Potentiometric Studies of Stability Constants and Speciation of Binary and Ternary Complexes of Metal (II) Ions with Amino Acids and Thiobarbituric Acid

Kayode Taiwo Ishola; Mary Adelaide Oladipo; Omobola Ajibike Odedokun; Oladapo Tunde Olanipekun

doi:doi:10.11648/j.ajac.20200801.14

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Potentiometric Studies of Stability Constants and Speciation of Binary and Ternary Complexes of Metal (II) Ions with Amino Acids and Thiobarbituric Acid

Kayode Taiwo Ishola, Mary Adelaide Oladipo, Omobola Ajibike Odedokun, Oladapo Tunde Olanipekun

Published in American Journal of Applied Chemistry (Volume 8, Issue 1)

Received: 29 February 2020 Accepted: 19 March 2020 Published: 13 April 2020

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Abstract

Several chelating agents have been widely used as scavengers to transport metals to or away from vulnerable sites due to their ability to form stable complexes with different metal ions. Many of the chelating agents have been reported to be toxic, non-biodegradable and inflexible for the recovery of bound metal ions. The inherent drawbacks with these chelating agents necessitate a search for their replacement. Therefore, the extent of coordination of L-tyrosine, L-histidine (secondary ligands) and Thiobarbituric acid (primary ligand) with Co(II), Cu(II) and Pb(II) in an aqueous medium at 27°C and 35°C has been examined potentiometrically with ionic strength maintained by 0.02M NaNO₃. The potentiometric equilibrium measurements showed that the ligands formed binary and ternary complexes with the metal ions. Ternary complexes were formed by simultaneous mechanisms and they were found to be more stable than the corresponding binary complexes. The order of stability was found to increase with an increase in the covalent index of the metal ions and decrease with increase in temperature. Speciation diagram showed the variation in stability constants of the binary and ternary complexes as the function of pH. The ligands exhibited high coordinating properties and could be used as metal scavengers for transportation of metals to or away from vulnerable sites. The binary metal complexes could be applied as a medium of transporting chemotherapeutic drugs to target sites or detoxifying poisonous substances which possesses donor atoms with chelating capability.

Published in	American Journal of Applied Chemistry (Volume 8, Issue 1)
DOI	10.11648/j.ajac.20200801.14
Page(s)	23-30
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Binary Complexes, Potentiometric, Speciation, Stability Constants, Ternary Complexes

