Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives

Sirsat Shivraj Balajirao; Jadhav Anilkumar Govindrao; Nilesh B Chavhan

doi:doi:10.11648/j.ijpc.20200601.11

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Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives

Sirsat Shivraj Balajirao, Jadhav Anilkumar Govindrao, Nilesh B Chavhan

Published in International Journal of Pharmacy and Chemistry (Volume 6, Issue 1)

Received: 18 March 2020 Accepted: 1 April 2020 Published: 30 April 2020

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Abstract

Chalcone derivatives were synthesis by the reaction of some 4-nitrobenzaldehyde derivatives with acotophenone then the product obtained E-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one. This product is chalcone is another react with guanidine nitrate. The hetrocyclic derivatives of guanidine nitrate respectively the final product have been characterized by elemental analysis. the product obtained is 1,6 dihydro 6(4-nitrophenyl) 4-phenylpyridine 2-amine. In present report novel pyrimidines were prepared from starting materials chalcone and guanidine nitrate. The resulting compound 1,6-dihydro-6-(4-nitrophenyl)-4 phenylpyrimidin 2 amine (2) was further reacted with 2 bis(methylthio)methylene malononitrile in the presence of catalytic amount of potassium carbonate in DMF under reflux condition that offered novel 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl) 6 phenyl 1H pyrimido[1,2 a]pyrimidine 3 carbonitrile (3). The synthesized compounds were characterized by spectral methods. The compound (3) possesses replaceable methylthio (-SCH₃) group at 2 position. The compound (3) react with various nucleophiles like substituted aromatic amines, aromatic phenols, hetryl amines and active methylene compounds to give 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl)-6-phenyl-1H-pyrimido[1,2-a]pyrimidine-3-carbonitrile –carbonitrile in good yields.

Published in	International Journal of Pharmacy and Chemistry (Volume 6, Issue 1)
DOI	10.11648/j.ijpc.20200601.11
Page(s)	1-5
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Claisen Schmidt Condensation, 2 bis(methylthio)methylene malononitrile Michael Addition Reaction, Pyrimidine

References

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APA Style

Sirsat Shivraj Balajirao, Jadhav Anilkumar Govindrao, Nilesh B Chavhan. (2020). Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives. International Journal of Pharmacy and Chemistry, 6(1), 1-5. https://doi.org/10.11648/j.ijpc.20200601.11

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ACS Style

Sirsat Shivraj Balajirao; Jadhav Anilkumar Govindrao; Nilesh B Chavhan. Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives. Int. J. Pharm. Chem. 2020, 6(1), 1-5. doi: 10.11648/j.ijpc.20200601.11

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AMA Style

Sirsat Shivraj Balajirao, Jadhav Anilkumar Govindrao, Nilesh B Chavhan. Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives. Int J Pharm Chem. 2020;6(1):1-5. doi: 10.11648/j.ijpc.20200601.11

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@article{10.11648/j.ijpc.20200601.11,
  author = {Sirsat Shivraj Balajirao and Jadhav Anilkumar Govindrao and Nilesh B Chavhan},
  title = {Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {6},
  number = {1},
  pages = {1-5},
  doi = {10.11648/j.ijpc.20200601.11},
  url = {https://doi.org/10.11648/j.ijpc.20200601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20200601.11},
  abstract = {Chalcone derivatives were synthesis by the reaction of some 4-nitrobenzaldehyde derivatives with acotophenone then the product obtained E-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one. This product is chalcone is another react with guanidine nitrate. The hetrocyclic derivatives of guanidine nitrate respectively the final product have been characterized by elemental analysis. the product obtained is 1,6 dihydro 6(4-nitrophenyl) 4-phenylpyridine 2-amine. In present report novel pyrimidines were prepared from starting materials chalcone and guanidine nitrate. The resulting compound 1,6-dihydro-6-(4-nitrophenyl)-4 phenylpyrimidin 2 amine (2) was further reacted with 2 bis(methylthio)methylene malononitrile in the presence of catalytic amount of potassium carbonate in DMF under reflux condition that offered novel 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl) 6 phenyl 1H pyrimido[1,2 a]pyrimidine 3 carbonitrile (3). The synthesized compounds were characterized by spectral methods. The compound (3) possesses replaceable methylthio (-SCH3) group at 2 position. The compound (3) react with various nucleophiles like substituted aromatic amines, aromatic phenols, hetryl amines and active methylene compounds to give 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl)-6-phenyl-1H-pyrimido[1,2-a]pyrimidine-3-carbonitrile –carbonitrile in good yields.},
 year = {2020}
}

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TY  - JOUR
T1  - Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives
AU  - Sirsat Shivraj Balajirao
AU  - Jadhav Anilkumar Govindrao
AU  - Nilesh B Chavhan
Y1  - 2020/04/30
PY  - 2020
N1  - https://doi.org/10.11648/j.ijpc.20200601.11
DO  - 10.11648/j.ijpc.20200601.11
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 1
EP  - 5
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20200601.11
AB  - Chalcone derivatives were synthesis by the reaction of some 4-nitrobenzaldehyde derivatives with acotophenone then the product obtained E-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one. This product is chalcone is another react with guanidine nitrate. The hetrocyclic derivatives of guanidine nitrate respectively the final product have been characterized by elemental analysis. the product obtained is 1,6 dihydro 6(4-nitrophenyl) 4-phenylpyridine 2-amine. In present report novel pyrimidines were prepared from starting materials chalcone and guanidine nitrate. The resulting compound 1,6-dihydro-6-(4-nitrophenyl)-4 phenylpyrimidin 2 amine (2) was further reacted with 2 bis(methylthio)methylene malononitrile in the presence of catalytic amount of potassium carbonate in DMF under reflux condition that offered novel 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl) 6 phenyl 1H pyrimido[1,2 a]pyrimidine 3 carbonitrile (3). The synthesized compounds were characterized by spectral methods. The compound (3) possesses replaceable methylthio (-SCH3) group at 2 position. The compound (3) react with various nucleophiles like substituted aromatic amines, aromatic phenols, hetryl amines and active methylene compounds to give 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl)-6-phenyl-1H-pyrimido[1,2-a]pyrimidine-3-carbonitrile –carbonitrile in good yields.
VL  - 6
IS  - 1
ER  -

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Author Information

Sirsat Shivraj Balajirao

P. G. Research Centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded, India
Jadhav Anilkumar Govindrao

P. G. Research Centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded, India
Nilesh B Chavhan

P. G. Research Centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded, India

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APA Style

Sirsat Shivraj Balajirao, Jadhav Anilkumar Govindrao, Nilesh B Chavhan. (2020). Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives. International Journal of Pharmacy and Chemistry, 6(1), 1-5. https://doi.org/10.11648/j.ijpc.20200601.11

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ACS Style

Sirsat Shivraj Balajirao; Jadhav Anilkumar Govindrao; Nilesh B Chavhan. Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives. Int. J. Pharm. Chem. 2020, 6(1), 1-5. doi: 10.11648/j.ijpc.20200601.11

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AMA Style

Sirsat Shivraj Balajirao, Jadhav Anilkumar Govindrao, Nilesh B Chavhan. Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives. Int J Pharm Chem. 2020;6(1):1-5. doi: 10.11648/j.ijpc.20200601.11

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@article{10.11648/j.ijpc.20200601.11,
  author = {Sirsat Shivraj Balajirao and Jadhav Anilkumar Govindrao and Nilesh B Chavhan},
  title = {Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {6},
  number = {1},
  pages = {1-5},
  doi = {10.11648/j.ijpc.20200601.11},
  url = {https://doi.org/10.11648/j.ijpc.20200601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20200601.11},
  abstract = {Chalcone derivatives were synthesis by the reaction of some 4-nitrobenzaldehyde derivatives with acotophenone then the product obtained E-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one. This product is chalcone is another react with guanidine nitrate. The hetrocyclic derivatives of guanidine nitrate respectively the final product have been characterized by elemental analysis. the product obtained is 1,6 dihydro 6(4-nitrophenyl) 4-phenylpyridine 2-amine. In present report novel pyrimidines were prepared from starting materials chalcone and guanidine nitrate. The resulting compound 1,6-dihydro-6-(4-nitrophenyl)-4 phenylpyrimidin 2 amine (2) was further reacted with 2 bis(methylthio)methylene malononitrile in the presence of catalytic amount of potassium carbonate in DMF under reflux condition that offered novel 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl) 6 phenyl 1H pyrimido[1,2 a]pyrimidine 3 carbonitrile (3). The synthesized compounds were characterized by spectral methods. The compound (3) possesses replaceable methylthio (-SCH3) group at 2 position. The compound (3) react with various nucleophiles like substituted aromatic amines, aromatic phenols, hetryl amines and active methylene compounds to give 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl)-6-phenyl-1H-pyrimido[1,2-a]pyrimidine-3-carbonitrile –carbonitrile in good yields.},
 year = {2020}
}

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TY  - JOUR
T1  - Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives
AU  - Sirsat Shivraj Balajirao
AU  - Jadhav Anilkumar Govindrao
AU  - Nilesh B Chavhan
Y1  - 2020/04/30
PY  - 2020
N1  - https://doi.org/10.11648/j.ijpc.20200601.11
DO  - 10.11648/j.ijpc.20200601.11
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 1
EP  - 5
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20200601.11
AB  - Chalcone derivatives were synthesis by the reaction of some 4-nitrobenzaldehyde derivatives with acotophenone then the product obtained E-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one. This product is chalcone is another react with guanidine nitrate. The hetrocyclic derivatives of guanidine nitrate respectively the final product have been characterized by elemental analysis. the product obtained is 1,6 dihydro 6(4-nitrophenyl) 4-phenylpyridine 2-amine. In present report novel pyrimidines were prepared from starting materials chalcone and guanidine nitrate. The resulting compound 1,6-dihydro-6-(4-nitrophenyl)-4 phenylpyrimidin 2 amine (2) was further reacted with 2 bis(methylthio)methylene malononitrile in the presence of catalytic amount of potassium carbonate in DMF under reflux condition that offered novel 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl) 6 phenyl 1H pyrimido[1,2 a]pyrimidine 3 carbonitrile (3). The synthesized compounds were characterized by spectral methods. The compound (3) possesses replaceable methylthio (-SCH3) group at 2 position. The compound (3) react with various nucleophiles like substituted aromatic amines, aromatic phenols, hetryl amines and active methylene compounds to give 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl)-6-phenyl-1H-pyrimido[1,2-a]pyrimidine-3-carbonitrile –carbonitrile in good yields.
VL  - 6
IS  - 1
ER  -

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