Preparation and Research of Hydrophilic Polyurethane Modified by Folate-Lactose

Liudmyla Kulyk; Iryna Gladyr; Rita Rozhnova; Dmytro Kuliesh; Nataliia Galatenko; Larisa Narazhaiko

doi:doi:10.11648/j.ajpst.20190502.14

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Preparation and Research of Hydrophilic Polyurethane Modified by Folate-Lactose

Liudmyla Kulyk, Iryna Gladyr, Rita Rozhnova, Dmytro Kuliesh, Nataliia Galatenko, Larisa Narazhaiko

Received: 21 May 2019 Accepted: 26 June 2019 Published: 9 July 2019

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Abstract

The biological active polyurethane (PU) based on diisocyanate prepolymer and folate-lactose (FL) was synthesized. Physical, mechanical and thermophysical properties of polymeric films were investigated. It was found that the value of the strength at break and elongation of PU with FL are higher by 83% and 22% than the corresponding physical and mechanical properties of the PU with D-lactose. According to the obtained results, the characteristic viscosity and water absorption of PU with FL are higher by 44% and 34% for the parameters of PU containing D-lactose. It has been established that prepeared PU are single-phase. The glass transition temperature is 247 K for PU with FL and 245 K for PU with D-lactose. At the same time, FL introduction into the polymer matrix causes decreasion of the heat jump value (ΔСр) to 0,1551 J/g(°C) for PU with FL sample and 0,2911 J/g(°C) for PU with D-lactose sample. Biodegradation of synthesized materials was investigated after incubation in physiological solution (0.9% NaCl) and biological medium 199 for 180 days. According to research results, polyurethane, modified by folate-lactose, retains sufficient performance for use within 6 months in conditions close to the human body. Biological activity and biocompatibility of synthesized polyurethane modified with FL were confirmed by tissue culture and histological methods.

DOI	10.11648/j.ajpst.20190502.14
Published in	American Journal of Polymer Science and Technology (Volume 5, Issue 2, June 2019)
Page(s)	63-72
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Folic Acid, Polyurethane, Lactose, Folate-Lactose, Biodegradation, Biocompatibility

References

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[2]	J. A. Braatz, C. L. Kehr. Pat. 4886866 USA, C 08G 18/10. “Contact lenses based on biocompatible polyurethane and polyurea-urethane hydrated polymers”, No. 312.331; appl. 16.02.1989; publ. 12.12.1989.
[3]	Xiangyu Liu, Yuqing Niu, Kevin C. Chen, Shiguo Chen. “Rapid hemostatic and mild polyurethane-urea foam wound dressing for promoting wound healing”, Materials Science and Engineering: C, 2017, Vol. 71, pp. 289-297.
[4]	Gubskij Yu. I. Biological Chemistry: Book / Gubskij Yu. I.. – Kiyv – Ternopil: Ukrmedkniga, - 2000. – 508 p.
[5]	A. K. T. Thulasidasan, A. P. Retnakumari, M. Shankar, V. Vijayakurup, S. Anwar, S. Thankachan, K. S. Pillai, J. J. Pillai, C. D. Nandan, V. V. Alex, T. J. Chirayil, S. Sundaram, G. S. V. Kumar, R. J. Anto (2017). Folic acid conjugation improves the bioavailability and chemosensitizing efficacy of curcumin-encapsulated PLGA-PEG nanoparticles towards paclitaxel chemotherapy. Oncotarget 8 (64), 107374–107389.
[6]	Z. He, J. Huang, Y. Xu, X. Zhang, Y. Teng, C. Huang, Y. Wu, X. Zhang, H. Zhang, W. Sun (2015). Co-delivery of cisplatin and paclitaxel by folic acid conjugated amphiphilic PEG-PLGA copolymer nanoparticles for the treatment of non-small lung cancer. Oncotarget 6 (39), 42150–42168.
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[8]	J. Zhang, S. Rana, R. S. Srivastava, R. D. Misra. On the chemical synthesis and drug delivery response of folate receptor-activeted, polyethylene glycol-functionalized magnetite nanoparties (2008). Acta Biomaterialia 4, 40-48.
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[10]	Qing Liu, Wenjing Guo, Mei Yang, Kejie Wang, Weijun Liu, Fanhong Wu. Release. Behavior of Folic Acid Grafted Hollow Hydroxyapatite as Drug Carrier. Advances in Polymer Technology, Volume 2019, Article ID 9562437, 9 pages.
[11]	O. S. Andrushina, R. A. Roznova, N. A. Galatenko, T. O. Kiselova. The Synthesis of New Polyurethane Ureas with Folic Acid (2010). Polymer Journal (18181724) 32, 84-88.
[12]	N. Galatenko, R. Rozhnova, L. Kulyk, D. Kulesh. The evaluation of biocompatibility and biological activity of composite materials with folate-derivative of ferrocene for medidine (2016). Chemistry, physics and technology of surface 7 (3), 344-353.
[13]	L. V. Kulyk, I. I. Gladyr, R. A. Rozhnova, N. A. Galatenko. The New biological active polyurethane with folate-lactose in own structure: synthesis and properties (2015). Ukrainian Chemical Journal 81 (8), 117-121.
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Liudmyla Kulyk, Iryna Gladyr, Rita Rozhnova, Dmytro Kuliesh, Nataliia Galatenko, et al. (2019). Preparation and Research of Hydrophilic Polyurethane Modified by Folate-Lactose. American Journal of Polymer Science and Technology, 5(2), 63-72. https://doi.org/10.11648/j.ajpst.20190502.14

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ACS Style

Liudmyla Kulyk; Iryna Gladyr; Rita Rozhnova; Dmytro Kuliesh; Nataliia Galatenko, et al. Preparation and Research of Hydrophilic Polyurethane Modified by Folate-Lactose. Am. J. Polym. Sci. Technol. 2019, 5(2), 63-72. doi: 10.11648/j.ajpst.20190502.14

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AMA Style

Liudmyla Kulyk, Iryna Gladyr, Rita Rozhnova, Dmytro Kuliesh, Nataliia Galatenko, et al. Preparation and Research of Hydrophilic Polyurethane Modified by Folate-Lactose. Am J Polym Sci Technol. 2019;5(2):63-72. doi: 10.11648/j.ajpst.20190502.14

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@article{10.11648/j.ajpst.20190502.14,
  author = {Liudmyla Kulyk and Iryna Gladyr and Rita Rozhnova and Dmytro Kuliesh and Nataliia Galatenko and Larisa Narazhaiko},
  title = {Preparation and Research of Hydrophilic Polyurethane Modified by Folate-Lactose},
  journal = {American Journal of Polymer Science and Technology},
  volume = {5},
  number = {2},
  pages = {63-72},
  doi = {10.11648/j.ajpst.20190502.14},
  url = {https://doi.org/10.11648/j.ajpst.20190502.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpst.20190502.14},
  abstract = {The biological active polyurethane (PU) based on diisocyanate prepolymer and folate-lactose (FL) was synthesized. Physical, mechanical and thermophysical properties of polymeric films were investigated. It was found that the value of the strength at break and elongation of PU with FL are higher by 83% and 22% than the corresponding physical and mechanical properties of the PU with D-lactose. According to the obtained results, the characteristic viscosity and water absorption of PU with FL are higher by 44% and 34% for the parameters of PU containing D-lactose. It has been established that prepeared PU are single-phase. The glass transition temperature is 247 K for PU with FL and 245 K for PU with D-lactose. At the same time, FL introduction into the polymer matrix causes decreasion of the heat jump value (ΔСр) to 0,1551 J/g(°C) for PU with FL sample and 0,2911 J/g(°C) for PU with D-lactose sample. Biodegradation of synthesized materials was investigated after incubation in physiological solution (0.9% NaCl) and biological medium 199 for 180 days. According to research results, polyurethane, modified by folate-lactose, retains sufficient performance for use within 6 months in conditions close to the human body. Biological activity and biocompatibility of synthesized polyurethane modified with FL were confirmed by tissue culture and histological methods.},
 year = {2019}
}

