High blood pressure or hypertension is a public health problem in Burkina Faso. According to official statistics, its prevalence rate is estimated at 20%. The management of this disease is long-term with chronic treatments. This leads the population to resort to efficient, accessible and cheaper herbal medicines. Anogeissus leiocarpa is one of the plants used in traditional medicine for the treatment of hypertension in Burkina Faso. Earlier preclinical studies have proved the efficacy and safety of trunk bark extract. In this investigation, bioactive chemical marker phytocompounds are sought for the development, quality control and standardization of the antihypertensive drug based on this plant. The extracts of this plant are prepared by decoction from trunk bark powder and then fractionated successively with solvents in order of increasing polarity (n-hexane, dichloromethane, ethyl acetate and 1-butanol). The fractions obtained are subjected to phytochemical screening. The antioxidant properties of the different extracts have also been studied since the chemical species known as free radicals, which cause oxidative stress, are related to hypertension. The evaluation of the contents of total phenolic compounds and total flavonoids, which would have antihypertensive properties, was carried out according to the method using Folin-Ciocalteu. The highest total phenolic and total flavonoid contents were obtained with the ethyl acetate fraction (89.52 mg tannic acid equivalent/g dry extract and 70.87 mg quercetin equivalent/g dry extract for flavonoids). The best antioxidant power is also obtained with the ethyl acetate fraction (IC50: 6.93µg /mL). Standardization tests using analytical methods have identified three compounds A, B and C whose structure determination is in progress. These compounds could be used as markers for quality control of the prototype antihypertensive phytodrugs developed.
| Published in | American Journal of Applied Chemistry (Volume 8, Issue 1) |
| DOI | 10.11648/j.ajac.20200801.12 |
| Page(s) | 6-12 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Anogeissus leiocarpa, Chemical Markers, Total Polyphenols, Total Flavonoids, Antioxidant Activity, HLC Profile
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APA Style
Benjamin Ouedraogo, Jules Yoda, Felix Kini, Jean Claude Ouedraogo, Marius Lompo, et al. (2020). Research of Bioactive Chemical Markers in Trunk Bark Extracts of Anogeissus leiocarpa, a Traditional Herbal Remedy for Hypertension. American Journal of Applied Chemistry, 8(1), 6-12. https://doi.org/10.11648/j.ajac.20200801.12
ACS Style
Benjamin Ouedraogo; Jules Yoda; Felix Kini; Jean Claude Ouedraogo; Marius Lompo, et al. Research of Bioactive Chemical Markers in Trunk Bark Extracts of Anogeissus leiocarpa, a Traditional Herbal Remedy for Hypertension. Am. J. Appl. Chem. 2020, 8(1), 6-12. doi: 10.11648/j.ajac.20200801.12
AMA Style
Benjamin Ouedraogo, Jules Yoda, Felix Kini, Jean Claude Ouedraogo, Marius Lompo, et al. Research of Bioactive Chemical Markers in Trunk Bark Extracts of Anogeissus leiocarpa, a Traditional Herbal Remedy for Hypertension. Am J Appl Chem. 2020;8(1):6-12. doi: 10.11648/j.ajac.20200801.12
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Download@article{10.11648/j.ajac.20200801.12,
author = {Benjamin Ouedraogo and Jules Yoda and Felix Kini and Jean Claude Ouedraogo and Marius Lompo and Sylvin Ouedraogo},
title = {Research of Bioactive Chemical Markers in Trunk Bark Extracts of Anogeissus leiocarpa, a Traditional Herbal Remedy for Hypertension},
journal = {American Journal of Applied Chemistry},
volume = {8},
number = {1},
pages = {6-12},
doi = {10.11648/j.ajac.20200801.12},
url = {https://doi.org/10.11648/j.ajac.20200801.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajac.20200801.12},
