Association of Magnesium Status with Poor Glycemic Control and Microangiopathic Complications (Neuropathy and Nephropathy) in Diabetic Patients in Dakar

Nènè Oumou Kesso Barry; Michel Assane Ndour; Moustapha Djite; Demba Diedhiou; Pape Matar Kandji; El Hadji Malick Ndour; Gueye-tall Fatou; Aissatou Diallo; Ahmed Limane Barage; Maimouna Ndour Mbaye; Philomène Lopez Sall; Papa Madieye Gueye

doi:doi:10.11648/j.ab.20190703.11

Association of Magnesium Status with Poor Glycemic Control and Microangiopathic Complications (Neuropathy and Nephropathy) in Diabetic Patients in Dakar

Nènè Oumou Kesso Barry, Michel Assane Ndour, Moustapha Djite, Demba Diedhiou, Pape Matar Kandji, El Hadji Malick Ndour, Gueye-tall Fatou, Aissatou Diallo, Ahmed Limane Barage, Maimouna Ndour Mbaye, Philomène Lopez Sall, Papa Madieye Gueye

Published in Advances in Biochemistry (Volume 7, Issue 3)

Received: 3 September 2019 Accepted: 27 September 2019 Published: 14 October 2019

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Abstract

Low serum magnesium level has been shown to be associated with diabetes mellitus and its complications. The objective of this study was to determine the magnesium status in our study population and its association with glycemic control and microangiopathic complications particularly neuropathy and nephropathy. This was a cross sectional and prospective study conducted among patients received as part of their follow-up at the Marc Sankalé center of the Abass Ndao hospital in Dakar. For each patient, blood samples and 24h urine collection were performed. Hypomagnesemia was defined for Mg concentrations <17 mg/L and statistical analysis was performed using the XLSTAT 2018 software. A total of 106 diabetic patients were enrolled consisting of 93 type 2 diabetics and 13 type 1 diabetics. Eighty percent of patients had hypomagnesemia compared to 20% who had normal magnesium levels. We found a significantly higher mean HbA1c level in the group of hypomagnesemic patients compared to patients with normal magnesium levels (p = 0.02) and significant negative correlation between magnesium and HbA1c (r = - 0.20, p = 0.03). The frequencies of neuropathy and nephropathy were comparable between the two groups with respectively p = 0.12 and p = 0.28. Our study shows a high frequency of hypomagnesemia in both type 1 and type 2 diabetes and a significant correlation of this hypomagnesemia with poor glycemic control. No association has been found between magnesium and the microangiopathic complications, but it nevertheless alerts clinicians to the possible need for magnesium supplementation in the management of diabetic patients.

Published in	Advances in Biochemistry (Volume 7, Issue 3)
DOI	10.11648/j.ab.20190703.11
Page(s)	59-64
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Diabetes, Magnesium Status, Glycemic Control, Diabetic Neuropathy, Diabetic Nephropathy

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APA Style

Nènè Oumou Kesso Barry, Michel Assane Ndour, Moustapha Djite, Demba Diedhiou, Pape Matar Kandji, et al. (2019). Association of Magnesium Status with Poor Glycemic Control and Microangiopathic Complications (Neuropathy and Nephropathy) in Diabetic Patients in Dakar. Advances in Biochemistry, 7(3), 59-64. https://doi.org/10.11648/j.ab.20190703.11

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ACS Style

Nènè Oumou Kesso Barry; Michel Assane Ndour; Moustapha Djite; Demba Diedhiou; Pape Matar Kandji, et al. Association of Magnesium Status with Poor Glycemic Control and Microangiopathic Complications (Neuropathy and Nephropathy) in Diabetic Patients in Dakar. Adv. Biochem. 2019, 7(3), 59-64. doi: 10.11648/j.ab.20190703.11

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AMA Style

Nènè Oumou Kesso Barry, Michel Assane Ndour, Moustapha Djite, Demba Diedhiou, Pape Matar Kandji, et al. Association of Magnesium Status with Poor Glycemic Control and Microangiopathic Complications (Neuropathy and Nephropathy) in Diabetic Patients in Dakar. Adv Biochem. 2019;7(3):59-64. doi: 10.11648/j.ab.20190703.11

