“Speb-Pebe” - Spicy Product Energy Booster Consumer Test and Its Effects on the Consumers’ Health

Andry Tahina Rabeharitsara; Nambinina Richard Randriana; Nambinina Richard Randriana

doi:doi:10.11648/j.ajac.20210906.12

| Peer-Reviewed

“Speb-Pebe” - Spicy Product Energy Booster Consumer Test and Its Effects on the Consumers’ Health

Andry Tahina Rabeharitsara, Nambinina Richard Randriana, Nambinina Richard Randriana

Published in American Journal of Applied Chemistry (Volume 9, Issue 6)

Received: 22 September 2021 Accepted: 13 October 2021 Published: 17 November 2021

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Abstract

The “spicy product energy booster (speb)” – “produit épicé boosteur d’énergie (pebe)” – “speb-pebe” was a spice food product composed mainly of “Capsicum chinense”, “Capsicum frutescens” and citric acid as active chemical molecules like preservative, catalyst and reactant. Thus, its important chemical bioactive molecules were capsaïcine, luteolin and quercetin; these molecules presented in their structure either ether and/or alcohol and/or amine and/or alkene organic functions which could reacted chemically with citric acid molecules catalyzed by citric acid protonic acid-H⁺ to give esters, esters of citric acid, amides and amides of citric acid. These chemical reactions were very important because these citric acid derivatives forms of “speb-pebe’s” bioactive molecules facilitated their partial or total solubilization and diffusion-transport through the organism particularly through the bloodstream via chylomicrons and lymphatic system. This efficient diffusion-transport allowed to the efficiency of their therapeutic vertues through the organism which were not only developed in this manuscript but also observed through a consumer test realized on the “speb-pebe” food product during one month such as its daily consumed quantity was limited to one teaspoon which corresponded to maximally 2g of “speb-pebe” respecting its components’ bioactive molecules daily limit of consumption including quercetin, capsaicin and luteolin. First, the results of this consumer test, realized on individuals, permitted to confirm that this “speb-pebe” food product was an energy booster. Indeed, the majority of individuals who participated in the “speb-pebe” consumption test had experienced an increase in their physical capacity and among adulthood who play sport, among student adolescent no one felt physical capacity decrease. Second, it was confirmed that the “speb-pebe” food product was classed by 43.48% of individuals as a taste and smell enhancing condiment which increased their appetite. Third, an appreciable spices’ bioactive molecules therapeutic virtues were confirmed by individuals participating this “speb-pebe” consumer test including non-detected of chronic and acute rhinitis, disappearance of psoriasis and the great majority of them felt their youth renewed; 76.20% of them were observed with normal increasing (38.10%) or stabilizing (38.10%) their weight at the end of the test without blood pressure disorder. These promising results was partly due to the probably regeneration of the chemical compound «phosphatidylserine-PS» particularly their two esters of fatty acids and an amino-acid organic functions by mechanisms described subsequently in this manuscript and the longevity of its activities as phagocyte by apoptosis where proteins probably plays significant role as citric acid protonic acid-H⁺ catalyst support.

Published in	American Journal of Applied Chemistry (Volume 9, Issue 6)
DOI	10.11648/j.ajac.20210906.12
Page(s)	186-201
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Capsicum chinense, “Produit épicé Boosteur d’énergie_pebe-speb”, Capsicum frutescens, Citric Acid, Capsaïcine, Luteolin, Quercetin, «phosphatidylserine-PS»

