Acute and Chronic Renal Diseases Associated with Different Drugs in Children

Sergey Postnikov; Anna Gratzhianskaya; Marya Kostyleva; Aleksey Ermilin

doi:doi:10.11648/j.ajp.20180403.14

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Acute and Chronic Renal Diseases Associated with Different Drugs in Children

Sergey Postnikov, Anna Gratzhianskaya, Marya Kostyleva, Aleksey Ermilin

Published in American Journal of Pediatrics (Volume 4, Issue 3)

Received: 28 June 2018 Accepted: 19 August 2018 Published: 19 September 2018

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Abstract

Drugs are common cause of renal damage - approximately 20% of out-patient and in-patient cases of acute renal failure are caused by drugs. The main reasons for this situation are the following: rapid growth of pharmaceutical market and therefore increased amount of drugs with known nephrotoxicity, aging of the population that is accompanied by the accumulation of such diseases like diabetes mellitus (DM), heart failure (HF), arterial hypertension (AH) following by the obligatory polypharmacy. On the other hand the achievements of contemporary medical science contribute to survivals of significant quantity of premature neonates with low and extremely low body weight. Thus the different types of pathological conditions like bronchopulmonary dysplasia (BPD), respiratory distress syndrome (RDS), sepsis, pneumonia, necrotic enterocolitis corresponding to such category of patients require aggressive treatment with off-label use. All factors listed above contribute to drug overload in the mentioned age-groups including drugs excreted by kidneys with possible damage of different renal structures and functions. The primary preventive measures could be the following: avoidance of the combination of drugs with known nephrotoxic effect, sufficient hydration and assessment of renal functioning using current biomarkers measuring before and in the progress of the treatment with potential nephrotoxic effect. It could be recommended the decreasing dose or interruption of the suspected drug in accordance with the deviation of parameters comparing to the baseline.

Published in	American Journal of Pediatrics (Volume 4, Issue 3)
DOI	10.11648/j.ajp.20180403.14
Page(s)	61-68
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Drug Nephrotoxicity, Mechanism, Damage of the Separate Nephron Structures, Risk Factors, Prevention

References

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APA Style

Sergey Postnikov, Anna Gratzhianskaya, Marya Kostyleva, Aleksey Ermilin. (2018). Acute and Chronic Renal Diseases Associated with Different Drugs in Children. American Journal of Pediatrics, 4(3), 61-68. https://doi.org/10.11648/j.ajp.20180403.14

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ACS Style

Sergey Postnikov; Anna Gratzhianskaya; Marya Kostyleva; Aleksey Ermilin. Acute and Chronic Renal Diseases Associated with Different Drugs in Children. Am. J. Pediatr. 2018, 4(3), 61-68. doi: 10.11648/j.ajp.20180403.14

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AMA Style

Sergey Postnikov, Anna Gratzhianskaya, Marya Kostyleva, Aleksey Ermilin. Acute and Chronic Renal Diseases Associated with Different Drugs in Children. Am J Pediatr. 2018;4(3):61-68. doi: 10.11648/j.ajp.20180403.14

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@article{10.11648/j.ajp.20180403.14,
  author = {Sergey Postnikov and Anna Gratzhianskaya and Marya Kostyleva and Aleksey Ermilin},
  title = {Acute and Chronic Renal Diseases Associated with Different Drugs in Children},
  journal = {American Journal of Pediatrics},
  volume = {4},
  number = {3},
  pages = {61-68},
  doi = {10.11648/j.ajp.20180403.14},
  url = {https://doi.org/10.11648/j.ajp.20180403.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20180403.14},
  abstract = {Drugs are common cause of renal damage - approximately 20% of out-patient and in-patient cases of acute renal failure are caused by drugs. The main reasons for this situation are the following: rapid growth of pharmaceutical market and therefore increased amount of drugs with known nephrotoxicity, aging of the population that is accompanied by the accumulation of such diseases like diabetes mellitus (DM), heart failure (HF), arterial hypertension (AH) following by the obligatory polypharmacy. On the other hand the achievements of contemporary medical science contribute to survivals of significant quantity of premature neonates with low and extremely low body weight. Thus the different types of pathological conditions like bronchopulmonary dysplasia (BPD), respiratory distress syndrome (RDS), sepsis, pneumonia, necrotic enterocolitis corresponding to such category of patients require aggressive treatment with off-label use. All factors listed above contribute to drug overload in the mentioned age-groups including drugs excreted by kidneys with possible damage of different renal structures and functions. The primary preventive measures could be the following: avoidance of the combination of drugs with known nephrotoxic effect, sufficient hydration and assessment of renal functioning using current biomarkers measuring before and in the progress of the treatment with potential nephrotoxic effect. It could be recommended the decreasing dose or interruption of the suspected drug in accordance with the deviation of parameters comparing to the baseline.},
 year = {2018}
}

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TY  - JOUR
T1  - Acute and Chronic Renal Diseases Associated with Different Drugs in Children
AU  - Sergey Postnikov
AU  - Anna Gratzhianskaya
AU  - Marya Kostyleva
AU  - Aleksey Ermilin
Y1  - 2018/09/19
PY  - 2018
N1  - https://doi.org/10.11648/j.ajp.20180403.14
DO  - 10.11648/j.ajp.20180403.14
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 61
EP  - 68
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20180403.14
AB  - Drugs are common cause of renal damage - approximately 20% of out-patient and in-patient cases of acute renal failure are caused by drugs. The main reasons for this situation are the following: rapid growth of pharmaceutical market and therefore increased amount of drugs with known nephrotoxicity, aging of the population that is accompanied by the accumulation of such diseases like diabetes mellitus (DM), heart failure (HF), arterial hypertension (AH) following by the obligatory polypharmacy. On the other hand the achievements of contemporary medical science contribute to survivals of significant quantity of premature neonates with low and extremely low body weight. Thus the different types of pathological conditions like bronchopulmonary dysplasia (BPD), respiratory distress syndrome (RDS), sepsis, pneumonia, necrotic enterocolitis corresponding to such category of patients require aggressive treatment with off-label use. All factors listed above contribute to drug overload in the mentioned age-groups including drugs excreted by kidneys with possible damage of different renal structures and functions. The primary preventive measures could be the following: avoidance of the combination of drugs with known nephrotoxic effect, sufficient hydration and assessment of renal functioning using current biomarkers measuring before and in the progress of the treatment with potential nephrotoxic effect. It could be recommended the decreasing dose or interruption of the suspected drug in accordance with the deviation of parameters comparing to the baseline.
VL  - 4
IS  - 3
ER  -

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Author Information

Sergey Postnikov

Chair of Clinical Pharmacology, Pirogov Russian National Research Medical University, Moscow, Russian Federation
Anna Gratzhianskaya

Chair of Clinical Pharmacology, Pirogov Russian National Research Medical University, Moscow, Russian Federation
Marya Kostyleva

Chair of Clinical Pharmacology, Pirogov Russian National Research Medical University, Moscow, Russian Federation
Aleksey Ermilin

Chair of Clinical Pharmacology, Pirogov Russian National Research Medical University, Moscow, Russian Federation

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APA Style

Sergey Postnikov, Anna Gratzhianskaya, Marya Kostyleva, Aleksey Ermilin. (2018). Acute and Chronic Renal Diseases Associated with Different Drugs in Children. American Journal of Pediatrics, 4(3), 61-68. https://doi.org/10.11648/j.ajp.20180403.14

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ACS Style

Sergey Postnikov; Anna Gratzhianskaya; Marya Kostyleva; Aleksey Ermilin. Acute and Chronic Renal Diseases Associated with Different Drugs in Children. Am. J. Pediatr. 2018, 4(3), 61-68. doi: 10.11648/j.ajp.20180403.14

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AMA Style

Sergey Postnikov, Anna Gratzhianskaya, Marya Kostyleva, Aleksey Ermilin. Acute and Chronic Renal Diseases Associated with Different Drugs in Children. Am J Pediatr. 2018;4(3):61-68. doi: 10.11648/j.ajp.20180403.14

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@article{10.11648/j.ajp.20180403.14,
  author = {Sergey Postnikov and Anna Gratzhianskaya and Marya Kostyleva and Aleksey Ermilin},
  title = {Acute and Chronic Renal Diseases Associated with Different Drugs in Children},
  journal = {American Journal of Pediatrics},
  volume = {4},
  number = {3},
  pages = {61-68},
  doi = {10.11648/j.ajp.20180403.14},
  url = {https://doi.org/10.11648/j.ajp.20180403.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20180403.14},
  abstract = {Drugs are common cause of renal damage - approximately 20% of out-patient and in-patient cases of acute renal failure are caused by drugs. The main reasons for this situation are the following: rapid growth of pharmaceutical market and therefore increased amount of drugs with known nephrotoxicity, aging of the population that is accompanied by the accumulation of such diseases like diabetes mellitus (DM), heart failure (HF), arterial hypertension (AH) following by the obligatory polypharmacy. On the other hand the achievements of contemporary medical science contribute to survivals of significant quantity of premature neonates with low and extremely low body weight. Thus the different types of pathological conditions like bronchopulmonary dysplasia (BPD), respiratory distress syndrome (RDS), sepsis, pneumonia, necrotic enterocolitis corresponding to such category of patients require aggressive treatment with off-label use. All factors listed above contribute to drug overload in the mentioned age-groups including drugs excreted by kidneys with possible damage of different renal structures and functions. The primary preventive measures could be the following: avoidance of the combination of drugs with known nephrotoxic effect, sufficient hydration and assessment of renal functioning using current biomarkers measuring before and in the progress of the treatment with potential nephrotoxic effect. It could be recommended the decreasing dose or interruption of the suspected drug in accordance with the deviation of parameters comparing to the baseline.},
 year = {2018}
}

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TY  - JOUR
T1  - Acute and Chronic Renal Diseases Associated with Different Drugs in Children
AU  - Sergey Postnikov
AU  - Anna Gratzhianskaya
AU  - Marya Kostyleva
AU  - Aleksey Ermilin
Y1  - 2018/09/19
PY  - 2018
N1  - https://doi.org/10.11648/j.ajp.20180403.14
DO  - 10.11648/j.ajp.20180403.14
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 61
EP  - 68
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20180403.14
AB  - Drugs are common cause of renal damage - approximately 20% of out-patient and in-patient cases of acute renal failure are caused by drugs. The main reasons for this situation are the following: rapid growth of pharmaceutical market and therefore increased amount of drugs with known nephrotoxicity, aging of the population that is accompanied by the accumulation of such diseases like diabetes mellitus (DM), heart failure (HF), arterial hypertension (AH) following by the obligatory polypharmacy. On the other hand the achievements of contemporary medical science contribute to survivals of significant quantity of premature neonates with low and extremely low body weight. Thus the different types of pathological conditions like bronchopulmonary dysplasia (BPD), respiratory distress syndrome (RDS), sepsis, pneumonia, necrotic enterocolitis corresponding to such category of patients require aggressive treatment with off-label use. All factors listed above contribute to drug overload in the mentioned age-groups including drugs excreted by kidneys with possible damage of different renal structures and functions. The primary preventive measures could be the following: avoidance of the combination of drugs with known nephrotoxic effect, sufficient hydration and assessment of renal functioning using current biomarkers measuring before and in the progress of the treatment with potential nephrotoxic effect. It could be recommended the decreasing dose or interruption of the suspected drug in accordance with the deviation of parameters comparing to the baseline.
VL  - 4
IS  - 3
ER  -

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