Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population

Weizhong Ji; Shizheng Wu; Qian Hou; Junming Luo

doi:doi:10.11648/j.aap.20180301.16

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Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population

Weizhong Ji, Shizheng Wu, Qian Hou, Junming Luo

Published in Advances in Applied Physiology (Volume 3, Issue 1)

Received: 7 August 2018 Accepted: 27 August 2018 Published: 27 September 2018

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Abstract

To investigate the correlation between ApoE gene polymorphism and cerebral infarction (CI) and cerebral hemorrhage (ICH) in Tibetan patients with cerebrovascular disease, and the distribution of ApoE genotype in Tibetan nationality. We collected 94 patients as the experimental group, which hospitalized in Qinghai Provincial People's Hospital, Guoluozhou People's Hospital and Qinghai University Affiliated Hospital, including 48 cases of cerebral infarction (mean age 61.39 ± 10.48 years); 46 cases of cerebral hemorrhage (mean age 63.17 ± 10.92 years), and 96 healthy Tibetan residents from the physical examination center of Qinghai Provincial People's Hospital as control group. The results showed that in In the Tibetan population, the CI group was the most common in the e3 alleles, with 48.0%, followed by e2 (37.5%) alleles, the rarest of which was e4 (14.6%). The most common one in ICH group were e2 (43.5%), e3 (45.7%) alleles, and the rarest one was e4 (10.9%). e3 was the most common allele in patients with Tibetan cerebrovascular disease. In the normal control group, e2 (49.0%) was the most common alleles, followed by e4 (33.3%), and e3 (17.7%). e3 allele may be a predisposing factor for cerebrovascular disease in Tibetan population. In Tibetan population, the majority alleles of ApoE were heterozygous E2/E3 and E2/E4, suggesting that hypoxia environment may be beneficial. The TG values in Tibetan populations varied among different alleles, suggesting that different alleles may influence lipid metabolism.

Published in	Advances in Applied Physiology (Volume 3, Issue 1)
DOI	10.11648/j.aap.20180301.16
Page(s)	38-43
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Apolipoprotein E, Polymorphism, Cerebrovascular Disease

References

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APA Style

Weizhong Ji, Shizheng Wu, Qian Hou, Junming Luo. (2018). Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population. Advances in Applied Physiology, 3(1), 38-43. https://doi.org/10.11648/j.aap.20180301.16

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ACS Style

Weizhong Ji; Shizheng Wu; Qian Hou; Junming Luo. Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population. Adv. Appl. Physiol. 2018, 3(1), 38-43. doi: 10.11648/j.aap.20180301.16

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AMA Style

Weizhong Ji, Shizheng Wu, Qian Hou, Junming Luo. Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population. Adv Appl Physiol. 2018;3(1):38-43. doi: 10.11648/j.aap.20180301.16

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@article{10.11648/j.aap.20180301.16,
  author = {Weizhong Ji and Shizheng Wu and Qian Hou and Junming Luo},
  title = {Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population},
  journal = {Advances in Applied Physiology},
  volume = {3},
  number = {1},
  pages = {38-43},
  doi = {10.11648/j.aap.20180301.16},
  url = {https://doi.org/10.11648/j.aap.20180301.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.aap.20180301.16},
  abstract = {To investigate the correlation between ApoE gene polymorphism and cerebral infarction (CI) and cerebral hemorrhage (ICH) in Tibetan patients with cerebrovascular disease, and the distribution of ApoE genotype in Tibetan nationality. We collected 94 patients as the experimental group, which hospitalized in Qinghai Provincial People's Hospital, Guoluozhou People's Hospital and Qinghai University Affiliated Hospital, including 48 cases of cerebral infarction (mean age 61.39 ± 10.48 years); 46 cases of cerebral hemorrhage (mean age 63.17 ± 10.92 years), and 96 healthy Tibetan residents from the physical examination center of Qinghai Provincial People's Hospital as control group. The results showed that in In the Tibetan population, the CI group was the most common in the e3 alleles, with 48.0%, followed by e2 (37.5%) alleles, the rarest of which was e4 (14.6%). The most common one in ICH group were e2 (43.5%), e3 (45.7%) alleles, and the rarest one was e4 (10.9%). e3 was the most common allele in patients with Tibetan cerebrovascular disease. In the normal control group, e2 (49.0%) was the most common alleles, followed by e4 (33.3%), and e3 (17.7%). e3 allele may be a predisposing factor for cerebrovascular disease in Tibetan population. In Tibetan population, the majority alleles of ApoE were heterozygous E2/E3 and E2/E4, suggesting that hypoxia environment may be beneficial. The TG values in Tibetan populations varied among different alleles, suggesting that different alleles may influence lipid metabolism.},
 year = {2018}
}