References

[1]	Nambinina Richard Randriana, Ernestine Ravomialisoa, Andry Tahina Rabeharitsara “Washing-Disinfectant Product Synthesis Tested During the Production of the “Speb-Pebe” - Spicy Product Energy Booster Characterized by Established Titration Procedures” American Journal of Applied Chemistry Volume 9, Issue 3, June 2021, Pages: 53-64 Received: May 17, 2021; Accepted: May 29, 2021; Published: Jun. 21, 2021.
[2]	Nambinina Richard Randriana, Rovatahianjanahary Behevitra, Andry Tahina Rabeharitsara: “Pine Wood Powder Treatment to B_XH⁺ Homogeneous Catalyst (H⁺/H₂SO₄) Supported on Its Aromatics’ and PNA’ Alkenes – Application in Black Citric Acid Polymer Synthesis”, American Journal of Polymer Science and Technology - Volume 4, Issue 1, March 2018, Pages: 1-27 - Chemical Process Engineering Department (E. S. P. A), Antananarivo University, Antananarivo, Madagascar.
[3]	Nambinina Richard Randriana, Raherimandimby Jaochim, Andry Tahina Rabeharitsara: “Trans-Esterification Between Citric Acid and Peanut Oil at Low pH and Ambient Temperature Catalyzed by Citric Acid and Sulfuric Acid Protonic Acid-H+”, American Journal of Applied Chemistry - Volume 8, Issue 4, August 2020, Pages: 100-116 - Chemical Process Engineering Department (E. S. P. A), Antananarivo University, Antananarivo, Madagascar.
[4]	Nambinina Richard Randriana, Sedraniaina Domoina Marie Esperance, Randriamanantena Ny Idealy Elite, Mampitefa Raïssa Faneva,, Andry Tahina Rabeharitsara: “Esterification Between Citric Acid and Callistemon citrinus, Rice-Husk, Garcinia dulcis Catalysed by Citric Acid’s-H+- Monomers and Polymers Formation Mechanism”, American Journal of Applied Chemistry - Volume 8, Issue 2, April 2020, Pages: 31-54 - Chemical Process Engineering Department (E. S. P. A), Antananarivo University, Antananarivo, Madagascar.
[5]	Nambinina Richard Randriana, Ratsimba Marie Hanitriniaina, Rakotomalala Alain Fabrice, Rakotosaona Rijalalaina,, Andry Tahina Rabeharitsara: “Synthesis of Glues with Citric Acid and Sulfuric Acid Protonic Acid-H+ as Catalysts Using Banana Peel and Kaki as Valorised Raw Materials” American Journal of Applied Chemistry Volume 9, Issue 1, February 2021, Pages: 21-35 Received: Jan. 14, 2021; Accepted: Jan. 22, 2021; Published: Jan. 28, 2021 - Chemical Process Engineering Department (E. S. P. A), Antananarivo University, Antananarivo, Madagascar.
[6]	Nambinina Richard Randriana, Raharilaza Paulin Merix, Andry Tahina Rabeharitsara: “Esterification Between Citric acid and Pumpkin Pips’ Organic Molecules – Esters Hydrolysis And Esters Used as Hydrocarbons Additives”, American Journal of Applied Chemistry - Volume 6, Issue 3, June 2018, Pages: 78-95 - Chemical Process Engineering Department (E. S. P. A), Antananarivo University, Antananarivo, Madagascar.
[7]	Robert Jarret, Terry Berke, Elizabeth A Baldwin, George Antonious: “Variability for Free Sugars and Organic Acids in Capsicum chinense” - March 2009, Chemistry & Biodiversity 6 (2): 138-45, doi: 10.1002/cbdv.200800046.
[8]	George F. Antonious “Capsaicinoids and Vitamins in Hot Pepper and Their Role in Disease Therapy“Submitted: January 16th 2018Reviewed: May 2nd 2018Published: November 5th 2018, DOI: 10.5772/intechopen.78243.
[9]	"Capsicum chinense” Jacq. The Plant List.
[10]	Carl Linnaeus (Carl von Linné) (1707-1778).
[11]	Carvalho, S. I. C.; Ragassi, C. F.; Bianchetti, L. B.; Reifschneider, F. J. B.; Buso, G. S. C.; Faleiro, F. G. (2014-09-12). "Morphological and genetic relationships between wild and domesticated forms of peppers (Capsicum frutescens L. and C. chinense Jacquin)" Genetics and Molecular Research. 13 (3): 7447–7464. doi: 10.4238/2014. September. 12. 11. ISSN 1676-5680. PMID 25222244.
[12]	Nosek, Thomas M. "Section 6/6ch4/s6ch4_6". Essentials of Human Physiology. Archived from the original on 2016-01-17.
[13]	Edgar, M.; Dawes, C.; O'Mullane, D. (2004). Saliva and Oral Health (3 ed.). British Dental Association. ISBN 978-0-904588-87-3.
[14]	Fejerskov, O.; Kidd, E. (2007). Dental Caries: The Disease and Its Clinical Management (2nd ed.). Wiley-Blackwell. ISBN 978-1-4051-3889-5.
[15]	“Les aliments riches en quercetine” https://conseils-naturels.com/aliments-riche-quercetine/
[16]	Département de l'Agriculture des États-Unis, «USDA Database for the Flavonoid Content of Selected Foods» [archive], sur http://www.nal.usda.gov [archive], National Agricultural Library, 2003.
[17]	Phenol Explorer INRA.
[18]	ANSES - Table de composition nutritionnelle des aliments - piments (Ciqual).
[19]	DJ Bennett and GW Kirby (1968) Constitution and biosynthesis of capsaicin. Journal of Chemical Society, 442-446.
[20]	Lee Y., Howard L. R., Villalon B. (1995) Flavonoids and antioxidant activity of fresh pepper (Capsicum annuum) cultivars. Journal of Food Science 60: 473-476.
[21]	Howard L. R., Talcott S. T., Brenes C. H., Villalon B. (2000) “Changes in phytochemical and antioxidant activity of selected pepper cultivars (Capsicum species) as influenced by maturity”. Journal of Agricultural and Food Chemistry 48: 1713-1720 PubMed (10820084).
[22]	Michael H. Davidson “Revue générale du métabolisme des lipides”, MD, FACC, FNLA, University of Chicagoa Medecine.
[23]	Jacques E. POISSON, «ALCALOÏDES», Encyclopædia Universalis.
[24]	J. B. Van Rijswijk, E. L. Boeke, J. M. Keizer, P. G. H. Mulder, H. M. Blom, W. J. Fokkens. Department of Otorhinolaryngology, Erasmus Medical Centre, Rotterdam, The Netherlands; Department of Epidemiology & Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands; Department of Otorhinolaryngology and Head & Neck Surgery, The Red Cross Hospital and The Juliana Children Hospital, The Hague, The Netherlands dans Allergy 58 (8), 754-761.
[25]	Marvin P. Fried, MD, Montefiore Medical Center, The University Hospital of Albert Einstein College of Medicine. “Rhinite non allergique”.