References

[1]	Swaddle, T. W. Inorganic Chemistry: An Industrial and Environmental Perspective. Chem. Educ. 1997, 74, 12, 13-99
[2]	Hernandez-Gil, J., Perello, L., Ortiz, R., Alzuet, G., GonzalezAlvarez, M. & Liu-Gonzalez, M. Synthesis, structure and biological properties of several binary and ternary complexes of copper(II) with ciprofloxacin and 1, 10 phenanthroline. Polyhedron, 2009, 28, 138–144.
[3]	Masoud, M. S., El-Merghany, A., Abd El-Kaway, M. Y. Synthesis and physico-chemical properties of biologically active purine complexes. Syn. React. Inorg. Met. Org. Nano Met. Chem., 2009, 39, 537–553.
[4]	Maslowska, J. & Owczarek, A. Potentiometric studies on mixed complexes of alkaline earth group metals with ascorbic and tartaric acid. Polish Journal of Chemistry, 1988, 62, 75-82.
[5]	Kleszczewska, E. The spectrophotometry determination of chelate complex: L-ascorbic acid with cuprum (II) and mercury (II) in alkaline solution. Polish Journal of Environmental Studies, 1999, 8 (5), 313 − 318.
[6]	Hughes, M. N. (1981). The Inorganic Chemistry of Biological Processes, 2nd edn., New York: John Wiley & Sons.
[7]	Liang, Y. M., Liu, C. M., Ma, Y. X. & Li. Q. S. Formylferrocene 5- phenyloxazole-2 carbonylhydrazone bivalent transition metal complexes. Transition Met. Chem.,. 1998, 23, 97-99.
[8]	Haran, R., Gairin, J. & Commenges, G. Gallium-71, carbon-13 and hydrogen-1NMR studies of the interactions of pyridoxal 5_-phosphate isonicotinyl hydrazone with gallium in aqueous solution. Inorg. Chim. Acta., 1980, 46, 63-67.
[9]	Parashar, K., Sharma, R. C., Kumar, A. & Mohan G. Stability studies in relation to IR data of some schiff base complexes of transition metals and their biological and pharmacological studies. Inorg. Chim. Acta., 1988, 151, 201-208.
[10]	Shailendrasingh, V. T., Mazahar, F. & Naikwadeb, S. D. study of binary complexes of transition metal ions and lanthanide metal ions with adenosine drug in mixed solvent system, Acta chim. pharm. Indica, 2013, 3 (1), 35-39.
[11]	Sumer, D. T., Devidas, T. M., Kamlesh, P. M., Rajesh, D. D. & Mangesh, S. T. Metal ligand stability constants of Th(III), Sm(III), Nd(III) and Pr(III) metalion complexes with 2 mercapto-4-substituted phenyl-6-substituted phenyl pyrimidines at 0.1 M ionic strength pH metrically, Der Pharma Chemica, 2011, 3 (6), 382-389.
[12]	Jeyaprakash, D., Paramasivam, S., Thirugnanasamy, E., Sutha, S. & Saravanan, R. Complexation Equilibria and Coordination Aspect of Zn(II) Complexes Contain 2 Aminobenzamide and some Bioactive Amino acid Mixed Ligands pH–metric, Spectroscopic and Thermodynamic Studies, Acta Chim. Slov., 2014, 61, 803–812.
[13]	Sangita, S., Dipika, D. & Madhurjya, N. A study of the formation constants of ternary and quaternary complexes of some bivalent transition metals, Journal of Serbian Chemical Society, 2010, 75 (1), 75–82.
[14]	Ammar, R. A., Al-mutiri, R. A. & Abdalla, M A. Equilibrium study of the mixedcomplexes of copper(II) with adenine and amino acids in aqueous solution. Journal of solution chemistry, 2010, 39, 727-737.
[15]	Naciye, T. & Suat, A. M. Complex Formation of Nickel(II) and Copper(II) with Barbituric Acid, International Journal of Analytical chemistry, 2014, 1-5.
[16]	Bhattacharya, M., Iqbal S. A. & Malik S. Studies on Furosemide Salicylaldehyde Schiff Base Complex with Copper(II) and Zinc(II). Asian journal of chemistry, 2006, 18, 1, 715-717.
[17]	Abdulbaset, A. Z., Mazahar, F. B. & Janrao, D. M. Study of stability constant of biological active molecules (drug) using potentiometric titration technique, Journal of Chemical, Biological and Physical Sciences, 2011, 2 (1), 67-8.
[18]	Siham A. L. & Reda, A. A. Mixed-ligand complex formation of cu(ii) with 1,2-diphenylethylenediamine as primary ligan and amino acids as secondary ligands. Int. J. electrochem. sci., 2012, 7, 7699-7711.
[19]	Jahangir, M. A., Ullah, M. R. & Mousume, A. Determination of stability constant of mixedn ligand complexes of Ni(II) and Cu(II) metal ions with Diethylenetriamine (DET) and Ethylenediamine(en), Glycine (gly), alpha-Alanine (alpha-ala), Phenylalanine (ph-ala). Oxalic acid (ox), Tyrosine (tyr), Journal of Ultra Scientist of Physical sciences, 2018, 30 (2), 12-1.
[20]	Verma, S., Singh, D., Kumar, R., Shukla, B. K. & Krishna, V. Equilibrium study and stability constants of mixed Ligand complexes of Biomolecules and Amino acids with Metal ions by Potentiometric method. Research Journal of Chemical Sciences, 2015, 5 (3), 42-48.
[21]	Farooque, B. A., Patel, S. K. & Quddri, S. H. A potentiometric study of stability of metal ion complexes with bidentate ligand. International Journal of Chemical Science, 2009, 7 (2), 1033-1038.
[22]	Nieboer, E. & Richardson, D. H. S. The replacement of the nondescript term 'heavy metals' by a biologically and chemically significant classification of metal ions, Environmental Pollution Series B, Chemical and Physical, 1980, 1 (1): 3-26.
[23]	Oladipo, M. A., Ishola, K. T. & Ajayeoba, T. A. Investigation of Extent of Interaction of Thiobarbituric Acid and Two Selected Amino Acids with Three Divalent Metal Ions in Aqueous-organic Medium at Different Temperatures. Current Journal of Applied Science and Technology, 2019, 36 (3), 1-8.
[24]	Shriver, D. F. & Atkins, P. W. Inorganic chemistry (3rd ed.) 1999. Oxford: University press.
[25]	Salvatore, M., Andrea, A., Arcangelo, M., Angelo, V. Electronic and vibrational polarizabilities of the twenty naturally occurring amino acids. Biophysical Chemistry, Elsevier, 2007, 132 (2-3), 139-146
[26]	Marcel, S., Jaap G. S., & Piet T. V. Polarizabilities of amino acid residues, Journal of Computational Methods in Sciences and Engineering, 2004, 4, 419–425.
[27]	Usama, E., Kenawy, I. M. Usama, E., Kenawy, I. M. & Abu, E. Y. G. Synthesis, thermal and spectral studies of first-row transition metal complexes with Girard-T reagent-based ligand Journal of Molecular Structure, 2007, 871 (3), 14-23.
[28]	Haider, S. Z. (1994). Introduction to modem inorganic chemistry. Dhaka, Bangladesh: Frieends International.

