Ceruloplasmin is a member of the multicopper oxidases family (MCOs), multidomain proteins capable of oxidizing many structurally unrelated compounds reducing oxygen to water. While MCOs show great oxidative versatility, they can only transfer electrons to molecular oxygen, which is the obligate electron acceptor. Therefore, MCOs should also be considered as ‘‘O2 consuming enzymes’’. The glycosylphosphatidylinositol anchored ceruloplasmin (GPI-Cp) isoform present on the surface of the plasma membrane, does not seem to be involved in copper and iron metabolism. Since hypoxia is also a common feature of many rapidly growing solid tumors, we postulate that the regulation of GPI-Cp could be the molecular event in the creation and the maintenance of hypoxia in tumor cells. By inhibiting the GPI-Cp expression, it would appear possible to attempt to overcome tumor hypoxia, thus improving the efficiency of radiotherapy.
| Published in | Advances in Biochemistry (Volume 1, Issue 2) |
| DOI | 10.11648/j.ab.20130102.13 |
| Page(s) | 22-27 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2013. Published by Science Publishing Group |
Hypoxia, Glycosylphosphatidylinositol-Ceruloplasmin, Multicopper Oxidases, Oxygen-Consuming Enzyme, Tumor
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APA Style
Roberto Arrigoni. (2013). The Possible Role of GPI-Ceruloplasmin in Hypoxia De Novo Creation and Maintenance. Advances in Biochemistry, 1(2), 22-27. https://doi.org/10.11648/j.ab.20130102.13
ACS Style
Roberto Arrigoni. The Possible Role of GPI-Ceruloplasmin in Hypoxia De Novo Creation and Maintenance. Adv. Biochem. 2013, 1(2), 22-27. doi: 10.11648/j.ab.20130102.13
AMA Style
Roberto Arrigoni. The Possible Role of GPI-Ceruloplasmin in Hypoxia De Novo Creation and Maintenance. Adv Biochem. 2013;1(2):22-27. doi: 10.11648/j.ab.20130102.13
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Download@article{10.11648/j.ab.20130102.13,
author = {Roberto Arrigoni},
title = {The Possible Role of GPI-Ceruloplasmin in Hypoxia De Novo Creation and Maintenance},
journal = {Advances in Biochemistry},
volume = {1},
number = {2},
pages = {22-27},
doi = {10.11648/j.ab.20130102.13},
url = {https://doi.org/10.11648/j.ab.20130102.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20130102.13},
abstract = {Ceruloplasmin is a member of the multicopper oxidases family (MCOs), multidomain proteins capable of oxidizing many structurally unrelated compounds reducing oxygen to water. While MCOs show great oxidative versatility, they can only transfer electrons to molecular oxygen, which is the obligate electron acceptor. Therefore, MCOs should also be considered as ‘‘O2 consuming enzymes’’. The glycosylphosphatidylinositol anchored ceruloplasmin (GPI-Cp) isoform present on the surface of the plasma membrane, does not seem to be involved in copper and iron metabolism. Since hypoxia is also a common feature of many rapidly growing solid tumors, we postulate that the regulation of GPI-Cp could be the molecular event in the creation and the maintenance of hypoxia in tumor cells. By inhibiting the GPI-Cp expression, it would appear possible to attempt to overcome tumor hypoxia, thus improving the efficiency of radiotherapy.},
year = {2013}
}
TY - JOUR T1 - The Possible Role of GPI-Ceruloplasmin in Hypoxia De Novo Creation and Maintenance AU - Roberto Arrigoni Y1 - 2013/06/30 PY - 2013 N1 - https://doi.org/10.11648/j.ab.20130102.13 DO - 10.11648/j.ab.20130102.13 T2 - Advances in Biochemistry JF - Advances in Biochemistry JO - Advances in Biochemistry SP - 22 EP - 27 PB - Science Publishing Group SN - 2329-0862 UR - https://doi.org/10.11648/j.ab.20130102.13 AB - Ceruloplasmin is a member of the multicopper oxidases family (MCOs), multidomain proteins capable of oxidizing many structurally unrelated compounds reducing oxygen to water. While MCOs show great oxidative versatility, they can only transfer electrons to molecular oxygen, which is the obligate electron acceptor. Therefore, MCOs should also be considered as ‘‘O2 consuming enzymes’’. The glycosylphosphatidylinositol anchored ceruloplasmin (GPI-Cp) isoform present on the surface of the plasma membrane, does not seem to be involved in copper and iron metabolism. Since hypoxia is also a common feature of many rapidly growing solid tumors, we postulate that the regulation of GPI-Cp could be the molecular event in the creation and the maintenance of hypoxia in tumor cells. By inhibiting the GPI-Cp expression, it would appear possible to attempt to overcome tumor hypoxia, thus improving the efficiency of radiotherapy. VL - 1 IS - 2 ER -
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