[26]	Nicola L. Jones, Souheil Shabaib, Philip M. Sherman «Capsaicin as an inhibitor of the growth of the gastric pathogen Helicobacter pylori» Elsevier – FEMS MICROBIOLOGY LETTERS 146 (1997) 223-227 – Division of Gastroenterology and Nutrition Research, The Hospital for Sick Children Departments of Pediatrics and Microbiology University of Toronto, Ont M5G 1X8 Canada – Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
[27]	Nimish Vakil, MD, University of Wisconsin School of Medicine and Public Health Dernière révision totale mars 2020\| Dernière modification du contenu mars 2020. ” Infection à Helicobacter pylori”.
[28]	Ágata Ramos-Torres, Alicia Bort, Cecilia Morell, Nieves Rodríguez-Henche, and Inés Díaz-Laviada: “The pepper's natural ingredient capsaicin induces autophagy blockage in prostate cancer cells” Department of System Biology, Biochemistry and Molecular Biology Unit, School of Medicine, Alcala University, Alcala de Henares 28871, Madrid, Spain 2016 Jan 12; 7 (2): 1569-83. doi: 10.18632/oncotarget.6415.
[29]	Kannan, Muthukumar; Riekhof, Wayne R.; Voelker, Dennis R. (2015). "Transport of Phosphatidylserine from the Endoplasmic Reticulum to the Site of Phosphatidylserine Decarboxylase2 in Yeast". Traffic. 16 (2): 123–134. doi: 10.1111/tra.12236. ISSN 1600-0854. PMID 25355612.
[30]	https://fr.wikipedia.org/wiki/Phosphatidylsérine
[31]	Catherine Sarazin L1S2 Biochimie 2016 - Structure Des Protides: Acides Aminés, Peptides, Protéines.
[32]	Camille Lefebvre, Léa Zubiria «La sérine: Tout sur cet acide aminé» - passeportsanté – Octobre 2017 – Juin 2018.
[33]	Ohlrogge JB, Jaworski JG (June 1997). "Regulation of fatty acid synthesis". Annual Review of Plant Physiology and Plant Molecular Biology. 48: 109–136. doi: 10.1146/annurev.arplant.48.1.109. PMID 15012259. S2CID 46348092.
[34]	«ZOSTRIX® - AFT pharmaceuticals».
[35]	Saebyeol Jang, Keith W. Kelley, Rodney W. Johnson. “Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1”. Proc Natl Acad Sci U S A. 2008 May 27; 105 (21): 7534–7539.
[36]	Dong, X.; Wang, Y.; Liu, T.; Wu, P.; Gao, J.; Xu, J.; Yang, B.; Hu, Y. “Flavonoids as Vasorelaxant Agents: Synthesis, Biological Evaluation and Quantitative Structure Activities Relationship (QSAR) Studies”. Molecules 2011, 16, 8257-8272.
[37]	Ko WG, Kang TH, Lee SJ, Kim YC, Lee BH. “Effects of luteolin on the inhibition of proliferation and induction of apoptosis in human myeloid leukaemia cells”. Phytother Res. 2002 May; 16 (3): 295-8. PMID 12164283.
[38]	Shin, Soon Young & Yong, Yeonjoong & Hong, Dae & Lee, Da & Lee, Da & Lee, Young. (2015). “Identification of flavonoids from Eriodictyon californicum and their cytotoxicity against HCT116 colon cancer cells”. Journal of the Korean Society for Applied Biological Chemistry. 58. 10.1007/s13765-015-0015-0.
[39]	Eddouks Mohamed, Chattopadhyay Debprasad. “Phytotherapy in the Management of Diabetes and Hypertension”. Bentham Science Publishers, 2012. eISBN: 978-1-60805-014-7.
[40]	Emran TB, Rahman MA, Uddin MMN, et al. “Molecular docking and inhibition studies on the interactions of Bacopa monnieri’s potent phytochemicals against pathogenic Staphylococcus aureus”. DARU Journal of Pharmaceutical Sciences. 2015; 23 (1): 26. doi: 10.1186/s40199-015-0106-9. PMID 25884228.
[41]	Agnes W. Boots, Guido R. M. M. Haenen et Aalt Bast, «Health effects of quercetin: From antioxidant to nutraceutical», European Journal of Pharmacology, vol. 585, nos 2-3,‎ 2008 https://fr.wikipedia.org/wiki/Quercétine
[42]	Andreas Kampkötter, Claudia Timpel, Ruben Felix Zurawski, Sven Ruhl, Yvonni Chovolou, Peter Proksch et Wim Wätjen, «Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin», Comparative Biochemistry and Physiology, vol. 149,‎ 2008, p. 314-323.
[43]	Akira Murakami, Hitoshi Ashida et Junji Terao, «Multitargeted cancer prévention by quercetin», Cancer Letters, vol. 269,‎ 2008.
[44]	R. L. Edwards, T. Lyon, S. E. Litwin, A. Rabovsky, J. D. Symons et T. Jalili, «Quercetin reduces blood pressure in hypertensive subjects» J. Nutr., vol. 137,‎ 2007.
[45]	A. W. Boots, M. Drent, V. C. J. de Boer, A. Bast et G. R. M. M., Haenen, «Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis», submitted for publication,‎ 2003.
[46]	DA Shoskes, SI Zeitlin, A Shaded et J Rajfer, «Quercetin in men with category III chronic prostatis: a preliminary prospective, double-blind, placebo-controled trial», Urology, vol. 54, no 6,‎ 1999.
[47]	Madhavan P Nair, Supriya Mahajan, Jessica L Reynolds, Ravikumar Aalinkeel, Harikrishnan Nair, Stanley A Schwartz, Chithan Kandaswami “The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system” Clinical and Vaccine Immunology. 2006 Mar; 13 (3): 319-28. doi: 10.1128/CVI.13.3.319-328.2006. Department of Medicine and Microbiology, Kaleida Health System, Buffalo General Hospital, State University of New York at Buffalo, Buffalo, NY 14203, USA. mnair@acsu.buffalo.edu
[48]	Walter Swardfager, Krista Lanctôt, Lana Rothenburg, Amy Wong, Jaclyn Cappell, Nathan Herrmann - “A meta-analysis of cytokines in Alzheimer's disease” Biological Psychiatry. 2010 Nov 15; 68 (10): 930-41. doi: 10.1016/j.biopsych.2010.06.012. Epub 2010 Aug 8. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
[49]	R M Locksley, N Killeen, M J Lenardo – “The TNF and TNF receptor superfamilies: integrating mammalian biology” Cell. 2001 Feb 23; 104 (4): 487-501. doi: 10.1016/s0092-8674(01)00237-9. Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. locksley@medicine.ucsf.edu
[50]	Yekta Dowlati 1, Nathan Herrmann, Walter Swardfager, Helena Liu, Lauren Sham, Elyse K Reim, Krista L Lanctôt – “A meta-analysis of cytokines in major depression” Biological Psychiatry. 2010 Mar 1; 67 (5): 446-57. doi: 10.1016/j.biopsych.2009.09.033. Epub 2009 Dec 16. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
