Type 2 diabetes or diabetes mellitus is a metabolic disorder characterized by an increase in blood sugar level. It is caused by a lack of insulin secretion, insulin action, or both. There are approximately 501,530 people living with diabetes in Côte d’Ivoire with an estimated prevalence of 5.19% in 2013. Unfortunately impairment of zinc and copper leads to increased oxidative stress, insulin resistance and diabetic complications. The study aimed to assess the zinc and copper status in patients with type 2 diabetes. This study involved 80 type 2 diabetics and 80 non-diabetic as controls. Glycated hemoglobin (HbA1c) was analyzed in whole blood using the Hitachi Roche Cobas C311. The serum assays of zinc and copper then of glycemia were carried out using a flame-air / acetylene atomic absorption spectrophotometer (AAS) of the brand Varian Spectr AA-20 Victoria, Australia and on the Cobas C311 respectively. A significant decrease in zinc content (P ˂ 0.0001) and a significant increase in copper content as well as the Cu / Zn ratio (P ˂ 0.0001) were observed in type 2 diabetic patients compared to non-diabetic control. The lower serum zinc values and the high Cu / Zn ratio could justify the high level of oxidative stress in patients with type 2 diabetes. Assessment of zinc and copper is essential in the monitoring of complications due to type 2 diabetes.
| Published in | Advances in Biochemistry (Volume 8, Issue 4) |
| DOI | 10.11648/j.ab.20200804.11 |
| Page(s) | 57-61 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Copper, Côte D'ivoire, Oxidative Stress, Type 2 Diabetics, Zinc
| [1] | American Diabetes Association. (2014). Diagnosis and classification of diabetes mellitus. Diabetes Care, 37(1): 81-90. |
| [2] | Farid, S. (2018). Study of correlation between anthropometric parameters (BMI, WC, WHR) and atherogenic index of plasma (AIP) in type 2 diabetics in Jeddah, Saudi Arabia. Global Journal of Bio-sciences and Biotechnology, 7(1): 60-69. |
| [3] | Fédération Internationale du Diabète.(2014). Atlas du diabète. 6e éd. FID; 159p. |
| [4] | Praveeena, S., Pasula, S., and Sameera. K. (2013). Trace elements in diabetes mellitus. Journal of Clinical Diagnostic Research, 7(9): 1863. |
| [5] | Dubey, P., Thakur, V. and Chattopadhyay, M. (2020). - Role of Minerals and Trace Elements in Diabetes and Insulin Resistance. Nutrients, 12(6): 1864. |
| [6] | Cheng, Z., Tseng, Y. and White M. (2010). Insulin signaling meets mitochondria in metabolism. Trends in Endocrinology and Metabolism, 21(10): 589–598. |
| [7] | Atari-Hajipirloo S., Valizadeh, N., Khadem-Ansari M., Rasmi Y., Kheradmand, F. (2016). Altered concentrations of copper, zinc, and iron are associated with increased levels of glycated hemoglobin in patients with type 2 diabetes mellitus and their first-degree relatives. International journal of endocrinology, 14(2): e33273. |
| [8] | Pujar, S., Pujar, L., Ganiger, A., Hiremath, K., Mannangji, N. and Bhuthal, M. (2014). Correlation of serum zinc, Magnesium, and copper with HbA1c in type 2 diabetes mellitus patients among Bagalkot population-A case control study. Medica Innovatica, 3(2): 4-8. |
| [9] | Miao, X., Sun, W., Fu, Y., Miao, L. and Cai, L. (2013). Zinc homeostasis in the metabolic syndrome and diabetes. Frontiers of medicine, 7(1): 31-52. |
| [10] | Toma, A., Makonnen, E. and Yimer, G. (2013). Role of zinc in diabetes mellitus, oxidative stress and other human healthy: a review article. American Journal of Research Communication, 1(11): 421-426. |
| [11] | Ghazi, D., Mahmoud, Z., Mohamad, O., Prem, C., Amin, J., Lubna, M., Buthaina, A., Ibrahim, M. and Mohamad, D. (2014). Zinc Status among Type (2) Diabetes Mellitus in the State of Qatar. Journal of Public Health Frontier, 3(1): 4-10. |
| [12] | Cruz, K. J., de Oliveira, A. and do Nascimento Marreiro, D. (2015). Antioxidant role of zinc in diabetes mellitus. World journal of diabetes, 6(2): 333-337. |
| [13] | Manideep, E., Aruna, P. and Kumar, A. (2018). Study of serum copper and zinc levels in association with albumin and uric acid as antioxidant markers in type II diabetes mellitus. International Journal of Clinical Biochemistry Research, 5(1): 106-111. |
| [14] | Lowe, J., Taveira‐da‐Silva, R. and Hilário‐Souza, E. (2017). Dissecting copper homeostasis in diabetes mellitus. International Union of Biochemistry and Molecular Biology Life, 69(4): 255-262. |
