Systemic Lupus Erythematosus (SLE) with Lupus Nephritis in a 15 Year-Old Male – A Case Report

Rahmi Utami; Syarifuddin Rauf

doi:doi:10.11648/j.ajp.20190501.16

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Systemic Lupus Erythematosus (SLE) with Lupus Nephritis in a 15 Year-Old Male – A Case Report

Rahmi Utami, Syarifuddin Rauf

Published in American Journal of Pediatrics (Volume 5, Issue 1)

Received: 14 January 2019 Accepted: 20 February 2019 Published: 21 March 2019

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Abstract

Systemic lupus erythematosus is a chronic autoimmune inflammatory disease that can affect any part of the body. Lupus Nephritis is one of the most common, and most important, serious manifestations of SLE particularly for male. We present a case of 15 year old male that is diagnosed with a systemic lupus erythematosus (SLE) based on 6 of the American College of Rheumatology (ACR), diagnostic criteria developed namely: malar rash, arthritis, photosensitive, kidney disorders (hematuria), immunological disorders (positive anti-dsDNA), and blood disorders (anemia, leucopenia). The result of the kidney’s biopsy indicated the patient already developed Lupus Nephritis.. The patient responded very well with corticosteroid. Although male patient with SLE is not commonly seen, the manifestations are life threatening and early detection of disease will lead to better outcome of the patient. Antimalaria drugs Hydrochloroquine is useful in patients with SLE glomerulonephritis. In consequences of their numerous beneficial effects, antimalarials appear to have a protective effect on survival in SLE.

Published in	American Journal of Pediatrics (Volume 5, Issue 1)
DOI	10.11648/j.ajp.20190501.16
Page(s)	28-33
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Systemic Lupus Erythematosus, Lupus Nephritis, Male SLE, Hydrochloroquine

References

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[3]	Renau AI, Isenberg DA. Male vs Female Lupus. A comparison of ethnicity, clinical features, serology and outcome over a 30 year period. DOI: 10.1177/0961203312444771.
[4]	Schwartzman-Morris J, Putterman C. Gender Differences in the Pathogenesis and Outcome of Lupus and of Lupus Nephritis. Hindawi Publishing Corp. Clinical and Development Immunology Vol. 2012, doi: 10.1155/2021/604892.
[5]	Boodhoo KM et al. Impact of sex disparities on the clinical manifestations in patients with systemic lupus erythematosus. A systematic review and meta-analysis. (2016) http://dx.doi.org/10.1097/MD.0000000000004272
[6]	Shakur Salim et al. Illustrated Textbook of Pediatrics, 2nd edition. New Delhi: Jaypee Brothers; 2015: 854-858.
[7]	Simmons SC, Smith L, Chang-miller A, Keddis MT. Antinuclear Antibody-Negative Lupus Nephritis with Full House Nephropathy : A Case Report and Review of the Literature. 2016; 85054: 451-459. doi: 10.1159/000443747.
[8]	Marks S, Sag E, Ravelli A, et al. G358 Performance of the new SLICC criteria for the classification of SLE in children Archives of Disease in Childhood 2014; 99: A147.
[9]	Thakral, A., & Klein-Gitelman, MS An Update on Treatment and Management of Pediatric Systemic Lupus Erythematosus. Rheumatology and Therapy. 2016; 3 (2), 209–219. http://doi.org/10.1007/s40744-016-0044-0
[10]	Almeida MTM et al. Male systemic lupus erythematosus, an overlooked diagnosis. PMC US National Library of Medicine National Institute of Health. (2011) doi: 10.4081/cp.2011.e103.
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[13]	Silverman Earl, Eddy Allison. Systemic Lupus Erythematosus. In: Cassidy JT, Petty RE, Textbook of Pediatric Rheumatology. 7th edition. Philadelphia: Elsevier Saunders; 2015: 285-317.
[14]	Kuhn A, Bonsmann G, Anders HJ, Herzer P, Tenbrock K, Schneider M: The diagnosis and treatment of systemic lupus erythematosus. Dtsch Arztebl Int 2015; 112: 423–32. DOI: 10.3238/arztebl.2015.0423.
[15]	Kadota et al. Analysis of Gender Differences in Genetic Risk: Association of TNFAIP 3 Polymorphism with Male Childhood Onset Systemic Lupus Erythematosus in the Japanese Population. PLoS ONE 8 (8): e72551. doi: 10.1371/journal.pone.0072551.
[16]	Klein-Gitelman MS. Pediatric Systemic Lupus Erythematosus Clinical Presentation (2018) Retrieved from https://emedicine.medscape/article/1008066-clinical?src=refgatesrc1
[17]	Weening JANJ, Agati VDD, Schwartz MM, et al. The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited NEPHROLOGY and RENAL PATHOLOGY SOCIETY WORKING GROUP ON THE. 2004; 1982 (1): 241-250. doi: 10.1097/01.ASN.0000108969.21691.5D.
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APA Style

Rahmi Utami, Syarifuddin Rauf. (2019). Systemic Lupus Erythematosus (SLE) with Lupus Nephritis in a 15 Year-Old Male – A Case Report. American Journal of Pediatrics, 5(1), 28-33. https://doi.org/10.11648/j.ajp.20190501.16

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ACS Style

Rahmi Utami; Syarifuddin Rauf. Systemic Lupus Erythematosus (SLE) with Lupus Nephritis in a 15 Year-Old Male – A Case Report. Am. J. Pediatr. 2019, 5(1), 28-33. doi: 10.11648/j.ajp.20190501.16

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AMA Style

Rahmi Utami, Syarifuddin Rauf. Systemic Lupus Erythematosus (SLE) with Lupus Nephritis in a 15 Year-Old Male – A Case Report. Am J Pediatr. 2019;5(1):28-33. doi: 10.11648/j.ajp.20190501.16

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@article{10.11648/j.ajp.20190501.16,
  author = {Rahmi Utami and Syarifuddin Rauf},
  title = {Systemic Lupus Erythematosus (SLE) with Lupus Nephritis in a 15 Year-Old Male – A Case Report},
  journal = {American Journal of Pediatrics},
  volume = {5},
  number = {1},
  pages = {28-33},
  doi = {10.11648/j.ajp.20190501.16},
  url = {https://doi.org/10.11648/j.ajp.20190501.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20190501.16},
  abstract = {Systemic lupus erythematosus is a chronic autoimmune inflammatory disease that can affect any part of the body. Lupus Nephritis is one of the most common, and most important, serious manifestations of SLE particularly for male. We present a case of 15 year old male that is diagnosed with a systemic lupus erythematosus (SLE) based on 6 of the American College of Rheumatology (ACR), diagnostic criteria developed namely: malar rash, arthritis, photosensitive, kidney disorders (hematuria), immunological disorders (positive anti-dsDNA), and blood disorders (anemia, leucopenia). The result of the kidney’s biopsy indicated the patient already developed Lupus Nephritis.. The patient responded very well with corticosteroid. Although male patient with SLE is not commonly seen, the manifestations are life threatening and early detection of disease will lead to better outcome of the patient. Antimalaria drugs Hydrochloroquine is useful in patients with SLE glomerulonephritis. In consequences of their numerous beneficial effects, antimalarials appear to have a protective effect on survival in SLE.},
 year = {2019}
}

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TY  - JOUR
T1  - Systemic Lupus Erythematosus (SLE) with Lupus Nephritis in a 15 Year-Old Male – A Case Report
AU  - Rahmi Utami
AU  - Syarifuddin Rauf
Y1  - 2019/03/21
PY  - 2019
N1  - https://doi.org/10.11648/j.ajp.20190501.16
DO  - 10.11648/j.ajp.20190501.16
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 28
EP  - 33
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20190501.16
AB  - Systemic lupus erythematosus is a chronic autoimmune inflammatory disease that can affect any part of the body. Lupus Nephritis is one of the most common, and most important, serious manifestations of SLE particularly for male. We present a case of 15 year old male that is diagnosed with a systemic lupus erythematosus (SLE) based on 6 of the American College of Rheumatology (ACR), diagnostic criteria developed namely: malar rash, arthritis, photosensitive, kidney disorders (hematuria), immunological disorders (positive anti-dsDNA), and blood disorders (anemia, leucopenia). The result of the kidney’s biopsy indicated the patient already developed Lupus Nephritis.. The patient responded very well with corticosteroid. Although male patient with SLE is not commonly seen, the manifestations are life threatening and early detection of disease will lead to better outcome of the patient. Antimalaria drugs Hydrochloroquine is useful in patients with SLE glomerulonephritis. In consequences of their numerous beneficial effects, antimalarials appear to have a protective effect on survival in SLE.
VL  - 5
IS  - 1
ER  -

