European Journal of Preventive Medicine

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Development of a Diet Management Scale for Pediatric Patients with Citrin Deficiency

Received: Mar. 15, 2020    Accepted: Mar. 31, 2020    Published: Apr. 23, 2020
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Abstract

Objective: This study aimed to develop a scale to assess the caregiversability to manage the dietary needs of pediatric patients with citrin deficiency (CD). Methods: 24 experts from 11 hospitals in mainland China participated in the Delphi research. Item analysis was performed on 61 caregivers of CD patients who were enrolled in the testing of the draft scale, and 153 caregivers attended the validity and reliability testing. The initial scale was made according to the suggestions by the 24 experts. Retest reliability method and Cronbach’s α coefficient method were used to evaluate the external and internal reliability of the scale, respectively; the scale validity was evaluated by content validity and construct validity. Results: A consensus was reached by 24 experts after two rounds of investigation, and a preliminary draft of the scale was formed consisting of three dimensions: Special dietary knowledge, Healthy dietary attitude and Dietary behavior. The expert authority coefficient was 0.887, and the Kendall coefficient was 0.201. The final scale Cronbach's alpha coefficient (α = 0.713) showed good internal consistency and balance stability. The retest reliability coefficient of the scale was 0.975, indicating good external stability. The total content validity index (S-CVI) was 0.981, and the content validity index (I-CVI) of each item varied between 0.913 and 1.0. On confirmatory factor analysis, the indicators CMIN/DF, RESAE, PNFI, NFI, TLI, IFI and CFI for the construct validity of the scale were 1.191, 0.053, 0.628, 0.796, 0.940, 0.954, and 0.951, respectively. Conclusion: The scale developed in this paper exhibited promising reliability and validity for the clinicians to evaluate the dietary management ability of the caregivers of pediatric CD patients.

DOI 10.11648/j.ejpm.20200802.12
Published in European Journal of Preventive Medicine ( Volume 8, Issue 2, March 2020 )
Page(s) 16-23
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Scale, Citrin Deficiency, Diet Manage, Caregiver

References
[1] Kobayashi K, Sinasac D, Iijima M, et al. The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein [J]. Nature Genetics, 1999, 22 (2): 159-163.
[2] Song Y Z, Deng M, Chen F P, et al. Genotypic and phenotypic features of citrin deficiency: Five-year experience in a Chinese pediatric center [J]. International Journal of Molecular Medicine, 2011, 28 (1): 33-40.
[3] Fukushima K, Yazaki M, Nakamura M, et al. Conventional Diet Therapy for Hyperammonemia is Risky in the Treatment of Hepatic Encephalopathy Associated with Citrin Deficiency [J]. Internal Medicine, 2010, 49 (3): 243-247.
[4] Imamura Y, Kobayashi K, Shibatou T, et al. Effectiveness of carbohydrate-restricted diet and arginine granules therapy for adult-onset type II citrullinemia: a case report of siblings showing homozygous SLC25A13 mutation with and without the disease [J]. Hepatology Research, 2003, 26 (1): 68-72.
[5] Kimura N, Kubo N, Narumi S et al. Liver Transplantation Versus Conservative Treatment for Adult-Onset Type II Citrullinemia: Our Experience and a Review of the Literature [J]. Transplantation Proceedings, 2013, 45 (9): 3432-3437.
[6] Hayasaka K, Numakura C, Toyota K, et al. Medium-chain triglyceride supplementation under a low-carbohydrate formula is a promising therapy for adult-onset type II citrullinemia [J]. Molecular Genetics and Metabolism Reports, 2014, 1: 42-50.
[7] Saheki T, Kobayashi K, Terashi M, et al. Reduced carbohydrate intake in citrin-deficient subjects [J]. Journal of Inherited Metabolic Disease, 2008, 31 (3): 386-394.
[8] Hayasaka K, Numakura C, Yamka M, et al. Medium-chain triglycerides supplement therapy with a low-carbohydrate formula can supply energy and enhance ammonia detoxification in the hepatocytes of patients with adult–onset type II citrullinemia [J]. Journal of Inherited Metabolic Disease, 2018, 41 (5): 777-784.
[9] Numakura C, Tamiya G, Ueki M, et al. Growth impairment in individuals with citrin deficiency [J]. Journal of Inherited Metabolic Disease, 2019, 42 (3): 501-508.
[10] Ge G. Development and evaluation of pre-diabetes self-management scale, [D]. Jinan University, 2016.
[11] Huang M, Gu Y, Zhang Y X, et al. Development and Evaluation of Evidence and Validity of Evidence-based Nursing Practice Readiness Assessment Scale [J]. Chinese Journal of Evidence-based Pediatr, 2017, 12 (2): 121-125.
[12] Rong Y M, Zhang Y X, Lou J H, et al. Development of patient care and family-centered nursing process scale and its reliability and validity evaluation [J]. Chinese Journal of Evidence-based Pediatr, 2015, 10 (2): 136-141.
[13] Wu M L. Questionnaire statistical analysis practice-SPSS operation and application [M]. Chongqing University Press, 2010: 159-160.
[14] Song Y Z, Zhang Z H, Lin W X, et al. SLC25A13 gene analysis in citrin deficiency: sixteen novel mutations in East Asian patients, and the mutation distribution in a large pediatric cohort in China [J]. PloS ONE, 2013, 8 (9): e74544.
[15] Zhang Z H, Yang ZG, Chen F P, et al. Screening for five prevalent mutations of SLC25A13 gene in Guangdong, China: a molecular epidemiologic survey of citrin deficiency [J]. The Tohoku Journal of Experimental Medicine, 2014, 233 (4): 275-281.
[16] Xu J, Gao M. Analysis of SLC25A13 gene mutations in five infants with neonatal intrahepatic cholestasis caused by citrin deficiency [J]. Chinese journal of medical genetics, 2018, 35 (1): 34-38.
[17] Zeng G. Modern epidemiological methods and application [M]. Beijing Medical University/China Union Medical University Joint Press, 1994: 250-270.
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    Ling Yan, Yuanzong Song, Meng Zhang, Jianwu Qiu, Chong Jiang, et al. (2020). Development of a Diet Management Scale for Pediatric Patients with Citrin Deficiency. European Journal of Preventive Medicine, 8(2), 16-23. https://doi.org/10.11648/j.ejpm.20200802.12

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    ACS Style

    Ling Yan; Yuanzong Song; Meng Zhang; Jianwu Qiu; Chong Jiang, et al. Development of a Diet Management Scale for Pediatric Patients with Citrin Deficiency. Eur. J. Prev. Med. 2020, 8(2), 16-23. doi: 10.11648/j.ejpm.20200802.12

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    AMA Style

    Ling Yan, Yuanzong Song, Meng Zhang, Jianwu Qiu, Chong Jiang, et al. Development of a Diet Management Scale for Pediatric Patients with Citrin Deficiency. Eur J Prev Med. 2020;8(2):16-23. doi: 10.11648/j.ejpm.20200802.12