| [15] | Olaniyan, O., Awonuga, M., Ajetunmobi, A., Adeleke, I., Fagbolade, O., Olabiyi, K., Oyekanmi, B. and Osadolor, H. (2012). Serum copper and zinc levels in Nigerian type 2 diabetic patients. African Journal of Diabetes Medicine, 20(2): 36-38. |
| [16] | Hordyjewska, A., Popiołek L. and Kocot, J. (2014). The many ‘‘faces’’ of copper in medicine and treatment. Biometals, 27(4): 611-621. |
| [17] | Bakacak, M., Kılınç, M., Serin, S., Ercan, Ö., Köstü, B., Avcı, F., Kıran, H. and Kıran, G. (2015). Changes in copper, zinc, and malondialdehyde levels and superoxide dismutase activities in pre-eclamptic pregnancies. Medical science monitor, 21: 2414-2420. |
| [18] | Deyhimi, F., Arabieh, M. and Parvin, L. (2006). Optimization of the Emerson–Trinder enzymatic reaction by response surface methodology. Biocatalysis and Biotransformation, 24: 263-271. |
| [19] | Banjoko, S., Oseni, F., Togun, R., Onayemi O., Emma-Okon, B. & Fakunle, J. (2012). Iron status in HIV-1 infection: implications in disease pathology. BMC Clinical Pathology, 12: 26-32. |
| [20] | Devi, T., Hijam, D., Dubey, A., Debnath, S., Oinam, P., Devi, N. and Singh, W. (2016). Study of serum zinc and copper levels in type 2 diabetes mellitus. International Journal of Contemporary Medical Research, 3(4): 1036-1040. |
| [21] | Sanghani, H., Parmar, V. and Khubchandani, A. (2018). Correlation of trace elements (serum zinc and copper) in type 2 diabetic patients with and without complications. International Journal of Clinical Biochemistry and Research, 5(2): 249-253. |
| [22] | Masood, N., Baloch, G., Ghori, R., Memon, I., Memon, M. and Memon, M. (2009). Serum zinc and magnesium in type-2 diabetic patients. Journal of College of Physicians and Surgeons Pakistan, 19(8): 483-486. |
| [23] | Khan, F., Al Jameil, N., Arjumand, S., Khan, M., Tabassum, H., Alenzi, N., Hijazy, S., Alenzi S., Subaie S. and Fatima S. (2015). Comparative study of serum copper, iron, magnesium, and zinc in type 2 diabetes-associated proteinuria. Biological Trace Element Research, 168(2): 321-329. |
| [24] | Tripathy, B., Chandalia, H., Das, A. and Rao, P. (2012). RSSDI Textbook of Diabetes Mellitus. Jaypee Brothers, Medical PublishersLTd, India. 259p. |
| [25] | Li, Y. (2014). Zinc and insulin in pancreatic beta-cells. Endocrine 45(2): 178-189. |
| [26] | Buchner, D., Charrier, A., Srinivasan, E., Wang, L., Paulsen, M., Ljungman, M., Bridges, D. and Saltiel, A. (2015). Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA. Journal of Biological Chemistry, 290(10): 6376-6386. |
| [27] | Kumar D., Priya V., Jaiprabhu J. & Ramalingam K., 2014. - Serum copper and zinc levels significance in type 2 diabetic patients Journal of Medical Science and Technology, 3(2): 79-81. |
| [28] | Omer, T., Saeed, A. and Elmukashfi, S. (2020). Assessment of Serum Zinc and Copper Levels among Sudanese Patients with Diabetes Mellitus Type 2 in Khartoum State-Sudan. Journal of Advances in Medicine Medical Research, 32(4): 120-125. |
| [29] | Sarkar, A., Dash, S., Barik, B., Muttigi, M., Kedage, V., Shetty, J. and Prakash, M. (2010). Copper and ceruloplasmin levels in relation to total thiols and GST in type 2 diabetes mellitus patients. Indian journal of clinical biochemistry, 25(1): 74-76. |
| [30] | Dworzański, J., Strycharz-Dudziak, M., Kliszczewska, E., Kiełczykowska, M., Dworzańska, A., Drop, B. and Polz-Dacewicz, M. (2020). Glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity in patients with diabetes mellitus type 2 infected with Epstein-Barr virus. Plos one, 15(3): e0230374. |
| [31] | Marreiro, D., Cruz, K., Morais, J., Beserra, J., Severo, J. and De Oliveira, A. (2017). Zinc and oxidative stress: current mechanisms. Antioxidants, 6(2): 1-10. |
APA Style
N’Guessan Assieoussou Jean-Luc, Boyvin Lydie, Bahi Gnogbo Alexis, Moke-Bedji Louise Odile, Yaye Yapi Guillaume, et al. (2020). Assessment of Serum Zinc and Copper Levels, and Cu / Zn Ratio Among Patients of Côte D’Ivoire with Type 2 Diabetes. Advances in Biochemistry, 8(4), 57-61. https://doi.org/10.11648/j.ab.20200804.11
ACS Style
N’Guessan Assieoussou Jean-Luc; Boyvin Lydie; Bahi Gnogbo Alexis; Moke-Bedji Louise Odile; Yaye Yapi Guillaume, et al. Assessment of Serum Zinc and Copper Levels, and Cu / Zn Ratio Among Patients of Côte D’Ivoire with Type 2 Diabetes. Adv. Biochem. 2020, 8(4), 57-61. doi: 10.11648/j.ab.20200804.11
