Fluid Overload in Children with Severe Sepsis and Septic Shock

Copana Raul; Diaz Willmer

doi:doi:10.11648/j.ajp.20190504.33

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Fluid Overload in Children with Severe Sepsis and Septic Shock

Copana Raul, Diaz Willmer

Published in American Journal of Pediatrics (Volume 5, Issue 4)

Received: 17 October 2019 Accepted: 20 December 2019 Published: 31 December 2019

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Abstract

Fluid therapy is one pillar of the treatment of septic shock, however, a hydric≥10% of the weight or Fluid Overload (FO>10%) is associated with poor hospital outcomes. The present study aims to determine the FO in patients with septic shock, and its main associations in terms of mortality and morbidity. An observational and descriptive study was conducted in 49 hospitalized children with septic shock in the PICU of the Manuel Ascencio Villarroel Children’s Hospital (MAVCH); The patients were divided into two groups according to the FO>10% (22 patients) and<10% (18 patients), for their descriptive analysis we included comparison of means and calculation of the OR. Regarding the water requirements, we observed that the group with FO>10% a mean of 5681ml; while in the group with ISCH<10% the mean was 3297.8ml (p=0.19) during first 72 hours, showing greater overload with the administration of colloids and blood products (p=0.02, p=0.004). Regarding hospital outcomes, was found morbidity associated with FO>10% (respiratory dysfunction, vasopressor requirement and renal replacement therapy); The length of hospitalization and FO were not different in groups (p=0.60), but there was higher mortality of patients with FO>10% (p=0.01, OR: 5.57 IC95% 1.4-21.8). Fluids therapy of in the patient with septic shock constitutes one of the first-line hemodynamic treatments, however in limited resources settings, overload should be avoided, mainly due to associated morbidity during the first 72 hours.

Published in	American Journal of Pediatrics (Volume 5, Issue 4)
DOI	10.11648/j.ajp.20190504.33
Page(s)	299-303
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Fluid Overload, Sepsis, Septic Shock, Fluid Therapy

References

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APA Style

Copana Raul, Diaz Willmer. (2019). Fluid Overload in Children with Severe Sepsis and Septic Shock. American Journal of Pediatrics, 5(4), 299-303. https://doi.org/10.11648/j.ajp.20190504.33

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ACS Style

Copana Raul; Diaz Willmer. Fluid Overload in Children with Severe Sepsis and Septic Shock. Am. J. Pediatr. 2019, 5(4), 299-303. doi: 10.11648/j.ajp.20190504.33

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AMA Style

Copana Raul, Diaz Willmer. Fluid Overload in Children with Severe Sepsis and Septic Shock. Am J Pediatr. 2019;5(4):299-303. doi: 10.11648/j.ajp.20190504.33

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@article{10.11648/j.ajp.20190504.33,
  author = {Copana Raul and Diaz Willmer},
  title = {Fluid Overload in Children with Severe Sepsis and Septic Shock},
  journal = {American Journal of Pediatrics},
  volume = {5},
  number = {4},
  pages = {299-303},
  doi = {10.11648/j.ajp.20190504.33},
  url = {https://doi.org/10.11648/j.ajp.20190504.33},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20190504.33},
  abstract = {Fluid therapy is one pillar of the treatment of septic shock, however, a hydric≥10% of the weight or Fluid Overload (FO>10%) is associated with poor hospital outcomes. The present study aims to determine the FO in patients with septic shock, and its main associations in terms of mortality and morbidity. An observational and descriptive study was conducted in 49 hospitalized children with septic shock in the PICU of the Manuel Ascencio Villarroel Children’s Hospital (MAVCH); The patients were divided into two groups according to the FO>10% (22 patients) and10% a mean of 5681ml; while in the group with ISCH10% (respiratory dysfunction, vasopressor requirement and renal replacement therapy); The length of hospitalization and FO were not different in groups (p=0.60), but there was higher mortality of patients with FO>10% (p=0.01, OR: 5.57 IC95% 1.4-21.8). Fluids therapy of in the patient with septic shock constitutes one of the first-line hemodynamic treatments, however in limited resources settings, overload should be avoided, mainly due to associated morbidity during the first 72 hours.},
 year = {2019}
}

