The experiment goal was the investigation of thyme (T), celery (C) and salinomycin effects on immune response, neurotransmitters related to milk production in Barki ewes. Total 72 mature ewes (2-3 years & 40±1.5 Kg BW) randomly pined equally into five groups. Group-1 was control; groups 2 & 3 received 20g/head/day T and C, respectively. Group-4 received 10g T+ 10g C/head/day, group-5 treated with salinomycin 1g/head/day. Samples collected during 2nd, 3rd trimester of pregnancy and on delivery day (DD); milk yield assessed on 15, 30 and 45-day postpartum. T and/or C and salinomycin increased (P<0.05) superoxide dismutase (SOD), reduced glutathione (GSH) and glutathione disulfide (GSSG) during mid-, late-pregnancy and DD compared to control, celery and thyme increase malondialdehyde (MDA) (p<0.05) during mid-and late-pregnancy, respectively compared to other groups. Nitric oxide (NO) levels increased in thyme X celery (TxC) group during mid-pregnancy and DD with insignificantly compared with other groups. During mid-pregnancy TxC treatment increased (p<0.05) serotonin (5-HT) levels compared with other groups, the same was dopamine (DA), norepinephrine (NE) and tryptophan (Trp) levels (P>0.05). During late pregnancy 5-HT, DA, NE & Trp increased (P<0.05) in the thyme and/or celery group. While on DD salinomycin increased neurotransmitters (P<0.05) with an insignificant increase in other groups. Milk yield increased (P<0.05) during 15, 30 and 45 days postpartum in T and/or C groups than control and salinomycin. In conclusion, the applied treatments had a significant effect on reproductive performance, immune response in ewes throughout pregnancy and DD periods, and milk production during the postpartum period.
| Published in | Advances in Applied Physiology (Volume 6, Issue 1) |
| DOI | 10.11648/j.aap.20210601.14 |
| Page(s) | 23-29 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Thyme, Celery, Salinomycin, Immune System, Neurotransmitters, Milk Yield, Ewes
| [1] | Anderson, S. M., MacLean, P. S., McManaman, J. L. and Neville, M. C. (2015). Lactation and its hormonal control. Knobil and Neill’s Physiology of Reproduction, Fourth Edition. http://dx.doi.org/10.1016/B978-0-12-397175-3.00031-4. |
| [2] | Lawrence, R. A. and Lawrence, RM (2011). Physiology of lactation. In Breastfeeding. 7th Ed., W. B. Saunders: Elsevier, 2011, pp. 62-97. https://doi.org/10.1016/B978-1-4377-0788-5.10003-3. |
| [3] | Grosso, C., Figueiredo, A. C., Burillo, J., Mainar, A. M., Urieta, J. S., Barroso, J. G. et al. (2010). Composition and antioxidant activity of Thymus vulgaris volatiles: comparison between supercritical fluid extraction and hydrodistillation. Journal of Separation Science. 33 (14): 2211-2218. |
| [4] | Hassanen, N. H., Eissa, A. M. F., Hafez, S. A. M. and Mosa, E. A., (2015). Antioxidant and antimicrobial activity of celery (Apium graveolens) and coriander (Coriandrum sativum) herb and seed essential oils. Int. J. Curr. Microbiol. App. Sci. 4 (3): 284-296. |
| [5] | Calsamiglia, S., Busquet, M., Cardozo, P., Castillejos, L. and Ferret, A. (2007). Essential oils as modifiers of rumen microbial fermentation: a review. J Dairy Sci 90: 2580–2595. |
| [6] | Stankevicius, M., Akuneca, I., Jakobsone, I. and Maruska, A. (2011). Comparative analysis of radical scav-enging and antioxidant activity of phenolic compounds present in everyday use spice plants by means of spectrophotometric and chromatographic methods. J Sep Sci 34: 1261–1267. |
| [7] | Cao, G., Chen, M., Song, Q., Liu, Y., Xie, L., Han, Y., Liu, Z., Ji, Y. and Jiang, Q. (2012) EGCG protects against UVB-induced apoptosis via oxidative stress and the JNK1/c-Jun pathway in ARPE19 cells. Mol Med Rep 5 (1): 54–59 |