AMA Style
N’Guessan Assieoussou Jean-Luc, Boyvin Lydie, Bahi Gnogbo Alexis, Moke-Bedji Louise Odile, Yaye Yapi Guillaume, et al. Assessment of Serum Zinc and Copper Levels, and Cu / Zn Ratio Among Patients of Côte D’Ivoire with Type 2 Diabetes. Adv Biochem. 2020;8(4):57-61. doi: 10.11648/j.ab.20200804.11
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.ab.20200804.11,
author = {N’Guessan Assieoussou Jean-Luc and Boyvin Lydie and Bahi Gnogbo Alexis and Moke-Bedji Louise Odile and Yaye Yapi Guillaume and Ankotche Amos and Djaman Allico Joseph},
title = {Assessment of Serum Zinc and Copper Levels, and Cu / Zn Ratio Among Patients of Côte D’Ivoire with Type 2 Diabetes},
journal = {Advances in Biochemistry},
volume = {8},
number = {4},
pages = {57-61},
doi = {10.11648/j.ab.20200804.11},
url = {https://doi.org/10.11648/j.ab.20200804.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20200804.11},
abstract = {Type 2 diabetes or diabetes mellitus is a metabolic disorder characterized by an increase in blood sugar level. It is caused by a lack of insulin secretion, insulin action, or both. There are approximately 501,530 people living with diabetes in Côte d’Ivoire with an estimated prevalence of 5.19% in 2013. Unfortunately impairment of zinc and copper leads to increased oxidative stress, insulin resistance and diabetic complications. The study aimed to assess the zinc and copper status in patients with type 2 diabetes. This study involved 80 type 2 diabetics and 80 non-diabetic as controls. Glycated hemoglobin (HbA1c) was analyzed in whole blood using the Hitachi Roche Cobas C311. The serum assays of zinc and copper then of glycemia were carried out using a flame-air / acetylene atomic absorption spectrophotometer (AAS) of the brand Varian Spectr AA-20 Victoria, Australia and on the Cobas C311 respectively. A significant decrease in zinc content (P ˂ 0.0001) and a significant increase in copper content as well as the Cu / Zn ratio (P ˂ 0.0001) were observed in type 2 diabetic patients compared to non-diabetic control. The lower serum zinc values and the high Cu / Zn ratio could justify the high level of oxidative stress in patients with type 2 diabetes. Assessment of zinc and copper is essential in the monitoring of complications due to type 2 diabetes.},
year = {2020}
}
TY - JOUR T1 - Assessment of Serum Zinc and Copper Levels, and Cu / Zn Ratio Among Patients of Côte D’Ivoire with Type 2 Diabetes AU - N’Guessan Assieoussou Jean-Luc AU - Boyvin Lydie AU - Bahi Gnogbo Alexis AU - Moke-Bedji Louise Odile AU - Yaye Yapi Guillaume AU - Ankotche Amos AU - Djaman Allico Joseph Y1 - 2020/11/27 PY - 2020 N1 - https://doi.org/10.11648/j.ab.20200804.11 DO - 10.11648/j.ab.20200804.11 T2 - Advances in Biochemistry JF - Advances in Biochemistry JO - Advances in Biochemistry SP - 57 EP - 61 PB - Science Publishing Group SN - 2329-0862 UR - https://doi.org/10.11648/j.ab.20200804.11 AB - Type 2 diabetes or diabetes mellitus is a metabolic disorder characterized by an increase in blood sugar level. It is caused by a lack of insulin secretion, insulin action, or both. There are approximately 501,530 people living with diabetes in Côte d’Ivoire with an estimated prevalence of 5.19% in 2013. Unfortunately impairment of zinc and copper leads to increased oxidative stress, insulin resistance and diabetic complications. The study aimed to assess the zinc and copper status in patients with type 2 diabetes. This study involved 80 type 2 diabetics and 80 non-diabetic as controls. Glycated hemoglobin (HbA1c) was analyzed in whole blood using the Hitachi Roche Cobas C311. The serum assays of zinc and copper then of glycemia were carried out using a flame-air / acetylene atomic absorption spectrophotometer (AAS) of the brand Varian Spectr AA-20 Victoria, Australia and on the Cobas C311 respectively. A significant decrease in zinc content (P ˂ 0.0001) and a significant increase in copper content as well as the Cu / Zn ratio (P ˂ 0.0001) were observed in type 2 diabetic patients compared to non-diabetic control. The lower serum zinc values and the high Cu / Zn ratio could justify the high level of oxidative stress in patients with type 2 diabetes. Assessment of zinc and copper is essential in the monitoring of complications due to type 2 diabetes. VL - 8 IS - 4 ER -
Information
Email: