Venous Cerebral Infarction Caused by Intake of Hormonal Contraceptives in Adolescents with Congenital Thrombophilia

Putilina Marina; Teplova Nataliya; Dvornikov Anton

doi:doi:10.11648/j.ajp.20200603.15

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Venous Cerebral Infarction Caused by Intake of Hormonal Contraceptives in Adolescents with Congenital Thrombophilia

Putilina Marina, Teplova Nataliya, Dvornikov Anton

Received: 18 April 2020 Accepted: 6 May 2020 Published: 15 May 2020

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Abstract

In recent years, an increase in dysmenorrhea among adolescents has been observed worldwide. Oral contraceptives are used in gynaecological practice to correct this condition. However, the prescription of drugs belonging to this group often misses the risk of developing vascular complications, such as cerebral venous thrombosis and cerebral venous infarction. Due to the growing percentage of patients with congenital genetic mutations, it is relevant and reasonable to consider the risk factors and clinical signs of venous infarction in adolescents. First, it is necessary to exclude congenital thrombophilia, factor V Leiden and prothrombin G20210A gene mutations, and deficiency of proteins C, S and antithrombin. Of particular notice are the young patients and adolescents with complaints of a first-time, intense, poorly treatable headache (or headache in anamnesis), changes in the eye fundus (edematous, hyperemic optic disks; dilated, plethoric veins in the fundus of the eye). In such cases, a thorough medical history is extremely important, including, in particular, detection of an infectious process, traumatic brain injury, venous thrombosis of any localization; the use of drugs (especially hormonal ones) that can provoke the development of a hypercoagulable state; and investigation of the family history. These measures will help to prevent development of a cerebral venous circulation disorder (venous infarction).

DOI	10.11648/j.ajp.20200603.15
Published in	American Journal of Pediatrics (Volume 6, Issue 3, September 2020)
Page(s)	199-206
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Venous Infarction, Thrombophilia, Oral Contraceptives

References

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APA Style

Putilina Marina, Teplova Nataliya, Dvornikov Anton. (2020). Venous Cerebral Infarction Caused by Intake of Hormonal Contraceptives in Adolescents with Congenital Thrombophilia. American Journal of Pediatrics, 6(3), 199-206. https://doi.org/10.11648/j.ajp.20200603.15

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ACS Style

Putilina Marina; Teplova Nataliya; Dvornikov Anton. Venous Cerebral Infarction Caused by Intake of Hormonal Contraceptives in Adolescents with Congenital Thrombophilia. Am. J. Pediatr. 2020, 6(3), 199-206. doi: 10.11648/j.ajp.20200603.15

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AMA Style

Putilina Marina, Teplova Nataliya, Dvornikov Anton. Venous Cerebral Infarction Caused by Intake of Hormonal Contraceptives in Adolescents with Congenital Thrombophilia. Am J Pediatr. 2020;6(3):199-206. doi: 10.11648/j.ajp.20200603.15

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@article{10.11648/j.ajp.20200603.15,
  author = {Putilina Marina and Teplova Nataliya and Dvornikov Anton},
  title = {Venous Cerebral Infarction Caused by Intake of Hormonal Contraceptives in Adolescents with Congenital Thrombophilia},
  journal = {American Journal of Pediatrics},
  volume = {6},
  number = {3},
  pages = {199-206},
  doi = {10.11648/j.ajp.20200603.15},
  url = {https://doi.org/10.11648/j.ajp.20200603.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200603.15},
  abstract = {In recent years, an increase in dysmenorrhea among adolescents has been observed worldwide. Oral contraceptives are used in gynaecological practice to correct this condition. However, the prescription of drugs belonging to this group often misses the risk of developing vascular complications, such as cerebral venous thrombosis and cerebral venous infarction. Due to the growing percentage of patients with congenital genetic mutations, it is relevant and reasonable to consider the risk factors and clinical signs of venous infarction in adolescents. First, it is necessary to exclude congenital thrombophilia, factor V Leiden and prothrombin G20210A gene mutations, and deficiency of proteins C, S and antithrombin. Of particular notice are the young patients and adolescents with complaints of a first-time, intense, poorly treatable headache (or headache in anamnesis), changes in the eye fundus (edematous, hyperemic optic disks; dilated, plethoric veins in the fundus of the eye). In such cases, a thorough medical history is extremely important, including, in particular, detection of an infectious process, traumatic brain injury, venous thrombosis of any localization; the use of drugs (especially hormonal ones) that can provoke the development of a hypercoagulable state; and investigation of the family history. These measures will help to prevent development of a cerebral venous circulation disorder (venous infarction).},
 year = {2020}
}

