The primary objective of this study was to determine the clinical improvement after oral magnesium (Mg2+) supplementation in severely malnourished children. The specific objectives were to observe the changes in clinical sign-symptoms between Mg2+ supplemented and un-supplemented group and to see serum Mg2+ level before and after oral Mg2+ supplementation. This observational study was conducted in three tertiary level hospitals in Dhaka city involving 60 severely malnourished children of 6-59 months of age by non-probability purposive sampling from July’2016 to June’2018. Children were divided into two groups; Group I was given standard management for severe acute malnutrition according to the national guideline, Group II received similar treatment plus oral Mg2+ supplementation. Improvement of the clinical profile and the serum Mg2+ level was observed in children treated with Mg2+ supplementation. The mean age of Group I children was 21.13±13.02 months and Group II was 22.52±12.13 months. Male female ratio was 1.2:1. Statistically significant improvement was observed in case of nausea/vomiting, appetite, generalized weakness and weight gain (p<0.01). Appearance, diarrhea, skin changes and edema also improved in Mg2+ supplemented group but the results were not significant. Post-treatment serum Mg2+ levels were significantly different in Group I and Group II i.e., 1.52±0.27mg/dL Vs 2.03±0.31mg/dL respectively (p<0.001). It was observed that oral Mg2+ supplementation improved clinical outcome in severely malnourished children. Further large scale randomized control trial is needed to more precisely delineate the beneficial role of oral Mg2+ supplementation in severely malnourished children.
| Published in | American Journal of Pediatrics (Volume 5, Issue 4) |
| DOI | 10.11648/j.ajp.20190504.17 |
| Page(s) | 209-213 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
Malnutrition, Magnesium, Supplementation
| [1] | Muller O, Krawinkel M. Malnutrition and Health in Developing Countries. CMAJ 2005; 173 (3): 279-86. |
| [2] | National Institute of Population Research and Training Ministry of Health and Family Welfare, Dhaka, Bangladesh. (2016) Bangladesh Demographic and Health Survey. [Accessed 25th December 2018]. Available at: https://dhsprogram.com/pubs/pdf/FR311/FR311.pdf. |
| [3] | World Health Organization. Management of Severe Malnutrition: A Manual for Physicians and Other Senior Health Workers. Geneva: 1999. p4. |
| [4] | Report of a joint FAO/WHO expert consultation Bangkok, Thailand. (2001) Human Vitamin and Mineral Requirements. [Accessed 25th December 2018]. Available at: http://www.fao.org/3/a-y2809e.pdf. |
| [5] | Greenbaum Larry A. Pathophysiology of Body Fluids and Fluid Therapy. In: Richard E. Behrman, Robert M. Kliegman, Hal B. Jenson, editors. Nelson Textbook of Pediatrics. 17th ed. Sunders Company; 2004. P 191-242. |
| [6] | Logan RW. Fluid, Electrolyte and Acid-base Disturbance. In: A. G Campbell, Neil Mntosh, editors. Forfar and Aneil’s Textbook of Pediatrics. 5th ed. Churchill Livingstone Company; 1998. P 409. |
| [7] | Singla PN, Chand P, Kumar A, Kachhawaha JS. Serum Magnesium Levels in Protein-energy Malnutrition. J Trop Pediatr 1998; 44: 117-19. |
| [8] | Deshmukh CT, Rane SA, Gurav MN. Hypomagnesemia in Pediatric Population in an Intensive Care Unit. J postgrad Med 2000; 48: 179-80. |
| [9] | Holick MF, Krane SM. Introduction to Bone and Mineral Metabolism. In: Brauwald Fauci, Kasper, Hauser. Longo, Jameson, editors. Harrison’s Principles of Internal Medicine. 15th ed. McGraw-Hill Companies; 2001. P 2192-2205. |
| [10] | Weisinger JR, Font EB. Magnesium and Phosphorus. The Lancet 1998; 352: 391-96. |
| [11] | Nichols BL, Alvarado J, Hazlewood CF, Viteri F. Magnesium Supplementation in Protein Calorie Malnutrition. Am J Clin Nutr 1978; 31 (1): 176-88. |
| [12] | Bhan MK. Bhandari N, Bahl R. Management of the Severely Malnourished Child: Perspective from Developing Countries. BMJ 2003; 326 (7381); 146-51. |
| [13] | Bangladesh Bureau of Statistics/UNICEF, Statistics Division, Ministry of Planning, Government of the Peoples’ Republic of Bangladesh. (2000) Child Nutrition Survey of Bangladesh. [Accessed 25th December 2018]. Available at: www.unicef.org/bangladesh/MICS_Final_21062015_Low.pdf. |
| [14] | Roy NC. Use of Mid-Upper Arm Circumference for Evaluation of Nutritional Status of Children and for Identification of High-Risk Groups for Malnutrition in Rural Bangladesh. J Health Popul. Nutr 2000; 18 (3): 171-80. |
| [15] | Karla K, Mital VP, Pal R, Goyal RK, Dayal l RS. Serum Electrolyte Studies in Malnutrition. Indian Pediatrics 1975; 12 (2): 1135-140. |
| [16] | Trowbridge FL, Newton LH, Campbell CC. Nutritional Status and Severity of Diarrhea. The Lancet 1981; 1: 1374-375. |
| [17] | Black RE, Brown KH, Becker S. Malnutrition is a Determining Factor in Diarrheal Duration, but Not Incidence, Among Young Children in a Longitudinal Study in Rural Bangladesh. Am J Clin Nutr 1984; 39: 87-94. |
| [18] | Caddell JI. Double Blind Clinical Trial to Assess Magnesium Therapy. NEJM 1967; 267: 535-40. |
| [19] | Shills ME. Experimental Human Magnesium Depletion. Medicine 1969; 48: 61-85. |
| [20] | Montgomery RD. Magnesium Metabolism in Infantile Protein Maknutrition. The Lancet 1960; 2: 74-75. |
APA Style
