Confirmation and Analysis of Fentanyl and Its Analogues Without the Standards

Wang Chengyun; Zhang Weiya; Yan Jie; Lin Junfeng; Xie Tangtang; Yang Zuojun

doi:doi:10.11648/j.ajche.20190701.15

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Confirmation and Analysis of Fentanyl and Its Analogues Without the Standards

Wang Chengyun, Zhang Weiya, Yan Jie, Lin Junfeng, Xie Tangtang, Yang Zuojun

Published in American Journal of Chemical Engineering (Volume 7, Issue 1)

Received: 11 March 2019 Published: 15 June 2019

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Abstract

In recent years, the number of controlled fentanyl species has increased gradually, and up to now, the number of controlled fentanyl species increased to twenty-seven. Since fentanyl standards are difficult to obtain, there are only several kinds of controlled fentanyl species involved in the literature, and the analysis of all 27 controlled fentanyl species have not been reported in the literature. Therefore, it is of great significance to establish a method for the rapid screening and confirmation of all 27 controlled fentanyl species without the use of standards. In this paper, an analytical method for the rapid screening and confirmation of 27 controlled fentanyl substances without the use of standards was established. Suspected samples were rapidly screened by ultra-high performance liquid chromatography/Orbitrap high resolution mass spectrometry (UPLC/Orbitrap HRMS). Qualitative identification was performed through the quasi-molecular ion accurate masses of target compounds. Confirmation was carried out by secondary ion segments. It is the first time that all of 27 controlled fentanyl substances was tested. The proposed method was simple, rapid and accurate, applicable for the rapid screening and confirmation of 27 controlled fentanyl substances without standards.

Published in	American Journal of Chemical Engineering (Volume 7, Issue 1)
DOI	10.11648/j.ajche.20190701.15
Page(s)	43-50
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Fentanyl, UPLC/Orbitrap HRMS, Screening

References

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APA Style

Wang Chengyun, Zhang Weiya, Yan Jie, Lin Junfeng, Xie Tangtang, et al. (2019). Confirmation and Analysis of Fentanyl and Its Analogues Without the Standards. American Journal of Chemical Engineering, 7(1), 43-50. https://doi.org/10.11648/j.ajche.20190701.15

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ACS Style

Wang Chengyun; Zhang Weiya; Yan Jie; Lin Junfeng; Xie Tangtang, et al. Confirmation and Analysis of Fentanyl and Its Analogues Without the Standards. Am. J. Chem. Eng. 2019, 7(1), 43-50. doi: 10.11648/j.ajche.20190701.15

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AMA Style

Wang Chengyun, Zhang Weiya, Yan Jie, Lin Junfeng, Xie Tangtang, et al. Confirmation and Analysis of Fentanyl and Its Analogues Without the Standards. Am J Chem Eng. 2019;7(1):43-50. doi: 10.11648/j.ajche.20190701.15

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@article{10.11648/j.ajche.20190701.15,
  author = {Wang Chengyun and Zhang Weiya and Yan Jie and Lin Junfeng and Xie Tangtang and Yang Zuojun},
  title = {Confirmation and Analysis of Fentanyl and Its Analogues Without the Standards},
  journal = {American Journal of Chemical Engineering},
  volume = {7},
  number = {1},
  pages = {43-50},
  doi = {10.11648/j.ajche.20190701.15},
  url = {https://doi.org/10.11648/j.ajche.20190701.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajche.20190701.15},
  abstract = {In recent years, the number of controlled fentanyl species has increased gradually, and up to now, the number of controlled fentanyl species increased to twenty-seven. Since fentanyl standards are difficult to obtain, there are only several kinds of controlled fentanyl species involved in the literature, and the analysis of all 27 controlled fentanyl species have not been reported in the literature. Therefore, it is of great significance to establish a method for the rapid screening and confirmation of all 27 controlled fentanyl species without the use of standards. In this paper, an analytical method for the rapid screening and confirmation of 27 controlled fentanyl substances without the use of standards was established. Suspected samples were rapidly screened by ultra-high performance liquid chromatography/Orbitrap high resolution mass spectrometry (UPLC/Orbitrap HRMS). Qualitative identification was performed through the quasi-molecular ion accurate masses of target compounds. Confirmation was carried out by secondary ion segments. It is the first time that all of 27 controlled fentanyl substances was tested. The proposed method was simple, rapid and accurate, applicable for the rapid screening and confirmation of 27 controlled fentanyl substances without standards.},
 year = {2019}
}

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TY  - JOUR
T1  - Confirmation and Analysis of Fentanyl and Its Analogues Without the Standards
AU  - Wang Chengyun
AU  - Zhang Weiya
AU  - Yan Jie
AU  - Lin Junfeng
AU  - Xie Tangtang
AU  - Yang Zuojun
Y1  - 2019/06/15
PY  - 2019
N1  - https://doi.org/10.11648/j.ajche.20190701.15
DO  - 10.11648/j.ajche.20190701.15
T2  - American Journal of Chemical Engineering
JF  - American Journal of Chemical Engineering
JO  - American Journal of Chemical Engineering
SP  - 43
EP  - 50
PB  - Science Publishing Group
SN  - 2330-8613
UR  - https://doi.org/10.11648/j.ajche.20190701.15
AB  - In recent years, the number of controlled fentanyl species has increased gradually, and up to now, the number of controlled fentanyl species increased to twenty-seven. Since fentanyl standards are difficult to obtain, there are only several kinds of controlled fentanyl species involved in the literature, and the analysis of all 27 controlled fentanyl species have not been reported in the literature. Therefore, it is of great significance to establish a method for the rapid screening and confirmation of all 27 controlled fentanyl species without the use of standards. In this paper, an analytical method for the rapid screening and confirmation of 27 controlled fentanyl substances without the use of standards was established. Suspected samples were rapidly screened by ultra-high performance liquid chromatography/Orbitrap high resolution mass spectrometry (UPLC/Orbitrap HRMS). Qualitative identification was performed through the quasi-molecular ion accurate masses of target compounds. Confirmation was carried out by secondary ion segments. It is the first time that all of 27 controlled fentanyl substances was tested. The proposed method was simple, rapid and accurate, applicable for the rapid screening and confirmation of 27 controlled fentanyl substances without standards.
VL  - 7
IS  - 1
ER  -

