Combination of Lactobacillus Rhamnosus LGG, Vitamin D3 and Zn in Preventing Atopic Dermatitis in Infancy

Ivana Filipovic; Olivera Ostojic; Vesna Vekovic; Milan Lackovic; Zorica Zivkovic

doi:doi:10.11648/j.ajp.20200603.26

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Combination of Lactobacillus Rhamnosus LGG, Vitamin D3 and Zn in Preventing Atopic Dermatitis in Infancy

Ivana Filipovic, Olivera Ostojic, Vesna Vekovic, Milan Lackovic, Zorica Zivkovic

Published in American Journal of Pediatrics (Volume 6, Issue 3)

Received: 7 May 2020 Accepted: 8 July 2020 Published: 17 July 2020

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Abstract

Introduction: With the prevalence of between 10-20% atopic dermatitis (AD) is one of the most common chronic diseases in infants and children. AD is characterized by itching and recurrent lesion. Mixtures of probiotics, including at the first place Lactobacillus rhamnosus LGG strain strains significantly decreased the risk of AD if given pre- and postnatally. Objective: The aim of the current study was to assess the effect of oral supplementation with LGG in infancy on eczema development and sensitization during the first 2 years of life. Material and methods: The study was a real life controlled observational study that included 96 patients (52 infants were treated with Lactobacillus rhamnosus with vitamin D3 and zinc, while the rest were advised to use only symptomatic treatment). Results: At the baseline the infants in the experiment group had higher values for SCORAD. During the follow up period a significant reduction in SCORAD was observed only in the group of participants who was treated with probiotics. They used also less topical treatments and antihistamines. Conclusions: This study has found that Lactobacillus rhamnosus GG (LGG) formulation with Zn and vitamin D3 supplementation during the postnatal period (in infancy and early childhood) reduce the severity of atopic dermatitis. Based on the findings it is recommended to introduce probiotic supplementation as well as vitamin D3 and zinc in infants and children with atopic dermatitis and positive family history.

Published in	American Journal of Pediatrics (Volume 6, Issue 3)
DOI	10.11648/j.ajp.20200603.26
Page(s)	273-277
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Atopic Dermatitis, Infants, Probiotics

References

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APA Style

Ivana Filipovic, Olivera Ostojic, Vesna Vekovic, Milan Lackovic, Zorica Zivkovic. (2020). Combination of Lactobacillus Rhamnosus LGG, Vitamin D3 and Zn in Preventing Atopic Dermatitis in Infancy. American Journal of Pediatrics, 6(3), 273-277. https://doi.org/10.11648/j.ajp.20200603.26

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ACS Style

Ivana Filipovic; Olivera Ostojic; Vesna Vekovic; Milan Lackovic; Zorica Zivkovic. Combination of Lactobacillus Rhamnosus LGG, Vitamin D3 and Zn in Preventing Atopic Dermatitis in Infancy. Am. J. Pediatr. 2020, 6(3), 273-277. doi: 10.11648/j.ajp.20200603.26

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AMA Style

Ivana Filipovic, Olivera Ostojic, Vesna Vekovic, Milan Lackovic, Zorica Zivkovic. Combination of Lactobacillus Rhamnosus LGG, Vitamin D3 and Zn in Preventing Atopic Dermatitis in Infancy. Am J Pediatr. 2020;6(3):273-277. doi: 10.11648/j.ajp.20200603.26

