In addition to its classical role in bone metabolism, vitamin D also has an immunomodulatory effects on immune function. Our aim was to determine the relation between serum 25-hydroxy vitamin D(25(OH)D) concentrations in newborns and their mothers with early onset neonatal sepsis (EOS). Also we aim to study the effect of severity of vitamin D deficiency on incidence of EOS. The design comprises a hospital- based case- control study. The study group consisted of 50 newborns with EOS who was admitted to neonatal intensive care unit and their mothers. Controls were 50 healthy newborns of the same age as the study group and their mothers. The study subjects were divided into insufficient, moderate and severe deficiency according to vitamin D level. There is no significant statistical difference between study and control groups in gestational week, birth weight, birth height, head circumference and age. The mean serum 25(OH)D concentrations in the study group newborns were significantly lower than those of the control group (11.58±4.883 ng/ml and 28.78±6.453 ng/ml respectively). The 25(0H)D concentrations of newborns were highly correlated with mothers’ serum in both groups. Severe vitamin D deficiency was significantly more common in the sepsis group. Data shows that 25(OH)D concentrations of the newborns were highly correlated with the level of CRP, duration of hospital stay, and complications caused by sepsis. Our findings suggest that newborns with vitamin D deficiency may have an increased risk of suffering from EOS. Newborns with more vitamin D deficiency were found to have higher CRP levels, a longer hospital stay, and a higher incidence of complications. The strong positive correlation between newborns’ and their mothers’ 25(OH)D concentrations makes that adequate vitamin D supplementation of mothers during pregnancy is of great importance, through a proper ante-natal care, especially in winter months.
| Published in | American Journal of Pediatrics (Volume 6, Issue 1) |
| DOI | 10.11648/j.ajp.20200601.18 |
| Page(s) | 46-51 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Neonatal, Vitamin D, Early Onset Sepsis
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APA Style
Dina Kamal Ali, Iman Abdel Mohsen Shaheen. (2020). The Relation Between Maternal / Neonatal Vitamin D Levels and Early Onset Neonatal Sepsis. American Journal of Pediatrics, 6(1), 46-51. https://doi.org/10.11648/j.ajp.20200601.18
ACS Style
Dina Kamal Ali; Iman Abdel Mohsen Shaheen. The Relation Between Maternal / Neonatal Vitamin D Levels and Early Onset Neonatal Sepsis. Am. J. Pediatr. 2020, 6(1), 46-51. doi: 10.11648/j.ajp.20200601.18
AMA Style
Dina Kamal Ali, Iman Abdel Mohsen Shaheen. The Relation Between Maternal / Neonatal Vitamin D Levels and Early Onset Neonatal Sepsis. Am J Pediatr. 2020;6(1):46-51. doi: 10.11648/j.ajp.20200601.18
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Download@article{10.11648/j.ajp.20200601.18,
author = {Dina Kamal Ali and Iman Abdel Mohsen Shaheen},
title = {The Relation Between Maternal / Neonatal Vitamin D Levels and Early Onset Neonatal Sepsis},
journal = {American Journal of Pediatrics},
volume = {6},
number = {1},
pages = {46-51},
doi = {10.11648/j.ajp.20200601.18},
url = {https://doi.org/10.11648/j.ajp.20200601.18},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200601.18},
abstract = {In addition to its classical role in bone metabolism, vitamin D also has an immunomodulatory effects on immune function. Our aim was to determine the relation between serum 25-hydroxy vitamin D(25(OH)D) concentrations in newborns and their mothers with early onset neonatal sepsis (EOS). Also we aim to study the effect of severity of vitamin D deficiency on incidence of EOS. The design comprises a hospital- based case- control study. The study group consisted of 50 newborns with EOS who was admitted to neonatal intensive care unit and their mothers. Controls were 50 healthy newborns of the same age as the study group and their mothers. The study subjects were divided into insufficient, moderate and severe deficiency according to vitamin D level. There is no significant statistical difference between study and control groups in gestational week, birth weight, birth height, head circumference and age. The mean serum 25(OH)D concentrations in the study group newborns were significantly lower than those of the control group (11.58±4.883 ng/ml and 28.78±6.453 ng/ml respectively). The 25(0H)D concentrations of newborns were highly correlated with mothers’ serum in both groups. Severe vitamin D deficiency was significantly more common in the sepsis group. Data shows that 25(OH)D concentrations of the newborns were highly correlated with the level of CRP, duration of hospital stay, and complications caused by sepsis. Our findings suggest that newborns with vitamin D deficiency may have an increased risk of suffering from EOS. Newborns with more vitamin D deficiency were found to have higher CRP levels, a longer hospital stay, and a higher incidence of complications. The strong positive correlation between newborns’ and their mothers’ 25(OH)D concentrations makes that adequate vitamin D supplementation of mothers during pregnancy is of great importance, through a proper ante-natal care, especially in winter months.},
year = {2020}
}
TY - JOUR T1 - The Relation Between Maternal / Neonatal Vitamin D Levels and Early Onset Neonatal Sepsis AU - Dina Kamal Ali AU - Iman Abdel Mohsen Shaheen Y1 - 2020/02/26 PY - 2020 N1 - https://doi.org/10.11648/j.ajp.20200601.18 DO - 10.11648/j.ajp.20200601.18 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 46 EP - 51 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20200601.18 AB - In addition to its classical role in bone metabolism, vitamin D also has an immunomodulatory effects on immune function. Our aim was to determine the relation between serum 25-hydroxy vitamin D(25(OH)D) concentrations in newborns and their mothers with early onset neonatal sepsis (EOS). Also we aim to study the effect of severity of vitamin D deficiency on incidence of EOS. The design comprises a hospital- based case- control study. The study group consisted of 50 newborns with EOS who was admitted to neonatal intensive care unit and their mothers. Controls were 50 healthy newborns of the same age as the study group and their mothers. The study subjects were divided into insufficient, moderate and severe deficiency according to vitamin D level. There is no significant statistical difference between study and control groups in gestational week, birth weight, birth height, head circumference and age. The mean serum 25(OH)D concentrations in the study group newborns were significantly lower than those of the control group (11.58±4.883 ng/ml and 28.78±6.453 ng/ml respectively). The 25(0H)D concentrations of newborns were highly correlated with mothers’ serum in both groups. Severe vitamin D deficiency was significantly more common in the sepsis group. Data shows that 25(OH)D concentrations of the newborns were highly correlated with the level of CRP, duration of hospital stay, and complications caused by sepsis. Our findings suggest that newborns with vitamin D deficiency may have an increased risk of suffering from EOS. Newborns with more vitamin D deficiency were found to have higher CRP levels, a longer hospital stay, and a higher incidence of complications. The strong positive correlation between newborns’ and their mothers’ 25(OH)D concentrations makes that adequate vitamin D supplementation of mothers during pregnancy is of great importance, through a proper ante-natal care, especially in winter months. VL - 6 IS - 1 ER -
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