Leucopenia, Neutropenia, Lymphopenia and Monocytopenia in a 15 year Old Girl with Iron Deficiency Anemia Responding to Iron Therapy: A Case Report

Sam Hassan; Tessy Augustine; Nidal Mahgoub

doi:doi:10.11648/j.ajp.20200603.35

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Leucopenia, Neutropenia, Lymphopenia and Monocytopenia in a 15 year Old Girl with Iron Deficiency Anemia Responding to Iron Therapy: A Case Report

Sam Hassan, Tessy Augustine, Nidal Mahgoub

Published in American Journal of Pediatrics (Volume 6, Issue 3)

Received: 8 July 2020 Accepted: 27 July 2020 Published: 18 August 2020

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Abstract

Despite the high prevalence of iron deficiency anemia (IDA) in children, extensive information about its impact on growth and cognitive functions, less is known about how it affects the non-erythrocytes cell lines and its implications. High erythropoietin levels in severe iron deficiency anemia may down regulate the production of non- erythroid precursors resulting in various cytopenia, however, the mechanism of this is not fully understood. Reports depicting the association of iron deficiency anemia with cytopenia is quite scarce in pediatric population. We report a case of a 15 year old girl presented with severe iron deficiency anemia and leucopenia, lymphopenia, neutropenia and monocytopenia who has no other evidence of bone marrow dysfunction. The patient responded to iron therapy with prompt reversal of all cell counts. It is therefore recommended to include iron study and plasma erythropoietin concentration in the evaluation of otherwise healthy children presenting with cytopenia. Likewise, to consider iron deficiency in the causative list of non-erythroid cytopenia such as neutropenia.

Published in	American Journal of Pediatrics (Volume 6, Issue 3)
DOI	10.11648/j.ajp.20200603.35
Page(s)	322-326
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Iron Deficiency Anemia, Erythropoietin, Leucopenia, Neutropenia, Monocytopenai, Lymphopenia

References

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APA Style

Sam Hassan, Tessy Augustine, Nidal Mahgoub. (2020). Leucopenia, Neutropenia, Lymphopenia and Monocytopenia in a 15 year Old Girl with Iron Deficiency Anemia Responding to Iron Therapy: A Case Report. American Journal of Pediatrics, 6(3), 322-326. https://doi.org/10.11648/j.ajp.20200603.35

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ACS Style

Sam Hassan; Tessy Augustine; Nidal Mahgoub. Leucopenia, Neutropenia, Lymphopenia and Monocytopenia in a 15 year Old Girl with Iron Deficiency Anemia Responding to Iron Therapy: A Case Report. Am. J. Pediatr. 2020, 6(3), 322-326. doi: 10.11648/j.ajp.20200603.35

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AMA Style

Sam Hassan, Tessy Augustine, Nidal Mahgoub. Leucopenia, Neutropenia, Lymphopenia and Monocytopenia in a 15 year Old Girl with Iron Deficiency Anemia Responding to Iron Therapy: A Case Report. Am J Pediatr. 2020;6(3):322-326. doi: 10.11648/j.ajp.20200603.35

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@article{10.11648/j.ajp.20200603.35,
  author = {Sam Hassan and Tessy Augustine and Nidal Mahgoub},
  title = {Leucopenia, Neutropenia, Lymphopenia and Monocytopenia in a 15 year Old Girl with Iron Deficiency Anemia Responding to Iron Therapy: A Case Report},
  journal = {American Journal of Pediatrics},
  volume = {6},
  number = {3},
  pages = {322-326},
  doi = {10.11648/j.ajp.20200603.35},
  url = {https://doi.org/10.11648/j.ajp.20200603.35},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200603.35},
  abstract = {Despite the high prevalence of iron deficiency anemia (IDA) in children, extensive information about its impact on growth and cognitive functions, less is known about how it affects the non-erythrocytes cell lines and its implications. High erythropoietin levels in severe iron deficiency anemia may down regulate the production of non- erythroid precursors resulting in various cytopenia, however, the mechanism of this is not fully understood. Reports depicting the association of iron deficiency anemia with cytopenia is quite scarce in pediatric population. We report a case of a 15 year old girl presented with severe iron deficiency anemia and leucopenia, lymphopenia, neutropenia and monocytopenia who has no other evidence of bone marrow dysfunction. The patient responded to iron therapy with prompt reversal of all cell counts. It is therefore recommended to include iron study and plasma erythropoietin concentration in the evaluation of otherwise healthy children presenting with cytopenia. Likewise, to consider iron deficiency in the causative list of non-erythroid cytopenia such as neutropenia.},
 year = {2020}
}