| [8] | Kolarovic, J; Popovic, M.; Mikov, M.; Mitic, R. and Gvozdenovic, L. (2009) Protective effects of celery juice in treatments with Doxorubicin. Molecules 14 (4): 1627–1638. |
| [9] | Wei, A. and Shibamoto, T. (2007) Antioxidant activities of essential oil mixtures toward skin lipid squalene oxidized by UV irradiation. Cutan Ocul Toxicol 26: 227–233. |
| [10] | Sapkota, A. R., Lefferts, L. Y., McKenzie, S. and Walker, P. (2007). What do we feed to food-production animals? A review of animal feed ingredients and their potential impacts on human health. Environmental Health Perspectives., 115 (5), pp. 663-670. |
| [11] | Jayatilleke, E. and Shaw, S. (1993). A High-Performance Liquid Chromatographic Assay for Reduced and Oxidized Glutathione in Biological Samples. 214 (2): 452-457. |
| [12] | Papadoyannis, L. N., Samanidou, V. F. and Nitsos, C. C. (1999). Simultaneous determination of nitrite and nitrate in drinking water and human serum by high performance anion-exchange chromatography and UV detection. J. Liquid Chromatogr. Related Technol., 22: 2023-2041. |
| [13] | Pagel, P., Blome, J. and Wolf, H. U. (2000). High-performance liquid chromatographic separation and measurement of various biogenic compound possibly involved in the pathomechanism of Parkinson's disease. J. Chromatog. B: Biomed. Sci. Appl., 746: 297-304. |
| [14] | SAS (1998). Statistical Analysis System User’s Guide, Release 6.0 edn. 4th edn, SAS Institute Inc. Cary, NC, USA. |
| [15] | Dhama, K., Latheef, S. K., Mani, S., Samad, H. A., Karthik, K., Tiwari, R., Khan, U. R. et al. (2015). Multiple Beneficial Applications and Modes of Action of Herbs in Poultry Health and Production-A Review. International Journal of Pharmacology 11: 152–176. doi: 10.3923/ijp.2015.152.176. |
| [16] | El-Zaher, H., Eid, S., Shaaban, M., Ahmed-Farid, O., Abd El Tawab, A., & Khattab, M. (2021). Ovarian activity and antioxidant indices during estrous cycle of Barki ewes under effect of thyme, celery and salinomycin as feed additives. Zygote, 29 (2), 155-160. doi: 10.1017/S0967199420000611. |
| [17] | Lee, K. W., Everts, H., Kappert, H. J., Wouterse, H., Frehner, M. And Beynen, a. C. (2004). Cinnamaldehyde, but Not Thymol, Counteracts the Carboxymethyl Cellulose-Induced Growth Depression in Female Broiler Chickens. International Journal of Poultry Science 3: 608–661. doi: 10.3923/ijps.2004.608.612. |
| [18] | Brogden, R. N., Carmine, A. A., Heel, R. C., Speight, T. M. and Avery, G. S. (1982). Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic. Drugs. 24 (5): 360-400. |
| [19] | Ben-Jonathan, N. and Munsick, R. A. (1980). Dopamine and Prolactin in Human Pregnancy. J Clin Endocrinol Metab 51: 1019-1025. |
| [20] | Andrews, Z. B. (2005). Neuroendocrine Regulation of Prolactin Secretion During Late Pregnancy: Easing the Transition into Lactation. Journal of Neuroendocrinology, 17: 466–473. |
| [21] | Grattan, D. R. and Averill, R. L. (1990). Effect of ovarian steroids on a nocturnal surge of prolactin secretion that precedes parturition in the rat. Endocrinology, 126: 1199–1205. |
| [22] | Eliot, R. J.; Klein, A. H.; Glatz, T. H.; Nathanielsz, P. W.; And Fisher, D. A. (1981). Plasma norepinephrine, epinephrine, and dopamine concentrations in maternal and fetal sheep during spontaneous parturition and in premature sheep during cortisol-induced parturition. Endocrinology, 108 (5): 1678-1682. |
| [23] | Lamming, G. E., Moseley, S. R., & McNeilly, J. R. (1974). Prolactin release in the sheep. Reproduction, 40 (1), 151-168. |
| [24] | Bishop, M. L., Fody, E. P. and Schoeff, L. E. (2013). Clinical chemistry: principles, techniques, and correlations. Lippincott Williams & Wilkins. |
| [25] | Kamberi, I. A., Mical, R. S. and Porter, J. C. (1971). Effect of anterior pituitary perfusion and intraventricular injection of catecholamines on prolactin release. Endocrinology 88: 1288. doi: 10.1210/endo-88-4-1012. |
| [26] | Lawson, D. M. and Gala, R. R. (1975). The influence of adrenergic, dopaminergic, cholinergic and serotoninergic drugs on plasma prolactin levels in ovariectomized, estrogen-treated rats. Endocrinology, 96 (2): 313-318. |
| [27] | Clemens JA, Sawyer BD, Cerimele B. 1977. Further evidence that serotonin is a neurotransmitter involved in the control of prolactin secretion. Endocrinology. 100 (3): 692-8. |
| [28] | Moore, S. A., Laporta, J., Crenshaw, T. D., Hernandez, L. L. (2015). Patterns of circulating serotonin and related metabolites in multiparous dairy cows in the peripartum period. J Dairy Sci., 98: 3754±3765. https://doi.org/10.3168/jds.2014-8841 PMID: 25828664. |
| [29] | Badawy, A. A. B. (2015). Tryptophan metabolism, disposition and utilization in pregnancy. Biosci. Rep. 35: art: e00261 / doi 10.1042/BSR20150197. |
| [30] | Tsuji, A.; Nakata, C.; Sano, M.; Fukuwatari, T. and Shibata, K. (2013). L-tryptophan metabolism in pregnant mice fed a high L-tryptophan diet and the effect on maternal, placental and fetal growth. Int. J. Tryptophan Res. 6, 21–33 PubMed. |
| [31] | Badawy, A. A. B. (2010). Perspective: plasma free tryptophan revisited: what you need to know and do before measuring it. J. Psychopharmacol. 24, 809–815 CrossRef PubMed. |
| [32] | Zotti, M., Colaianna, M., Morgese, M. G., Tucci, P., Schiavone, S., Avato, P., & Trabace, (2013). Carvacrol: from ancient flavoring to neuromodulatory agent. Molecules. 18 (6): 6161-72. |
| [33] | Zava, D. T., Dollbaum, C. M. and Blen, M. (1998). Estrogen and progestin bioactivity of foods, herbs and spices. Exp Biol Med (Maywood), 217, 369–78. |
| [34] | Modaresi, M; Ghalamkari, G. and Jalalizand, A. (2012). The effect of celery (Apium graveolens) extract on the reproductive hormones in male mice. APCBEE Procedia 4, 99–104. |
| [35] | Van-Duursen, M. B. M. (2017). Modulation of estrogen synthesis and metabolism by phytoestrogens in vitro and the implications for women's health. Toxicol Res (Camb). 1; 6 (6): 772–794. |
| [36] | Bak M. J., Gupta S. D., Wahler J. and Suh N. (2016). Role of dietary bioactive natural products in estrogen receptor-positive breast cancer. Semin Cancer Biol. 40, 170–91. |
| [37] | Miao, J., Adewole, D., Liu, S., Xi, P., Yang, C., & Yin, Y. (2019). Tryptophan Supplementation Increases Reproduction Performance, Milk Yield, and Milk Composition in Lactating Sows and Growth Performance of Their Piglets. Journal of agricultural and food chemistry, 67 (18), 5096-5104. |
APA Style
Sherif Yousif Eid, Omar Abdel Hamid Ahmed-Farid, Hussein Mostafa El-Zaher, Mahmoud Mohammed Shabaan. (2021). Thyme, Celery and Salinomycin Implication on Antioxidant Capacity and Neurotransmitters Related to Milk Production in Pregnant Barki Ewes. Advances in Applied Physiology, 6(1), 23-29. https://doi.org/10.11648/j.aap.20210601.14
ACS Style
Sherif Yousif Eid; Omar Abdel Hamid Ahmed-Farid; Hussein Mostafa El-Zaher; Mahmoud Mohammed Shabaan. Thyme, Celery and Salinomycin Implication on Antioxidant Capacity and Neurotransmitters Related to Milk Production in Pregnant Barki Ewes. Adv. Appl. Physiol. 2021, 6(1), 23-29. doi: 10.11648/j.aap.20210601.14
AMA Style
Sherif Yousif Eid, Omar Abdel Hamid Ahmed-Farid, Hussein Mostafa El-Zaher, Mahmoud Mohammed Shabaan. Thyme, Celery and Salinomycin Implication on Antioxidant Capacity and Neurotransmitters Related to Milk Production in Pregnant Barki Ewes. Adv Appl Physiol. 2021;6(1):23-29. doi: 10.11648/j.aap.20210601.14