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Kayode Taiwo Ishola, Mary Adelaide Oladipo, Omobola Ajibike Odedokun, Oladapo Tunde Olanipekun. (2020). Potentiometric Studies of Stability Constants and Speciation of Binary and Ternary Complexes of Metal (II) Ions with Amino Acids and Thiobarbituric Acid. American Journal of Applied Chemistry, 8(1), 23-30. https://doi.org/10.11648/j.ajac.20200801.14

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ACS Style

Kayode Taiwo Ishola; Mary Adelaide Oladipo; Omobola Ajibike Odedokun; Oladapo Tunde Olanipekun. Potentiometric Studies of Stability Constants and Speciation of Binary and Ternary Complexes of Metal (II) Ions with Amino Acids and Thiobarbituric Acid. Am. J. Appl. Chem. 2020, 8(1), 23-30. doi: 10.11648/j.ajac.20200801.14

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AMA Style

Kayode Taiwo Ishola, Mary Adelaide Oladipo, Omobola Ajibike Odedokun, Oladapo Tunde Olanipekun. Potentiometric Studies of Stability Constants and Speciation of Binary and Ternary Complexes of Metal (II) Ions with Amino Acids and Thiobarbituric Acid. Am J Appl Chem. 2020;8(1):23-30. doi: 10.11648/j.ajac.20200801.14

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@article{10.11648/j.ajac.20200801.14,
  author = {Kayode Taiwo Ishola and Mary Adelaide Oladipo and Omobola Ajibike Odedokun and Oladapo Tunde Olanipekun},
  title = {Potentiometric Studies of Stability Constants and Speciation of Binary and Ternary Complexes of Metal (II) Ions with Amino Acids and Thiobarbituric Acid},
  journal = {American Journal of Applied Chemistry},
  volume = {8},
  number = {1},
  pages = {23-30},
  doi = {10.11648/j.ajac.20200801.14},
  url = {https://doi.org/10.11648/j.ajac.20200801.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajac.20200801.14},
  abstract = {Several chelating agents have been widely used as scavengers to transport metals to or away from vulnerable sites due to their ability to form stable complexes with different metal ions. Many of the chelating agents have been reported to be toxic, non-biodegradable and inflexible for the recovery of bound metal ions. The inherent drawbacks with these chelating agents necessitate a search for their replacement. Therefore, the extent of coordination of L-tyrosine, L-histidine (secondary ligands) and Thiobarbituric acid (primary ligand) with Co(II), Cu(II) and Pb(II) in an aqueous medium at 27°C and 35°C has been examined potentiometrically with ionic strength maintained by 0.02M NaNO3. The potentiometric equilibrium measurements showed that the ligands formed binary and ternary complexes with the metal ions. Ternary complexes were formed by simultaneous mechanisms and they were found to be more stable than the corresponding binary complexes. The order of stability was found to increase with an increase in the covalent index of the metal ions and decrease with increase in temperature. Speciation diagram showed the variation in stability constants of the binary and ternary complexes as the function of pH. The ligands exhibited high coordinating properties and could be used as metal scavengers for transportation of metals to or away from vulnerable sites. The binary metal complexes could be applied as a medium of transporting chemotherapeutic drugs to target sites or detoxifying poisonous substances which possesses donor atoms with chelating capability.},
 year = {2020}
}

