The Difference of Anti-HBs Levels in Babies Vaccinated with Hepatitis B Vaccine Between at 2, 4, 6 Months with 2, 3, 4 Months Schedule in Denpasar

Vania Catleya Estina; I Gusti Ngurah Sanjaya Putra; Dyah Kanya Wati; Hendra Santoso; I Gusti Agung Ngurah Sugitha Adnyana; Komang Ayu Witarini

doi:doi:10.11648/j.ajp.20220801.12

The Difference of Anti-HBs Levels in Babies Vaccinated with Hepatitis B Vaccine Between at 2, 4, 6 Months with 2, 3, 4 Months Schedule in Denpasar

Vania Catleya Estina, I Gusti Ngurah Sanjaya Putra, Dyah Kanya Wati, Hendra Santoso, I Gusti Agung Ngurah Sugitha Adnyana, Komang Ayu Witarini

Published in American Journal of Pediatrics (Volume 8, Issue 1)

Received: 8 December 2021 Accepted: 6 January 2022 Published: 12 January 2022

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Abstract

Background: Hepatitis B virus is one of the causes of the major health problem throughout the world. Hepatitis B vaccine is one way to control HBV infections effectively. The prevalence of HB infection shows a decreased effectivity of Hepatitis B vaccination. Objective: To discover the differences in anti-HBs levels between two schedules of vaccination recommended by the Indonesian Pediatric Society (at 2, 4, 6 months vs 2, 3, 4 months of age). Methods: This was an observational study on healthy babies comparing the effect of two treatment groups, each consisting of 30 subjects. Subjects were chosen by stratified random sampling. Blood samples were withdrawn three months after the subjects received their last dose of Hepatitis B vaccination, either in 2, 4, 6 months schedule (Group 1) or in 2, 3, 4 months schedule (Group 2). We used the independent t-test to assess the mean differences between the anti-HBs levels of the two groups. A p-value of<0.05 was considered statistically significant. Results: We found a significant difference in anti-HBs levels between Group 1 and Group 2 (820.06 mIU/ml vs 540.54 mIU/ml, respectively, p=0.002). Conclusion: Both vaccination schedules produced protective anti-HBs levels three months after the completed schedule. The anti-HBs level in group 1 produced higher anti-HBs level compared to Group 2.

Published in	American Journal of Pediatrics (Volume 8, Issue 1)
DOI	10.11648/j.ajp.20220801.12
Page(s)	6-9
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Children, Hepatitis B, Anti-HBs, Vaccination, Indonesia

References

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APA Style

Vania Catleya Estina, I Gusti Ngurah Sanjaya Putra, Dyah Kanya Wati, Hendra Santoso, I Gusti Agung Ngurah Sugitha Adnyana, et al. (2022). The Difference of Anti-HBs Levels in Babies Vaccinated with Hepatitis B Vaccine Between at 2, 4, 6 Months with 2, 3, 4 Months Schedule in Denpasar. American Journal of Pediatrics, 8(1), 6-9. https://doi.org/10.11648/j.ajp.20220801.12

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ACS Style

Vania Catleya Estina; I Gusti Ngurah Sanjaya Putra; Dyah Kanya Wati; Hendra Santoso; I Gusti Agung Ngurah Sugitha Adnyana, et al. The Difference of Anti-HBs Levels in Babies Vaccinated with Hepatitis B Vaccine Between at 2, 4, 6 Months with 2, 3, 4 Months Schedule in Denpasar. Am. J. Pediatr. 2022, 8(1), 6-9. doi: 10.11648/j.ajp.20220801.12

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AMA Style

Vania Catleya Estina, I Gusti Ngurah Sanjaya Putra, Dyah Kanya Wati, Hendra Santoso, I Gusti Agung Ngurah Sugitha Adnyana, et al. The Difference of Anti-HBs Levels in Babies Vaccinated with Hepatitis B Vaccine Between at 2, 4, 6 Months with 2, 3, 4 Months Schedule in Denpasar. Am J Pediatr. 2022;8(1):6-9. doi: 10.11648/j.ajp.20220801.12

