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Case Report: Treating Cryptococcal Meningoencephalitis with Chinese Herbal Medicine Based on Macro Natural Law of Traditional Chinese Medicine

Received: 20 May 2020    Accepted: 8 June 2020    Published: 20 June 2020
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Abstract

Background: Over the past few decades, Expansion, Cryptococcus infection. Has become a worldwide Common fungal infections. Cryptococcus prevention has many difficulties in clinical application. Survivors Neurological sequelae are also common Cryptococcal Meningoencephal, CM. In China, Traditional Chinese Medicine tends to been used for poor fungal treatment or sequelae. Case presentation: We present a 47-year-old patient with cryptococcal encephalitis who’s clinical manifestations are atypical, and it is easy to misdiagnose. The first symptom was headache after tooth extraction, followed by fever. The diagnosis was confirmed 6 months after the onset of the disease. After antifungal treatment for 18 days, Headache and fever not reduced and multiple adverse effects such as impaired internal organs. The use of antifungal therapy has serious adverse reactions and poor treatment effects. When the disease is in critical condition, the modern medical antifungal treatment is ineffective and resistant to help. Using traditional Chinese medicine theory, it acknowledges the harmonious unity between man and nature, instead of looking for better resistance Fungal drugs, but by changing the internal environmental stability of the body, after 5 days of initial treatment, the patient no longer had fever, headache, snore, appetite restored and normal bowel movements, the nervous system function gradually recovers. No fever or headache occurred within 5 months, neurological function gradually recovered, head MRI improved, and cerebrospinal fluid culture was negative. After 7 months, the patient still had no fever, headache, snore, he can take care of himself, normal language expression can be done, farm work at home, one person can do food shopping and cooking, etc., limb muscle strength is normal, muscle tension is not high, No positive neurological examination. Conclusion: Traditional Chinese medicine modalities may be considered for treatment When western medicine treatment of cryptococcal encephalitis is not effective, based on appropriate syndrome pattern assessment.

Published in International Journal of Chinese Medicine (Volume 4, Issue 2)
DOI 10.11648/j.ijcm.20200402.13
Page(s) 27-31
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Cryptococcal Meningoencephalitis, Traditional Chinese Medicine, Chinese Herbs

References
[1] Scriven JE, Graham LM, Schutz C, et al. The CSF immune response in HIV-1-associated cryptococcal meningitis:macrophage activation, correlates of disease severity, and effect of antiretroviral therapy [J]. J Acquir Immune Defic Syndr, 2017, 75: 299-307.
[2] Park BJ, Wannemuehler KA, Marston BJ, et al. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV / AIDS [J]. AIDS, 2009, 23 (4): 525-530.
[3] Husain S, Wagener MM, Singh N. Cryptococcus neoformans infection in organ transplant recipients: variables influencing clinical characteristics and outcome [J]. Emerg Infect Dis, 2001, 7 (3): 375-381.
[4] Oladele RO, Denning DW. Burden of serious fungal infection in Nigeria [J]. West Afr J Med, 2014, 33 (2): 107-114.
[5] Shahapur PR, Bidri RC. Recent trends in the spectrum of opportunistic infections in human immunodeficiency virus infected in-dividuals on antiretroviral therapy in South India [J]. J Nat Sci Biol Med, 2014, 5 (2): 392-396.
[6] Shi M, Mody CH. Fungal infection in the brain: what we learned from intravital imaging [J]. Front immunal, 2016, 7: 292.
[7] Tseng HK, Huang TY, Wu AY, et al. How cryptococcus interacts with the blood-brain barrier [J]. Future Microbiol, 2015, 10 (10): 1669-82.
[8] Kambugu A, Meya DB, Rhein J, et al. Outcomes of cryptococcal meningitis in Uganda before and after the availability of highly active antire-troviral therapy [J]. Clin Infect Dis, 2008, 46 (11): 1694-1701.
[9] Carlson RD, Rolfes MA, Birkenkamp KE, et al. Predictors of neurocognitive outcomes on antiretroviral therapy after cryptococcal meningitis: Aprospective cohort study [J]. Metab Brain Dis, 2014, 29 (2): 269-279.
[10] Barluzzi R, Brozzetti A, Mariucci G, et al. Establishment of pro-tective immunity against cerebral cryptococcosis by means of an avirulent, non melanogenic Cryptococcus neoformans strain [J]. J Neuroimmunol, 2000, 109 (2): 75-86.
[11] Devi SJ, Schneerson R, Egan W, et al. Cryptococcus neoformans serotype A glucuronoxylomannan-protein conjugate vaccines: synthesis, characterization, and immunogenicity [J]. Infect Immun, 1991, 59 (10): 3700-3707.
[12] Zhu Shine. The difference and blend of Chinese and Western medicine [M]. Beijing: People's Medical Publishing House, 2000.124, 255
[13] Xing Yurui Editor. Basic Theory of Traditional Chinese Medicine [M]. Shaanxi: Shaanxi Science and Technology Press, 2005: 1
[14] Man Xi refute. Chinese medicine-a unique science [J]. Zhejiang Journal of Traditional Chinese Medicine, 1980, 15 (11): 33
[15] Sun Guangren. Basic Theory of Chinese Medicine [M]. Beijing: Beijing Chinese Medicine Press, 2007 (1): 46-52.
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  • APA Style

