Croton lobatus L. is medicinal plant widely used in traditional medicine, but little known in literature for its biological properties. Aims were to study its phytochemical composition and some biological properties and influence of acid hydrolysis on biological activities and chemical composition of Croton lobatus L. extracts. Successive extractions with solvents of increasing polarity (cyclohexane, ethyl acetate, and methanol) were carried out on powder of Croton lobatus L. leaves. Evaluation of xanthine oxidase, acetylcholinesterase, 5-lipoxygenase and α-amylase inhibitions, antioxidant activity was performed. Acid hydrolysis effect was evaluated by comparison of chemical composition and xanthine oxidase, α-amylase inhibition activities of hydrolyzed and unhydrolyzed extracts. Results showed that at 50 mg/L Croton lobatus L. has very small antioxidant activity (3.4 - 4.9%), small inhibitory activity of 5-lipoxygenase (6.3-6.9%), inhibitory activity of acetylcholinesterase between (2.7 - 31.3%), moderate inhibitory activity of α-amylase (52.8 - 64.3%), moderate inhibitory activity of xanthine oxidase (22.2 - 62.6%). Croton lobatus L. could be used in diabetes and gout treatments, given results of α-amylase inhibition and xanthine oxidase. Acid hydrolysis has negative effect on process of xanthine oxidase inhibition and on chemical composition.
| Published in | American Journal of Applied Chemistry (Volume 8, Issue 1) |
| DOI | 10.11648/j.ajac.20200801.13 |
| Page(s) | 13-22 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Croton lobatus L., Antioxidant, Acetylcholinesterase, Xanthine Oxidase, α-amylase, 5-Lipoxygenase, Inhibition, Acid Hydrolysis
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APA Style
Marthe Dominique Chodaton-Zinsou, Fidèle Mahoudo Assogba, Eléonore Yayi-Ladékan, Fernand Gbaguidi, Mansourou Moudachirou, et al. (2020). Phytochemical Composition, Biological Activities of Croton lobatus L. Leaves, Hydrolysis Effect on Activities and Chemical Composition. American Journal of Applied Chemistry, 8(1), 13-22. https://doi.org/10.11648/j.ajac.20200801.13
ACS Style
Marthe Dominique Chodaton-Zinsou; Fidèle Mahoudo Assogba; Eléonore Yayi-Ladékan; Fernand Gbaguidi; Mansourou Moudachirou, et al. Phytochemical Composition, Biological Activities of Croton lobatus L. Leaves, Hydrolysis Effect on Activities and Chemical Composition. Am. J. Appl. Chem. 2020, 8(1), 13-22. doi: 10.11648/j.ajac.20200801.13
AMA Style
Marthe Dominique Chodaton-Zinsou, Fidèle Mahoudo Assogba, Eléonore Yayi-Ladékan, Fernand Gbaguidi, Mansourou Moudachirou, et al. Phytochemical Composition, Biological Activities of Croton lobatus L. Leaves, Hydrolysis Effect on Activities and Chemical Composition. Am J Appl Chem. 2020;8(1):13-22. doi: 10.11648/j.ajac.20200801.13
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Download@article{10.11648/j.ajac.20200801.13,
author = {Marthe Dominique Chodaton-Zinsou and Fidèle Mahoudo Assogba and Eléonore Yayi-Ladékan and Fernand Gbaguidi and Mansourou Moudachirou and Joachim Djimon Gbénou},
title = {Phytochemical Composition, Biological Activities of Croton lobatus L. Leaves, Hydrolysis Effect on Activities and Chemical Composition},
journal = {American Journal of Applied Chemistry},
volume = {8},
number = {1},
pages = {13-22},
doi = {10.11648/j.ajac.20200801.13},
url = {https://doi.org/10.11648/j.ajac.20200801.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajac.20200801.13},
abstract = {Croton lobatus L. is medicinal plant widely used in traditional medicine, but little known in literature for its biological properties. Aims were to study its phytochemical composition and some biological properties and influence of acid hydrolysis on biological activities and chemical composition of Croton lobatus L. extracts. Successive extractions with solvents of increasing polarity (cyclohexane, ethyl acetate, and methanol) were carried out on powder of Croton lobatus L. leaves. Evaluation of xanthine oxidase, acetylcholinesterase, 5-lipoxygenase and α-amylase inhibitions, antioxidant activity was performed. Acid hydrolysis effect was evaluated by comparison of chemical composition and xanthine oxidase, α-amylase inhibition activities of hydrolyzed and unhydrolyzed extracts. Results showed that at 50 mg/L Croton lobatus L. has very small antioxidant activity (3.4 - 4.9%), small inhibitory activity of 5-lipoxygenase (6.3-6.9%), inhibitory activity of acetylcholinesterase between (2.7 - 31.3%), moderate inhibitory activity of α-amylase (52.8 - 64.3%), moderate inhibitory activity of xanthine oxidase (22.2 - 62.6%). Croton lobatus L. could be used in diabetes and gout treatments, given results of α-amylase inhibition and xanthine oxidase. Acid hydrolysis has negative effect on process of xanthine oxidase inhibition and on chemical composition.},
year = {2020}
}
TY - JOUR T1 - Phytochemical Composition, Biological Activities of Croton lobatus L. Leaves, Hydrolysis Effect on Activities and Chemical Composition AU - Marthe Dominique Chodaton-Zinsou AU - Fidèle Mahoudo Assogba AU - Eléonore Yayi-Ladékan AU - Fernand Gbaguidi AU - Mansourou Moudachirou AU - Joachim Djimon Gbénou Y1 - 2020/03/10 PY - 2020 N1 - https://doi.org/10.11648/j.ajac.20200801.13 DO - 10.11648/j.ajac.20200801.13 T2 - American Journal of Applied Chemistry JF - American Journal of Applied Chemistry JO - American Journal of Applied Chemistry SP - 13 EP - 22 PB - Science Publishing Group SN - 2330-8745 UR - https://doi.org/10.11648/j.ajac.20200801.13 AB - Croton lobatus L. is medicinal plant widely used in traditional medicine, but little known in literature for its biological properties. Aims were to study its phytochemical composition and some biological properties and influence of acid hydrolysis on biological activities and chemical composition of Croton lobatus L. extracts. Successive extractions with solvents of increasing polarity (cyclohexane, ethyl acetate, and methanol) were carried out on powder of Croton lobatus L. leaves. Evaluation of xanthine oxidase, acetylcholinesterase, 5-lipoxygenase and α-amylase inhibitions, antioxidant activity was performed. Acid hydrolysis effect was evaluated by comparison of chemical composition and xanthine oxidase, α-amylase inhibition activities of hydrolyzed and unhydrolyzed extracts. Results showed that at 50 mg/L Croton lobatus L. has very small antioxidant activity (3.4 - 4.9%), small inhibitory activity of 5-lipoxygenase (6.3-6.9%), inhibitory activity of acetylcholinesterase between (2.7 - 31.3%), moderate inhibitory activity of α-amylase (52.8 - 64.3%), moderate inhibitory activity of xanthine oxidase (22.2 - 62.6%). Croton lobatus L. could be used in diabetes and gout treatments, given results of α-amylase inhibition and xanthine oxidase. Acid hydrolysis has negative effect on process of xanthine oxidase inhibition and on chemical composition. VL - 8 IS - 1 ER -
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