[51]	Haiming Chen, Chuanjian Lu, Huazhen Liu, Maojie Wang, Hui Zhao, Yuhong Yan, Ling Han – “Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway” Elsevier International Immunopharmacology Volume 48, July 2017, Pages 110-117 https://doi.org/10.1016/j.intimp.2017.04.022 Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510115, PR China; Postdoctoral Programme, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510115, PR China; Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, PR China.
[52]	Solomon Habtemariam, Abebech Belai – “Natural Therapies of the Inflammatory Bowel Disease: The Case of Rutin and its Aglycone, Quercetin” Mini Reviews In Medicinal Chemistry - doi: 10.2174/1389557517666170120152417. Pharmacognosy Research Laboratories & Herbal Analysis Services, Chatham-Maritime, Kent ME4 4TB. United Kingdom. - Enteric Neuroscience Lab, Health Sciences Research Centre, Department of Life Sciences, University of Roehampton London, Whitelands College, Holybourne Avenue, London SW15 4JD. United Kingdom.
[53]	R K Oldham – “Natural killer cells: artifact to reality: an odyssey in biology” Cancer metastasis review - 1983; 2 (4): 323-36. doi: 10.1007/BF00048565.
[54]	David Ermert, Maria J Niemiec, Marc Röhm, Andreas Glenthøj, Niels Borregaard, Constantin F Urban – “Candida albicans escapes from mouse neutrophils” Journal of leukocyte biology - 2013 Aug; 94 (2): 223-36. doi: 10.1189/jlb.0213063. Epub 2013 May 6. Laboratory for Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, Umeå University, Sjukhusområdet 6C, 90185 Umeå, Sweden.
[55]	V Witko-Sarsat, P Rieu, B Descamps-Latscha, P Lesavre, L Halbwachs-Mecarelli – “Neutrophils: molecules, functions and pathophysiological aspects” Laboratory investigation a journal of technical methods and pathology. 2000 May; 80 (5): 617-53. doi: 10.1038/labinvest.3780067. INSERM U507, Necker Hospital, Paris, France. witko-sarsat@necker.fr
[56]	R. Clark, S. Klebanoff – “The neutrophil: Function and clinical disorders” Corpus ID: 82086000 Published 1978 Medicine.
[57]	Carl Nathan – “Neutrophils and immunity: challenges and opportunities” Nature Review Immunology. 2006 Mar; 6 (3): 173-82. doi: 10.1038/nri1785. Department of Microbiology and Immunology, Weill Cornell Medical College, Weill Graduate School of Medical Sciences of Cornell University, Box 57, 1300 York Avenue, New York 10021, USA. cnathan@med.cornell.edu
[58]	Paul Ehrlich – “Beiträge für Theorie und Praxis der histologischen Färbung” Leipzig, 1878.
[59]	Elaine Zayas Marcelino da Silva, Maria Célia Jamur, Constance Oliver – “Mast cell function: a new vision of an old cell” The journal of histochemistry and cytochemistry: official journal of the histochemistry society 2014 Oct; 62 (10): 698-738. doi: 10.1369/0022155414545334. Epub 2014 Jul 25. Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil (EZMDS, MCJ, CO) coliver@fmrp.usp.br
[60]	Stavros Polyzoidis, Triantafyllia Koletsa, Smaro Panagiotidou, Keyoumars Ashkan, and Theoharis C. Theoharidescorresponding author – “Mast cells in meningiomas and brain inflammation” Journal of neuroinflammation 2015; 12: 170. Published online 2015 Sep 17. doi: 10.1186/s12974-015-0388-3.
[61]	Jinmin Lee, Sarah L. Veatch, Barbara Baird, and David Holowka – “Molecular mechanisms of spontaneous and directed mast cell motility” Journal of leukocyte biology 2012 Nov; 92 (5): 1029–1041. doi: 10.1189/jlb.0212091.
[62]	Borros Arneth – “Gut-brain axis biochemical signalling from the gastrointestinal tract to the central nervous system: gut dysbiosis and altered brain function” Postgraduate medical journal - 2018 Aug; 94 (1114): 446-452. doi: 10.1136/postgradmedj-2017-135424. Epub 2018 Jul 19. Justus-Liebig-Universität Gießen.
[63]	Jacek Budzyński, Maria Kłopocka – “Brain-gut axis in the pathogenesis of Helicobacter pylori infection” World J Gastroenterol 2014 May 14; 20 (18): 5212-25. doi: 10.3748/wjg.v20.i18.5212. Jacek Budzyński, Department of Gastroenterology, Vascular Diseases and Internal Medicine, Nicolaus Copernicus University, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-168 Bydgoszcz, Poland.
[64]	Marilia Carabotti, Annunziata Scirocco, Maria Antonietta Maselli, and Carola Severia – “The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems” Ann Gastroenterol. 2015 Apr-Jun; 28 (2): 203–209. PMCID: PMC4367209 - PMID: 25830558.
[65]	https://psychscenehub.com/psychinsights/the-simplified-guide-to-the-gut-brain-axis/
[66]	Antonina A Mikocka-Walus, Deborah A Turnbull, Nicole T Moulding, Ian G Wilson, Jane M Andrews, Gerald J Holtmann – “Controversies surrounding the comorbidity of depression and anxiety in inflammatory bowel disease patients: a literature review” Inflammatory bowel diseases 2007 Feb; 13 (2): 225-34. doi: 10.1002/ibd.20062. School of Psychology, University of Adelaide, Adelaide, SA, Australia. antonina.mikockawalus@adelaide.edu.au
[67]	Kinga Bobińska, Elżbieta Gałecka, Janusz Szemraj, Piotr Gałecki, Monika Talarowska – “Is there a link between TNF gene expression and cognitive deficits in depression?” Acta biochimica polonica 2017; 64 (1): 65-73. doi: 10.18388/abp.2016_1276. Epub 2016 Dec 16. Department of Adult Psychiatry, Medical University of Lodz, Łódź, Poland - Department of Pulmonology and Allergology, Medical University of Lodz, Łódź, Poland - Department of Medical Biochemistry, Medical University of Lodz, Łódź, Poland.
[68]	Epithelium Meaning in the Cambridge English Dictionary. dictionary.cambridge.org
[69]	Eurell, Jo Ann C.; et al., eds. (2006). Dellmann's textbook of veterinary histology. Wiley-Blackwell. p. 18. ISBN 978-0-7817-4148-4.
[70]	Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2007) - "Ch. 13: Box on morphology of squamous cell carcinoma". Robbins Basic Pathology (8th ed.). Philadelphia: Saunders. ISBN 978-1-4160-2973-1.