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@article{10.11648/j.ajp.20220801.12,
  author = {Vania Catleya Estina and I Gusti Ngurah Sanjaya Putra and Dyah Kanya Wati and Hendra Santoso and I Gusti Agung Ngurah Sugitha Adnyana and Komang Ayu Witarini},
  title = {The Difference of Anti-HBs Levels in Babies Vaccinated with Hepatitis B Vaccine Between at 2, 4, 6 Months with 2, 3, 4 Months Schedule in Denpasar},
  journal = {American Journal of Pediatrics},
  volume = {8},
  number = {1},
  pages = {6-9},
  doi = {10.11648/j.ajp.20220801.12},
  url = {https://doi.org/10.11648/j.ajp.20220801.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220801.12},
  abstract = {Background: Hepatitis B virus is one of the causes of the major health problem throughout the world. Hepatitis B vaccine is one way to control HBV infections effectively. The prevalence of HB infection shows a decreased effectivity of Hepatitis B vaccination. Objective: To discover the differences in anti-HBs levels between two schedules of vaccination recommended by the Indonesian Pediatric Society (at 2, 4, 6 months vs 2, 3, 4 months of age). Methods: This was an observational study on healthy babies comparing the effect of two treatment groups, each consisting of 30 subjects. Subjects were chosen by stratified random sampling. Blood samples were withdrawn three months after the subjects received their last dose of Hepatitis B vaccination, either in 2, 4, 6 months schedule (Group 1) or in 2, 3, 4 months schedule (Group 2). We used the independent t-test to assess the mean differences between the anti-HBs levels of the two groups. A p-value ofResults: We found a significant difference in anti-HBs levels between Group 1 and Group 2 (820.06 mIU/ml vs 540.54 mIU/ml, respectively, p=0.002). Conclusion: Both vaccination schedules produced protective anti-HBs levels three months after the completed schedule. The anti-HBs level in group 1 produced higher anti-HBs level compared to Group 2.},
 year = {2022}
}

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TY  - JOUR
T1  - The Difference of Anti-HBs Levels in Babies Vaccinated with Hepatitis B Vaccine Between at 2, 4, 6 Months with 2, 3, 4 Months Schedule in Denpasar
AU  - Vania Catleya Estina
AU  - I Gusti Ngurah Sanjaya Putra
AU  - Dyah Kanya Wati
AU  - Hendra Santoso
AU  - I Gusti Agung Ngurah Sugitha Adnyana
AU  - Komang Ayu Witarini
Y1  - 2022/01/12
PY  - 2022
N1  - https://doi.org/10.11648/j.ajp.20220801.12
DO  - 10.11648/j.ajp.20220801.12
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 6
EP  - 9
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20220801.12
AB  - Background: Hepatitis B virus is one of the causes of the major health problem throughout the world. Hepatitis B vaccine is one way to control HBV infections effectively. The prevalence of HB infection shows a decreased effectivity of Hepatitis B vaccination. Objective: To discover the differences in anti-HBs levels between two schedules of vaccination recommended by the Indonesian Pediatric Society (at 2, 4, 6 months vs 2, 3, 4 months of age). Methods: This was an observational study on healthy babies comparing the effect of two treatment groups, each consisting of 30 subjects. Subjects were chosen by stratified random sampling. Blood samples were withdrawn three months after the subjects received their last dose of Hepatitis B vaccination, either in 2, 4, 6 months schedule (Group 1) or in 2, 3, 4 months schedule (Group 2). We used the independent t-test to assess the mean differences between the anti-HBs levels of the two groups. A p-value ofResults: We found a significant difference in anti-HBs levels between Group 1 and Group 2 (820.06 mIU/ml vs 540.54 mIU/ml, respectively, p=0.002). Conclusion: Both vaccination schedules produced protective anti-HBs levels three months after the completed schedule. The anti-HBs level in group 1 produced higher anti-HBs level compared to Group 2.
VL  - 8
IS  - 1
ER  -

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Author Information

Vania Catleya Estina

Department of Child Health, Medical Faculty of Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
I Gusti Ngurah Sanjaya Putra

Department of Child Health, Medical Faculty of Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
Dyah Kanya Wati

Department of Child Health, Medical Faculty of Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
Hendra Santoso

Department of Child Health, Medical Faculty of Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
I Gusti Agung Ngurah Sugitha Adnyana

Department of Child Health, Medical Faculty of Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
Komang Ayu Witarini

Department of Child Health, Medical Faculty of Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia

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APA Style

Vania Catleya Estina, I Gusti Ngurah Sanjaya Putra, Dyah Kanya Wati, Hendra Santoso, I Gusti Agung Ngurah Sugitha Adnyana, et al. (2022). The Difference of Anti-HBs Levels in Babies Vaccinated with Hepatitis B Vaccine Between at 2, 4, 6 Months with 2, 3, 4 Months Schedule in Denpasar. American Journal of Pediatrics, 8(1), 6-9. https://doi.org/10.11648/j.ajp.20220801.12

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ACS Style

Vania Catleya Estina; I Gusti Ngurah Sanjaya Putra; Dyah Kanya Wati; Hendra Santoso; I Gusti Agung Ngurah Sugitha Adnyana, et al. The Difference of Anti-HBs Levels in Babies Vaccinated with Hepatitis B Vaccine Between at 2, 4, 6 Months with 2, 3, 4 Months Schedule in Denpasar. Am. J. Pediatr. 2022, 8(1), 6-9. doi: 10.11648/j.ajp.20220801.12

