American Journal of Pediatrics

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Post-Streptococcal Syndrome in a 5-Years Old Boy with Sever Vitamin D Deficiency Only Responding to Monoclonal Antibody: First Case Report

Received: Apr. 23, 2018    Accepted: May 16, 2018    Published: Jun. 12, 2018
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Abstract

Despite the reduction in incidence of Group A Streptococcal (GAS) infections in the last few decades its global burden on mortality and morbidity remained significantly high and represent major concerns in many developing countries. These morbidities and mortalities can be serious in immunocompromised individuals. It has been shown for the last two decades that vitamin D plays an important role in the immune system modulation and its deficiency were associated with recurrent and sever infections. Only few literatures were written about the vitamin D deficiency and GAS infections and very scarce about its complications. One of the rarely reported complications of GAS infections is post-streptococcal systemic vasculitis. The association of this complications and the vitamin D deficiency was not reported before. We report for the first time a 5 years old boy presented with sever post-scarlet fever vasculitis with sever vitamin D deficiency, only responded to monoclonal antibody infusion. The presentation was complicated by more than one complications of GAS infection, hence difficult to diagnose initially and found to have sever vitamin D deficiency which we concluded is the causative factor for these complications. On correction of vitamin D level the deranged immunological and other factors causing the vasculitis were corrected subsequent to vitamin D correction. It is therefore recommended to check vitamin D concentration in cases of sever GAS especially in association with its complications such as the systemic vasculitis.

DOI 10.11648/j.ajp.20180402.12
Published in American Journal of Pediatrics ( Volume 4, Issue 2, June 2018 )
Page(s) 25-30
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Streptococcal Infection, Scarlet Fever, Vitamin D Deficiency, Vasculitis

References
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Cite This Article
  • APA Style

    Sam Hassan, Farsheed Zakir, Sameer Sajwani. (2018). Post-Streptococcal Syndrome in a 5-Years Old Boy with Sever Vitamin D Deficiency Only Responding to Monoclonal Antibody: First Case Report. American Journal of Pediatrics, 4(2), 25-30. https://doi.org/10.11648/j.ajp.20180402.12

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    ACS Style

    Sam Hassan; Farsheed Zakir; Sameer Sajwani. Post-Streptococcal Syndrome in a 5-Years Old Boy with Sever Vitamin D Deficiency Only Responding to Monoclonal Antibody: First Case Report. Am. J. Pediatr. 2018, 4(2), 25-30. doi: 10.11648/j.ajp.20180402.12

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    AMA Style

    Sam Hassan, Farsheed Zakir, Sameer Sajwani. Post-Streptococcal Syndrome in a 5-Years Old Boy with Sever Vitamin D Deficiency Only Responding to Monoclonal Antibody: First Case Report. Am J Pediatr. 2018;4(2):25-30. doi: 10.11648/j.ajp.20180402.12

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  • @article{10.11648/j.ajp.20180402.12,
      author = {Sam Hassan and Farsheed Zakir and Sameer Sajwani},
      title = {Post-Streptococcal Syndrome in a 5-Years Old Boy with Sever Vitamin D Deficiency Only Responding to Monoclonal Antibody: First Case Report},
      journal = {American Journal of Pediatrics},
      volume = {4},
      number = {2},
      pages = {25-30},
      doi = {10.11648/j.ajp.20180402.12},
      url = {https://doi.org/10.11648/j.ajp.20180402.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajp.20180402.12},
      abstract = {Despite the reduction in incidence of Group A Streptococcal (GAS) infections in the last few decades its global burden on mortality and morbidity remained significantly high and represent major concerns in many developing countries. These morbidities and mortalities can be serious in immunocompromised individuals. It has been shown for the last two decades that vitamin D plays an important role in the immune system modulation and its deficiency were associated with recurrent and sever infections. Only few literatures were written about the vitamin D deficiency and GAS infections and very scarce about its complications. One of the rarely reported complications of GAS infections is post-streptococcal systemic vasculitis. The association of this complications and the vitamin D deficiency was not reported before. We report for the first time a 5 years old boy presented with sever post-scarlet fever vasculitis with sever vitamin D deficiency, only responded to monoclonal antibody infusion. The presentation was complicated by more than one complications of GAS infection, hence difficult to diagnose initially and found to have sever vitamin D deficiency which we concluded is the causative factor for these complications. On correction of vitamin D level the deranged immunological and other factors causing the vasculitis were corrected subsequent to vitamin D correction. It is therefore recommended to check vitamin D concentration in cases of sever GAS especially in association with its complications such as the systemic vasculitis.},
     year = {2018}
    }
    

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    AU  - Sam Hassan
    AU  - Farsheed Zakir
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    DO  - 10.11648/j.ajp.20180402.12
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
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    AB  - Despite the reduction in incidence of Group A Streptococcal (GAS) infections in the last few decades its global burden on mortality and morbidity remained significantly high and represent major concerns in many developing countries. These morbidities and mortalities can be serious in immunocompromised individuals. It has been shown for the last two decades that vitamin D plays an important role in the immune system modulation and its deficiency were associated with recurrent and sever infections. Only few literatures were written about the vitamin D deficiency and GAS infections and very scarce about its complications. One of the rarely reported complications of GAS infections is post-streptococcal systemic vasculitis. The association of this complications and the vitamin D deficiency was not reported before. We report for the first time a 5 years old boy presented with sever post-scarlet fever vasculitis with sever vitamin D deficiency, only responded to monoclonal antibody infusion. The presentation was complicated by more than one complications of GAS infection, hence difficult to diagnose initially and found to have sever vitamin D deficiency which we concluded is the causative factor for these complications. On correction of vitamin D level the deranged immunological and other factors causing the vasculitis were corrected subsequent to vitamin D correction. It is therefore recommended to check vitamin D concentration in cases of sever GAS especially in association with its complications such as the systemic vasculitis.
    VL  - 4
    IS  - 2
    ER  - 

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Author Information
  • Department of Pediatrics, Mediclinic City Hospital, Dubai, United Arab Emirates

  • Department of Pediatrics, Mediclinic City Hospital, Dubai, United Arab Emirates

  • Department of Pediatrics, Mediclinic City Hospital, Dubai, United Arab Emirates

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