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Author Information

Rahmi Utami

Department of Pediatrics, Faculty of Medicine Hasanuddin University, Makassar, Indonesia
Syarifuddin Rauf

Department of Pediatrics, Faculty of Medicine Hasanuddin University, Makassar, Indonesia

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APA Style

Rahmi Utami, Syarifuddin Rauf. (2019). Systemic Lupus Erythematosus (SLE) with Lupus Nephritis in a 15 Year-Old Male – A Case Report. American Journal of Pediatrics, 5(1), 28-33. https://doi.org/10.11648/j.ajp.20190501.16

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ACS Style

Rahmi Utami; Syarifuddin Rauf. Systemic Lupus Erythematosus (SLE) with Lupus Nephritis in a 15 Year-Old Male – A Case Report. Am. J. Pediatr. 2019, 5(1), 28-33. doi: 10.11648/j.ajp.20190501.16

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AMA Style

Rahmi Utami, Syarifuddin Rauf. Systemic Lupus Erythematosus (SLE) with Lupus Nephritis in a 15 Year-Old Male – A Case Report. Am J Pediatr. 2019;5(1):28-33. doi: 10.11648/j.ajp.20190501.16

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@article{10.11648/j.ajp.20190501.16,
  author = {Rahmi Utami and Syarifuddin Rauf},
  title = {Systemic Lupus Erythematosus (SLE) with Lupus Nephritis in a 15 Year-Old Male – A Case Report},
  journal = {American Journal of Pediatrics},
  volume = {5},
  number = {1},
  pages = {28-33},
  doi = {10.11648/j.ajp.20190501.16},
  url = {https://doi.org/10.11648/j.ajp.20190501.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20190501.16},
  abstract = {Systemic lupus erythematosus is a chronic autoimmune inflammatory disease that can affect any part of the body. Lupus Nephritis is one of the most common, and most important, serious manifestations of SLE particularly for male. We present a case of 15 year old male that is diagnosed with a systemic lupus erythematosus (SLE) based on 6 of the American College of Rheumatology (ACR), diagnostic criteria developed namely: malar rash, arthritis, photosensitive, kidney disorders (hematuria), immunological disorders (positive anti-dsDNA), and blood disorders (anemia, leucopenia). The result of the kidney’s biopsy indicated the patient already developed Lupus Nephritis.. The patient responded very well with corticosteroid. Although male patient with SLE is not commonly seen, the manifestations are life threatening and early detection of disease will lead to better outcome of the patient. Antimalaria drugs Hydrochloroquine is useful in patients with SLE glomerulonephritis. In consequences of their numerous beneficial effects, antimalarials appear to have a protective effect on survival in SLE.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Systemic Lupus Erythematosus (SLE) with Lupus Nephritis in a 15 Year-Old Male – A Case Report
AU  - Rahmi Utami
AU  - Syarifuddin Rauf
Y1  - 2019/03/21
PY  - 2019
N1  - https://doi.org/10.11648/j.ajp.20190501.16
DO  - 10.11648/j.ajp.20190501.16
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 28
EP  - 33
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20190501.16
AB  - Systemic lupus erythematosus is a chronic autoimmune inflammatory disease that can affect any part of the body. Lupus Nephritis is one of the most common, and most important, serious manifestations of SLE particularly for male. We present a case of 15 year old male that is diagnosed with a systemic lupus erythematosus (SLE) based on 6 of the American College of Rheumatology (ACR), diagnostic criteria developed namely: malar rash, arthritis, photosensitive, kidney disorders (hematuria), immunological disorders (positive anti-dsDNA), and blood disorders (anemia, leucopenia). The result of the kidney’s biopsy indicated the patient already developed Lupus Nephritis.. The patient responded very well with corticosteroid. Although male patient with SLE is not commonly seen, the manifestations are life threatening and early detection of disease will lead to better outcome of the patient. Antimalaria drugs Hydrochloroquine is useful in patients with SLE glomerulonephritis. In consequences of their numerous beneficial effects, antimalarials appear to have a protective effect on survival in SLE.
VL  - 5
IS  - 1
ER  -

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