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@article{10.11648/j.ajp.20200603.26,
  author = {Ivana Filipovic and Olivera Ostojic and Vesna Vekovic and Milan Lackovic and Zorica Zivkovic},
  title = {Combination of Lactobacillus Rhamnosus LGG, Vitamin D3 and Zn in Preventing Atopic Dermatitis in Infancy},
  journal = {American Journal of Pediatrics},
  volume = {6},
  number = {3},
  pages = {273-277},
  doi = {10.11648/j.ajp.20200603.26},
  url = {https://doi.org/10.11648/j.ajp.20200603.26},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200603.26},
  abstract = {Introduction: With the prevalence of between 10-20% atopic dermatitis (AD) is one of the most common chronic diseases in infants and children. AD is characterized by itching and recurrent lesion. Mixtures of probiotics, including at the first place Lactobacillus rhamnosus LGG strain strains significantly decreased the risk of AD if given pre- and postnatally. Objective: The aim of the current study was to assess the effect of oral supplementation with LGG in infancy on eczema development and sensitization during the first 2 years of life. Material and methods: The study was a real life controlled observational study that included 96 patients (52 infants were treated with Lactobacillus rhamnosus with vitamin D3 and zinc, while the rest were advised to use only symptomatic treatment). Results: At the baseline the infants in the experiment group had higher values for SCORAD. During the follow up period a significant reduction in SCORAD was observed only in the group of participants who was treated with probiotics. They used also less topical treatments and antihistamines. Conclusions: This study has found that Lactobacillus rhamnosus GG (LGG) formulation with Zn and vitamin D3 supplementation during the postnatal period (in infancy and early childhood) reduce the severity of atopic dermatitis. Based on the findings it is recommended to introduce probiotic supplementation as well as vitamin D3 and zinc in infants and children with atopic dermatitis and positive family history.},
 year = {2020}
}

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TY  - JOUR
T1  - Combination of Lactobacillus Rhamnosus LGG, Vitamin D3 and Zn in Preventing Atopic Dermatitis in Infancy
AU  - Ivana Filipovic
AU  - Olivera Ostojic
AU  - Vesna Vekovic
AU  - Milan Lackovic
AU  - Zorica Zivkovic
Y1  - 2020/07/17
PY  - 2020
N1  - https://doi.org/10.11648/j.ajp.20200603.26
DO  - 10.11648/j.ajp.20200603.26
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 273
EP  - 277
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20200603.26
AB  - Introduction: With the prevalence of between 10-20% atopic dermatitis (AD) is one of the most common chronic diseases in infants and children. AD is characterized by itching and recurrent lesion. Mixtures of probiotics, including at the first place Lactobacillus rhamnosus LGG strain strains significantly decreased the risk of AD if given pre- and postnatally. Objective: The aim of the current study was to assess the effect of oral supplementation with LGG in infancy on eczema development and sensitization during the first 2 years of life. Material and methods: The study was a real life controlled observational study that included 96 patients (52 infants were treated with Lactobacillus rhamnosus with vitamin D3 and zinc, while the rest were advised to use only symptomatic treatment). Results: At the baseline the infants in the experiment group had higher values for SCORAD. During the follow up period a significant reduction in SCORAD was observed only in the group of participants who was treated with probiotics. They used also less topical treatments and antihistamines. Conclusions: This study has found that Lactobacillus rhamnosus GG (LGG) formulation with Zn and vitamin D3 supplementation during the postnatal period (in infancy and early childhood) reduce the severity of atopic dermatitis. Based on the findings it is recommended to introduce probiotic supplementation as well as vitamin D3 and zinc in infants and children with atopic dermatitis and positive family history.
VL  - 6
IS  - 3
ER  -

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Author Information

Ivana Filipovic

Hospital for Gynecology and Obstetric - Neonatology Department, University Hospital dr Dragisa Misovic, Begrade, Serbia
Olivera Ostojic

University Hospital dr Dragisa Misovic-Pediatric Department, Belgrade, Serbia
Vesna Vekovic

University Hospital dr Dragisa Misovic-Pediatric Department, Belgrade, Serbia
Milan Lackovic

Hospital for Gynecology and Obstetric - Neonatology Department, University Hospital dr Dragisa Misovic, Begrade, Serbia
Zorica Zivkovic

University Hospital dr Dragisa Misovic-Pediatric Department, Belgrade, Serbia

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APA Style

Ivana Filipovic, Olivera Ostojic, Vesna Vekovic, Milan Lackovic, Zorica Zivkovic. (2020). Combination of Lactobacillus Rhamnosus LGG, Vitamin D3 and Zn in Preventing Atopic Dermatitis in Infancy. American Journal of Pediatrics, 6(3), 273-277. https://doi.org/10.11648/j.ajp.20200603.26

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ACS Style

Ivana Filipovic; Olivera Ostojic; Vesna Vekovic; Milan Lackovic; Zorica Zivkovic. Combination of Lactobacillus Rhamnosus LGG, Vitamin D3 and Zn in Preventing Atopic Dermatitis in Infancy. Am. J. Pediatr. 2020, 6(3), 273-277. doi: 10.11648/j.ajp.20200603.26