Abdullah Al Baki, A. Z. M. Motiur Rahman, Md. Shohidul Islam Khan, Md. Arif Rabbany, Kamrunnaher Shultana, et al. (2019). Clinical Improvement After Oral Magnesium Supplementation in Children with Severe Acute Malnutrition-An Observational Study. American Journal of Pediatrics, 5(4), 209-213. https://doi.org/10.11648/j.ajp.20190504.17
ACS Style
Abdullah Al Baki; A. Z. M. Motiur Rahman; Md. Shohidul Islam Khan; Md. Arif Rabbany; Kamrunnaher Shultana, et al. Clinical Improvement After Oral Magnesium Supplementation in Children with Severe Acute Malnutrition-An Observational Study. Am. J. Pediatr. 2019, 5(4), 209-213. doi: 10.11648/j.ajp.20190504.17
AMA Style
Abdullah Al Baki, A. Z. M. Motiur Rahman, Md. Shohidul Islam Khan, Md. Arif Rabbany, Kamrunnaher Shultana, et al. Clinical Improvement After Oral Magnesium Supplementation in Children with Severe Acute Malnutrition-An Observational Study. Am J Pediatr. 2019;5(4):209-213. doi: 10.11648/j.ajp.20190504.17
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.ajp.20190504.17,
author = {Abdullah Al Baki and A. Z. M. Motiur Rahman and Md. Shohidul Islam Khan and Md. Arif Rabbany and Kamrunnaher Shultana and Dhiman Chowdhury and Muhammad Ismail Hasan and Mohammad Morshad Alam and Md. Mozammel Haque},
title = {Clinical Improvement After Oral Magnesium Supplementation in Children with Severe Acute Malnutrition-An Observational Study},
journal = {American Journal of Pediatrics},
volume = {5},
number = {4},
pages = {209-213},
doi = {10.11648/j.ajp.20190504.17},
url = {https://doi.org/10.11648/j.ajp.20190504.17},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20190504.17},
abstract = {The primary objective of this study was to determine the clinical improvement after oral magnesium (Mg2+) supplementation in severely malnourished children. The specific objectives were to observe the changes in clinical sign-symptoms between Mg2+ supplemented and un-supplemented group and to see serum Mg2+ level before and after oral Mg2+ supplementation. This observational study was conducted in three tertiary level hospitals in Dhaka city involving 60 severely malnourished children of 6-59 months of age by non-probability purposive sampling from July’2016 to June’2018. Children were divided into two groups; Group I was given standard management for severe acute malnutrition according to the national guideline, Group II received similar treatment plus oral Mg2+ supplementation. Improvement of the clinical profile and the serum Mg2+ level was observed in children treated with Mg2+ supplementation. The mean age of Group I children was 21.13±13.02 months and Group II was 22.52±12.13 months. Male female ratio was 1.2:1. Statistically significant improvement was observed in case of nausea/vomiting, appetite, generalized weakness and weight gain (p2+ supplemented group but the results were not significant. Post-treatment serum Mg2+ levels were significantly different in Group I and Group II i.e., 1.52±0.27mg/dL Vs 2.03±0.31mg/dL respectively (p2+ supplementation improved clinical outcome in severely malnourished children. Further large scale randomized control trial is needed to more precisely delineate the beneficial role of oral Mg2+ supplementation in severely malnourished children.},
year = {2019}
}
TY - JOUR T1 - Clinical Improvement After Oral Magnesium Supplementation in Children with Severe Acute Malnutrition-An Observational Study AU - Abdullah Al Baki AU - A. Z. M. Motiur Rahman AU - Md. Shohidul Islam Khan AU - Md. Arif Rabbany AU - Kamrunnaher Shultana AU - Dhiman Chowdhury AU - Muhammad Ismail Hasan AU - Mohammad Morshad Alam AU - Md. Mozammel Haque Y1 - 2019/10/11 PY - 2019 N1 - https://doi.org/10.11648/j.ajp.20190504.17 DO - 10.11648/j.ajp.20190504.17 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 209 EP - 213 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20190504.17 AB - The primary objective of this study was to determine the clinical improvement after oral magnesium (Mg2+) supplementation in severely malnourished children. The specific objectives were to observe the changes in clinical sign-symptoms between Mg2+ supplemented and un-supplemented group and to see serum Mg2+ level before and after oral Mg2+ supplementation. This observational study was conducted in three tertiary level hospitals in Dhaka city involving 60 severely malnourished children of 6-59 months of age by non-probability purposive sampling from July’2016 to June’2018. Children were divided into two groups; Group I was given standard management for severe acute malnutrition according to the national guideline, Group II received similar treatment plus oral Mg2+ supplementation. Improvement of the clinical profile and the serum Mg2+ level was observed in children treated with Mg2+ supplementation. The mean age of Group I children was 21.13±13.02 months and Group II was 22.52±12.13 months. Male female ratio was 1.2:1. Statistically significant improvement was observed in case of nausea/vomiting, appetite, generalized weakness and weight gain (p2+ supplemented group but the results were not significant. Post-treatment serum Mg2+ levels were significantly different in Group I and Group II i.e., 1.52±0.27mg/dL Vs 2.03±0.31mg/dL respectively (p2+ supplementation improved clinical outcome in severely malnourished children. Further large scale randomized control trial is needed to more precisely delineate the beneficial role of oral Mg2+ supplementation in severely malnourished children. VL - 5 IS - 4 ER -
Information
Email: