Sepsis is the third leading cause of death in neonates after asphyxia and low birth weight babies (LBW). Abnormal blood glucose, both hypoglycemia and hyperglycemia, were common metabolic changes in neonatal sepsis. This condition can higher the risk of morbidity and mortality in neonatal sepsis. The aim of this study is to prove the difference in mortality of neonatal sepsis with abnormal blood glucose compared to normal blood glucose. This was a cohort retrospective study with subjects were neonate with 28-42 weeks of gestational age with neonatal sepsis confirmed from clinical sign or blood culture at neonatal ward Sanglah hospital in the period January-August 2020. Subjects were classified as abnormal and normal blood glucose level. Chi-square test was used to assess the difference of mortality in blood glucose level. Multivariate analysis was performed with logistic regression. A total of 64 subjects with abnormal blood glucose and 64 subjects with normal blood glucose were included in this study. Mortality in subject with abnormal blood glucose was 50% and 17.2% with normal blood glucose (P<0,005). Multivariate analysis found abnormal blood glucose increases the risk of mortality 3,04 times compare with normal blood glucose (95% CI 1.09 to 8,45, P<0.033). Mechanical ventilation and asphyxia can also increase the risk of mortality in neonatal sepsis by 12,33 times (95% CI 3,99 to 38,07, P<0,001) and 8.17 times (95% CI 2,35 to 28,37, P<0,001) respectively. Subanalysis found hypoglycemia increases the risk of mortality 3.75 times compare to normoglycemia (95% CI 2.06 to 6.82, P<0.005), and hyperglycemia increases the risk of mortality 2.12 times compare to normoglycemia (95% CI 1.04 to 4.26, P=0.035). Conclusion there are significant difference of mortality in neonatal sepsis with abnormal blood glucose which is higher than normal blood glucose level. This research also found mechanical ventilation and asphyxia can effect the mortality in neonatal sepsis.
| Published in | American Journal of Pediatrics (Volume 7, Issue 1) |
| DOI | 10.11648/j.ajp.20210701.13 |
| Page(s) | 9-13 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Neonate, Abnormal Blood Glucose Level, Neonatal Sepsis
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APA Style
Made Laksmi Dewi Adnyana, I Gusti Ngurah Sanjaya, Made Sukmawati, Ni Putu Siadi Purniti, Ida Bagus Subanada, et al. (2021). Mortality of Neonatal Sepsis with Abnormal Blood Glucose Level. American Journal of Pediatrics, 7(1), 9-13. https://doi.org/10.11648/j.ajp.20210701.13
ACS Style
Made Laksmi Dewi Adnyana; I Gusti Ngurah Sanjaya; Made Sukmawati; Ni Putu Siadi Purniti; Ida Bagus Subanada, et al. Mortality of Neonatal Sepsis with Abnormal Blood Glucose Level. Am. J. Pediatr. 2021, 7(1), 9-13. doi: 10.11648/j.ajp.20210701.13
AMA Style
Made Laksmi Dewi Adnyana, I Gusti Ngurah Sanjaya, Made Sukmawati, Ni Putu Siadi Purniti, Ida Bagus Subanada, et al. Mortality of Neonatal Sepsis with Abnormal Blood Glucose Level. Am J Pediatr. 2021;7(1):9-13. doi: 10.11648/j.ajp.20210701.13
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Download@article{10.11648/j.ajp.20210701.13,
author = {Made Laksmi Dewi Adnyana and I Gusti Ngurah Sanjaya and Made Sukmawati and Ni Putu Siadi Purniti and Ida Bagus Subanada and I Wayan Gustawan},
title = {Mortality of Neonatal Sepsis with Abnormal Blood Glucose Level},
journal = {American Journal of Pediatrics},
volume = {7},
number = {1},
pages = {9-13},
doi = {10.11648/j.ajp.20210701.13},
url = {https://doi.org/10.11648/j.ajp.20210701.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20210701.13},
abstract = {Sepsis is the third leading cause of death in neonates after asphyxia and low birth weight babies (LBW). Abnormal blood glucose, both hypoglycemia and hyperglycemia, were common metabolic changes in neonatal sepsis. This condition can higher the risk of morbidity and mortality in neonatal sepsis. The aim of this study is to prove the difference in mortality of neonatal sepsis with abnormal blood glucose compared to normal blood glucose. This was a cohort retrospective study with subjects were neonate with 28-42 weeks of gestational age with neonatal sepsis confirmed from clinical sign or blood culture at neonatal ward Sanglah hospital in the period January-August 2020. Subjects were classified as abnormal and normal blood glucose level. Chi-square test was used to assess the difference of mortality in blood glucose level. Multivariate analysis was performed with logistic regression. A total of 64 subjects with abnormal blood glucose and 64 subjects with normal blood glucose were included in this study. Mortality in subject with abnormal blood glucose was 50% and 17.2% with normal blood glucose (PPPPPP=0.035). Conclusion there are significant difference of mortality in neonatal sepsis with abnormal blood glucose which is higher than normal blood glucose level. This research also found mechanical ventilation and asphyxia can effect the mortality in neonatal sepsis.},
year = {2021}
}
TY - JOUR T1 - Mortality of Neonatal Sepsis with Abnormal Blood Glucose Level AU - Made Laksmi Dewi Adnyana AU - I Gusti Ngurah Sanjaya AU - Made Sukmawati AU - Ni Putu Siadi Purniti AU - Ida Bagus Subanada AU - I Wayan Gustawan Y1 - 2021/02/10 PY - 2021 N1 - https://doi.org/10.11648/j.ajp.20210701.13 DO - 10.11648/j.ajp.20210701.13 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 9 EP - 13 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20210701.13 AB - Sepsis is the third leading cause of death in neonates after asphyxia and low birth weight babies (LBW). Abnormal blood glucose, both hypoglycemia and hyperglycemia, were common metabolic changes in neonatal sepsis. This condition can higher the risk of morbidity and mortality in neonatal sepsis. The aim of this study is to prove the difference in mortality of neonatal sepsis with abnormal blood glucose compared to normal blood glucose. This was a cohort retrospective study with subjects were neonate with 28-42 weeks of gestational age with neonatal sepsis confirmed from clinical sign or blood culture at neonatal ward Sanglah hospital in the period January-August 2020. Subjects were classified as abnormal and normal blood glucose level. Chi-square test was used to assess the difference of mortality in blood glucose level. Multivariate analysis was performed with logistic regression. A total of 64 subjects with abnormal blood glucose and 64 subjects with normal blood glucose were included in this study. Mortality in subject with abnormal blood glucose was 50% and 17.2% with normal blood glucose (PPPPPP=0.035). Conclusion there are significant difference of mortality in neonatal sepsis with abnormal blood glucose which is higher than normal blood glucose level. This research also found mechanical ventilation and asphyxia can effect the mortality in neonatal sepsis. VL - 7 IS - 1 ER -
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