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AMA Style

Vania Catleya Estina, I Gusti Ngurah Sanjaya Putra, Dyah Kanya Wati, Hendra Santoso, I Gusti Agung Ngurah Sugitha Adnyana, et al. The Difference of Anti-HBs Levels in Babies Vaccinated with Hepatitis B Vaccine Between at 2, 4, 6 Months with 2, 3, 4 Months Schedule in Denpasar. Am J Pediatr. 2022;8(1):6-9. doi: 10.11648/j.ajp.20220801.12

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@article{10.11648/j.ajp.20220801.12,
  author = {Vania Catleya Estina and I Gusti Ngurah Sanjaya Putra and Dyah Kanya Wati and Hendra Santoso and I Gusti Agung Ngurah Sugitha Adnyana and Komang Ayu Witarini},
  title = {The Difference of Anti-HBs Levels in Babies Vaccinated with Hepatitis B Vaccine Between at 2, 4, 6 Months with 2, 3, 4 Months Schedule in Denpasar},
  journal = {American Journal of Pediatrics},
  volume = {8},
  number = {1},
  pages = {6-9},
  doi = {10.11648/j.ajp.20220801.12},
  url = {https://doi.org/10.11648/j.ajp.20220801.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220801.12},
  abstract = {Background: Hepatitis B virus is one of the causes of the major health problem throughout the world. Hepatitis B vaccine is one way to control HBV infections effectively. The prevalence of HB infection shows a decreased effectivity of Hepatitis B vaccination. Objective: To discover the differences in anti-HBs levels between two schedules of vaccination recommended by the Indonesian Pediatric Society (at 2, 4, 6 months vs 2, 3, 4 months of age). Methods: This was an observational study on healthy babies comparing the effect of two treatment groups, each consisting of 30 subjects. Subjects were chosen by stratified random sampling. Blood samples were withdrawn three months after the subjects received their last dose of Hepatitis B vaccination, either in 2, 4, 6 months schedule (Group 1) or in 2, 3, 4 months schedule (Group 2). We used the independent t-test to assess the mean differences between the anti-HBs levels of the two groups. A p-value ofResults: We found a significant difference in anti-HBs levels between Group 1 and Group 2 (820.06 mIU/ml vs 540.54 mIU/ml, respectively, p=0.002). Conclusion: Both vaccination schedules produced protective anti-HBs levels three months after the completed schedule. The anti-HBs level in group 1 produced higher anti-HBs level compared to Group 2.},
 year = {2022}
}

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TY  - JOUR
T1  - The Difference of Anti-HBs Levels in Babies Vaccinated with Hepatitis B Vaccine Between at 2, 4, 6 Months with 2, 3, 4 Months Schedule in Denpasar
AU  - Vania Catleya Estina
AU  - I Gusti Ngurah Sanjaya Putra
AU  - Dyah Kanya Wati
AU  - Hendra Santoso
AU  - I Gusti Agung Ngurah Sugitha Adnyana
AU  - Komang Ayu Witarini
Y1  - 2022/01/12
PY  - 2022
N1  - https://doi.org/10.11648/j.ajp.20220801.12
DO  - 10.11648/j.ajp.20220801.12
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 6
EP  - 9
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20220801.12
AB  - Background: Hepatitis B virus is one of the causes of the major health problem throughout the world. Hepatitis B vaccine is one way to control HBV infections effectively. The prevalence of HB infection shows a decreased effectivity of Hepatitis B vaccination. Objective: To discover the differences in anti-HBs levels between two schedules of vaccination recommended by the Indonesian Pediatric Society (at 2, 4, 6 months vs 2, 3, 4 months of age). Methods: This was an observational study on healthy babies comparing the effect of two treatment groups, each consisting of 30 subjects. Subjects were chosen by stratified random sampling. Blood samples were withdrawn three months after the subjects received their last dose of Hepatitis B vaccination, either in 2, 4, 6 months schedule (Group 1) or in 2, 3, 4 months schedule (Group 2). We used the independent t-test to assess the mean differences between the anti-HBs levels of the two groups. A p-value ofResults: We found a significant difference in anti-HBs levels between Group 1 and Group 2 (820.06 mIU/ml vs 540.54 mIU/ml, respectively, p=0.002). Conclusion: Both vaccination schedules produced protective anti-HBs levels three months after the completed schedule. The anti-HBs level in group 1 produced higher anti-HBs level compared to Group 2.
VL  - 8
IS  - 1
ER  -

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