Interrelationship between Testosterone Level and Aldo-Keto Reductase Activity in the Blood of Different Ages Rats

Vadim Vyacheslavovich Davydov; Evgeniya Romanovna Grabovetskaya

doi:doi:10.11648/j.ab.20140203.11

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Interrelationship between Testosterone Level and Aldo-Keto Reductase Activity in the Blood of Different Ages Rats

Vadim Vyacheslavovich Davydov, Evgeniya Romanovna Grabovetskaya

Published in Advances in Biochemistry (Volume 2, Issue 3)

Received: 4 June 2014 Accepted: 22 June 2014 Published: 30 June 2014

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Abstract

Aldo-keto reductases play an important role in cell protection against oxidative stress and in the modulation of resistance to the effect of stress damaging factors during ontogenesis. However, there are no clear concepts about changing of their catalytic properties in the process of individual development to date. The reason may be age-dependent changes in hormonal regulation. Still there is no information about the hormonal regulation of aldo-keto reductases. Taking this into account, the present study investigated the effect of testosterone on aldo-keto reductase activity of the blood of the rats of different ages. It has been found that an increased level of testosterone in the blood of rats from 1.5 to 26 months of age was accompanied by an increased aldo-keto reductase activity and the modulation in the structure of isozymes spectrum of aldo-keto reductases. Intramuscular injections of testosterone to pubertal and adult rats increased aldo-keto reductase activity of the blood, which did not occur in immature and aged animals. The obtained data suggest that testosterone is involved in the regulation of the synthesis of individual aldo-keto reductase isozymes.

Published in	Advances in Biochemistry (Volume 2, Issue 3)
DOI	10.11648/j.ab.20140203.11
Page(s)	40-44
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Testosterone, Aldo-Keto Reductase, Blood, Ontogenesis

References

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APA Style

Vadim Vyacheslavovich Davydov, Evgeniya Romanovna Grabovetskaya. (2014). Interrelationship between Testosterone Level and Aldo-Keto Reductase Activity in the Blood of Different Ages Rats. Advances in Biochemistry, 2(3), 40-44. https://doi.org/10.11648/j.ab.20140203.11

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ACS Style

Vadim Vyacheslavovich Davydov; Evgeniya Romanovna Grabovetskaya. Interrelationship between Testosterone Level and Aldo-Keto Reductase Activity in the Blood of Different Ages Rats. Adv. Biochem. 2014, 2(3), 40-44. doi: 10.11648/j.ab.20140203.11

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AMA Style

Vadim Vyacheslavovich Davydov, Evgeniya Romanovna Grabovetskaya. Interrelationship between Testosterone Level and Aldo-Keto Reductase Activity in the Blood of Different Ages Rats. Adv Biochem. 2014;2(3):40-44. doi: 10.11648/j.ab.20140203.11

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@article{10.11648/j.ab.20140203.11,
  author = {Vadim Vyacheslavovich Davydov and Evgeniya Romanovna Grabovetskaya},
  title = {Interrelationship between Testosterone Level and Aldo-Keto Reductase Activity in the Blood of Different Ages Rats},
  journal = {Advances in Biochemistry},
  volume = {2},
  number = {3},
  pages = {40-44},
  doi = {10.11648/j.ab.20140203.11},
  url = {https://doi.org/10.11648/j.ab.20140203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20140203.11},
  abstract = {Aldo-keto reductases play an important role in cell protection against oxidative stress and in the modulation of resistance to the effect of stress damaging factors during ontogenesis. However, there are no clear concepts about changing of their catalytic properties in the process of individual development to date. The reason may be age-dependent changes in hormonal regulation. Still there is no information about the hormonal regulation of aldo-keto reductases. Taking this into account, the present study investigated the effect of testosterone on aldo-keto reductase activity of the blood of the rats of different ages. It has been found that an increased level of testosterone in the blood of rats from 1.5 to 26 months of age was accompanied by an increased aldo-keto reductase activity and the modulation in the structure of isozymes spectrum of aldo-keto reductases. Intramuscular injections of testosterone to pubertal and adult rats increased aldo-keto reductase activity of the blood, which did not occur in immature and aged animals. The obtained data suggest that testosterone is involved in the regulation of the synthesis of individual aldo-keto reductase isozymes.},
 year = {2014}
}

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TY  - JOUR
T1  - Interrelationship between Testosterone Level and Aldo-Keto Reductase Activity in the Blood of Different Ages Rats
AU  - Vadim Vyacheslavovich Davydov
AU  - Evgeniya Romanovna Grabovetskaya
Y1  - 2014/06/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ab.20140203.11
DO  - 10.11648/j.ab.20140203.11
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 40
EP  - 44
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20140203.11
AB  - Aldo-keto reductases play an important role in cell protection against oxidative stress and in the modulation of resistance to the effect of stress damaging factors during ontogenesis. However, there are no clear concepts about changing of their catalytic properties in the process of individual development to date. The reason may be age-dependent changes in hormonal regulation. Still there is no information about the hormonal regulation of aldo-keto reductases. Taking this into account, the present study investigated the effect of testosterone on aldo-keto reductase activity of the blood of the rats of different ages. It has been found that an increased level of testosterone in the blood of rats from 1.5 to 26 months of age was accompanied by an increased aldo-keto reductase activity and the modulation in the structure of isozymes spectrum of aldo-keto reductases. Intramuscular injections of testosterone to pubertal and adult rats increased aldo-keto reductase activity of the blood, which did not occur in immature and aged animals. The obtained data suggest that testosterone is involved in the regulation of the synthesis of individual aldo-keto reductase isozymes.
VL  - 2
IS  - 3
ER  -

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Author Information

Vadim Vyacheslavovich Davydov

Department of Biochemistry, V.N. Karazin Kharkov National University, Kharkov, Ukraine
Evgeniya Romanovna Grabovetskaya

Department of Medical and Bioorganic Chemistry, Kharkov National Medical University, Kharkov, Ukraine

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Plain Text BibTeX RIS

APA Style

Vadim Vyacheslavovich Davydov, Evgeniya Romanovna Grabovetskaya. (2014). Interrelationship between Testosterone Level and Aldo-Keto Reductase Activity in the Blood of Different Ages Rats. Advances in Biochemistry, 2(3), 40-44. https://doi.org/10.11648/j.ab.20140203.11

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ACS Style

Vadim Vyacheslavovich Davydov; Evgeniya Romanovna Grabovetskaya. Interrelationship between Testosterone Level and Aldo-Keto Reductase Activity in the Blood of Different Ages Rats. Adv. Biochem. 2014, 2(3), 40-44. doi: 10.11648/j.ab.20140203.11

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AMA Style

Vadim Vyacheslavovich Davydov, Evgeniya Romanovna Grabovetskaya. Interrelationship between Testosterone Level and Aldo-Keto Reductase Activity in the Blood of Different Ages Rats. Adv Biochem. 2014;2(3):40-44. doi: 10.11648/j.ab.20140203.11

Copy | Download

@article{10.11648/j.ab.20140203.11,
  author = {Vadim Vyacheslavovich Davydov and Evgeniya Romanovna Grabovetskaya},
  title = {Interrelationship between Testosterone Level and Aldo-Keto Reductase Activity in the Blood of Different Ages Rats},
  journal = {Advances in Biochemistry},
  volume = {2},
  number = {3},
  pages = {40-44},
  doi = {10.11648/j.ab.20140203.11},
  url = {https://doi.org/10.11648/j.ab.20140203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20140203.11},
  abstract = {Aldo-keto reductases play an important role in cell protection against oxidative stress and in the modulation of resistance to the effect of stress damaging factors during ontogenesis. However, there are no clear concepts about changing of their catalytic properties in the process of individual development to date. The reason may be age-dependent changes in hormonal regulation. Still there is no information about the hormonal regulation of aldo-keto reductases. Taking this into account, the present study investigated the effect of testosterone on aldo-keto reductase activity of the blood of the rats of different ages. It has been found that an increased level of testosterone in the blood of rats from 1.5 to 26 months of age was accompanied by an increased aldo-keto reductase activity and the modulation in the structure of isozymes spectrum of aldo-keto reductases. Intramuscular injections of testosterone to pubertal and adult rats increased aldo-keto reductase activity of the blood, which did not occur in immature and aged animals. The obtained data suggest that testosterone is involved in the regulation of the synthesis of individual aldo-keto reductase isozymes.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Interrelationship between Testosterone Level and Aldo-Keto Reductase Activity in the Blood of Different Ages Rats
AU  - Vadim Vyacheslavovich Davydov
AU  - Evgeniya Romanovna Grabovetskaya
Y1  - 2014/06/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ab.20140203.11
DO  - 10.11648/j.ab.20140203.11
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 40
EP  - 44
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20140203.11
AB  - Aldo-keto reductases play an important role in cell protection against oxidative stress and in the modulation of resistance to the effect of stress damaging factors during ontogenesis. However, there are no clear concepts about changing of their catalytic properties in the process of individual development to date. The reason may be age-dependent changes in hormonal regulation. Still there is no information about the hormonal regulation of aldo-keto reductases. Taking this into account, the present study investigated the effect of testosterone on aldo-keto reductase activity of the blood of the rats of different ages. It has been found that an increased level of testosterone in the blood of rats from 1.5 to 26 months of age was accompanied by an increased aldo-keto reductase activity and the modulation in the structure of isozymes spectrum of aldo-keto reductases. Intramuscular injections of testosterone to pubertal and adult rats increased aldo-keto reductase activity of the blood, which did not occur in immature and aged animals. The obtained data suggest that testosterone is involved in the regulation of the synthesis of individual aldo-keto reductase isozymes.
VL  - 2
IS  - 3
ER  -

Copy | Download