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AMA Style

Ivana Filipovic, Olivera Ostojic, Vesna Vekovic, Milan Lackovic, Zorica Zivkovic. Combination of Lactobacillus Rhamnosus LGG, Vitamin D3 and Zn in Preventing Atopic Dermatitis in Infancy. Am J Pediatr. 2020;6(3):273-277. doi: 10.11648/j.ajp.20200603.26

Copy | Download

@article{10.11648/j.ajp.20200603.26,
  author = {Ivana Filipovic and Olivera Ostojic and Vesna Vekovic and Milan Lackovic and Zorica Zivkovic},
  title = {Combination of Lactobacillus Rhamnosus LGG, Vitamin D3 and Zn in Preventing Atopic Dermatitis in Infancy},
  journal = {American Journal of Pediatrics},
  volume = {6},
  number = {3},
  pages = {273-277},
  doi = {10.11648/j.ajp.20200603.26},
  url = {https://doi.org/10.11648/j.ajp.20200603.26},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200603.26},
  abstract = {Introduction: With the prevalence of between 10-20% atopic dermatitis (AD) is one of the most common chronic diseases in infants and children. AD is characterized by itching and recurrent lesion. Mixtures of probiotics, including at the first place Lactobacillus rhamnosus LGG strain strains significantly decreased the risk of AD if given pre- and postnatally. Objective: The aim of the current study was to assess the effect of oral supplementation with LGG in infancy on eczema development and sensitization during the first 2 years of life. Material and methods: The study was a real life controlled observational study that included 96 patients (52 infants were treated with Lactobacillus rhamnosus with vitamin D3 and zinc, while the rest were advised to use only symptomatic treatment). Results: At the baseline the infants in the experiment group had higher values for SCORAD. During the follow up period a significant reduction in SCORAD was observed only in the group of participants who was treated with probiotics. They used also less topical treatments and antihistamines. Conclusions: This study has found that Lactobacillus rhamnosus GG (LGG) formulation with Zn and vitamin D3 supplementation during the postnatal period (in infancy and early childhood) reduce the severity of atopic dermatitis. Based on the findings it is recommended to introduce probiotic supplementation as well as vitamin D3 and zinc in infants and children with atopic dermatitis and positive family history.},
 year = {2020}
}

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TY  - JOUR
T1  - Combination of Lactobacillus Rhamnosus LGG, Vitamin D3 and Zn in Preventing Atopic Dermatitis in Infancy
AU  - Ivana Filipovic
AU  - Olivera Ostojic
AU  - Vesna Vekovic
AU  - Milan Lackovic
AU  - Zorica Zivkovic
Y1  - 2020/07/17
PY  - 2020
N1  - https://doi.org/10.11648/j.ajp.20200603.26
DO  - 10.11648/j.ajp.20200603.26
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 273
EP  - 277
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20200603.26
AB  - Introduction: With the prevalence of between 10-20% atopic dermatitis (AD) is one of the most common chronic diseases in infants and children. AD is characterized by itching and recurrent lesion. Mixtures of probiotics, including at the first place Lactobacillus rhamnosus LGG strain strains significantly decreased the risk of AD if given pre- and postnatally. Objective: The aim of the current study was to assess the effect of oral supplementation with LGG in infancy on eczema development and sensitization during the first 2 years of life. Material and methods: The study was a real life controlled observational study that included 96 patients (52 infants were treated with Lactobacillus rhamnosus with vitamin D3 and zinc, while the rest were advised to use only symptomatic treatment). Results: At the baseline the infants in the experiment group had higher values for SCORAD. During the follow up period a significant reduction in SCORAD was observed only in the group of participants who was treated with probiotics. They used also less topical treatments and antihistamines. Conclusions: This study has found that Lactobacillus rhamnosus GG (LGG) formulation with Zn and vitamin D3 supplementation during the postnatal period (in infancy and early childhood) reduce the severity of atopic dermatitis. Based on the findings it is recommended to introduce probiotic supplementation as well as vitamin D3 and zinc in infants and children with atopic dermatitis and positive family history.
VL  - 6
IS  - 3
ER  -

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