[71]	Alberts B, Johnson A, Lewis J, et al. – “Molecular Biology of the Cell. 4th edition.” - New York: Garland Science; 2002.
[72]	Daniel P. Kaufman; Terrence Sanvictores; Michael Costanza – “Weibel Palade Bodies” SUNY Upstate Medical University, Touro University, Nevada, State University of NY Upstate.
[73]	Kalagara T, Moutsis T, Yang Y, Pappelbaum KI, Farken A, Cladder-Micus L, Vidal-Y-Sy S, John A, Bauer AT, Moerschbacher BM, Schneider SW, Gorzelanny C. “The endothelial glycocalyx anchors von Willebrand factor fibers to the vascular endothelium”. Blood Adv. 2018 Sep 25; 2 (18): 2347-2357.
[74]	Nicholas R., KunioMD, Martin A., SchreiberMD “Topical Hemostatic Agents” - Consultative Hemostasis and Thrombosis (Third Edition) - Expert Consult - Online and Print - 2013, Pages 538-545 – Elsevier.
[75]	Jorge Escribano, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing, Michelle B. Chen, Conceptualization, Data curation, Investigation, Writing – review & editing, Emad Moeendarbary, Data curation, Validation, Writing – review & editing, Xuan Cao, Methodology, Writing – review & editing, Vivek Shenoy, Methodology, Writing – review & editing, Jose Manuel Garcia-Aznar, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing,Roger D. Kamm, Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing and Fabian Spill, Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing *Andrew D. McCulloch, Editor – “Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation” - PLoS Comput Biol. 2019 May; 15 (5): e1006395. Published online 2019 May 2. doi: 10.1371/journal.pcbi.1006395 Department of Mechanical Engineering, University of Zaragoza, Zaragoza, Spain, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Bioengineering, Stanford University, Stanford, California, United States of America, Department of Mechanical Engineering, University College London, London, United Kingdom, Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, BioSystems and Micromechanics (BioSyM), Singapore-MIT Alliance for Research and Technology, Singapore, Singapore, School of Mathematics, University of Birmingham, Birmingham, United Kingdom, University of California San Diego, United States.
[76]	M Iantorno, U Campia, N Di Daniele, S Nistico, G B Forleo, C Cardillo, M Tesauro – “Obesity, inflammation and endothelial dysfunction” J Biol Regul Homeost Agents. Apr-Jun 2014; 28 (2): 169-76. PMID: 25001649.
[77]	Martin K Reriani, Lilach O Lerman, and Amir Lerman – “Endothelial function as a functional expression of cardiovascular risk factors” Biomark Med. 2010 Jun; 4 (3): 351–360. doi: 10.2217/bmm.10.61.
[78]	G J Blake, P M Ridker – “Inflammatory bio-markers and cardiovascular risk prediction” Journal of Internal medicine - 2002 Oct; 252 (4): 283-94. doi: 10.1046/j.1365-2796.2002.01019.x. Center for Cardiovascular Disease Prevention and the Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA.
[79]	Yoshiko Mizuno, Robert Francis Jacob, R Preston Mason – “Inflammation and the development of atherosclerosis” Journal of atherosclerosis and thrombosis 2011; 18 (5): 351-8. doi: 10.5551/jat.7591. Epub 2011 Mar 18. Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Japan.
[80]	Esther Lopez-Garcia, Frank B Hu – “Nutrition and the endothelium” current diabetes report - 2004 Aug; 4 (4): 253-9- doi: 10.1007/s11892-004-0076-7. Department of Nutrition, Harvard School of Public Health and Channing Laboratory, 665 Huntington Avenue, Boston, MA 02115, USA. elopezga@hsph.harvard.edu
[81]	Mikko I Mäyränpää, Hanna M Heikkilä, Ken A Lindstedt, Andrew F Walls, Petri T Kovanen – “Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion” coronary artery disease - 2006 Nov; 17 (7): 611-21. doi: 10.1097/01.mca.0000224420.67304.4d. Wihuri Research Institute, University of Helsinki, Helsinki, Finland.
[82]	Lars Lind - “Circulating markers of inflammation and atherosclerosis” - Atherosclerosis. 2003 Aug; 169 (2): 203-14. doi: 10.1016/s0021-9150(03)00012-1.
[83]	A B Thompson, R A Robbins, D J Romberger, J H Sisson, J R Spurzem, H Teschler, S I Rennard – “Immunological functions of the pulmonary epithelium” The European respiratory journal - 1995 Jan; 8 (1): 127-49. doi: 10.1183/09031936.95.08010127. Dept of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-5300, USA.
[84]	V Godding, J M Stark, J B Sedgwick, W W Busse – “Adhesion of activated eosinophils to respiratory epithelial cells is enhanced by tumor necrosis factor-alpha and interleukin-1 beta” American journal of respiratory cell and molecular biology - 1995 Nov; 13 (5): 555-62. doi: 10.1165/ajrcmb.13.5.7576691. UCL Mont-Godinne and Experimental Medicine Unit (ICP), Catholic University of Louvain, Belgium.
[85]	J M Stark, V Godding, J B Sedgwick, W W Busse – “Respiratory syncytial virus infection enhances neutrophil and eosinophil adhesion to cultured respiratory epithelial cells. Roles of CD18 and intercellular adhesion molecule-1” Journal of immunology (Baltimore Md-1950) - 1996 Jun 15; 156 (12): 4774-82. Pulmonary Medicine, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, OH, USA.
[86]	Maurizio Marini MD, Enza Vittori PhD, Jan Hollemborg PhD, Sabrina Mattoli MD, PhD – “Expression of the potent inflammatory cytokines, granulocyte-macrophage-colony-stimulating factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma” Journal of Allergy and Clinical Immunology Volume 89, Issue 5, May 1992, Pages 1001-1009.
[87]	G D Martich, R L Danner, M Ceska, A F Suffredini – “Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents” The journal of experimental medicine - 1991 Apr 1; 173 (4): 1021-4. doi: 10.1084/jem.173.4.1021. Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland 20892.
[88]	Murray RF, Harper HW, Granner DK, Mayes PA, Rodwell VW (2006). Harper's Illustrated Biochemistry. New York: Lange Medical Books/McGraw-Hill. ISBN 978-0-07-146197-9.