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TY  - JOUR
T1  - Preparation and Research of Hydrophilic Polyurethane Modified by Folate-Lactose
AU  - Liudmyla Kulyk
AU  - Iryna Gladyr
AU  - Rita Rozhnova
AU  - Dmytro Kuliesh
AU  - Nataliia Galatenko
AU  - Larisa Narazhaiko
Y1  - 2019/07/09
PY  - 2019
N1  - https://doi.org/10.11648/j.ajpst.20190502.14
DO  - 10.11648/j.ajpst.20190502.14
T2  - American Journal of Polymer Science and Technology
JF  - American Journal of Polymer Science and Technology
JO  - American Journal of Polymer Science and Technology
SP  - 63
EP  - 72
PB  - Science Publishing Group
SN  - 2575-5986
UR  - https://doi.org/10.11648/j.ajpst.20190502.14
AB  - The biological active polyurethane (PU) based on diisocyanate prepolymer and folate-lactose (FL) was synthesized. Physical, mechanical and thermophysical properties of polymeric films were investigated. It was found that the value of the strength at break and elongation of PU with FL are higher by 83% and 22% than the corresponding physical and mechanical properties of the PU with D-lactose. According to the obtained results, the characteristic viscosity and water absorption of PU with FL are higher by 44% and 34% for the parameters of PU containing D-lactose. It has been established that prepeared PU are single-phase. The glass transition temperature is 247 K for PU with FL and 245 K for PU with D-lactose. At the same time, FL introduction into the polymer matrix causes decreasion of the heat jump value (ΔСр) to 0,1551 J/g(°C) for PU with FL sample and 0,2911 J/g(°C) for PU with D-lactose sample. Biodegradation of synthesized materials was investigated after incubation in physiological solution (0.9% NaCl) and biological medium 199 for 180 days. According to research results, polyurethane, modified by folate-lactose, retains sufficient performance for use within 6 months in conditions close to the human body. Biological activity and biocompatibility of synthesized polyurethane modified with FL were confirmed by tissue culture and histological methods.
VL  - 5
IS  - 2
ER  -

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Author Information

Liudmyla Kulyk

Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of National Academy of Science of Ukraine, Kyiv, Ukraine
Iryna Gladyr

Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of National Academy of Science of Ukraine, Kyiv, Ukraine
Rita Rozhnova

Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of National Academy of Science of Ukraine, Kyiv, Ukraine
Dmytro Kuliesh

Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of National Academy of Science of Ukraine, Kyiv, Ukraine
Nataliia Galatenko

Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of National Academy of Science of Ukraine, Kyiv, Ukraine
Larisa Narazhaiko

Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of National Academy of Science of Ukraine, Kyiv, Ukraine

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APA Style

Liudmyla Kulyk, Iryna Gladyr, Rita Rozhnova, Dmytro Kuliesh, Nataliia Galatenko, et al. (2019). Preparation and Research of Hydrophilic Polyurethane Modified by Folate-Lactose. American Journal of Polymer Science and Technology, 5(2), 63-72. https://doi.org/10.11648/j.ajpst.20190502.14

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ACS Style

Liudmyla Kulyk; Iryna Gladyr; Rita Rozhnova; Dmytro Kuliesh; Nataliia Galatenko, et al. Preparation and Research of Hydrophilic Polyurethane Modified by Folate-Lactose. Am. J. Polym. Sci. Technol. 2019, 5(2), 63-72. doi: 10.11648/j.ajpst.20190502.14

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AMA Style

Liudmyla Kulyk, Iryna Gladyr, Rita Rozhnova, Dmytro Kuliesh, Nataliia Galatenko, et al. Preparation and Research of Hydrophilic Polyurethane Modified by Folate-Lactose. Am J Polym Sci Technol. 2019;5(2):63-72. doi: 10.11648/j.ajpst.20190502.14