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TY  - JOUR
T1  - Fluid Overload in Children with Severe Sepsis and Septic Shock
AU  - Copana Raul
AU  - Diaz Willmer
Y1  - 2019/12/31
PY  - 2019
N1  - https://doi.org/10.11648/j.ajp.20190504.33
DO  - 10.11648/j.ajp.20190504.33
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 299
EP  - 303
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20190504.33
AB  - Fluid therapy is one pillar of the treatment of septic shock, however, a hydric≥10% of the weight or Fluid Overload (FO>10%) is associated with poor hospital outcomes. The present study aims to determine the FO in patients with septic shock, and its main associations in terms of mortality and morbidity. An observational and descriptive study was conducted in 49 hospitalized children with septic shock in the PICU of the Manuel Ascencio Villarroel Children’s Hospital (MAVCH); The patients were divided into two groups according to the FO>10% (22 patients) and10% a mean of 5681ml; while in the group with ISCH10% (respiratory dysfunction, vasopressor requirement and renal replacement therapy); The length of hospitalization and FO were not different in groups (p=0.60), but there was higher mortality of patients with FO>10% (p=0.01, OR: 5.57 IC95% 1.4-21.8). Fluids therapy of in the patient with septic shock constitutes one of the first-line hemodynamic treatments, however in limited resources settings, overload should be avoided, mainly due to associated morbidity during the first 72 hours.
VL  - 5
IS  - 4
ER  -

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Author Information

Copana Raul

Pediatric Intensive Care Department, Manuel Ascencio Villarroel Children′s Hospital, Cochabamba, Bolivia
Diaz Willmer

Pediatric Intensive Care Department, Ovidio Aliaga Uria Chidren′s Hospital, La Paz, Bolivia

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APA Style

Copana Raul, Diaz Willmer. (2019). Fluid Overload in Children with Severe Sepsis and Septic Shock. American Journal of Pediatrics, 5(4), 299-303. https://doi.org/10.11648/j.ajp.20190504.33

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ACS Style

Copana Raul; Diaz Willmer. Fluid Overload in Children with Severe Sepsis and Septic Shock. Am. J. Pediatr. 2019, 5(4), 299-303. doi: 10.11648/j.ajp.20190504.33

Copy | Download

AMA Style

Copana Raul, Diaz Willmer. Fluid Overload in Children with Severe Sepsis and Septic Shock. Am J Pediatr. 2019;5(4):299-303. doi: 10.11648/j.ajp.20190504.33

Copy | Download

@article{10.11648/j.ajp.20190504.33,
  author = {Copana Raul and Diaz Willmer},
  title = {Fluid Overload in Children with Severe Sepsis and Septic Shock},
  journal = {American Journal of Pediatrics},
  volume = {5},
  number = {4},
  pages = {299-303},
  doi = {10.11648/j.ajp.20190504.33},
  url = {https://doi.org/10.11648/j.ajp.20190504.33},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20190504.33},
  abstract = {Fluid therapy is one pillar of the treatment of septic shock, however, a hydric≥10% of the weight or Fluid Overload (FO>10%) is associated with poor hospital outcomes. The present study aims to determine the FO in patients with septic shock, and its main associations in terms of mortality and morbidity. An observational and descriptive study was conducted in 49 hospitalized children with septic shock in the PICU of the Manuel Ascencio Villarroel Children’s Hospital (MAVCH); The patients were divided into two groups according to the FO>10% (22 patients) and10% a mean of 5681ml; while in the group with ISCH10% (respiratory dysfunction, vasopressor requirement and renal replacement therapy); The length of hospitalization and FO were not different in groups (p=0.60), but there was higher mortality of patients with FO>10% (p=0.01, OR: 5.57 IC95% 1.4-21.8). Fluids therapy of in the patient with septic shock constitutes one of the first-line hemodynamic treatments, however in limited resources settings, overload should be avoided, mainly due to associated morbidity during the first 72 hours.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Fluid Overload in Children with Severe Sepsis and Septic Shock
AU  - Copana Raul
AU  - Diaz Willmer
Y1  - 2019/12/31
PY  - 2019
N1  - https://doi.org/10.11648/j.ajp.20190504.33
DO  - 10.11648/j.ajp.20190504.33
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 299
EP  - 303
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20190504.33
AB  - Fluid therapy is one pillar of the treatment of septic shock, however, a hydric≥10% of the weight or Fluid Overload (FO>10%) is associated with poor hospital outcomes. The present study aims to determine the FO in patients with septic shock, and its main associations in terms of mortality and morbidity. An observational and descriptive study was conducted in 49 hospitalized children with septic shock in the PICU of the Manuel Ascencio Villarroel Children’s Hospital (MAVCH); The patients were divided into two groups according to the FO>10% (22 patients) and10% a mean of 5681ml; while in the group with ISCH10% (respiratory dysfunction, vasopressor requirement and renal replacement therapy); The length of hospitalization and FO were not different in groups (p=0.60), but there was higher mortality of patients with FO>10% (p=0.01, OR: 5.57 IC95% 1.4-21.8). Fluids therapy of in the patient with septic shock constitutes one of the first-line hemodynamic treatments, however in limited resources settings, overload should be avoided, mainly due to associated morbidity during the first 72 hours.
VL  - 5
IS  - 4
ER  -

Copy | Download