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Download@article{10.11648/j.aap.20210601.14,
author = {Sherif Yousif Eid and Omar Abdel Hamid Ahmed-Farid and Hussein Mostafa El-Zaher and Mahmoud Mohammed Shabaan},
title = {Thyme, Celery and Salinomycin Implication on Antioxidant Capacity and Neurotransmitters Related to Milk Production in Pregnant Barki Ewes},
journal = {Advances in Applied Physiology},
volume = {6},
number = {1},
pages = {23-29},
doi = {10.11648/j.aap.20210601.14},
url = {https://doi.org/10.11648/j.aap.20210601.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.aap.20210601.14},
abstract = {The experiment goal was the investigation of thyme (T), celery (C) and salinomycin effects on immune response, neurotransmitters related to milk production in Barki ewes. Total 72 mature ewes (2-3 years & 40±1.5 Kg BW) randomly pined equally into five groups. Group-1 was control; groups 2 & 3 received 20g/head/day T and C, respectively. Group-4 received 10g T+ 10g C/head/day, group-5 treated with salinomycin 1g/head/day. Samples collected during 2nd, 3rd trimester of pregnancy and on delivery day (DD); milk yield assessed on 15, 30 and 45-day postpartum. T and/or C and salinomycin increased (P0.05). During late pregnancy 5-HT, DA, NE & Trp increased (P<0.05) in the thyme and/or celery group. While on DD salinomycin increased neurotransmitters (P<0.05) with an insignificant increase in other groups. Milk yield increased (P<0.05) during 15, 30 and 45 days postpartum in T and/or C groups than control and salinomycin. In conclusion, the applied treatments had a significant effect on reproductive performance, immune response in ewes throughout pregnancy and DD periods, and milk production during the postpartum period.},
year = {2021}
}
TY - JOUR T1 - Thyme, Celery and Salinomycin Implication on Antioxidant Capacity and Neurotransmitters Related to Milk Production in Pregnant Barki Ewes AU - Sherif Yousif Eid AU - Omar Abdel Hamid Ahmed-Farid AU - Hussein Mostafa El-Zaher AU - Mahmoud Mohammed Shabaan Y1 - 2021/05/31 PY - 2021 N1 - https://doi.org/10.11648/j.aap.20210601.14 DO - 10.11648/j.aap.20210601.14 T2 - Advances in Applied Physiology JF - Advances in Applied Physiology JO - Advances in Applied Physiology SP - 23 EP - 29 PB - Science Publishing Group SN - 2471-9714 UR - https://doi.org/10.11648/j.aap.20210601.14 AB - The experiment goal was the investigation of thyme (T), celery (C) and salinomycin effects on immune response, neurotransmitters related to milk production in Barki ewes. Total 72 mature ewes (2-3 years & 40±1.5 Kg BW) randomly pined equally into five groups. Group-1 was control; groups 2 & 3 received 20g/head/day T and C, respectively. Group-4 received 10g T+ 10g C/head/day, group-5 treated with salinomycin 1g/head/day. Samples collected during 2nd, 3rd trimester of pregnancy and on delivery day (DD); milk yield assessed on 15, 30 and 45-day postpartum. T and/or C and salinomycin increased (P0.05). During late pregnancy 5-HT, DA, NE & Trp increased (P<0.05) in the thyme and/or celery group. While on DD salinomycin increased neurotransmitters (P<0.05) with an insignificant increase in other groups. Milk yield increased (P<0.05) during 15, 30 and 45 days postpartum in T and/or C groups than control and salinomycin. In conclusion, the applied treatments had a significant effect on reproductive performance, immune response in ewes throughout pregnancy and DD periods, and milk production during the postpartum period. VL - 6 IS - 1 ER -
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