    Bian Wei, Wang Huanqun, Zou Weiwu, Gan Ting. (2020). Case Report: Treating Cryptococcal Meningoencephalitis with Chinese Herbal Medicine Based on Macro Natural Law of Traditional Chinese Medicine. International Journal of Chinese Medicine, 4(2), 27-31. https://doi.org/10.11648/j.ijcm.20200402.13

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    ACS Style

    Bian Wei; Wang Huanqun; Zou Weiwu; Gan Ting. Case Report: Treating Cryptococcal Meningoencephalitis with Chinese Herbal Medicine Based on Macro Natural Law of Traditional Chinese Medicine. Int. J. Chin. Med. 2020, 4(2), 27-31. doi: 10.11648/j.ijcm.20200402.13

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    AMA Style

    Bian Wei, Wang Huanqun, Zou Weiwu, Gan Ting. Case Report: Treating Cryptococcal Meningoencephalitis with Chinese Herbal Medicine Based on Macro Natural Law of Traditional Chinese Medicine. Int J Chin Med. 2020;4(2):27-31. doi: 10.11648/j.ijcm.20200402.13

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  • @article{10.11648/j.ijcm.20200402.13,
      author = {Bian Wei and Wang Huanqun and Zou Weiwu and Gan Ting},
      title = {Case Report: Treating Cryptococcal Meningoencephalitis with Chinese Herbal Medicine Based on Macro Natural Law of Traditional Chinese Medicine},
      journal = {International Journal of Chinese Medicine},
      volume = {4},
      number = {2},
      pages = {27-31},
      doi = {10.11648/j.ijcm.20200402.13},
      url = {https://doi.org/10.11648/j.ijcm.20200402.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20200402.13},
      abstract = {Background: Over the past few decades, Expansion, Cryptococcus infection. Has become a worldwide Common fungal infections. Cryptococcus prevention has many difficulties in clinical application. Survivors Neurological sequelae are also common Cryptococcal Meningoencephal, CM. In China, Traditional Chinese Medicine tends to been used for poor fungal treatment or sequelae. Case presentation: We present a 47-year-old patient with cryptococcal encephalitis who’s clinical manifestations are atypical, and it is easy to misdiagnose. The first symptom was headache after tooth extraction, followed by fever. The diagnosis was confirmed 6 months after the onset of the disease. After antifungal treatment for 18 days, Headache and fever not reduced and multiple adverse effects such as impaired internal organs. The use of antifungal therapy has serious adverse reactions and poor treatment effects. When the disease is in critical condition, the modern medical antifungal treatment is ineffective and resistant to help. Using traditional Chinese medicine theory, it acknowledges the harmonious unity between man and nature, instead of looking for better resistance Fungal drugs, but by changing the internal environmental stability of the body, after 5 days of initial treatment, the patient no longer had fever, headache, snore, appetite restored and normal bowel movements, the nervous system function gradually recovers. No fever or headache occurred within 5 months, neurological function gradually recovered, head MRI improved, and cerebrospinal fluid culture was negative. After 7 months, the patient still had no fever, headache, snore, he can take care of himself, normal language expression can be done, farm work at home, one person can do food shopping and cooking, etc., limb muscle strength is normal, muscle tension is not high, No positive neurological examination. Conclusion: Traditional Chinese medicine modalities may be considered for treatment When western medicine treatment of cryptococcal encephalitis is not effective, based on appropriate syndrome pattern assessment.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Case Report: Treating Cryptococcal Meningoencephalitis with Chinese Herbal Medicine Based on Macro Natural Law of Traditional Chinese Medicine
