Differences Between Quality of Life in Children with Infrequent and Frequent Relapse of Nephrotic Syndrome

Ni Putu Eka Suwitri; I Ketut Suarta; I Gusti Ayu Trisna Windiani

doi:doi:10.11648/j.ajp.20190504.30

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Differences Between Quality of Life in Children with Infrequent and Frequent Relapse of Nephrotic Syndrome

Ni Putu Eka Suwitri, I Ketut Suarta, I Gusti Ayu Trisna Windiani

Published in American Journal of Pediatrics (Volume 5, Issue 4)

Received: 15 November 2019 Accepted: 9 December 2019 Published: 19 December 2019

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Abstract

Nephrotic syndrome is a common disease in children. The syndrome consists of massive proteinuria, hypoalbuminemia, edema and hypercholesterolemia which may lead to relapse and remission episodes, thus affect child’s quality of life. The objective was to determine the quality of life difference between children with infrequent and frequent relapse of nephrotic syndrome. This study was an observational analytic study with cross-sectional design, conducted at the Pediatric outpatient clinic in Sanglah Hospital, Denpasar, Indonesia, from January 2016 to January 2017. Independent t-test was performed to assess quality of life differences in patients with infrequent and frequent relapse of nephrotic syndrome, with significancy level p <0.05 and precision set at 95% confidence interval. The quality of life in children was measured by PedsQL 4.0 Generic Core Scales Questionnaire. Subjects consisted of 14 infrequent relapse samples and 14 frequent relapse samples. The average scores of quality of life in children based on their parents’ reports were 85.70 (8.96) from infrequent relapse group and 82.24 (12.56) from the frequent relapse group (p=0.410). Meanwhile, based on the children’s report, the quality of life score were 88.79 (9.30) from infrequent relapse group and 82.59 (12.09) from frequent relapse group (p=0.194). This study concluded that there was no significant difference of physical, emotional, social, school functions subscale scores and quality of life score based on children and parents’ reports in both groups.

Published in	American Journal of Pediatrics (Volume 5, Issue 4)
DOI	10.11648/j.ajp.20190504.30
Page(s)	281-285
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Nephrotic Syndrome, Relapse, Quality of Life, PedsQL, Children

References

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[5]	Vogt BA, Avner ED. Conditions particularly associated with proteinuria: nephrotic syndrome. In: Behrman, R. E., Kliegman, R. M., Jenson, H. B., editors. Nelson Textbook of Pediatrics. 17 ed. New Delhi: Elsevier India; 2004. p. 1753–7.
[6]	Leonard MB, Feldman HI, Shulths J, Zemel BS, Foster BJ, Stalling YA. Long-term, high-dose glucocorticoids and bone mineral content in childhood glucocorticoid-sensitive nephrotic syndrome. N Engl J Med 2004; 352: 868-75.
[7]	Manti P, Giannakopoulos G, Giouroukou E, Angelaki HG, Stefanidis CJ, Mitsioni A, et al. Psychosocial and cognitive function in children with nephrotic syndrome: association with disease and treatment variables. 2013 [cited 2014 July 20]. Available from: http://www.bpsmedicine.com/content/7/1/10.
[8]	Varni JW. The PedsQLTM: measurement model for the pediatric quality of life inventory. Med Care 1999; 37: 126-39.
[9]	Soetjiningsih. Tumbuh kembang anak dengan kondisi kesehatan kronik. In: Narendra MB, Sularyo T, Soetjiningsih, Suyitno H, Ranuh IGN, Wiradisuria S, editors. Buku Ajar II Tumbuh Kembang Anak dan Remaja. Jakarta: Sagung Seto; 2005. p. 61-9.
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[12]	Rosita IR. Perbedaan kualitas hidup anak dengan sindrom nefrotik resisten steroid dan sindrom nefrotik relaps. 2013 [cited 2014 July 22]. Available from: http://eprints.undip.ac.id/33308/1/Ika Rara.pdf.
[13]	Soliday E, Grey S, Lande MB. Behavioral effects of corticosteroids in steroid-sensitive nephrotic syndrome. Pediatrics 1999; 104: 51.
[14]	Niaudet P. Long-term outcome of children with steroid-sensitive idiopathic nephrotic syndrome. Clin J Am Soc Nephrol 2009; 4: 1547-8.
[15]	Damanik MP. Hubungan antara human leucocyte antigens (HLA) dengan NS primer pada anak di RSUP Dr. Sardjito Yogyakarta. (Disertasi). Yogyakarta: Medica Fakultas Kedokteran Universitas Gajah Mada Yogyakarta; 2006.
[16]	Foster BJ, Shults J, Zemel BS, Leonard MB. Risk factors for glucocorticoid-induced obesity in children with steroid-sensitive nephrotic syndrome. Pediatr Nephrol 2006; 21: 973-80.
[17]	Taylor VH, Forhan M, Vigod SN, Mclntyre RS, Morrison KM. The impact of obesity on quality of life. Best Pract Res Clin Endocrinol Metab 2013; 27: 139-46.
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APA Style