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Andry Tahina Rabeharitsara, Nambinina Richard Randriana, Nambinina Richard Randriana. (2021). “Speb-Pebe” - Spicy Product Energy Booster Consumer Test and Its Effects on the Consumers’ Health. American Journal of Applied Chemistry, 9(6), 186-201. https://doi.org/10.11648/j.ajac.20210906.12

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Andry Tahina Rabeharitsara; Nambinina Richard Randriana; Nambinina Richard Randriana. “Speb-Pebe” - Spicy Product Energy Booster Consumer Test and Its Effects on the Consumers’ Health. Am. J. Appl. Chem. 2021, 9(6), 186-201. doi: 10.11648/j.ajac.20210906.12

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Andry Tahina Rabeharitsara, Nambinina Richard Randriana, Nambinina Richard Randriana. “Speb-Pebe” - Spicy Product Energy Booster Consumer Test and Its Effects on the Consumers’ Health. Am J Appl Chem. 2021;9(6):186-201. doi: 10.11648/j.ajac.20210906.12

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@article{10.11648/j.ajac.20210906.12,
  author = {Andry Tahina Rabeharitsara and Nambinina Richard Randriana and Nambinina Richard Randriana},
  title = {“Speb-Pebe” - Spicy Product Energy Booster Consumer Test and Its Effects on the Consumers’ Health},
  journal = {American Journal of Applied Chemistry},
  volume = {9},
  number = {6},
  pages = {186-201},
  doi = {10.11648/j.ajac.20210906.12},
  url = {https://doi.org/10.11648/j.ajac.20210906.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajac.20210906.12},
  abstract = {The “spicy product energy booster (speb)” – “produit épicé boosteur d’énergie (pebe)” – “speb-pebe” was a spice food product composed mainly of “Capsicum chinense”, “Capsicum frutescens” and citric acid as active chemical molecules like preservative, catalyst and reactant. Thus, its important chemical bioactive molecules were capsaïcine, luteolin and quercetin; these molecules presented in their structure either ether and/or alcohol and/or amine and/or alkene organic functions which could reacted chemically with citric acid molecules catalyzed by citric acid protonic acid-H+ to give esters, esters of citric acid, amides and amides of citric acid. These chemical reactions were very important because these citric acid derivatives forms of “speb-pebe’s” bioactive molecules facilitated their partial or total solubilization and diffusion-transport through the organism particularly through the bloodstream via chylomicrons and lymphatic system. This efficient diffusion-transport allowed to the efficiency of their therapeutic vertues through the organism which were not only developed in this manuscript but also observed through a consumer test realized on the “speb-pebe” food product during one month such as its daily consumed quantity was limited to one teaspoon which corresponded to maximally 2g of “speb-pebe” respecting its components’ bioactive molecules daily limit of consumption including quercetin, capsaicin and luteolin. First, the results of this consumer test, realized on individuals, permitted to confirm that this “speb-pebe” food product was an energy booster. Indeed, the majority of individuals who participated in the “speb-pebe” consumption test had experienced an increase in their physical capacity and among adulthood who play sport, among student adolescent no one felt physical capacity decrease. Second, it was confirmed that the “speb-pebe” food product was classed by 43.48% of individuals as a taste and smell enhancing condiment which increased their appetite. Third, an appreciable spices’ bioactive molecules therapeutic virtues were confirmed by individuals participating this “speb-pebe” consumer test including non-detected of chronic and acute rhinitis, disappearance of psoriasis and the great majority of them felt their youth renewed; 76.20% of them were observed with normal increasing (38.10%) or stabilizing (38.10%) their weight at the end of the test without blood pressure disorder. These promising results was partly due to the probably regeneration of the chemical compound «phosphatidylserine-PS» particularly their two esters of fatty acids and an amino-acid organic functions by mechanisms described subsequently in this manuscript and the longevity of its activities as phagocyte by apoptosis where proteins probably plays significant role as citric acid protonic acid-H+ catalyst support.},
 year = {2021}
}