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@article{10.11648/j.ajpst.20190502.14,
  author = {Liudmyla Kulyk and Iryna Gladyr and Rita Rozhnova and Dmytro Kuliesh and Nataliia Galatenko and Larisa Narazhaiko},
  title = {Preparation and Research of Hydrophilic Polyurethane Modified by Folate-Lactose},
  journal = {American Journal of Polymer Science and Technology},
  volume = {5},
  number = {2},
  pages = {63-72},
  doi = {10.11648/j.ajpst.20190502.14},
  url = {https://doi.org/10.11648/j.ajpst.20190502.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpst.20190502.14},
  abstract = {The biological active polyurethane (PU) based on diisocyanate prepolymer and folate-lactose (FL) was synthesized. Physical, mechanical and thermophysical properties of polymeric films were investigated. It was found that the value of the strength at break and elongation of PU with FL are higher by 83% and 22% than the corresponding physical and mechanical properties of the PU with D-lactose. According to the obtained results, the characteristic viscosity and water absorption of PU with FL are higher by 44% and 34% for the parameters of PU containing D-lactose. It has been established that prepeared PU are single-phase. The glass transition temperature is 247 K for PU with FL and 245 K for PU with D-lactose. At the same time, FL introduction into the polymer matrix causes decreasion of the heat jump value (ΔСр) to 0,1551 J/g(°C) for PU with FL sample and 0,2911 J/g(°C) for PU with D-lactose sample. Biodegradation of synthesized materials was investigated after incubation in physiological solution (0.9% NaCl) and biological medium 199 for 180 days. According to research results, polyurethane, modified by folate-lactose, retains sufficient performance for use within 6 months in conditions close to the human body. Biological activity and biocompatibility of synthesized polyurethane modified with FL were confirmed by tissue culture and histological methods.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Preparation and Research of Hydrophilic Polyurethane Modified by Folate-Lactose
AU  - Liudmyla Kulyk
AU  - Iryna Gladyr
AU  - Rita Rozhnova
AU  - Dmytro Kuliesh
AU  - Nataliia Galatenko
AU  - Larisa Narazhaiko
Y1  - 2019/07/09
PY  - 2019
N1  - https://doi.org/10.11648/j.ajpst.20190502.14
DO  - 10.11648/j.ajpst.20190502.14
T2  - American Journal of Polymer Science and Technology
JF  - American Journal of Polymer Science and Technology
JO  - American Journal of Polymer Science and Technology
SP  - 63
EP  - 72
PB  - Science Publishing Group
SN  - 2575-5986
UR  - https://doi.org/10.11648/j.ajpst.20190502.14
AB  - The biological active polyurethane (PU) based on diisocyanate prepolymer and folate-lactose (FL) was synthesized. Physical, mechanical and thermophysical properties of polymeric films were investigated. It was found that the value of the strength at break and elongation of PU with FL are higher by 83% and 22% than the corresponding physical and mechanical properties of the PU with D-lactose. According to the obtained results, the characteristic viscosity and water absorption of PU with FL are higher by 44% and 34% for the parameters of PU containing D-lactose. It has been established that prepeared PU are single-phase. The glass transition temperature is 247 K for PU with FL and 245 K for PU with D-lactose. At the same time, FL introduction into the polymer matrix causes decreasion of the heat jump value (ΔСр) to 0,1551 J/g(°C) for PU with FL sample and 0,2911 J/g(°C) for PU with D-lactose sample. Biodegradation of synthesized materials was investigated after incubation in physiological solution (0.9% NaCl) and biological medium 199 for 180 days. According to research results, polyurethane, modified by folate-lactose, retains sufficient performance for use within 6 months in conditions close to the human body. Biological activity and biocompatibility of synthesized polyurethane modified with FL were confirmed by tissue culture and histological methods.
VL  - 5
IS  - 2
ER  -

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