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TY  - JOUR
T1  - Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population
AU  - Weizhong Ji
AU  - Shizheng Wu
AU  - Qian Hou
AU  - Junming Luo
Y1  - 2018/09/27
PY  - 2018
N1  - https://doi.org/10.11648/j.aap.20180301.16
DO  - 10.11648/j.aap.20180301.16
T2  - Advances in Applied Physiology
JF  - Advances in Applied Physiology
JO  - Advances in Applied Physiology
SP  - 38
EP  - 43
PB  - Science Publishing Group
SN  - 2471-9714
UR  - https://doi.org/10.11648/j.aap.20180301.16
AB  - To investigate the correlation between ApoE gene polymorphism and cerebral infarction (CI) and cerebral hemorrhage (ICH) in Tibetan patients with cerebrovascular disease, and the distribution of ApoE genotype in Tibetan nationality. We collected 94 patients as the experimental group, which hospitalized in Qinghai Provincial People's Hospital, Guoluozhou People's Hospital and Qinghai University Affiliated Hospital, including 48 cases of cerebral infarction (mean age 61.39 ± 10.48 years); 46 cases of cerebral hemorrhage (mean age 63.17 ± 10.92 years), and 96 healthy Tibetan residents from the physical examination center of Qinghai Provincial People's Hospital as control group. The results showed that in In the Tibetan population, the CI group was the most common in the e3 alleles, with 48.0%, followed by e2 (37.5%) alleles, the rarest of which was e4 (14.6%). The most common one in ICH group were e2 (43.5%), e3 (45.7%) alleles, and the rarest one was e4 (10.9%). e3 was the most common allele in patients with Tibetan cerebrovascular disease. In the normal control group, e2 (49.0%) was the most common alleles, followed by e4 (33.3%), and e3 (17.7%). e3 allele may be a predisposing factor for cerebrovascular disease in Tibetan population. In Tibetan population, the majority alleles of ApoE were heterozygous E2/E3 and E2/E4, suggesting that hypoxia environment may be beneficial. The TG values in Tibetan populations varied among different alleles, suggesting that different alleles may influence lipid metabolism.
VL  - 3
IS  - 1
ER  -

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Author Information

Weizhong Ji

Department of Neurology, Qinghai Provincial People’s Hospital, Xining, P. R. China
Shizheng Wu

Department of Neurology, Qinghai Provincial People’s Hospital, Xining, P. R. China
Qian Hou

Department of Neurology, Qinghai Provincial People’s Hospital, Xining, P. R. China
Junming Luo

Department of Pathology, Qinghai Provincial People’s Hospital, Xining, P. R. China

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APA Style

Weizhong Ji, Shizheng Wu, Qian Hou, Junming Luo. (2018). Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population. Advances in Applied Physiology, 3(1), 38-43. https://doi.org/10.11648/j.aap.20180301.16

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ACS Style

Weizhong Ji; Shizheng Wu; Qian Hou; Junming Luo. Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population. Adv. Appl. Physiol. 2018, 3(1), 38-43. doi: 10.11648/j.aap.20180301.16

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AMA Style

Weizhong Ji, Shizheng Wu, Qian Hou, Junming Luo. Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population. Adv Appl Physiol. 2018;3(1):38-43. doi: 10.11648/j.aap.20180301.16

