Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria

Jamal Wadi Al Ramahi; Ahmad Al-Abdouh; Nour Hasan; Ghayda Haddad; Mohammad Al Baba; Ahmad Al Aaraj; Mahmoud Fakhri; Lamya Abu Shanab; Belal Harara; Mahmoud Barbarawi

doi:doi:10.11648/j.ijidt.20190403.11

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Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria

Jamal Wadi Al Ramahi, Ahmad Al-Abdouh, Nour Hasan, Ghayda Haddad, Mohammad Al Baba, Ahmad Al Aaraj, Mahmoud Fakhri, Lamya Abu Shanab, Belal Harara, Mahmoud Barbarawi

Received: 26 July 2019 Accepted: 20 August 2019 Published: 6 September 2019

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Abstract

A prospective patient surveillance and analysis in three urban hospitals with the objective of comparing the mortality rates among patients with antimicrobials-sensitive versus -resistant gram-negative bacterial bloodstream infections. The analysis focused on the rates of in-hospital and 28-days mortality. There were 189 patients with BSI, drug-susceptible gram-negative bacteria (DSGNB) 40.7%, multi-drug resistant bacteria (MDRGNB) 42.3% and extensive-drug resistant bacteria (XDRGNB) 16.9%. The mean age, gender, SOFA score on the initial evaluation, APACHE II score, comorbidities, identified bacterial species, and BSI-associated diagnoses were not statistically different except for VAP (P = 0.000) in the XDRGNB infected patients. In-hospital and 28-days mortalities were significantly higher in the XDRGNB-BSI group (P = 0.000), and ICU length of stay (P = 0.000). XDRGNB-BSI was significantly higher in inappropriate and delayed treated patients (P < 0.05). Logistic regression analysis demonstrated no significant interaction for the 28 days mortality neither with the admission diagnoses, the antimicrobial class (except aminoglycosides), the comorbidities (except for solid tumors) (P > 0.05, Nagelkerke R² < 0.4). In conclusion, BSI due to multiple class antimicrobial resistance has higher mortality and ICU length of stay.

DOI	10.11648/j.ijidt.20190403.11
Published in	International Journal of Infectious Diseases and Therapy (Volume 4, Issue 3, September 2019)
Page(s)	33-39
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Multidrug-resistant Bacteria, Extensive Drug-resistant Bacteria, Bloodstream Infection, Appropriate Therapy, ICU Length of Stay

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APA Style

Jamal Wadi Al Ramahi, Ahmad Al-Abdouh, Nour Hasan, Ghayda Haddad, Mohammad Al Baba, et al. (2019). Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria. International Journal of Infectious Diseases and Therapy, 4(3), 33-39. https://doi.org/10.11648/j.ijidt.20190403.11

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ACS Style

Jamal Wadi Al Ramahi; Ahmad Al-Abdouh; Nour Hasan; Ghayda Haddad; Mohammad Al Baba, et al. Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria. Int. J. Infect. Dis. Ther. 2019, 4(3), 33-39. doi: 10.11648/j.ijidt.20190403.11

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AMA Style

Jamal Wadi Al Ramahi, Ahmad Al-Abdouh, Nour Hasan, Ghayda Haddad, Mohammad Al Baba, et al. Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria. Int J Infect Dis Ther. 2019;4(3):33-39. doi: 10.11648/j.ijidt.20190403.11

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@article{10.11648/j.ijidt.20190403.11,
  author = {Jamal Wadi Al Ramahi and Ahmad Al-Abdouh and Nour Hasan and Ghayda Haddad and Mohammad Al Baba and Ahmad Al Aaraj and Mahmoud Fakhri and Lamya Abu Shanab and Belal Harara and Mahmoud Barbarawi},
  title = {Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {4},
  number = {3},
  pages = {33-39},
  doi = {10.11648/j.ijidt.20190403.11},
  url = {https://doi.org/10.11648/j.ijidt.20190403.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20190403.11},
  abstract = {A prospective patient surveillance and analysis in three urban hospitals with the objective of comparing the mortality rates among patients with antimicrobials-sensitive versus -resistant gram-negative bacterial bloodstream infections. The analysis focused on the rates of in-hospital and 28-days mortality. There were 189 patients with BSI, drug-susceptible gram-negative bacteria (DSGNB) 40.7%, multi-drug resistant bacteria (MDRGNB) 42.3% and extensive-drug resistant bacteria (XDRGNB) 16.9%. The mean age, gender, SOFA score on the initial evaluation, APACHE II score, comorbidities, identified bacterial species, and BSI-associated diagnoses were not statistically different except for VAP (P = 0.000) in the XDRGNB infected patients. In-hospital and 28-days mortalities were significantly higher in the XDRGNB-BSI group (P = 0.000), and ICU length of stay (P = 0.000). XDRGNB-BSI was significantly higher in inappropriate and delayed treated patients (P  0.05, Nagelkerke R2 < 0.4). In conclusion, BSI due to multiple class antimicrobial resistance has higher mortality and ICU length of stay.},
 year = {2019}
}

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TY  - JOUR
T1  - Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria
AU  - Jamal Wadi Al Ramahi
AU  - Ahmad Al-Abdouh
AU  - Nour Hasan
AU  - Ghayda Haddad
AU  - Mohammad Al Baba
AU  - Ahmad Al Aaraj
AU  - Mahmoud Fakhri
AU  - Lamya Abu Shanab
AU  - Belal Harara
AU  - Mahmoud Barbarawi
Y1  - 2019/09/06
PY  - 2019
N1  - https://doi.org/10.11648/j.ijidt.20190403.11
DO  - 10.11648/j.ijidt.20190403.11
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 33
EP  - 39
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20190403.11
AB  - A prospective patient surveillance and analysis in three urban hospitals with the objective of comparing the mortality rates among patients with antimicrobials-sensitive versus -resistant gram-negative bacterial bloodstream infections. The analysis focused on the rates of in-hospital and 28-days mortality. There were 189 patients with BSI, drug-susceptible gram-negative bacteria (DSGNB) 40.7%, multi-drug resistant bacteria (MDRGNB) 42.3% and extensive-drug resistant bacteria (XDRGNB) 16.9%. The mean age, gender, SOFA score on the initial evaluation, APACHE II score, comorbidities, identified bacterial species, and BSI-associated diagnoses were not statistically different except for VAP (P = 0.000) in the XDRGNB infected patients. In-hospital and 28-days mortalities were significantly higher in the XDRGNB-BSI group (P = 0.000), and ICU length of stay (P = 0.000). XDRGNB-BSI was significantly higher in inappropriate and delayed treated patients (P  0.05, Nagelkerke R2 < 0.4). In conclusion, BSI due to multiple class antimicrobial resistance has higher mortality and ICU length of stay.
VL  - 4
IS  - 3
ER  -

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Author Information

Jamal Wadi Al Ramahi

Department of Medicine, School of Medicine, University of Jordan, Amman, Jordan
Ahmad Al-Abdouh

Department of Internal Medicine, Al Takhassusi Hospital, Amman, Jordan
Nour Hasan

Department of Pharmacy, Al Khalidi Hospital, Amman, Jordan
Ghayda Haddad

Department of Pharmacy, Al Khalidi Hospital, Amman, Jordan
Mohammad Al Baba

Department of Internal Medicine, Al Takhassusi Hospital, Amman, Jordan
Ahmad Al Aaraj

Department of Internal Medicine, Al Takhassusi Hospital, Amman, Jordan
Mahmoud Fakhri

Department of Medicine, Jordan Hospital, Amman, Jordan
Lamya Abu Shanab

Department of Pharmacy, Jordan Hospital, Amman, Jordan
Belal Harara

Department of Intensive Care Unit, Al Khalidi Hospital, Amman, Jordan
Mahmoud Barbarawi

Department of Internal Medicine, Al Takhassusi Hospital, Amman, Jordan

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APA Style

Jamal Wadi Al Ramahi, Ahmad Al-Abdouh, Nour Hasan, Ghayda Haddad, Mohammad Al Baba, et al. (2019). Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria. International Journal of Infectious Diseases and Therapy, 4(3), 33-39. https://doi.org/10.11648/j.ijidt.20190403.11

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ACS Style

Jamal Wadi Al Ramahi; Ahmad Al-Abdouh; Nour Hasan; Ghayda Haddad; Mohammad Al Baba, et al. Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria. Int. J. Infect. Dis. Ther. 2019, 4(3), 33-39. doi: 10.11648/j.ijidt.20190403.11

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AMA Style

Jamal Wadi Al Ramahi, Ahmad Al-Abdouh, Nour Hasan, Ghayda Haddad, Mohammad Al Baba, et al. Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria. Int J Infect Dis Ther. 2019;4(3):33-39. doi: 10.11648/j.ijidt.20190403.11

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@article{10.11648/j.ijidt.20190403.11,
  author = {Jamal Wadi Al Ramahi and Ahmad Al-Abdouh and Nour Hasan and Ghayda Haddad and Mohammad Al Baba and Ahmad Al Aaraj and Mahmoud Fakhri and Lamya Abu Shanab and Belal Harara and Mahmoud Barbarawi},
  title = {Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {4},
  number = {3},
  pages = {33-39},
  doi = {10.11648/j.ijidt.20190403.11},
  url = {https://doi.org/10.11648/j.ijidt.20190403.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20190403.11},
  abstract = {A prospective patient surveillance and analysis in three urban hospitals with the objective of comparing the mortality rates among patients with antimicrobials-sensitive versus -resistant gram-negative bacterial bloodstream infections. The analysis focused on the rates of in-hospital and 28-days mortality. There were 189 patients with BSI, drug-susceptible gram-negative bacteria (DSGNB) 40.7%, multi-drug resistant bacteria (MDRGNB) 42.3% and extensive-drug resistant bacteria (XDRGNB) 16.9%. The mean age, gender, SOFA score on the initial evaluation, APACHE II score, comorbidities, identified bacterial species, and BSI-associated diagnoses were not statistically different except for VAP (P = 0.000) in the XDRGNB infected patients. In-hospital and 28-days mortalities were significantly higher in the XDRGNB-BSI group (P = 0.000), and ICU length of stay (P = 0.000). XDRGNB-BSI was significantly higher in inappropriate and delayed treated patients (P  0.05, Nagelkerke R2 < 0.4). In conclusion, BSI due to multiple class antimicrobial resistance has higher mortality and ICU length of stay.},
 year = {2019}
}

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TY  - JOUR
T1  - Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria
AU  - Jamal Wadi Al Ramahi
AU  - Ahmad Al-Abdouh
AU  - Nour Hasan
AU  - Ghayda Haddad
AU  - Mohammad Al Baba
AU  - Ahmad Al Aaraj
AU  - Mahmoud Fakhri
AU  - Lamya Abu Shanab
AU  - Belal Harara
AU  - Mahmoud Barbarawi
Y1  - 2019/09/06
PY  - 2019
N1  - https://doi.org/10.11648/j.ijidt.20190403.11
DO  - 10.11648/j.ijidt.20190403.11
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 33
EP  - 39
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20190403.11
AB  - A prospective patient surveillance and analysis in three urban hospitals with the objective of comparing the mortality rates among patients with antimicrobials-sensitive versus -resistant gram-negative bacterial bloodstream infections. The analysis focused on the rates of in-hospital and 28-days mortality. There were 189 patients with BSI, drug-susceptible gram-negative bacteria (DSGNB) 40.7%, multi-drug resistant bacteria (MDRGNB) 42.3% and extensive-drug resistant bacteria (XDRGNB) 16.9%. The mean age, gender, SOFA score on the initial evaluation, APACHE II score, comorbidities, identified bacterial species, and BSI-associated diagnoses were not statistically different except for VAP (P = 0.000) in the XDRGNB infected patients. In-hospital and 28-days mortalities were significantly higher in the XDRGNB-BSI group (P = 0.000), and ICU length of stay (P = 0.000). XDRGNB-BSI was significantly higher in inappropriate and delayed treated patients (P  0.05, Nagelkerke R2 < 0.4). In conclusion, BSI due to multiple class antimicrobial resistance has higher mortality and ICU length of stay.
VL  - 4
IS  - 3
ER  -

Copy | Download