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@article{10.11648/j.ab.20190703.11,
  author = {Nènè Oumou Kesso Barry and Michel Assane Ndour and Moustapha Djite and Demba Diedhiou and Pape Matar Kandji and El Hadji Malick Ndour and Gueye-tall Fatou and Aissatou Diallo and Ahmed Limane Barage and Maimouna Ndour Mbaye and Philomène Lopez Sall and Papa Madieye Gueye},
  title = {Association of Magnesium Status with Poor Glycemic Control and Microangiopathic Complications (Neuropathy and Nephropathy) in Diabetic Patients in Dakar},
  journal = {Advances in Biochemistry},
  volume = {7},
  number = {3},
  pages = {59-64},
  doi = {10.11648/j.ab.20190703.11},
  url = {https://doi.org/10.11648/j.ab.20190703.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20190703.11},
  abstract = {Low serum magnesium level has been shown to be associated with diabetes mellitus and its complications. The objective of this study was to determine the magnesium status in our study population and its association with glycemic control and microangiopathic complications particularly neuropathy and nephropathy. This was a cross sectional and prospective study conducted among patients received as part of their follow-up at the Marc Sankalé center of the Abass Ndao hospital in Dakar. For each patient, blood samples and 24h urine collection were performed. Hypomagnesemia was defined for Mg concentrations p = 0.02) and significant negative correlation between magnesium and HbA1c (r = - 0.20, p = 0.03). The frequencies of neuropathy and nephropathy were comparable between the two groups with respectively p = 0.12 and p = 0.28. Our study shows a high frequency of hypomagnesemia in both type 1 and type 2 diabetes and a significant correlation of this hypomagnesemia with poor glycemic control. No association has been found between magnesium and the microangiopathic complications, but it nevertheless alerts clinicians to the possible need for magnesium supplementation in the management of diabetic patients.},
 year = {2019}
}

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TY  - JOUR
T1  - Association of Magnesium Status with Poor Glycemic Control and Microangiopathic Complications (Neuropathy and Nephropathy) in Diabetic Patients in Dakar
AU  - Nènè Oumou Kesso Barry
AU  - Michel Assane Ndour
AU  - Moustapha Djite
AU  - Demba Diedhiou
AU  - Pape Matar Kandji
AU  - El Hadji Malick Ndour
AU  - Gueye-tall Fatou
AU  - Aissatou Diallo
AU  - Ahmed Limane Barage
AU  - Maimouna Ndour Mbaye
AU  - Philomène Lopez Sall
AU  - Papa Madieye Gueye
Y1  - 2019/10/14
PY  - 2019
N1  - https://doi.org/10.11648/j.ab.20190703.11
DO  - 10.11648/j.ab.20190703.11
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 59
EP  - 64
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20190703.11
AB  - Low serum magnesium level has been shown to be associated with diabetes mellitus and its complications. The objective of this study was to determine the magnesium status in our study population and its association with glycemic control and microangiopathic complications particularly neuropathy and nephropathy. This was a cross sectional and prospective study conducted among patients received as part of their follow-up at the Marc Sankalé center of the Abass Ndao hospital in Dakar. For each patient, blood samples and 24h urine collection were performed. Hypomagnesemia was defined for Mg concentrations p = 0.02) and significant negative correlation between magnesium and HbA1c (r = - 0.20, p = 0.03). The frequencies of neuropathy and nephropathy were comparable between the two groups with respectively p = 0.12 and p = 0.28. Our study shows a high frequency of hypomagnesemia in both type 1 and type 2 diabetes and a significant correlation of this hypomagnesemia with poor glycemic control. No association has been found between magnesium and the microangiopathic complications, but it nevertheless alerts clinicians to the possible need for magnesium supplementation in the management of diabetic patients.
VL  - 7
IS  - 3
ER  -

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Author Information

Nènè Oumou Kesso Barry

Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta Diop, Dakar, Senegal
Michel Assane Ndour

Department of Internal Medicine, Abass Ndao Hospital Center, Dakar, Senegal
Moustapha Djite

Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta Diop, Dakar, Senegal
Demba Diedhiou

Department of Internal Medicine, Abass Ndao Hospital Center, Dakar, Senegal
Pape Matar Kandji

Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta Diop, Dakar, Senegal
El Hadji Malick Ndour

Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal
Gueye-tall Fatou

Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal
Aissatou Diallo

Department of Internal Medicine, Abass Ndao Hospital Center, Dakar, Senegal
Ahmed Limane Barage

Department of Internal Medicine, Abass Ndao Hospital Center, Dakar, Senegal
Maimouna Ndour Mbaye

Department of Internal Medicine, Abass Ndao Hospital Center, Dakar, Senegal
Philomène Lopez Sall

Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal
Papa Madieye Gueye

Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta Diop, Dakar, Senegal

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APA Style

Nènè Oumou Kesso Barry, Michel Assane Ndour, Moustapha Djite, Demba Diedhiou, Pape Matar Kandji, et al. (2019). Association of Magnesium Status with Poor Glycemic Control and Microangiopathic Complications (Neuropathy and Nephropathy) in Diabetic Patients in Dakar. Advances in Biochemistry, 7(3), 59-64. https://doi.org/10.11648/j.ab.20190703.11

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ACS Style

Nènè Oumou Kesso Barry; Michel Assane Ndour; Moustapha Djite; Demba Diedhiou; Pape Matar Kandji, et al. Association of Magnesium Status with Poor Glycemic Control and Microangiopathic Complications (Neuropathy and Nephropathy) in Diabetic Patients in Dakar. Adv. Biochem. 2019, 7(3), 59-64. doi: 10.11648/j.ab.20190703.11

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AMA Style

Nènè Oumou Kesso Barry, Michel Assane Ndour, Moustapha Djite, Demba Diedhiou, Pape Matar Kandji, et al. Association of Magnesium Status with Poor Glycemic Control and Microangiopathic Complications (Neuropathy and Nephropathy) in Diabetic Patients in Dakar. Adv Biochem. 2019;7(3):59-64. doi: 10.11648/j.ab.20190703.11

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@article{10.11648/j.ab.20190703.11,
  author = {Nènè Oumou Kesso Barry and Michel Assane Ndour and Moustapha Djite and Demba Diedhiou and Pape Matar Kandji and El Hadji Malick Ndour and Gueye-tall Fatou and Aissatou Diallo and Ahmed Limane Barage and Maimouna Ndour Mbaye and Philomène Lopez Sall and Papa Madieye Gueye},
  title = {Association of Magnesium Status with Poor Glycemic Control and Microangiopathic Complications (Neuropathy and Nephropathy) in Diabetic Patients in Dakar},
  journal = {Advances in Biochemistry},
  volume = {7},
  number = {3},
  pages = {59-64},
  doi = {10.11648/j.ab.20190703.11},
  url = {https://doi.org/10.11648/j.ab.20190703.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20190703.11},
  abstract = {Low serum magnesium level has been shown to be associated with diabetes mellitus and its complications. The objective of this study was to determine the magnesium status in our study population and its association with glycemic control and microangiopathic complications particularly neuropathy and nephropathy. This was a cross sectional and prospective study conducted among patients received as part of their follow-up at the Marc Sankalé center of the Abass Ndao hospital in Dakar. For each patient, blood samples and 24h urine collection were performed. Hypomagnesemia was defined for Mg concentrations p = 0.02) and significant negative correlation between magnesium and HbA1c (r = - 0.20, p = 0.03). The frequencies of neuropathy and nephropathy were comparable between the two groups with respectively p = 0.12 and p = 0.28. Our study shows a high frequency of hypomagnesemia in both type 1 and type 2 diabetes and a significant correlation of this hypomagnesemia with poor glycemic control. No association has been found between magnesium and the microangiopathic complications, but it nevertheless alerts clinicians to the possible need for magnesium supplementation in the management of diabetic patients.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Association of Magnesium Status with Poor Glycemic Control and Microangiopathic Complications (Neuropathy and Nephropathy) in Diabetic Patients in Dakar
AU  - Nènè Oumou Kesso Barry
AU  - Michel Assane Ndour
AU  - Moustapha Djite
AU  - Demba Diedhiou
AU  - Pape Matar Kandji
AU  - El Hadji Malick Ndour
AU  - Gueye-tall Fatou
AU  - Aissatou Diallo
AU  - Ahmed Limane Barage
AU  - Maimouna Ndour Mbaye
AU  - Philomène Lopez Sall
AU  - Papa Madieye Gueye
Y1  - 2019/10/14
PY  - 2019
N1  - https://doi.org/10.11648/j.ab.20190703.11
DO  - 10.11648/j.ab.20190703.11
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 59
EP  - 64
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20190703.11
AB  - Low serum magnesium level has been shown to be associated with diabetes mellitus and its complications. The objective of this study was to determine the magnesium status in our study population and its association with glycemic control and microangiopathic complications particularly neuropathy and nephropathy. This was a cross sectional and prospective study conducted among patients received as part of their follow-up at the Marc Sankalé center of the Abass Ndao hospital in Dakar. For each patient, blood samples and 24h urine collection were performed. Hypomagnesemia was defined for Mg concentrations p = 0.02) and significant negative correlation between magnesium and HbA1c (r = - 0.20, p = 0.03). The frequencies of neuropathy and nephropathy were comparable between the two groups with respectively p = 0.12 and p = 0.28. Our study shows a high frequency of hypomagnesemia in both type 1 and type 2 diabetes and a significant correlation of this hypomagnesemia with poor glycemic control. No association has been found between magnesium and the microangiopathic complications, but it nevertheless alerts clinicians to the possible need for magnesium supplementation in the management of diabetic patients.
VL  - 7
IS  - 3
ER  -

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