The search of non-invasive methods of diagnosis of kidney disease, new biomarkers of injury and its level is very important at present time. Such markers are KIM-1 (kidney injury molecule - 1), TGF-β1 (transforming growth factor - β1), RBP (retinol-binding protein) and β2-MG (β2 – microglobulin). β2-MG and RBP are low molecular weight proteins which are rapidly filtered in the glomerulus and catabolized in the renal tubules after resorption by cells of proximal part. These proteins aren't reabsorbed and appear in the urine in the pathology of the tubules. This fact allows using β2-MG and RBP for diagnostics of injury of the proximal tubules. KIM-1 isn't detected in normal kidney tissue. However, the expression level of this biomarker increases significantly on the surface of the epithelial cells of the proximal tubules after ischemic or toxic damage of kidneys. For this reasons KIM-1 is an ideal markers of kidney injury and allows differentiating ischemic damage from prerenal azotemia and chronic kidney disease (CKD). TGF-β1 indicates endothelial dysfunction and fibroangiogenesis which are the basis of remodeling of the microvascular bed of the kidney in various kinds of glomerulopathies. The results of determination of concentration in serum and urine are presented in this article. The introduction of KIM-1, TGF-β1, RBP and β2-MG into clinical practice will expand the possibility of diagnosis of kidney diseases, allow non-invasive monitoring of progression and the effectiveness of nephroprotective therapy.
| Published in |
American Journal of Pediatrics (Volume 6, Issue 1)
This article belongs to the Special Issue Chronic Kidney Disease in Children |
| DOI | 10.11648/j.ajp.20200601.16 |
| Page(s) | 37-41 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Kidney, Injury, Markers, Urine, Serum
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APA Style
Hanna Bialkevich, Ina Kazyra, Alexander Sukalo. (2020). New Biomarkers in the Diagnosis of Kidney Injury in Children with Hereditary Nephritis and Tubulopaties. American Journal of Pediatrics, 6(1), 37-41. https://doi.org/10.11648/j.ajp.20200601.16
ACS Style
Hanna Bialkevich; Ina Kazyra; Alexander Sukalo. New Biomarkers in the Diagnosis of Kidney Injury in Children with Hereditary Nephritis and Tubulopaties. Am. J. Pediatr. 2020, 6(1), 37-41. doi: 10.11648/j.ajp.20200601.16
AMA Style
Hanna Bialkevich, Ina Kazyra, Alexander Sukalo. New Biomarkers in the Diagnosis of Kidney Injury in Children with Hereditary Nephritis and Tubulopaties. Am J Pediatr. 2020;6(1):37-41. doi: 10.11648/j.ajp.20200601.16
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Download@article{10.11648/j.ajp.20200601.16,
author = {Hanna Bialkevich and Ina Kazyra and Alexander Sukalo},
title = {New Biomarkers in the Diagnosis of Kidney Injury in Children with Hereditary Nephritis and Tubulopaties},
journal = {American Journal of Pediatrics},
volume = {6},
number = {1},
pages = {37-41},
doi = {10.11648/j.ajp.20200601.16},
url = {https://doi.org/10.11648/j.ajp.20200601.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200601.16},
abstract = {The search of non-invasive methods of diagnosis of kidney disease, new biomarkers of injury and its level is very important at present time. Such markers are KIM-1 (kidney injury molecule - 1), TGF-β1 (transforming growth factor - β1), RBP (retinol-binding protein) and β2-MG (β2 – microglobulin). β2-MG and RBP are low molecular weight proteins which are rapidly filtered in the glomerulus and catabolized in the renal tubules after resorption by cells of proximal part. These proteins aren't reabsorbed and appear in the urine in the pathology of the tubules. This fact allows using β2-MG and RBP for diagnostics of injury of the proximal tubules. KIM-1 isn't detected in normal kidney tissue. However, the expression level of this biomarker increases significantly on the surface of the epithelial cells of the proximal tubules after ischemic or toxic damage of kidneys. For this reasons KIM-1 is an ideal markers of kidney injury and allows differentiating ischemic damage from prerenal azotemia and chronic kidney disease (CKD). TGF-β1 indicates endothelial dysfunction and fibroangiogenesis which are the basis of remodeling of the microvascular bed of the kidney in various kinds of glomerulopathies. The results of determination of concentration in serum and urine are presented in this article. The introduction of KIM-1, TGF-β1, RBP and β2-MG into clinical practice will expand the possibility of diagnosis of kidney diseases, allow non-invasive monitoring of progression and the effectiveness of nephroprotective therapy.},
year = {2020}
}
TY - JOUR T1 - New Biomarkers in the Diagnosis of Kidney Injury in Children with Hereditary Nephritis and Tubulopaties AU - Hanna Bialkevich AU - Ina Kazyra AU - Alexander Sukalo Y1 - 2020/02/18 PY - 2020 N1 - https://doi.org/10.11648/j.ajp.20200601.16 DO - 10.11648/j.ajp.20200601.16 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 37 EP - 41 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20200601.16 AB - The search of non-invasive methods of diagnosis of kidney disease, new biomarkers of injury and its level is very important at present time. Such markers are KIM-1 (kidney injury molecule - 1), TGF-β1 (transforming growth factor - β1), RBP (retinol-binding protein) and β2-MG (β2 – microglobulin). β2-MG and RBP are low molecular weight proteins which are rapidly filtered in the glomerulus and catabolized in the renal tubules after resorption by cells of proximal part. These proteins aren't reabsorbed and appear in the urine in the pathology of the tubules. This fact allows using β2-MG and RBP for diagnostics of injury of the proximal tubules. KIM-1 isn't detected in normal kidney tissue. However, the expression level of this biomarker increases significantly on the surface of the epithelial cells of the proximal tubules after ischemic or toxic damage of kidneys. For this reasons KIM-1 is an ideal markers of kidney injury and allows differentiating ischemic damage from prerenal azotemia and chronic kidney disease (CKD). TGF-β1 indicates endothelial dysfunction and fibroangiogenesis which are the basis of remodeling of the microvascular bed of the kidney in various kinds of glomerulopathies. The results of determination of concentration in serum and urine are presented in this article. The introduction of KIM-1, TGF-β1, RBP and β2-MG into clinical practice will expand the possibility of diagnosis of kidney diseases, allow non-invasive monitoring of progression and the effectiveness of nephroprotective therapy. VL - 6 IS - 1 ER -
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