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TY  - JOUR
T1  - Leucopenia, Neutropenia, Lymphopenia and Monocytopenia in a 15 year Old Girl with Iron Deficiency Anemia Responding to Iron Therapy: A Case Report
AU  - Sam Hassan
AU  - Tessy Augustine
AU  - Nidal Mahgoub
Y1  - 2020/08/18
PY  - 2020
N1  - https://doi.org/10.11648/j.ajp.20200603.35
DO  - 10.11648/j.ajp.20200603.35
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 322
EP  - 326
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20200603.35
AB  - Despite the high prevalence of iron deficiency anemia (IDA) in children, extensive information about its impact on growth and cognitive functions, less is known about how it affects the non-erythrocytes cell lines and its implications. High erythropoietin levels in severe iron deficiency anemia may down regulate the production of non- erythroid precursors resulting in various cytopenia, however, the mechanism of this is not fully understood. Reports depicting the association of iron deficiency anemia with cytopenia is quite scarce in pediatric population. We report a case of a 15 year old girl presented with severe iron deficiency anemia and leucopenia, lymphopenia, neutropenia and monocytopenia who has no other evidence of bone marrow dysfunction. The patient responded to iron therapy with prompt reversal of all cell counts. It is therefore recommended to include iron study and plasma erythropoietin concentration in the evaluation of otherwise healthy children presenting with cytopenia. Likewise, to consider iron deficiency in the causative list of non-erythroid cytopenia such as neutropenia.
VL  - 6
IS  - 3
ER  -

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Author Information

Sam Hassan

Department of Pediatrics, Mediclinic City Hospital, Dubai, United Arab Emirates
Tessy Augustine

Department of Pediatrics, Mediclinic City Hospital, Dubai, United Arab Emirates
Nidal Mahgoub

Department of Pediatrics, Mediclinic City Hospital, Dubai, United Arab Emirates

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Plain Text BibTeX RIS

APA Style

Sam Hassan, Tessy Augustine, Nidal Mahgoub. (2020). Leucopenia, Neutropenia, Lymphopenia and Monocytopenia in a 15 year Old Girl with Iron Deficiency Anemia Responding to Iron Therapy: A Case Report. American Journal of Pediatrics, 6(3), 322-326. https://doi.org/10.11648/j.ajp.20200603.35

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ACS Style

Sam Hassan; Tessy Augustine; Nidal Mahgoub. Leucopenia, Neutropenia, Lymphopenia and Monocytopenia in a 15 year Old Girl with Iron Deficiency Anemia Responding to Iron Therapy: A Case Report. Am. J. Pediatr. 2020, 6(3), 322-326. doi: 10.11648/j.ajp.20200603.35

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AMA Style

Sam Hassan, Tessy Augustine, Nidal Mahgoub. Leucopenia, Neutropenia, Lymphopenia and Monocytopenia in a 15 year Old Girl with Iron Deficiency Anemia Responding to Iron Therapy: A Case Report. Am J Pediatr. 2020;6(3):322-326. doi: 10.11648/j.ajp.20200603.35

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@article{10.11648/j.ajp.20200603.35,
  author = {Sam Hassan and Tessy Augustine and Nidal Mahgoub},
  title = {Leucopenia, Neutropenia, Lymphopenia and Monocytopenia in a 15 year Old Girl with Iron Deficiency Anemia Responding to Iron Therapy: A Case Report},
  journal = {American Journal of Pediatrics},
  volume = {6},
  number = {3},
  pages = {322-326},
  doi = {10.11648/j.ajp.20200603.35},
  url = {https://doi.org/10.11648/j.ajp.20200603.35},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200603.35},
  abstract = {Despite the high prevalence of iron deficiency anemia (IDA) in children, extensive information about its impact on growth and cognitive functions, less is known about how it affects the non-erythrocytes cell lines and its implications. High erythropoietin levels in severe iron deficiency anemia may down regulate the production of non- erythroid precursors resulting in various cytopenia, however, the mechanism of this is not fully understood. Reports depicting the association of iron deficiency anemia with cytopenia is quite scarce in pediatric population. We report a case of a 15 year old girl presented with severe iron deficiency anemia and leucopenia, lymphopenia, neutropenia and monocytopenia who has no other evidence of bone marrow dysfunction. The patient responded to iron therapy with prompt reversal of all cell counts. It is therefore recommended to include iron study and plasma erythropoietin concentration in the evaluation of otherwise healthy children presenting with cytopenia. Likewise, to consider iron deficiency in the causative list of non-erythroid cytopenia such as neutropenia.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Leucopenia, Neutropenia, Lymphopenia and Monocytopenia in a 15 year Old Girl with Iron Deficiency Anemia Responding to Iron Therapy: A Case Report
AU  - Sam Hassan
AU  - Tessy Augustine
AU  - Nidal Mahgoub
Y1  - 2020/08/18
PY  - 2020
N1  - https://doi.org/10.11648/j.ajp.20200603.35
DO  - 10.11648/j.ajp.20200603.35
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 322
EP  - 326
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20200603.35
AB  - Despite the high prevalence of iron deficiency anemia (IDA) in children, extensive information about its impact on growth and cognitive functions, less is known about how it affects the non-erythrocytes cell lines and its implications. High erythropoietin levels in severe iron deficiency anemia may down regulate the production of non- erythroid precursors resulting in various cytopenia, however, the mechanism of this is not fully understood. Reports depicting the association of iron deficiency anemia with cytopenia is quite scarce in pediatric population. We report a case of a 15 year old girl presented with severe iron deficiency anemia and leucopenia, lymphopenia, neutropenia and monocytopenia who has no other evidence of bone marrow dysfunction. The patient responded to iron therapy with prompt reversal of all cell counts. It is therefore recommended to include iron study and plasma erythropoietin concentration in the evaluation of otherwise healthy children presenting with cytopenia. Likewise, to consider iron deficiency in the causative list of non-erythroid cytopenia such as neutropenia.
VL  - 6
IS  - 3
ER  -

Copy | Download