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  • @article{10.11648/j.ejpm.20200802.12,
      author = {Ling Yan and Yuanzong Song and Meng Zhang and Jianwu Qiu and Chong Jiang and Qingran Lin},
      title = {Development of a Diet Management Scale for Pediatric Patients with Citrin Deficiency},
      journal = {European Journal of Preventive Medicine},
      volume = {8},
      number = {2},
      pages = {16-23},
      doi = {10.11648/j.ejpm.20200802.12},
      url = {https://doi.org/10.11648/j.ejpm.20200802.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ejpm.20200802.12},
      abstract = {Objective: This study aimed to develop a scale to assess the caregiversability to manage the dietary needs of pediatric patients with citrin deficiency (CD). Methods: 24 experts from 11 hospitals in mainland China participated in the Delphi research. Item analysis was performed on 61 caregivers of CD patients who were enrolled in the testing of the draft scale, and 153 caregivers attended the validity and reliability testing. The initial scale was made according to the suggestions by the 24 experts. Retest reliability method and Cronbach’s α coefficient method were used to evaluate the external and internal reliability of the scale, respectively; the scale validity was evaluated by content validity and construct validity. Results: A consensus was reached by 24 experts after two rounds of investigation, and a preliminary draft of the scale was formed consisting of three dimensions: Special dietary knowledge, Healthy dietary attitude and Dietary behavior. The expert authority coefficient was 0.887, and the Kendall coefficient was 0.201. The final scale Cronbach's alpha coefficient (α = 0.713) showed good internal consistency and balance stability. The retest reliability coefficient of the scale was 0.975, indicating good external stability. The total content validity index (S-CVI) was 0.981, and the content validity index (I-CVI) of each item varied between 0.913 and 1.0. On confirmatory factor analysis, the indicators CMIN/DF, RESAE, PNFI, NFI, TLI, IFI and CFI for the construct validity of the scale were 1.191, 0.053, 0.628, 0.796, 0.940, 0.954, and 0.951, respectively. Conclusion: The scale developed in this paper exhibited promising reliability and validity for the clinicians to evaluate the dietary management ability of the caregivers of pediatric CD patients.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Development of a Diet Management Scale for Pediatric Patients with Citrin Deficiency
    AU  - Ling Yan
    AU  - Yuanzong Song
    AU  - Meng Zhang
    AU  - Jianwu Qiu
    AU  - Chong Jiang
    AU  - Qingran Lin
    Y1  - 2020/04/23
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ejpm.20200802.12
    DO  - 10.11648/j.ejpm.20200802.12
    T2  - European Journal of Preventive Medicine
    JF  - European Journal of Preventive Medicine
    JO  - European Journal of Preventive Medicine
    SP  - 16
    EP  - 23
    PB  - Science Publishing Group
    SN  - 2330-8230
    UR  - https://doi.org/10.11648/j.ejpm.20200802.12
    AB  - Objective: This study aimed to develop a scale to assess the caregiversability to manage the dietary needs of pediatric patients with citrin deficiency (CD). Methods: 24 experts from 11 hospitals in mainland China participated in the Delphi research. Item analysis was performed on 61 caregivers of CD patients who were enrolled in the testing of the draft scale, and 153 caregivers attended the validity and reliability testing. The initial scale was made according to the suggestions by the 24 experts. Retest reliability method and Cronbach’s α coefficient method were used to evaluate the external and internal reliability of the scale, respectively; the scale validity was evaluated by content validity and construct validity. Results: A consensus was reached by 24 experts after two rounds of investigation, and a preliminary draft of the scale was formed consisting of three dimensions: Special dietary knowledge, Healthy dietary attitude and Dietary behavior. The expert authority coefficient was 0.887, and the Kendall coefficient was 0.201. The final scale Cronbach's alpha coefficient (α = 0.713) showed good internal consistency and balance stability. The retest reliability coefficient of the scale was 0.975, indicating good external stability. The total content validity index (S-CVI) was 0.981, and the content validity index (I-CVI) of each item varied between 0.913 and 1.0. On confirmatory factor analysis, the indicators CMIN/DF, RESAE, PNFI, NFI, TLI, IFI and CFI for the construct validity of the scale were 1.191, 0.053, 0.628, 0.796, 0.940, 0.954, and 0.951, respectively. Conclusion: The scale developed in this paper exhibited promising reliability and validity for the clinicians to evaluate the dietary management ability of the caregivers of pediatric CD patients.
    VL  - 8
    IS  - 2
    ER  - 

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Author Information
  • Department of Nursing, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Pediatrics, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Nursing, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Pediatrics, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Stomatologist, Nanfang Hospital, Southern Medical University, Guangzhou, China

  • Department of Nursing, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Section