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TY  - JOUR
T1  - Potentiometric Studies of Stability Constants and Speciation of Binary and Ternary Complexes of Metal (II) Ions with Amino Acids and Thiobarbituric Acid
AU  - Kayode Taiwo Ishola
AU  - Mary Adelaide Oladipo
AU  - Omobola Ajibike Odedokun
AU  - Oladapo Tunde Olanipekun
Y1  - 2020/04/13
PY  - 2020
N1  - https://doi.org/10.11648/j.ajac.20200801.14
DO  - 10.11648/j.ajac.20200801.14
T2  - American Journal of Applied Chemistry
JF  - American Journal of Applied Chemistry
JO  - American Journal of Applied Chemistry
SP  - 23
EP  - 30
PB  - Science Publishing Group
SN  - 2330-8745
UR  - https://doi.org/10.11648/j.ajac.20200801.14
AB  - Several chelating agents have been widely used as scavengers to transport metals to or away from vulnerable sites due to their ability to form stable complexes with different metal ions. Many of the chelating agents have been reported to be toxic, non-biodegradable and inflexible for the recovery of bound metal ions. The inherent drawbacks with these chelating agents necessitate a search for their replacement. Therefore, the extent of coordination of L-tyrosine, L-histidine (secondary ligands) and Thiobarbituric acid (primary ligand) with Co(II), Cu(II) and Pb(II) in an aqueous medium at 27°C and 35°C has been examined potentiometrically with ionic strength maintained by 0.02M NaNO3. The potentiometric equilibrium measurements showed that the ligands formed binary and ternary complexes with the metal ions. Ternary complexes were formed by simultaneous mechanisms and they were found to be more stable than the corresponding binary complexes. The order of stability was found to increase with an increase in the covalent index of the metal ions and decrease with increase in temperature. Speciation diagram showed the variation in stability constants of the binary and ternary complexes as the function of pH. The ligands exhibited high coordinating properties and could be used as metal scavengers for transportation of metals to or away from vulnerable sites. The binary metal complexes could be applied as a medium of transporting chemotherapeutic drugs to target sites or detoxifying poisonous substances which possesses donor atoms with chelating capability.
VL  - 8
IS  - 1
ER  -

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Author Information

Kayode Taiwo Ishola

Department of Chemistry, Federal College of Education, (Special), Oyo, Nigeria
Mary Adelaide Oladipo

Department of Chemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
Omobola Ajibike Odedokun

Department of Chemistry, Federal College of Education, (Special), Oyo, Nigeria
Oladapo Tunde Olanipekun

Department of Chemistry, Federal College of Education, (Special), Oyo, Nigeria

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APA Style

Kayode Taiwo Ishola, Mary Adelaide Oladipo, Omobola Ajibike Odedokun, Oladapo Tunde Olanipekun. (2020). Potentiometric Studies of Stability Constants and Speciation of Binary and Ternary Complexes of Metal (II) Ions with Amino Acids and Thiobarbituric Acid. American Journal of Applied Chemistry, 8(1), 23-30. https://doi.org/10.11648/j.ajac.20200801.14

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ACS Style

Kayode Taiwo Ishola; Mary Adelaide Oladipo; Omobola Ajibike Odedokun; Oladapo Tunde Olanipekun. Potentiometric Studies of Stability Constants and Speciation of Binary and Ternary Complexes of Metal (II) Ions with Amino Acids and Thiobarbituric Acid. Am. J. Appl. Chem. 2020, 8(1), 23-30. doi: 10.11648/j.ajac.20200801.14

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AMA Style

Kayode Taiwo Ishola, Mary Adelaide Oladipo, Omobola Ajibike Odedokun, Oladapo Tunde Olanipekun. Potentiometric Studies of Stability Constants and Speciation of Binary and Ternary Complexes of Metal (II) Ions with Amino Acids and Thiobarbituric Acid. Am J Appl Chem. 2020;8(1):23-30. doi: 10.11648/j.ajac.20200801.14

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@article{10.11648/j.ajac.20200801.14,
  author = {Kayode Taiwo Ishola and Mary Adelaide Oladipo and Omobola Ajibike Odedokun and Oladapo Tunde Olanipekun},
  title = {Potentiometric Studies of Stability Constants and Speciation of Binary and Ternary Complexes of Metal (II) Ions with Amino Acids and Thiobarbituric Acid},
  journal = {American Journal of Applied Chemistry},
  volume = {8},
  number = {1},
  pages = {23-30},
  doi = {10.11648/j.ajac.20200801.14},
  url = {https://doi.org/10.11648/j.ajac.20200801.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajac.20200801.14},
  abstract = {Several chelating agents have been widely used as scavengers to transport metals to or away from vulnerable sites due to their ability to form stable complexes with different metal ions. Many of the chelating agents have been reported to be toxic, non-biodegradable and inflexible for the recovery of bound metal ions. The inherent drawbacks with these chelating agents necessitate a search for their replacement. Therefore, the extent of coordination of L-tyrosine, L-histidine (secondary ligands) and Thiobarbituric acid (primary ligand) with Co(II), Cu(II) and Pb(II) in an aqueous medium at 27°C and 35°C has been examined potentiometrically with ionic strength maintained by 0.02M NaNO3. The potentiometric equilibrium measurements showed that the ligands formed binary and ternary complexes with the metal ions. Ternary complexes were formed by simultaneous mechanisms and they were found to be more stable than the corresponding binary complexes. The order of stability was found to increase with an increase in the covalent index of the metal ions and decrease with increase in temperature. Speciation diagram showed the variation in stability constants of the binary and ternary complexes as the function of pH. The ligands exhibited high coordinating properties and could be used as metal scavengers for transportation of metals to or away from vulnerable sites. The binary metal complexes could be applied as a medium of transporting chemotherapeutic drugs to target sites or detoxifying poisonous substances which possesses donor atoms with chelating capability.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Potentiometric Studies of Stability Constants and Speciation of Binary and Ternary Complexes of Metal (II) Ions with Amino Acids and Thiobarbituric Acid
AU  - Kayode Taiwo Ishola
AU  - Mary Adelaide Oladipo
AU  - Omobola Ajibike Odedokun
AU  - Oladapo Tunde Olanipekun
Y1  - 2020/04/13
PY  - 2020
N1  - https://doi.org/10.11648/j.ajac.20200801.14
DO  - 10.11648/j.ajac.20200801.14
T2  - American Journal of Applied Chemistry
JF  - American Journal of Applied Chemistry
JO  - American Journal of Applied Chemistry
SP  - 23
EP  - 30
PB  - Science Publishing Group
SN  - 2330-8745
UR  - https://doi.org/10.11648/j.ajac.20200801.14
AB  - Several chelating agents have been widely used as scavengers to transport metals to or away from vulnerable sites due to their ability to form stable complexes with different metal ions. Many of the chelating agents have been reported to be toxic, non-biodegradable and inflexible for the recovery of bound metal ions. The inherent drawbacks with these chelating agents necessitate a search for their replacement. Therefore, the extent of coordination of L-tyrosine, L-histidine (secondary ligands) and Thiobarbituric acid (primary ligand) with Co(II), Cu(II) and Pb(II) in an aqueous medium at 27°C and 35°C has been examined potentiometrically with ionic strength maintained by 0.02M NaNO3. The potentiometric equilibrium measurements showed that the ligands formed binary and ternary complexes with the metal ions. Ternary complexes were formed by simultaneous mechanisms and they were found to be more stable than the corresponding binary complexes. The order of stability was found to increase with an increase in the covalent index of the metal ions and decrease with increase in temperature. Speciation diagram showed the variation in stability constants of the binary and ternary complexes as the function of pH. The ligands exhibited high coordinating properties and could be used as metal scavengers for transportation of metals to or away from vulnerable sites. The binary metal complexes could be applied as a medium of transporting chemotherapeutic drugs to target sites or detoxifying poisonous substances which possesses donor atoms with chelating capability.
VL  - 8
IS  - 1
ER  -

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