@article{10.11648/j.abb.20170502.11,
  author = {Mahendra Kumar Trivedi and Alice Branton and Dahryn Trivedi and Gopal Nayak and William Dean Plikerd and Peter L. Surguy and Robert John Kock and Rolando Baptista Piedad and Russell Phillip Callas and Sakina A. Ansari and Sandra Lee Barrett and Sara Friedman and Steven Lee Christie and Su-Mei Chen Liu and Susan Elizabeth Starling and Susan Jones and Susan Mardis Allen and Susanne Kathrin Wasmus and Terry Ann Benczik and Thomas Charles Slade and Thomas Orban and Victoria L. Vannes and Victoria Margot Schlosser and Yusif Sarkis Yamin Albino and Parthasarathi Panda and Kalyan Kumar Sethi and Snehasis Jana},
  title = {LC-MS and NMR Based Structural Characterization and Isotopic Abundance Ratio Analysis of Magnesium Gluconate Treated with the Consciousness Energy Healing},
  journal = {Advances in Bioscience and Bioengineering},
  volume = {5},
  number = {2},
  pages = {22-31},
  doi = {10.11648/j.abb.20170502.11},
  url = {https://doi.org/10.11648/j.abb.20170502.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.abb.20170502.11},
  abstract = {Magnesium gluconate is widely used pharmaceutical/nutraceutical compound for the prevention and treatment of magnesium deficiency diseases. The present study was designed to explore the effect of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on magnesium gluconate for the change in the structural properties and isotopic abundance ratio (PM+1/PM and PM+2/PM) using LC-MS and NMR spectroscopy. Magnesium gluconate was divided into two parts – one part was control, and another part was treated with The Trivedi Effect® - Energy of Consciousness Healing Treatment remotely by twenty renowned Biofield Energy Healers and defined as The Trivedi Effect® treated sample. The LC-MS analysis of both the control and Biofield Energy Treated samples indicated the presence of mass of the protonated magnesium gluconate at m/z 415 at the retention time of 1.52 min and fragmentation pattern of both samples were almost identical. The relative peak intensities of the fragment ions were significantly altered in the treated sample compared to the control sample. The proton and carbon signals for CH, CH2 and CO groups in the proton and carbon NMR spectra of the control and treated samples were found same. The percentage change in the isotopic abundance ratio of PM+1/PM (2H/1H or 13C/12C or 17O/16O or 25Mg/24Mg) was significantly decreased in the treated sample by 48.87% compared to the control sample. Subsequently, the isotopic abundance ratio of PM+2/PM (18O/16O or 26Mg/24Mg) in the treated sample was significantly increased by 29.18% compared with the control sample. In summary, 13C, 2H, 17O, and 25Mg contributions from (C12H23MgO14)+ to m/z 416; 18O and 26Mg contributions from (C12H23MgO14)+ to m/z 417 in the treated sample were significantly altered compared with the control sample. Thus, The Trivedi Effect® Treated magnesium gluconate might be helpful to design the novel potent enzyme inhibitors using its kinetic isotope effects. Consequently, The Trivedi Effect® Treated magnesium gluconate would be valuable for designing better pharmaceutical and/or nutraceutical formulations through its altered physicochemical and thermal properties, which might be providing better therapeutic response against various diseases such as diabetes mellitus, allergy, aging, inflammatory diseases, immunological disorders, and other chronic infections.},
 year = {2017}
}

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TY  - JOUR
T1  - LC-MS and NMR Based Structural Characterization and Isotopic Abundance Ratio Analysis of Magnesium Gluconate Treated with the Consciousness Energy Healing
AU  - Mahendra Kumar Trivedi
AU  - Alice Branton
AU  - Dahryn Trivedi
AU  - Gopal Nayak
AU  - William Dean Plikerd
AU  - Peter L. Surguy
AU  - Robert John Kock
AU  - Rolando Baptista Piedad
AU  - Russell Phillip Callas
AU  - Sakina A. Ansari
AU  - Sandra Lee Barrett
AU  - Sara Friedman
AU  - Steven Lee Christie
AU  - Su-Mei Chen Liu
AU  - Susan Elizabeth Starling
AU  - Susan Jones
AU  - Susan Mardis Allen
AU  - Susanne Kathrin Wasmus
AU  - Terry Ann Benczik
AU  - Thomas Charles Slade
AU  - Thomas Orban
AU  - Victoria L. Vannes
AU  - Victoria Margot Schlosser
AU  - Yusif Sarkis Yamin Albino
AU  - Parthasarathi Panda
AU  - Kalyan Kumar Sethi
AU  - Snehasis Jana
Y1  - 2017/04/01
PY  - 2017
N1  - https://doi.org/10.11648/j.abb.20170502.11
DO  - 10.11648/j.abb.20170502.11
T2  - Advances in Bioscience and Bioengineering
JF  - Advances in Bioscience and Bioengineering
JO  - Advances in Bioscience and Bioengineering
SP  - 22
EP  - 31
PB  - Science Publishing Group
SN  - 2330-4162
UR  - https://doi.org/10.11648/j.abb.20170502.11
AB  - Magnesium gluconate is widely used pharmaceutical/nutraceutical compound for the prevention and treatment of magnesium deficiency diseases. The present study was designed to explore the effect of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on magnesium gluconate for the change in the structural properties and isotopic abundance ratio (PM+1/PM and PM+2/PM) using LC-MS and NMR spectroscopy. Magnesium gluconate was divided into two parts – one part was control, and another part was treated with The Trivedi Effect® - Energy of Consciousness Healing Treatment remotely by twenty renowned Biofield Energy Healers and defined as The Trivedi Effect® treated sample. The LC-MS analysis of both the control and Biofield Energy Treated samples indicated the presence of mass of the protonated magnesium gluconate at m/z 415 at the retention time of 1.52 min and fragmentation pattern of both samples were almost identical. The relative peak intensities of the fragment ions were significantly altered in the treated sample compared to the control sample. The proton and carbon signals for CH, CH2 and CO groups in the proton and carbon NMR spectra of the control and treated samples were found same. The percentage change in the isotopic abundance ratio of PM+1/PM (2H/1H or 13C/12C or 17O/16O or 25Mg/24Mg) was significantly decreased in the treated sample by 48.87% compared to the control sample. Subsequently, the isotopic abundance ratio of PM+2/PM (18O/16O or 26Mg/24Mg) in the treated sample was significantly increased by 29.18% compared with the control sample. In summary, 13C, 2H, 17O, and 25Mg contributions from (C12H23MgO14)+ to m/z 416; 18O and 26Mg contributions from (C12H23MgO14)+ to m/z 417 in the treated sample were significantly altered compared with the control sample. Thus, The Trivedi Effect® Treated magnesium gluconate might be helpful to design the novel potent enzyme inhibitors using its kinetic isotope effects. Consequently, The Trivedi Effect® Treated magnesium gluconate would be valuable for designing better pharmaceutical and/or nutraceutical formulations through its altered physicochemical and thermal properties, which might be providing better therapeutic response against various diseases such as diabetes mellitus, allergy, aging, inflammatory diseases, immunological disorders, and other chronic infections.
VL  - 5
IS  - 2
ER  - 

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