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Antibacterial Activity in Pyrimidine Derivatives in Lab, Using Agar Well-diffusion Method - An Update on Novel Research

Received: Nov. 22, 2019    Accepted: Jan. 02, 2020    Published: Feb. 14, 2020
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Abstract

Pyrimidine derivatives have been in use since ages. Pyrimidine derivatives have shown wide range of pharmacological actions. However still many activities haven’t been researched so far. It is because of this reason the derivatives of the pyrimidine compounds was selected for the present study. In the present research work, it is all about the newer compounds being developed, designed, and experimented for their pharmacological actions. The current research shows the antibacterial activity tested in the new compounds designed in the laboratory. The antimicrobial activities were tested using agar plate and well diffusion method was especially selected for the present research work. Complete and proper steps were followed as per the guidelines. All precautions were taken while carrying out research for the derivative compounds in the present study. The designed compound showed effective and positive antibacterial activity present in the compound designed in the laboratory. Activity on both Gram positive and Gram negative microbes was tested, and the outcomes were in affirmation of the derivative compounds to be studied further for their pharmacological activities on both Gram positive and Gram negative microbes, and the outcomes were in affirmation of the derivative compounds to be studied further for their pharmacological activities for the derivative compounds selected in the present study. As a researcher, it is recommended to carry out further research on the same compound and being tested for other pharmacological activities.

DOI 10.11648/j.pst.20190302.12
Published in Pharmaceutical Science and Technology ( Volume 3, Issue 2, December 2019 )
Page(s) 40-47
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Antibacterial Activity, Pyrimidine, Toxicity

References
[1] David, A. Williams, and Thomas, L., 2002. Foye’s principles of medicinal chemistry. Fifth edition, pp. 12-13.
[2] Remington, the science and practice of pharmacy Fifth edition, pp. 458.
[3] Copenhaver, A., and Kleinschmidt, B., 1952 Chemistry of heterocyclic compounds. British patent. Vol. 46. pp. 663, 303.
[4] Singh, H. and Kapoor, V. K., 2003. Medicinal and pharmaceutical chemistry, pp. 29.
[5] Agarwal, O. P., 2002 Organic chemistry, Reaction and Reagent, pp. 735.
[6] Jain, M. K., andSharnevas, S. C., 2006 Organic chemistry. Vol. 22, pp. 997-999.
[7] Sasada, T. Kobayashi, F. Sakai, N. Konakahara, T., 2009. Synthesis of pyrimidine. Organic Letters. Vol. 11, pp. 2161-2164.
[8] Ahmad, O. K. Hill, M. D. Movassaghi, M., 2009. Synthesis of pyrimidine. Journal of Organic Chemistry. Vol. 74, pp. 8460-8463.
[9] Barthakur, M. G. Borthakur, M. Devi, P. Saikia, C. JSaikia,. A. Bora, U. Chetia, A. Boruah, R. C., 2007. Synthesis of pyrazolopyrimidinederivativesSynthetic Organic Chemistry, 223-226.
[10] Movassaghi, M. Hill, M. D., 2006. Synthesis of pyrimidine derivatives. Journal of American Chemical Society. Vol. 128, pp. 14254-14255.
[11] Collins, A. H., 2009. Microbiological methods. London: Butterworth. Vol. 2, pp: 223-227.
[12] Carter, S. J., 1990. Cooper and Gunn’s tutorial pharmacy Delhi: CBS publishers and distributors. Vol. 6, pp. 349.
[13] Jacob, V. Michael, A. 1999 Nutrition Vol. 49, pp. 1-17.
[14] Magaldi, S. Mata-Essayag, C. Capriles, H. D. Collela, M. T. Olaizola, C. 2004. Well diffusion for antifungal susceptibility testing. International Journal of Infectious Diseases. Vol. 8, pp. 39-45.
[15] Buege, J. A. Aust, S. D., 1978. Suppression of fatty acid synthase by dietary polyunsaturated fatty acids is mediated by fat itself, not by peroxidative mechanismJournal of Biochemistry and Molecular Biology. Vol. 30, pp. 302.
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  • APA Style

    Sudha Singh, Shamim Ahmad, Devansh Mehta, Shamsher Alam. (2020). Antibacterial Activity in Pyrimidine Derivatives in Lab, Using Agar Well-diffusion Method - An Update on Novel Research. Pharmaceutical Science and Technology, 3(2), 40-47. https://doi.org/10.11648/j.pst.20190302.12