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TY  - JOUR
T1  - “Speb-Pebe” - Spicy Product Energy Booster Consumer Test and Its Effects on the Consumers’ Health
AU  - Andry Tahina Rabeharitsara
AU  - Nambinina Richard Randriana
AU  - Nambinina Richard Randriana
Y1  - 2021/11/17
PY  - 2021
N1  - https://doi.org/10.11648/j.ajac.20210906.12
DO  - 10.11648/j.ajac.20210906.12
T2  - American Journal of Applied Chemistry
JF  - American Journal of Applied Chemistry
JO  - American Journal of Applied Chemistry
SP  - 186
EP  - 201
PB  - Science Publishing Group
SN  - 2330-8745
UR  - https://doi.org/10.11648/j.ajac.20210906.12
AB  - The “spicy product energy booster (speb)” – “produit épicé boosteur d’énergie (pebe)” – “speb-pebe” was a spice food product composed mainly of “Capsicum chinense”, “Capsicum frutescens” and citric acid as active chemical molecules like preservative, catalyst and reactant. Thus, its important chemical bioactive molecules were capsaïcine, luteolin and quercetin; these molecules presented in their structure either ether and/or alcohol and/or amine and/or alkene organic functions which could reacted chemically with citric acid molecules catalyzed by citric acid protonic acid-H+ to give esters, esters of citric acid, amides and amides of citric acid. These chemical reactions were very important because these citric acid derivatives forms of “speb-pebe’s” bioactive molecules facilitated their partial or total solubilization and diffusion-transport through the organism particularly through the bloodstream via chylomicrons and lymphatic system. This efficient diffusion-transport allowed to the efficiency of their therapeutic vertues through the organism which were not only developed in this manuscript but also observed through a consumer test realized on the “speb-pebe” food product during one month such as its daily consumed quantity was limited to one teaspoon which corresponded to maximally 2g of “speb-pebe” respecting its components’ bioactive molecules daily limit of consumption including quercetin, capsaicin and luteolin. First, the results of this consumer test, realized on individuals, permitted to confirm that this “speb-pebe” food product was an energy booster. Indeed, the majority of individuals who participated in the “speb-pebe” consumption test had experienced an increase in their physical capacity and among adulthood who play sport, among student adolescent no one felt physical capacity decrease. Second, it was confirmed that the “speb-pebe” food product was classed by 43.48% of individuals as a taste and smell enhancing condiment which increased their appetite. Third, an appreciable spices’ bioactive molecules therapeutic virtues were confirmed by individuals participating this “speb-pebe” consumer test including non-detected of chronic and acute rhinitis, disappearance of psoriasis and the great majority of them felt their youth renewed; 76.20% of them were observed with normal increasing (38.10%) or stabilizing (38.10%) their weight at the end of the test without blood pressure disorder. These promising results was partly due to the probably regeneration of the chemical compound «phosphatidylserine-PS» particularly their two esters of fatty acids and an amino-acid organic functions by mechanisms described subsequently in this manuscript and the longevity of its activities as phagocyte by apoptosis where proteins probably plays significant role as citric acid protonic acid-H+ catalyst support.
VL  - 9
IS  - 6
ER  -

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Author Information

Andry Tahina Rabeharitsara

Chemical Process Engineering Department (E. S. P. A), Antananarivo University, Antananarivo, Madagascar
Nambinina Richard Randriana

Chemical Process Engineering Department (E. S. P. A), Antananarivo University, Antananarivo, Madagascar
Nambinina Richard Randriana

Chemical Process Engineering Department (E. S. P. A), Antananarivo University, Antananarivo, Madagascar

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APA Style

Andry Tahina Rabeharitsara, Nambinina Richard Randriana, Nambinina Richard Randriana. (2021). “Speb-Pebe” - Spicy Product Energy Booster Consumer Test and Its Effects on the Consumers’ Health. American Journal of Applied Chemistry, 9(6), 186-201. https://doi.org/10.11648/j.ajac.20210906.12

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ACS Style

Andry Tahina Rabeharitsara; Nambinina Richard Randriana; Nambinina Richard Randriana. “Speb-Pebe” - Spicy Product Energy Booster Consumer Test and Its Effects on the Consumers’ Health. Am. J. Appl. Chem. 2021, 9(6), 186-201. doi: 10.11648/j.ajac.20210906.12

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AMA Style

Andry Tahina Rabeharitsara, Nambinina Richard Randriana, Nambinina Richard Randriana. “Speb-Pebe” - Spicy Product Energy Booster Consumer Test and Its Effects on the Consumers’ Health. Am J Appl Chem. 2021;9(6):186-201. doi: 10.11648/j.ajac.20210906.12

