, the unavailability of chemotherapy in urothelial carcinoma to enable multimodal treatment, and the heaviness and complexity of radical cystectomy.},
 year = {2020}
}

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TY  - JOUR
T1  - Oncological Outcomes and Morbidity of Radical Cystectomy for Bladder Cancer: Experience of a Senegalese Centre
AU  - Aboubacar Traore
AU  - Cyrille Ze Ondo
AU  - Alioune Sarr
AU  - Babacar Sine
AU  - Modou Ndiaye
AU  - Abdoulaye Ndiath
AU  - Yaya Sow
AU  - Boubacar Fall
AU  - Babacar Diao
AU  - Pape Ameth Fall
AU  - Alain Khassim Ndoye
AU  - Mamadou Ba
Y1  - 2020/03/10
PY  - 2020
N1  - https://doi.org/10.11648/j.ijcu.20200401.14
DO  - 10.11648/j.ijcu.20200401.14
T2  - International Journal of Clinical Urology
JF  - International Journal of Clinical Urology
JO  - International Journal of Clinical Urology
SP  - 17
EP  - 20
PB  - Science Publishing Group
SN  - 2640-1355
UR  - https://doi.org/10.11648/j.ijcu.20200401.14
AB  - The purpose of this paperwork is to assess the oncological findings and the morbidity rate after complete cystectomy in our department. Patients and methods: We conducted a backward and descriptive study during a 80-month-period range from September 2011 to May 2018, in the Urology Department of Aristide Le Dantec Teaching Hospital standing as a referral structure in our country (Senegal). Results: Nineteen patients were included accounting for 13 men and 6 women corresponding to a sex ratio of 2. The mean age was at 58 years old (extremes range from 32 to 77 years old). Radical cystectomy consisted of an anterior pelvectomy and transileal cutaneous ureterostomy by Bricker approach in 6 women, a radical cystoprostatectomy with transileal cutaneous ureterostomy by Bricker approach in 12 men and a radical cystoprostatectomy followed by Studer orthotopic neobladder in 1 patient. Early post-operative morbidity consisted of one case of parietal suppuration (grade I), two cases of evisceration (grade IIIb), one case of digestive fistula (grade IIIb), and uroperitoneal peritonitis (grade IIIb) secondary to suture loosening of the uretero-ileal anastomosis (which occurred in the patient who had Studer neobladder). This patient died in resuscitation ward after surgical repair of the uretero-iliary anastomosis. Late complications were a case of acute pyelonephritis three months after cystectomy and a case of flanged occlusion. Two patients with urothelial carcinoma had received adjuvant chemotherapy using the M-VAC protocol. After an average follow-up of 15 months we recorded 13 deaths, three patients were lost of sight and three others respectively lived 4 years and 2 months, 5years and 8 months and 6years and 8 months after radical cystectomy. Mean overall survival was 15 months (4.2 to 25.8 months) with a median survival of 6 months. The only patient who had Studer neobladder died one week after cystectomy. The mean overall survival after previous pelvectomy was 17.2 months and that after cystoprostatectomy was 15.18 months. Conclusion: This work highlights the very poor prognosis of bladder cancers in our context linked to the advanced stage of tumours at the time of diagnosis, the rarity of endoscopic equipment essential for the diagnosis, treatment and monitoring of bladder cancers, the frequency of radiochemically resistant squamous cell carcinoma, the unavailability of chemotherapy in urothelial carcinoma to enable multimodal treatment, and the heaviness and complexity of radical cystectomy.
VL  - 4
IS  - 1
ER  -

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