Ni Putu Eka Suwitri, I Ketut Suarta, I Gusti Ayu Trisna Windiani. (2019). Differences Between Quality of Life in Children with Infrequent and Frequent Relapse of Nephrotic Syndrome. American Journal of Pediatrics, 5(4), 281-285. https://doi.org/10.11648/j.ajp.20190504.30

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ACS Style

Ni Putu Eka Suwitri; I Ketut Suarta; I Gusti Ayu Trisna Windiani. Differences Between Quality of Life in Children with Infrequent and Frequent Relapse of Nephrotic Syndrome. Am. J. Pediatr. 2019, 5(4), 281-285. doi: 10.11648/j.ajp.20190504.30

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AMA Style

Ni Putu Eka Suwitri, I Ketut Suarta, I Gusti Ayu Trisna Windiani. Differences Between Quality of Life in Children with Infrequent and Frequent Relapse of Nephrotic Syndrome. Am J Pediatr. 2019;5(4):281-285. doi: 10.11648/j.ajp.20190504.30

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@article{10.11648/j.ajp.20190504.30,
  author = {Ni Putu Eka Suwitri and I Ketut Suarta and I Gusti Ayu Trisna Windiani},
  title = {Differences Between Quality of Life in Children with Infrequent and Frequent Relapse of Nephrotic Syndrome},
  journal = {American Journal of Pediatrics},
  volume = {5},
  number = {4},
  pages = {281-285},
  doi = {10.11648/j.ajp.20190504.30},
  url = {https://doi.org/10.11648/j.ajp.20190504.30},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20190504.30},
  abstract = {Nephrotic syndrome is a common disease in children. The syndrome consists of massive proteinuria, hypoalbuminemia, edema and hypercholesterolemia which may lead to relapse and remission episodes, thus affect child’s quality of life. The objective was to determine the quality of life difference between children with infrequent and frequent relapse of nephrotic syndrome. This study was an observational analytic study with cross-sectional design, conducted at the Pediatric outpatient clinic in Sanglah Hospital, Denpasar, Indonesia, from January 2016 to January 2017. Independent t-test was performed to assess quality of life differences in patients with infrequent and frequent relapse of nephrotic syndrome, with significancy level p <0.05 and precision set at 95% confidence interval. The quality of life in children was measured by PedsQL 4.0 Generic Core Scales Questionnaire. Subjects consisted of 14 infrequent relapse samples and 14 frequent relapse samples. The average scores of quality of life in children based on their parents’ reports were 85.70 (8.96) from infrequent relapse group and 82.24 (12.56) from the frequent relapse group (p=0.410). Meanwhile, based on the children’s report, the quality of life score were 88.79 (9.30) from infrequent relapse group and 82.59 (12.09) from frequent relapse group (p=0.194). This study concluded that there was no significant difference of physical, emotional, social, school functions subscale scores and quality of life score based on children and parents’ reports in both groups.},
 year = {2019}
}

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TY  - JOUR
T1  - Differences Between Quality of Life in Children with Infrequent and Frequent Relapse of Nephrotic Syndrome
AU  - Ni Putu Eka Suwitri
AU  - I Ketut Suarta
AU  - I Gusti Ayu Trisna Windiani
Y1  - 2019/12/19
PY  - 2019
N1  - https://doi.org/10.11648/j.ajp.20190504.30
DO  - 10.11648/j.ajp.20190504.30
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 281
EP  - 285
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20190504.30
AB  - Nephrotic syndrome is a common disease in children. The syndrome consists of massive proteinuria, hypoalbuminemia, edema and hypercholesterolemia which may lead to relapse and remission episodes, thus affect child’s quality of life. The objective was to determine the quality of life difference between children with infrequent and frequent relapse of nephrotic syndrome. This study was an observational analytic study with cross-sectional design, conducted at the Pediatric outpatient clinic in Sanglah Hospital, Denpasar, Indonesia, from January 2016 to January 2017. Independent t-test was performed to assess quality of life differences in patients with infrequent and frequent relapse of nephrotic syndrome, with significancy level p <0.05 and precision set at 95% confidence interval. The quality of life in children was measured by PedsQL 4.0 Generic Core Scales Questionnaire. Subjects consisted of 14 infrequent relapse samples and 14 frequent relapse samples. The average scores of quality of life in children based on their parents’ reports were 85.70 (8.96) from infrequent relapse group and 82.24 (12.56) from the frequent relapse group (p=0.410). Meanwhile, based on the children’s report, the quality of life score were 88.79 (9.30) from infrequent relapse group and 82.59 (12.09) from frequent relapse group (p=0.194). This study concluded that there was no significant difference of physical, emotional, social, school functions subscale scores and quality of life score based on children and parents’ reports in both groups.
VL  - 5
IS  - 4
ER  -

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Author Information

Ni Putu Eka Suwitri

Department of Child Health, Faculty of Medicine, Udayana University, Denpasar, Indonesia
I Ketut Suarta

Department of Child Health, Faculty of Medicine, Udayana University, Denpasar, Indonesia
I Gusti Ayu Trisna Windiani

Department of Child Health, Faculty of Medicine, Udayana University, Denpasar, Indonesia

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APA Style

Ni Putu Eka Suwitri, I Ketut Suarta, I Gusti Ayu Trisna Windiani. (2019). Differences Between Quality of Life in Children with Infrequent and Frequent Relapse of Nephrotic Syndrome. American Journal of Pediatrics, 5(4), 281-285. https://doi.org/10.11648/j.ajp.20190504.30

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ACS Style

Ni Putu Eka Suwitri; I Ketut Suarta; I Gusti Ayu Trisna Windiani. Differences Between Quality of Life in Children with Infrequent and Frequent Relapse of Nephrotic Syndrome. Am. J. Pediatr. 2019, 5(4), 281-285. doi: 10.11648/j.ajp.20190504.30

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AMA Style

Ni Putu Eka Suwitri, I Ketut Suarta, I Gusti Ayu Trisna Windiani. Differences Between Quality of Life in Children with Infrequent and Frequent Relapse of Nephrotic Syndrome. Am J Pediatr. 2019;5(4):281-285. doi: 10.11648/j.ajp.20190504.30

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@article{10.11648/j.ajp.20190504.30,
  author = {Ni Putu Eka Suwitri and I Ketut Suarta and I Gusti Ayu Trisna Windiani},
  title = {Differences Between Quality of Life in Children with Infrequent and Frequent Relapse of Nephrotic Syndrome},
  journal = {American Journal of Pediatrics},
  volume = {5},
  number = {4},
  pages = {281-285},
  doi = {10.11648/j.ajp.20190504.30},
  url = {https://doi.org/10.11648/j.ajp.20190504.30},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20190504.30},
  abstract = {Nephrotic syndrome is a common disease in children. The syndrome consists of massive proteinuria, hypoalbuminemia, edema and hypercholesterolemia which may lead to relapse and remission episodes, thus affect child’s quality of life. The objective was to determine the quality of life difference between children with infrequent and frequent relapse of nephrotic syndrome. This study was an observational analytic study with cross-sectional design, conducted at the Pediatric outpatient clinic in Sanglah Hospital, Denpasar, Indonesia, from January 2016 to January 2017. Independent t-test was performed to assess quality of life differences in patients with infrequent and frequent relapse of nephrotic syndrome, with significancy level p <0.05 and precision set at 95% confidence interval. The quality of life in children was measured by PedsQL 4.0 Generic Core Scales Questionnaire. Subjects consisted of 14 infrequent relapse samples and 14 frequent relapse samples. The average scores of quality of life in children based on their parents’ reports were 85.70 (8.96) from infrequent relapse group and 82.24 (12.56) from the frequent relapse group (p=0.410). Meanwhile, based on the children’s report, the quality of life score were 88.79 (9.30) from infrequent relapse group and 82.59 (12.09) from frequent relapse group (p=0.194). This study concluded that there was no significant difference of physical, emotional, social, school functions subscale scores and quality of life score based on children and parents’ reports in both groups.},
 year = {2019}
}

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TY  - JOUR
T1  - Differences Between Quality of Life in Children with Infrequent and Frequent Relapse of Nephrotic Syndrome
AU  - Ni Putu Eka Suwitri
AU  - I Ketut Suarta
AU  - I Gusti Ayu Trisna Windiani
Y1  - 2019/12/19
PY  - 2019
N1  - https://doi.org/10.11648/j.ajp.20190504.30
DO  - 10.11648/j.ajp.20190504.30
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 281
EP  - 285
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20190504.30
AB  - Nephrotic syndrome is a common disease in children. The syndrome consists of massive proteinuria, hypoalbuminemia, edema and hypercholesterolemia which may lead to relapse and remission episodes, thus affect child’s quality of life. The objective was to determine the quality of life difference between children with infrequent and frequent relapse of nephrotic syndrome. This study was an observational analytic study with cross-sectional design, conducted at the Pediatric outpatient clinic in Sanglah Hospital, Denpasar, Indonesia, from January 2016 to January 2017. Independent t-test was performed to assess quality of life differences in patients with infrequent and frequent relapse of nephrotic syndrome, with significancy level p <0.05 and precision set at 95% confidence interval. The quality of life in children was measured by PedsQL 4.0 Generic Core Scales Questionnaire. Subjects consisted of 14 infrequent relapse samples and 14 frequent relapse samples. The average scores of quality of life in children based on their parents’ reports were 85.70 (8.96) from infrequent relapse group and 82.24 (12.56) from the frequent relapse group (p=0.410). Meanwhile, based on the children’s report, the quality of life score were 88.79 (9.30) from infrequent relapse group and 82.59 (12.09) from frequent relapse group (p=0.194). This study concluded that there was no significant difference of physical, emotional, social, school functions subscale scores and quality of life score based on children and parents’ reports in both groups.
VL  - 5
IS  - 4
ER  -

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