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TY  - JOUR
T1  - Venous Cerebral Infarction Caused by Intake of Hormonal Contraceptives in Adolescents with Congenital Thrombophilia
AU  - Putilina Marina
AU  - Teplova Nataliya
AU  - Dvornikov Anton
Y1  - 2020/05/15
PY  - 2020
N1  - https://doi.org/10.11648/j.ajp.20200603.15
DO  - 10.11648/j.ajp.20200603.15
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 199
EP  - 206
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20200603.15
AB  - In recent years, an increase in dysmenorrhea among adolescents has been observed worldwide. Oral contraceptives are used in gynaecological practice to correct this condition. However, the prescription of drugs belonging to this group often misses the risk of developing vascular complications, such as cerebral venous thrombosis and cerebral venous infarction. Due to the growing percentage of patients with congenital genetic mutations, it is relevant and reasonable to consider the risk factors and clinical signs of venous infarction in adolescents. First, it is necessary to exclude congenital thrombophilia, factor V Leiden and prothrombin G20210A gene mutations, and deficiency of proteins C, S and antithrombin. Of particular notice are the young patients and adolescents with complaints of a first-time, intense, poorly treatable headache (or headache in anamnesis), changes in the eye fundus (edematous, hyperemic optic disks; dilated, plethoric veins in the fundus of the eye). In such cases, a thorough medical history is extremely important, including, in particular, detection of an infectious process, traumatic brain injury, venous thrombosis of any localization; the use of drugs (especially hormonal ones) that can provoke the development of a hypercoagulable state; and investigation of the family history. These measures will help to prevent development of a cerebral venous circulation disorder (venous infarction).
VL  - 6
IS  - 3
ER  -

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Author Information

Putilina Marina

Department of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
Teplova Nataliya

Department of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
Dvornikov Anton

Department of Dermatology and Venereology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation

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APA Style

Putilina Marina, Teplova Nataliya, Dvornikov Anton. (2020). Venous Cerebral Infarction Caused by Intake of Hormonal Contraceptives in Adolescents with Congenital Thrombophilia. American Journal of Pediatrics, 6(3), 199-206. https://doi.org/10.11648/j.ajp.20200603.15

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ACS Style

Putilina Marina; Teplova Nataliya; Dvornikov Anton. Venous Cerebral Infarction Caused by Intake of Hormonal Contraceptives in Adolescents with Congenital Thrombophilia. Am. J. Pediatr. 2020, 6(3), 199-206. doi: 10.11648/j.ajp.20200603.15

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AMA Style

Putilina Marina, Teplova Nataliya, Dvornikov Anton. Venous Cerebral Infarction Caused by Intake of Hormonal Contraceptives in Adolescents with Congenital Thrombophilia. Am J Pediatr. 2020;6(3):199-206. doi: 10.11648/j.ajp.20200603.15

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@article{10.11648/j.ajp.20200603.15,
  author = {Putilina Marina and Teplova Nataliya and Dvornikov Anton},
  title = {Venous Cerebral Infarction Caused by Intake of Hormonal Contraceptives in Adolescents with Congenital Thrombophilia},
  journal = {American Journal of Pediatrics},
  volume = {6},
  number = {3},
  pages = {199-206},
  doi = {10.11648/j.ajp.20200603.15},
  url = {https://doi.org/10.11648/j.ajp.20200603.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200603.15},
  abstract = {In recent years, an increase in dysmenorrhea among adolescents has been observed worldwide. Oral contraceptives are used in gynaecological practice to correct this condition. However, the prescription of drugs belonging to this group often misses the risk of developing vascular complications, such as cerebral venous thrombosis and cerebral venous infarction. Due to the growing percentage of patients with congenital genetic mutations, it is relevant and reasonable to consider the risk factors and clinical signs of venous infarction in adolescents. First, it is necessary to exclude congenital thrombophilia, factor V Leiden and prothrombin G20210A gene mutations, and deficiency of proteins C, S and antithrombin. Of particular notice are the young patients and adolescents with complaints of a first-time, intense, poorly treatable headache (or headache in anamnesis), changes in the eye fundus (edematous, hyperemic optic disks; dilated, plethoric veins in the fundus of the eye). In such cases, a thorough medical history is extremely important, including, in particular, detection of an infectious process, traumatic brain injury, venous thrombosis of any localization; the use of drugs (especially hormonal ones) that can provoke the development of a hypercoagulable state; and investigation of the family history. These measures will help to prevent development of a cerebral venous circulation disorder (venous infarction).},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Venous Cerebral Infarction Caused by Intake of Hormonal Contraceptives in Adolescents with Congenital Thrombophilia
AU  - Putilina Marina
AU  - Teplova Nataliya
AU  - Dvornikov Anton
Y1  - 2020/05/15
PY  - 2020
N1  - https://doi.org/10.11648/j.ajp.20200603.15
DO  - 10.11648/j.ajp.20200603.15
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 199
EP  - 206
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20200603.15
AB  - In recent years, an increase in dysmenorrhea among adolescents has been observed worldwide. Oral contraceptives are used in gynaecological practice to correct this condition. However, the prescription of drugs belonging to this group often misses the risk of developing vascular complications, such as cerebral venous thrombosis and cerebral venous infarction. Due to the growing percentage of patients with congenital genetic mutations, it is relevant and reasonable to consider the risk factors and clinical signs of venous infarction in adolescents. First, it is necessary to exclude congenital thrombophilia, factor V Leiden and prothrombin G20210A gene mutations, and deficiency of proteins C, S and antithrombin. Of particular notice are the young patients and adolescents with complaints of a first-time, intense, poorly treatable headache (or headache in anamnesis), changes in the eye fundus (edematous, hyperemic optic disks; dilated, plethoric veins in the fundus of the eye). In such cases, a thorough medical history is extremely important, including, in particular, detection of an infectious process, traumatic brain injury, venous thrombosis of any localization; the use of drugs (especially hormonal ones) that can provoke the development of a hypercoagulable state; and investigation of the family history. These measures will help to prevent development of a cerebral venous circulation disorder (venous infarction).
VL  - 6
IS  - 3
ER  -

Copy | Download