Copy | Download

@article{10.11648/j.ajac.20210906.12,
  author = {Andry Tahina Rabeharitsara and Nambinina Richard Randriana and Nambinina Richard Randriana},
  title = {“Speb-Pebe” - Spicy Product Energy Booster Consumer Test and Its Effects on the Consumers’ Health},
  journal = {American Journal of Applied Chemistry},
  volume = {9},
  number = {6},
  pages = {186-201},
  doi = {10.11648/j.ajac.20210906.12},
  url = {https://doi.org/10.11648/j.ajac.20210906.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajac.20210906.12},
  abstract = {The “spicy product energy booster (speb)” – “produit épicé boosteur d’énergie (pebe)” – “speb-pebe” was a spice food product composed mainly of “Capsicum chinense”, “Capsicum frutescens” and citric acid as active chemical molecules like preservative, catalyst and reactant. Thus, its important chemical bioactive molecules were capsaïcine, luteolin and quercetin; these molecules presented in their structure either ether and/or alcohol and/or amine and/or alkene organic functions which could reacted chemically with citric acid molecules catalyzed by citric acid protonic acid-H+ to give esters, esters of citric acid, amides and amides of citric acid. These chemical reactions were very important because these citric acid derivatives forms of “speb-pebe’s” bioactive molecules facilitated their partial or total solubilization and diffusion-transport through the organism particularly through the bloodstream via chylomicrons and lymphatic system. This efficient diffusion-transport allowed to the efficiency of their therapeutic vertues through the organism which were not only developed in this manuscript but also observed through a consumer test realized on the “speb-pebe” food product during one month such as its daily consumed quantity was limited to one teaspoon which corresponded to maximally 2g of “speb-pebe” respecting its components’ bioactive molecules daily limit of consumption including quercetin, capsaicin and luteolin. First, the results of this consumer test, realized on individuals, permitted to confirm that this “speb-pebe” food product was an energy booster. Indeed, the majority of individuals who participated in the “speb-pebe” consumption test had experienced an increase in their physical capacity and among adulthood who play sport, among student adolescent no one felt physical capacity decrease. Second, it was confirmed that the “speb-pebe” food product was classed by 43.48% of individuals as a taste and smell enhancing condiment which increased their appetite. Third, an appreciable spices’ bioactive molecules therapeutic virtues were confirmed by individuals participating this “speb-pebe” consumer test including non-detected of chronic and acute rhinitis, disappearance of psoriasis and the great majority of them felt their youth renewed; 76.20% of them were observed with normal increasing (38.10%) or stabilizing (38.10%) their weight at the end of the test without blood pressure disorder. These promising results was partly due to the probably regeneration of the chemical compound «phosphatidylserine-PS» particularly their two esters of fatty acids and an amino-acid organic functions by mechanisms described subsequently in this manuscript and the longevity of its activities as phagocyte by apoptosis where proteins probably plays significant role as citric acid protonic acid-H+ catalyst support.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - “Speb-Pebe” - Spicy Product Energy Booster Consumer Test and Its Effects on the Consumers’ Health
AU  - Andry Tahina Rabeharitsara
AU  - Nambinina Richard Randriana
AU  - Nambinina Richard Randriana
Y1  - 2021/11/17
PY  - 2021
N1  - https://doi.org/10.11648/j.ajac.20210906.12
DO  - 10.11648/j.ajac.20210906.12
T2  - American Journal of Applied Chemistry
JF  - American Journal of Applied Chemistry
JO  - American Journal of Applied Chemistry
SP  - 186
EP  - 201
PB  - Science Publishing Group
SN  - 2330-8745
UR  - https://doi.org/10.11648/j.ajac.20210906.12
AB  - The “spicy product energy booster (speb)” – “produit épicé boosteur d’énergie (pebe)” – “speb-pebe” was a spice food product composed mainly of “Capsicum chinense”, “Capsicum frutescens” and citric acid as active chemical molecules like preservative, catalyst and reactant. Thus, its important chemical bioactive molecules were capsaïcine, luteolin and quercetin; these molecules presented in their structure either ether and/or alcohol and/or amine and/or alkene organic functions which could reacted chemically with citric acid molecules catalyzed by citric acid protonic acid-H+ to give esters, esters of citric acid, amides and amides of citric acid. These chemical reactions were very important because these citric acid derivatives forms of “speb-pebe’s” bioactive molecules facilitated their partial or total solubilization and diffusion-transport through the organism particularly through the bloodstream via chylomicrons and lymphatic system. This efficient diffusion-transport allowed to the efficiency of their therapeutic vertues through the organism which were not only developed in this manuscript but also observed through a consumer test realized on the “speb-pebe” food product during one month such as its daily consumed quantity was limited to one teaspoon which corresponded to maximally 2g of “speb-pebe” respecting its components’ bioactive molecules daily limit of consumption including quercetin, capsaicin and luteolin. First, the results of this consumer test, realized on individuals, permitted to confirm that this “speb-pebe” food product was an energy booster. Indeed, the majority of individuals who participated in the “speb-pebe” consumption test had experienced an increase in their physical capacity and among adulthood who play sport, among student adolescent no one felt physical capacity decrease. Second, it was confirmed that the “speb-pebe” food product was classed by 43.48% of individuals as a taste and smell enhancing condiment which increased their appetite. Third, an appreciable spices’ bioactive molecules therapeutic virtues were confirmed by individuals participating this “speb-pebe” consumer test including non-detected of chronic and acute rhinitis, disappearance of psoriasis and the great majority of them felt their youth renewed; 76.20% of them were observed with normal increasing (38.10%) or stabilizing (38.10%) their weight at the end of the test without blood pressure disorder. These promising results was partly due to the probably regeneration of the chemical compound «phosphatidylserine-PS» particularly their two esters of fatty acids and an amino-acid organic functions by mechanisms described subsequently in this manuscript and the longevity of its activities as phagocyte by apoptosis where proteins probably plays significant role as citric acid protonic acid-H+ catalyst support.
VL  - 9
IS  - 6
ER  -

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