American Journal of Heterocyclic Chemistry

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Antibacterial Effects and Synthesized New Derivatives of 4-Hydroxy-Chromen-2-One

Received: Jan. 28, 2019    Accepted: Mar. 21, 2019    Published: Apr. 15, 2019
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Abstract

In present paper, we report the organic syntheses of three compounds exactly 4-hydroxy-chromen-2-one and describe the results of antibacterial activity of purified compounds. Compounds 4-(4-Methoxy-phenylamino)-2-oxo-2H-chromene-3-sulfonyl chloride (a). N-{3-[Diethoxy-(2-hydroxy-phenyl)-methyl]-2-oxo-2H-chromen-4-yl}-acetamide (b), 4-(6-Nitro-benzothiazol-2-ylamino)-2-oxo-2H-chromene-3-carbaldehyde (c), have been synthesized and characterized using melting points, IR spectra, 1H-NMR and 13C-NMR spectra. Our research goal is synthesis novel organic compounds which prove high level of antibacterial activity. The antibacterial activity of synthesized compounds and streptomycin and cefalexine at concentrations of 2mg/ml, 3mg/ml and 5mg/ml, have been evaluated against three strains of bacterial culture; Staphylococcus aureus, E. coli and Bacillus cereus. The compounds show bacteriostatic and bactericidal activity in high level and also synthetized compounds has been characterized using advanced instrumental methods of analysis.

DOI 10.11648/j.ajhc.20190501.13
Published in American Journal of Heterocyclic Chemistry ( Volume 5, Issue 1, March 2019 )
Page(s) 7-10
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Coumarine Derivatives, Antibacterial Activity, IR, 1H-NM, 13C-NMR, Streptomycine

References
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[13] Vyas. KB, Nimavat. KS, Jani. GR, Hathi. MV, Synthesis and microbial activity of coumarin derivatives metal complex: An in vitro evaluation. Orbital, 2009; 1: (183-192). Design, synthesis of novel azo derivatives of benzimidazole as potent antibacterial and anti tubercular agents
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    Aziz Behrami, Florent Dobroshi. (2019). Antibacterial Effects and Synthesized New Derivatives of 4-Hydroxy-Chromen-2-One. American Journal of Heterocyclic Chemistry, 5(1), 7-10. https://doi.org/10.11648/j.ajhc.20190501.13

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    ACS Style

    Aziz Behrami; Florent Dobroshi. Antibacterial Effects and Synthesized New Derivatives of 4-Hydroxy-Chromen-2-One. Am. J. Heterocycl. Chem. 2019, 5(1), 7-10. doi: 10.11648/j.ajhc.20190501.13

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    AMA Style

    Aziz Behrami, Florent Dobroshi. Antibacterial Effects and Synthesized New Derivatives of 4-Hydroxy-Chromen-2-One. Am J Heterocycl Chem. 2019;5(1):7-10. doi: 10.11648/j.ajhc.20190501.13

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  • @article{10.11648/j.ajhc.20190501.13,
      author = {Aziz Behrami and Florent Dobroshi},
      title = {Antibacterial Effects and Synthesized New Derivatives of 4-Hydroxy-Chromen-2-One},
      journal = {American Journal of Heterocyclic Chemistry},
      volume = {5},
      number = {1},
      pages = {7-10},
      doi = {10.11648/j.ajhc.20190501.13},
      url = {https://doi.org/10.11648/j.ajhc.20190501.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajhc.20190501.13},
      abstract = {In present paper, we report the organic syntheses of three compounds exactly 4-hydroxy-chromen-2-one and describe the results of antibacterial activity of purified compounds. Compounds 4-(4-Methoxy-phenylamino)-2-oxo-2H-chromene-3-sulfonyl chloride (a). N-{3-[Diethoxy-(2-hydroxy-phenyl)-methyl]-2-oxo-2H-chromen-4-yl}-acetamide (b), 4-(6-Nitro-benzothiazol-2-ylamino)-2-oxo-2H-chromene-3-carbaldehyde (c), have been synthesized and characterized using melting points, IR spectra, 1H-NMR and 13C-NMR spectra. Our research goal is synthesis novel organic compounds which prove high level of antibacterial activity. The antibacterial activity of synthesized compounds and streptomycin and cefalexine at concentrations of 2mg/ml, 3mg/ml and 5mg/ml, have been evaluated against three strains of bacterial culture; Staphylococcus aureus, E. coli and Bacillus cereus. The compounds show bacteriostatic and bactericidal activity in high level and also synthetized compounds has been characterized using advanced instrumental methods of analysis.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Antibacterial Effects and Synthesized New Derivatives of 4-Hydroxy-Chromen-2-One
    AU  - Aziz Behrami
    AU  - Florent Dobroshi
    Y1  - 2019/04/15
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ajhc.20190501.13
    DO  - 10.11648/j.ajhc.20190501.13
    T2  - American Journal of Heterocyclic Chemistry
    JF  - American Journal of Heterocyclic Chemistry
    JO  - American Journal of Heterocyclic Chemistry
    SP  - 7
    EP  - 10
    PB  - Science Publishing Group
    SN  - 2575-5722
    UR  - https://doi.org/10.11648/j.ajhc.20190501.13
    AB  - In present paper, we report the organic syntheses of three compounds exactly 4-hydroxy-chromen-2-one and describe the results of antibacterial activity of purified compounds. Compounds 4-(4-Methoxy-phenylamino)-2-oxo-2H-chromene-3-sulfonyl chloride (a). N-{3-[Diethoxy-(2-hydroxy-phenyl)-methyl]-2-oxo-2H-chromen-4-yl}-acetamide (b), 4-(6-Nitro-benzothiazol-2-ylamino)-2-oxo-2H-chromene-3-carbaldehyde (c), have been synthesized and characterized using melting points, IR spectra, 1H-NMR and 13C-NMR spectra. Our research goal is synthesis novel organic compounds which prove high level of antibacterial activity. The antibacterial activity of synthesized compounds and streptomycin and cefalexine at concentrations of 2mg/ml, 3mg/ml and 5mg/ml, have been evaluated against three strains of bacterial culture; Staphylococcus aureus, E. coli and Bacillus cereus. The compounds show bacteriostatic and bactericidal activity in high level and also synthetized compounds has been characterized using advanced instrumental methods of analysis.
    VL  - 5
    IS  - 1
    ER  - 

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Author Information
  • Department of Food Technology, University of Mitrovica “Isa Boletini”, Mitrovica, Kosova

  • Department of Food Technology, University of Mitrovica “Isa Boletini”, Mitrovica, Kosova

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