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    ACS Style

    Sudha Singh; Shamim Ahmad; Devansh Mehta; Shamsher Alam. Antibacterial Activity in Pyrimidine Derivatives in Lab, Using Agar Well-diffusion Method - An Update on Novel Research. Pharm. Sci. Technol. 2020, 3(2), 40-47. doi: 10.11648/j.pst.20190302.12

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    AMA Style

    Sudha Singh, Shamim Ahmad, Devansh Mehta, Shamsher Alam. Antibacterial Activity in Pyrimidine Derivatives in Lab, Using Agar Well-diffusion Method - An Update on Novel Research. Pharm Sci Technol. 2020;3(2):40-47. doi: 10.11648/j.pst.20190302.12

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  • @article{10.11648/j.pst.20190302.12,
      author = {Sudha Singh and Shamim Ahmad and Devansh Mehta and Shamsher Alam},
      title = {Antibacterial Activity in Pyrimidine Derivatives in Lab, Using Agar Well-diffusion Method - An Update on Novel Research},
      journal = {Pharmaceutical Science and Technology},
      volume = {3},
      number = {2},
      pages = {40-47},
      doi = {10.11648/j.pst.20190302.12},
      url = {https://doi.org/10.11648/j.pst.20190302.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.pst.20190302.12},
      abstract = {Pyrimidine derivatives have been in use since ages. Pyrimidine derivatives have shown wide range of pharmacological actions. However still many activities haven’t been researched so far. It is because of this reason the derivatives of the pyrimidine compounds was selected for the present study. In the present research work, it is all about the newer compounds being developed, designed, and experimented for their pharmacological actions. The current research shows the antibacterial activity tested in the new compounds designed in the laboratory. The antimicrobial activities were tested using agar plate and well diffusion method was especially selected for the present research work. Complete and proper steps were followed as per the guidelines. All precautions were taken while carrying out research for the derivative compounds in the present study. The designed compound showed effective and positive antibacterial activity present in the compound designed in the laboratory. Activity on both Gram positive and Gram negative microbes was tested, and the outcomes were in affirmation of the derivative compounds to be studied further for their pharmacological activities on both Gram positive and Gram negative microbes, and the outcomes were in affirmation of the derivative compounds to be studied further for their pharmacological activities for the derivative compounds selected in the present study. As a researcher, it is recommended to carry out further research on the same compound and being tested for other pharmacological activities.},
     year = {2020}
    }
    

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    AU  - Devansh Mehta
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    DO  - 10.11648/j.pst.20190302.12
    T2  - Pharmaceutical Science and Technology
    JF  - Pharmaceutical Science and Technology
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    AB  - Pyrimidine derivatives have been in use since ages. Pyrimidine derivatives have shown wide range of pharmacological actions. However still many activities haven’t been researched so far. It is because of this reason the derivatives of the pyrimidine compounds was selected for the present study. In the present research work, it is all about the newer compounds being developed, designed, and experimented for their pharmacological actions. The current research shows the antibacterial activity tested in the new compounds designed in the laboratory. The antimicrobial activities were tested using agar plate and well diffusion method was especially selected for the present research work. Complete and proper steps were followed as per the guidelines. All precautions were taken while carrying out research for the derivative compounds in the present study. The designed compound showed effective and positive antibacterial activity present in the compound designed in the laboratory. Activity on both Gram positive and Gram negative microbes was tested, and the outcomes were in affirmation of the derivative compounds to be studied further for their pharmacological activities on both Gram positive and Gram negative microbes, and the outcomes were in affirmation of the derivative compounds to be studied further for their pharmacological activities for the derivative compounds selected in the present study. As a researcher, it is recommended to carry out further research on the same compound and being tested for other pharmacological activities.
    VL  - 3
    IS  - 2
    ER  - 

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Author Information
  • Department of Pharmaceutical Technology, Translam Institute of Pharmaceutical Education and Research, Meerut, India

  • Department of Pharmaceutical Technology, Translam Institute of Pharmaceutical Education and Research, Meerut, India

  • Department of Pharmaceutical Technology, Translam Institute of Pharmaceutical Education and Research, Meerut, India

  • Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan Universiy, Jazan, Saudi Arabia

  • Section