Effect of Inhaled Nitrogen Oxide on the Plasma Concentration of Cytokines and Endogenous Nitrogen Oxide

Vladimir Vladimirovich Estrin; Marina Gaevna Pukhtinskaya

doi:doi:10.11648/j.ajp.20210702.15

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Effect of Inhaled Nitrogen Oxide on the Plasma Concentration of Cytokines and Endogenous Nitrogen Oxide

Vladimir Vladimirovich Estrin, Marina Gaevna Pukhtinskaya

Published in American Journal of Pediatrics (Volume 7, Issue 2)

Received: 22 March 2021 Accepted: 7 April 2021 Published: 20 April 2021

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Abstract

Rationale. The nitrogen oxide molecule (NO) is a fundamental factor of the anti-infectious resistance of an organism. Research objective. To evaluate the effectiveness and safety of the prevention of sepsis by the inhalation of nitrogen oxide (iNO) in newborns with respiratory pathology on artificial pulmonary ventilation. Methods. Controlled, randomized, blind clinical trial included 97 newborns with respiratory pathology for artificial pulmonary ventilation. Patients received standard intensive therapy. The main group (n=44) received inhaled nitrogen oxide. The control group (n=53) did not receive inhaled nitrogen oxide. On Days 1, 3, and 20, the plasma concentrations of IL-1ß, IL-6, IL-8, TNF-α, G-CSF, s-Fas, FGF, and nitrogen oxide were measured by capture ELISA. Results. Inhaled nitrogen oxide as a part of intensive care decreased the rate of sepsis development, the duration of mechanical ventilation, and the period of hospitalization. It provided a tendency towards a decrease in the rate of lethal outcomes and reduced cytokine aggression. Conclusions. Inhaled nitrogen oxide in standard intensive care effectively and safely prevented the development of sepsis in newborns with respiratory pathology on artificial lung ventilation. A decrease in the concentration of pro-inflammatory cytokines, including IL-6, against the background of nitrogen oxide inhalation, confirmed the possibility of using inhaled nitrogen oxide as a therapy for COVID-19.

Published in	American Journal of Pediatrics (Volume 7, Issue 2)
DOI	10.11648/j.ajp.20210702.15
Page(s)	62-67
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Sepsis, Newborn, Nitrogen Oxide Inhalation

References

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Vladimir Vladimirovich Estrin, Marina Gaevna Pukhtinskaya. (2021). Effect of Inhaled Nitrogen Oxide on the Plasma Concentration of Cytokines and Endogenous Nitrogen Oxide. American Journal of Pediatrics, 7(2), 62-67. https://doi.org/10.11648/j.ajp.20210702.15

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ACS Style

Vladimir Vladimirovich Estrin; Marina Gaevna Pukhtinskaya. Effect of Inhaled Nitrogen Oxide on the Plasma Concentration of Cytokines and Endogenous Nitrogen Oxide. Am. J. Pediatr. 2021, 7(2), 62-67. doi: 10.11648/j.ajp.20210702.15

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AMA Style

Vladimir Vladimirovich Estrin, Marina Gaevna Pukhtinskaya. Effect of Inhaled Nitrogen Oxide on the Plasma Concentration of Cytokines and Endogenous Nitrogen Oxide. Am J Pediatr. 2021;7(2):62-67. doi: 10.11648/j.ajp.20210702.15

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@article{10.11648/j.ajp.20210702.15,
  author = {Vladimir Vladimirovich Estrin and Marina Gaevna Pukhtinskaya},
  title = {Effect of Inhaled Nitrogen Oxide on the Plasma Concentration of Cytokines and Endogenous Nitrogen Oxide},
  journal = {American Journal of Pediatrics},
  volume = {7},
  number = {2},
  pages = {62-67},
  doi = {10.11648/j.ajp.20210702.15},
  url = {https://doi.org/10.11648/j.ajp.20210702.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20210702.15},
  abstract = {Rationale. The nitrogen oxide molecule (NO) is a fundamental factor of the anti-infectious resistance of an organism. Research objective. To evaluate the effectiveness and safety of the prevention of sepsis by the inhalation of nitrogen oxide (iNO) in newborns with respiratory pathology on artificial pulmonary ventilation. Methods. Controlled, randomized, blind clinical trial included 97 newborns with respiratory pathology for artificial pulmonary ventilation. Patients received standard intensive therapy. The main group (n=44) received inhaled nitrogen oxide. The control group (n=53) did not receive inhaled nitrogen oxide. On Days 1, 3, and 20, the plasma concentrations of IL-1ß, IL-6, IL-8, TNF-α, G-CSF, s-Fas, FGF, and nitrogen oxide were measured by capture ELISA. Results. Inhaled nitrogen oxide as a part of intensive care decreased the rate of sepsis development, the duration of mechanical ventilation, and the period of hospitalization. It provided a tendency towards a decrease in the rate of lethal outcomes and reduced cytokine aggression. Conclusions. Inhaled nitrogen oxide in standard intensive care effectively and safely prevented the development of sepsis in newborns with respiratory pathology on artificial lung ventilation. A decrease in the concentration of pro-inflammatory cytokines, including IL-6, against the background of nitrogen oxide inhalation, confirmed the possibility of using inhaled nitrogen oxide as a therapy for COVID-19.},
 year = {2021}
}

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TY - JOUR
T1 - Effect of Inhaled Nitrogen Oxide on the Plasma Concentration of Cytokines and Endogenous Nitrogen Oxide
AU - Vladimir Vladimirovich Estrin
AU - Marina Gaevna Pukhtinskaya
Y1 - 2021/04/20
PY - 2021
N1 - https://doi.org/10.11648/j.ajp.20210702.15
DO - 10.11648/j.ajp.20210702.15
T2 - American Journal of Pediatrics
JF - American Journal of Pediatrics
JO - American Journal of Pediatrics
SP - 62
EP - 67
PB - Science Publishing Group
SN - 2472-0909
UR - https://doi.org/10.11648/j.ajp.20210702.15
AB - Rationale. The nitrogen oxide molecule (NO) is a fundamental factor of the anti-infectious resistance of an organism. Research objective. To evaluate the effectiveness and safety of the prevention of sepsis by the inhalation of nitrogen oxide (iNO) in newborns with respiratory pathology on artificial pulmonary ventilation. Methods. Controlled, randomized, blind clinical trial included 97 newborns with respiratory pathology for artificial pulmonary ventilation. Patients received standard intensive therapy. The main group (n=44) received inhaled nitrogen oxide. The control group (n=53) did not receive inhaled nitrogen oxide. On Days 1, 3, and 20, the plasma concentrations of IL-1ß, IL-6, IL-8, TNF-α, G-CSF, s-Fas, FGF, and nitrogen oxide were measured by capture ELISA. Results. Inhaled nitrogen oxide as a part of intensive care decreased the rate of sepsis development, the duration of mechanical ventilation, and the period of hospitalization. It provided a tendency towards a decrease in the rate of lethal outcomes and reduced cytokine aggression. Conclusions. Inhaled nitrogen oxide in standard intensive care effectively and safely prevented the development of sepsis in newborns with respiratory pathology on artificial lung ventilation. A decrease in the concentration of pro-inflammatory cytokines, including IL-6, against the background of nitrogen oxide inhalation, confirmed the possibility of using inhaled nitrogen oxide as a therapy for COVID-19.
VL - 7
IS - 2
ER -

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Author Information

Vladimir Vladimirovich Estrin

Department of Anesthesiology and Resuscitation, State Medical University, Rostov-on-Don, Russia
Marina Gaevna Pukhtinskaya

Department of Anesthesiology and Resuscitation, State Medical University, Rostov-on-Don, Russia

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Vladimir Vladimirovich Estrin, Marina Gaevna Pukhtinskaya. (2021). Effect of Inhaled Nitrogen Oxide on the Plasma Concentration of Cytokines and Endogenous Nitrogen Oxide. American Journal of Pediatrics, 7(2), 62-67. https://doi.org/10.11648/j.ajp.20210702.15

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ACS Style

Vladimir Vladimirovich Estrin; Marina Gaevna Pukhtinskaya. Effect of Inhaled Nitrogen Oxide on the Plasma Concentration of Cytokines and Endogenous Nitrogen Oxide. Am. J. Pediatr. 2021, 7(2), 62-67. doi: 10.11648/j.ajp.20210702.15

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Vladimir Vladimirovich Estrin, Marina Gaevna Pukhtinskaya. Effect of Inhaled Nitrogen Oxide on the Plasma Concentration of Cytokines and Endogenous Nitrogen Oxide. Am J Pediatr. 2021;7(2):62-67. doi: 10.11648/j.ajp.20210702.15

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@article{10.11648/j.ajp.20210702.15,
  author = {Vladimir Vladimirovich Estrin and Marina Gaevna Pukhtinskaya},
  title = {Effect of Inhaled Nitrogen Oxide on the Plasma Concentration of Cytokines and Endogenous Nitrogen Oxide},
  journal = {American Journal of Pediatrics},
  volume = {7},
  number = {2},
  pages = {62-67},
  doi = {10.11648/j.ajp.20210702.15},
  url = {https://doi.org/10.11648/j.ajp.20210702.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20210702.15},
  abstract = {Rationale. The nitrogen oxide molecule (NO) is a fundamental factor of the anti-infectious resistance of an organism. Research objective. To evaluate the effectiveness and safety of the prevention of sepsis by the inhalation of nitrogen oxide (iNO) in newborns with respiratory pathology on artificial pulmonary ventilation. Methods. Controlled, randomized, blind clinical trial included 97 newborns with respiratory pathology for artificial pulmonary ventilation. Patients received standard intensive therapy. The main group (n=44) received inhaled nitrogen oxide. The control group (n=53) did not receive inhaled nitrogen oxide. On Days 1, 3, and 20, the plasma concentrations of IL-1ß, IL-6, IL-8, TNF-α, G-CSF, s-Fas, FGF, and nitrogen oxide were measured by capture ELISA. Results. Inhaled nitrogen oxide as a part of intensive care decreased the rate of sepsis development, the duration of mechanical ventilation, and the period of hospitalization. It provided a tendency towards a decrease in the rate of lethal outcomes and reduced cytokine aggression. Conclusions. Inhaled nitrogen oxide in standard intensive care effectively and safely prevented the development of sepsis in newborns with respiratory pathology on artificial lung ventilation. A decrease in the concentration of pro-inflammatory cytokines, including IL-6, against the background of nitrogen oxide inhalation, confirmed the possibility of using inhaled nitrogen oxide as a therapy for COVID-19.},
 year = {2021}
}

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