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Author Information

Wang Chengyun

The Testing and Technology Center for Industrial Products, Shenzhen Custom, Shenzhen, P. R. China
Zhang Weiya

The Testing and Technology Center for Industrial Products, Shenzhen Custom, Shenzhen, P. R. China
Yan Jie

The Testing and Technology Center for Industrial Products, Shenzhen Custom, Shenzhen, P. R. China
Lin Junfeng

Shenzhen Academy of Inspection and Quarantine, Shenzhen, P. R. China
Xie Tangtang

Shenzhen Academy of Inspection and Quarantine, Shenzhen, P. R. China
Yang Zuojun

Shenzhen Academy of Inspection and Quarantine, Shenzhen, P. R. China

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Plain Text BibTeX RIS

APA Style

Wang Chengyun, Zhang Weiya, Yan Jie, Lin Junfeng, Xie Tangtang, et al. (2019). Confirmation and Analysis of Fentanyl and Its Analogues Without the Standards. American Journal of Chemical Engineering, 7(1), 43-50. https://doi.org/10.11648/j.ajche.20190701.15

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ACS Style

Wang Chengyun; Zhang Weiya; Yan Jie; Lin Junfeng; Xie Tangtang, et al. Confirmation and Analysis of Fentanyl and Its Analogues Without the Standards. Am. J. Chem. Eng. 2019, 7(1), 43-50. doi: 10.11648/j.ajche.20190701.15

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AMA Style

Wang Chengyun, Zhang Weiya, Yan Jie, Lin Junfeng, Xie Tangtang, et al. Confirmation and Analysis of Fentanyl and Its Analogues Without the Standards. Am J Chem Eng. 2019;7(1):43-50. doi: 10.11648/j.ajche.20190701.15

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@article{10.11648/j.ajche.20190701.15,
  author = {Wang Chengyun and Zhang Weiya and Yan Jie and Lin Junfeng and Xie Tangtang and Yang Zuojun},
  title = {Confirmation and Analysis of Fentanyl and Its Analogues Without the Standards},
  journal = {American Journal of Chemical Engineering},
  volume = {7},
  number = {1},
  pages = {43-50},
  doi = {10.11648/j.ajche.20190701.15},
  url = {https://doi.org/10.11648/j.ajche.20190701.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajche.20190701.15},
  abstract = {In recent years, the number of controlled fentanyl species has increased gradually, and up to now, the number of controlled fentanyl species increased to twenty-seven. Since fentanyl standards are difficult to obtain, there are only several kinds of controlled fentanyl species involved in the literature, and the analysis of all 27 controlled fentanyl species have not been reported in the literature. Therefore, it is of great significance to establish a method for the rapid screening and confirmation of all 27 controlled fentanyl species without the use of standards. In this paper, an analytical method for the rapid screening and confirmation of 27 controlled fentanyl substances without the use of standards was established. Suspected samples were rapidly screened by ultra-high performance liquid chromatography/Orbitrap high resolution mass spectrometry (UPLC/Orbitrap HRMS). Qualitative identification was performed through the quasi-molecular ion accurate masses of target compounds. Confirmation was carried out by secondary ion segments. It is the first time that all of 27 controlled fentanyl substances was tested. The proposed method was simple, rapid and accurate, applicable for the rapid screening and confirmation of 27 controlled fentanyl substances without standards.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Confirmation and Analysis of Fentanyl and Its Analogues Without the Standards
AU  - Wang Chengyun
AU  - Zhang Weiya
AU  - Yan Jie
AU  - Lin Junfeng
AU  - Xie Tangtang
AU  - Yang Zuojun
Y1  - 2019/06/15
PY  - 2019
N1  - https://doi.org/10.11648/j.ajche.20190701.15
DO  - 10.11648/j.ajche.20190701.15
T2  - American Journal of Chemical Engineering
JF  - American Journal of Chemical Engineering
JO  - American Journal of Chemical Engineering
SP  - 43
EP  - 50
PB  - Science Publishing Group
SN  - 2330-8613
UR  - https://doi.org/10.11648/j.ajche.20190701.15
AB  - In recent years, the number of controlled fentanyl species has increased gradually, and up to now, the number of controlled fentanyl species increased to twenty-seven. Since fentanyl standards are difficult to obtain, there are only several kinds of controlled fentanyl species involved in the literature, and the analysis of all 27 controlled fentanyl species have not been reported in the literature. Therefore, it is of great significance to establish a method for the rapid screening and confirmation of all 27 controlled fentanyl species without the use of standards. In this paper, an analytical method for the rapid screening and confirmation of 27 controlled fentanyl substances without the use of standards was established. Suspected samples were rapidly screened by ultra-high performance liquid chromatography/Orbitrap high resolution mass spectrometry (UPLC/Orbitrap HRMS). Qualitative identification was performed through the quasi-molecular ion accurate masses of target compounds. Confirmation was carried out by secondary ion segments. It is the first time that all of 27 controlled fentanyl substances was tested. The proposed method was simple, rapid and accurate, applicable for the rapid screening and confirmation of 27 controlled fentanyl substances without standards.
VL  - 7
IS  - 1
ER  -

Copy | Download