Copy | Download

@article{10.11648/j.aap.20180301.16,
  author = {Weizhong Ji and Shizheng Wu and Qian Hou and Junming Luo},
  title = {Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population},
  journal = {Advances in Applied Physiology},
  volume = {3},
  number = {1},
  pages = {38-43},
  doi = {10.11648/j.aap.20180301.16},
  url = {https://doi.org/10.11648/j.aap.20180301.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.aap.20180301.16},
  abstract = {To investigate the correlation between ApoE gene polymorphism and cerebral infarction (CI) and cerebral hemorrhage (ICH) in Tibetan patients with cerebrovascular disease, and the distribution of ApoE genotype in Tibetan nationality. We collected 94 patients as the experimental group, which hospitalized in Qinghai Provincial People's Hospital, Guoluozhou People's Hospital and Qinghai University Affiliated Hospital, including 48 cases of cerebral infarction (mean age 61.39 ± 10.48 years); 46 cases of cerebral hemorrhage (mean age 63.17 ± 10.92 years), and 96 healthy Tibetan residents from the physical examination center of Qinghai Provincial People's Hospital as control group. The results showed that in In the Tibetan population, the CI group was the most common in the e3 alleles, with 48.0%, followed by e2 (37.5%) alleles, the rarest of which was e4 (14.6%). The most common one in ICH group were e2 (43.5%), e3 (45.7%) alleles, and the rarest one was e4 (10.9%). e3 was the most common allele in patients with Tibetan cerebrovascular disease. In the normal control group, e2 (49.0%) was the most common alleles, followed by e4 (33.3%), and e3 (17.7%). e3 allele may be a predisposing factor for cerebrovascular disease in Tibetan population. In Tibetan population, the majority alleles of ApoE were heterozygous E2/E3 and E2/E4, suggesting that hypoxia environment may be beneficial. The TG values in Tibetan populations varied among different alleles, suggesting that different alleles may influence lipid metabolism.},
 year = {2018}
}

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TY  - JOUR
T1  - Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population
AU  - Weizhong Ji
AU  - Shizheng Wu
AU  - Qian Hou
AU  - Junming Luo
Y1  - 2018/09/27
PY  - 2018
N1  - https://doi.org/10.11648/j.aap.20180301.16
DO  - 10.11648/j.aap.20180301.16
T2  - Advances in Applied Physiology
JF  - Advances in Applied Physiology
JO  - Advances in Applied Physiology
SP  - 38
EP  - 43
PB  - Science Publishing Group
SN  - 2471-9714
UR  - https://doi.org/10.11648/j.aap.20180301.16
AB  - To investigate the correlation between ApoE gene polymorphism and cerebral infarction (CI) and cerebral hemorrhage (ICH) in Tibetan patients with cerebrovascular disease, and the distribution of ApoE genotype in Tibetan nationality. We collected 94 patients as the experimental group, which hospitalized in Qinghai Provincial People's Hospital, Guoluozhou People's Hospital and Qinghai University Affiliated Hospital, including 48 cases of cerebral infarction (mean age 61.39 ± 10.48 years); 46 cases of cerebral hemorrhage (mean age 63.17 ± 10.92 years), and 96 healthy Tibetan residents from the physical examination center of Qinghai Provincial People's Hospital as control group. The results showed that in In the Tibetan population, the CI group was the most common in the e3 alleles, with 48.0%, followed by e2 (37.5%) alleles, the rarest of which was e4 (14.6%). The most common one in ICH group were e2 (43.5%), e3 (45.7%) alleles, and the rarest one was e4 (10.9%). e3 was the most common allele in patients with Tibetan cerebrovascular disease. In the normal control group, e2 (49.0%) was the most common alleles, followed by e4 (33.3%), and e3 (17.7%). e3 allele may be a predisposing factor for cerebrovascular disease in Tibetan population. In Tibetan population, the majority alleles of ApoE were heterozygous E2/E3 and E2/E4, suggesting that hypoxia environment may be beneficial. The TG values in Tibetan populations varied among different alleles, suggesting that different alleles may influence lipid metabolism.
VL  - 3
IS  - 1
ER  -

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