abstract = {High blood pressure or hypertension is a public health problem in Burkina Faso. According to official statistics, its prevalence rate is estimated at 20%. The management of this disease is long-term with chronic treatments. This leads the population to resort to efficient, accessible and cheaper herbal medicines. Anogeissus leiocarpa is one of the plants used in traditional medicine for the treatment of hypertension in Burkina Faso. Earlier preclinical studies have proved the efficacy and safety of trunk bark extract. In this investigation, bioactive chemical marker phytocompounds are sought for the development, quality control and standardization of the antihypertensive drug based on this plant. The extracts of this plant are prepared by decoction from trunk bark powder and then fractionated successively with solvents in order of increasing polarity (n-hexane, dichloromethane, ethyl acetate and 1-butanol). The fractions obtained are subjected to phytochemical screening. The antioxidant properties of the different extracts have also been studied since the chemical species known as free radicals, which cause oxidative stress, are related to hypertension. The evaluation of the contents of total phenolic compounds and total flavonoids, which would have antihypertensive properties, was carried out according to the method using Folin-Ciocalteu. The highest total phenolic and total flavonoid contents were obtained with the ethyl acetate fraction (89.52 mg tannic acid equivalent/g dry extract and 70.87 mg quercetin equivalent/g dry extract for flavonoids). The best antioxidant power is also obtained with the ethyl acetate fraction (IC50: 6.93µg /mL). Standardization tests using analytical methods have identified three compounds A, B and C whose structure determination is in progress. These compounds could be used as markers for quality control of the prototype antihypertensive phytodrugs developed.},
year = {2020}
}
TY - JOUR T1 - Research of Bioactive Chemical Markers in Trunk Bark Extracts of Anogeissus leiocarpa, a Traditional Herbal Remedy for Hypertension AU - Benjamin Ouedraogo AU - Jules Yoda AU - Felix Kini AU - Jean Claude Ouedraogo AU - Marius Lompo AU - Sylvin Ouedraogo Y1 - 2020/02/18 PY - 2020 N1 - https://doi.org/10.11648/j.ajac.20200801.12 DO - 10.11648/j.ajac.20200801.12 T2 - American Journal of Applied Chemistry JF - American Journal of Applied Chemistry JO - American Journal of Applied Chemistry SP - 6 EP - 12 PB - Science Publishing Group SN - 2330-8745 UR - https://doi.org/10.11648/j.ajac.20200801.12 AB - High blood pressure or hypertension is a public health problem in Burkina Faso. According to official statistics, its prevalence rate is estimated at 20%. The management of this disease is long-term with chronic treatments. This leads the population to resort to efficient, accessible and cheaper herbal medicines. Anogeissus leiocarpa is one of the plants used in traditional medicine for the treatment of hypertension in Burkina Faso. Earlier preclinical studies have proved the efficacy and safety of trunk bark extract. In this investigation, bioactive chemical marker phytocompounds are sought for the development, quality control and standardization of the antihypertensive drug based on this plant. The extracts of this plant are prepared by decoction from trunk bark powder and then fractionated successively with solvents in order of increasing polarity (n-hexane, dichloromethane, ethyl acetate and 1-butanol). The fractions obtained are subjected to phytochemical screening. The antioxidant properties of the different extracts have also been studied since the chemical species known as free radicals, which cause oxidative stress, are related to hypertension. The evaluation of the contents of total phenolic compounds and total flavonoids, which would have antihypertensive properties, was carried out according to the method using Folin-Ciocalteu. The highest total phenolic and total flavonoid contents were obtained with the ethyl acetate fraction (89.52 mg tannic acid equivalent/g dry extract and 70.87 mg quercetin equivalent/g dry extract for flavonoids). The best antioxidant power is also obtained with the ethyl acetate fraction (IC50: 6.93µg /mL). Standardization tests using analytical methods have identified three compounds A, B and C whose structure determination is in progress. These compounds could be used as markers for quality control of the prototype antihypertensive phytodrugs developed. VL - 8 IS - 1 ER -
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