    AU  - Bian Wei
    AU  - Wang Huanqun
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    AU  - Gan Ting
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    DO  - 10.11648/j.ijcm.20200402.13
    T2  - International Journal of Chinese Medicine
    JF  - International Journal of Chinese Medicine
    JO  - International Journal of Chinese Medicine
    SP  - 27
    EP  - 31
    PB  - Science Publishing Group
    SN  - 2578-9473
    UR  - https://doi.org/10.11648/j.ijcm.20200402.13
    AB  - Background: Over the past few decades, Expansion, Cryptococcus infection. Has become a worldwide Common fungal infections. Cryptococcus prevention has many difficulties in clinical application. Survivors Neurological sequelae are also common Cryptococcal Meningoencephal, CM. In China, Traditional Chinese Medicine tends to been used for poor fungal treatment or sequelae. Case presentation: We present a 47-year-old patient with cryptococcal encephalitis who’s clinical manifestations are atypical, and it is easy to misdiagnose. The first symptom was headache after tooth extraction, followed by fever. The diagnosis was confirmed 6 months after the onset of the disease. After antifungal treatment for 18 days, Headache and fever not reduced and multiple adverse effects such as impaired internal organs. The use of antifungal therapy has serious adverse reactions and poor treatment effects. When the disease is in critical condition, the modern medical antifungal treatment is ineffective and resistant to help. Using traditional Chinese medicine theory, it acknowledges the harmonious unity between man and nature, instead of looking for better resistance Fungal drugs, but by changing the internal environmental stability of the body, after 5 days of initial treatment, the patient no longer had fever, headache, snore, appetite restored and normal bowel movements, the nervous system function gradually recovers. No fever or headache occurred within 5 months, neurological function gradually recovered, head MRI improved, and cerebrospinal fluid culture was negative. After 7 months, the patient still had no fever, headache, snore, he can take care of himself, normal language expression can be done, farm work at home, one person can do food shopping and cooking, etc., limb muscle strength is normal, muscle tension is not high, No positive neurological examination. Conclusion: Traditional Chinese medicine modalities may be considered for treatment When western medicine treatment of cryptococcal encephalitis is not effective, based on appropriate syndrome pattern assessment.
    VL  - 4
    IS  - 2
    ER  - 

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Author Information
  • Department of Rehabilitation, Chongqing Yongchuan Hospital of Traditional Chinese Medicine, Chongqing, China

  • Department of Neurology, Chongqing Yongchuan Hospital of Traditional Chinese Medicine, Chongqing, China

  • Department of Neurology, Chongqing Yongchuan Hospital of Traditional Chinese Medicine, Chongqing, China

  • Department of Neurology, Chongqing Yongchuan Hospital of Traditional Chinese Medicine, Chongqing, China

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