Introduction: Bacterial meningitis is a severe acute infection of the central nervous system that caused by bacteria. The antibiotic should be given immediately. An appropriate antibiotic may reduce the morbidity and mortality caused by bacterial meningitis. This study aims to evaluate the bacterial pattern and antibiotic sensitivity in children bacterial meningitis at tertiary hospital in Denpasar. Material and methods: This retrospective descriptive study was using a cross-sectional design that involved pediatric patients aged 1 month-18 years old with suspected bacterial meningitis who underwent a lumbar puncture at Sanglah Hospital from January 2019 to December 2020. The diagnosis of bacterial meningitis was made based on cerebrospinal fluid culture and antibiotic sensitivity test. Samples were taken by consecutive sampling method and would be excluded if the medical record was incomplete. Results: There were ninety five pediatric patients treated with suspected meningitis. Thirty-three subjects had positive cerebrospinal fluid culture results with eight of them were contaminants. The proportion of bacterial meningitis was 26.3%. Bacterial meningitis was more common in children younger less than two years old (72%) compare with older children. The most gram-positive bacteria were Staphylococcus sp. while for gram-negative was Acinetobacter sp. and Sphingomonas paucimobilis. Vancomycin had a high sensitivity (92.8%) for gram-positive therapy, while for gram-negative it was cephalosporin drug which is ceftriaxone and cefepime (63.6%). Conclusion: Ceftriaxone as the main choice of empiric therapy still has high sensitivity to gram-negative bacteria but low sensitivity to gram-positive bacteria.
| Published in | American Journal of Pediatrics (Volume 8, Issue 2) |
| DOI | 10.11648/j.ajp.20220802.27 |
| Page(s) | 146-151 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Bacterial Meningitis, Children, Pathogens, Antibiotics
| [1] | Care SE, Group CW, Unit HI. Meningitis: Emergency Management in children key points. Statew Paediatr Guidel. 2019; (subtype III): 1–12. |
| [2] | Oordt-Speets AM, Bolijn R, Van Hoorn RC, Bhavsar A, Kyaw MH. Global etiology of bacterial meningitis: A systematic review and meta-analysis. PLoS One. 2018; 13 (6): 1–16. |
| [3] | Zunt JR, Kassebaum NJ, Blake N, Glennie L, Wright C, Nichols E, et al. Global, regional, and national burden of meningitis, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2018; 17 (12): 1061–82. |
| [4] | WHO. Defeating Meningitis by 2030 : baseline situation analysis. 2010 MenAfriVac® vaccine launch Burkina Faso. 2019; (February): 68. |
| [5] | Gessner BD, Sutanto A, Linehan M, Djelantik IGG, Fletcher T, Gerudug IK, et al. Incidences of vaccine-preventable Haemophilus influenzae type b pneumonia and meningitis in Indonesian children: hamlet-randomised vaccine-probe trial. Lancet [Internet]. 2005 Jan; 365 (9453): 43–52. |
| [6] | Kristianti GH, Made Suwarba IGN, Mahalini DS, Wayan Gustawan I, Made Gede Dwi Lingga Utama I. Bacteria and Antibiotic Susceptibility Patterns of Cerebrospinal Fluid Isolated in Children with Bacterial Meningitis at Sanglah Hospital, Bali from 2016 to 2018. Clin Neurol Neurosci [Internet]. 2020; 4 (3): 51. |
| [7] | Yanuar W, Sari IP, Nuryastuti T. Evaluasi Terapi Antibiotik Empirik Terhadap Clinical Outcome pada Pasien Anak Dengan Meningitis Bakteri di Bangsal Rawat Inap RSUP Dr. Sardjito Yogyakarta 2010-2015. Maj Farm. 2019; 14 (2): 49. |
| [8] | Alamarat Z, Hasbun R. Management of acute bacterial meningitis in children. Infect Drug Resist. 2020; 13: 4077–89. |
| [9] | Alam A. Kejadian Meningitis Bakterial pada Anak usia 6-18 bulan yang Menderita Kejang Demam Pertama. Sari Pediatr. 2016; 13 (4): 293. |
| [10] | Tacon CL, Flower O. Diagnosis and Management of Bacterial Meningitis in the Paediatric Population: A Review. Emerg Med Int. 2012; 2012: 1–8. |
| [11] | Yulianto F, Mahalini DS, Made Suwarba IGN. Neutrophil-Lymphocyte Ratio as a Predictor of Bacterial Meningitis in Children. Clin Neurol Neurosci. 2021; 5 (2): 30. |
| [12] | Mengistu A, Gaeseb J, Uaaka G, Ndjavera C, Kambyambya K, Indongo L, et al. Antimicrobial sensitivity patterns of cerebrospinal fluid (CSF) isolates in Namibia: Implications for empirical antibiotic treatment of meningitis. J Pharm Policy Pract. 2013; 6 (1): 1–10. |
| [13] | Assegu Fenta D, Lemma K, Tadele H, Tadesse BT, Derese B. Erratum: Antimicrobial sensitivity profile and bacterial isolates among suspected pyogenic meningitis patients attending at Hawassa University Hospital: Cross-sectional study (BMC Microbiology (2020) 20: 125 DOI: 10.1186/s12866-020-01808-5). BMC Microbiol. 2020; 20 (1): 1–10. |
| [14] | Garg R, Shaw T, Mukhopadhyay C. Contamination of CSF culture: Serious risk to patient safety. Int J Infect Dis. 2020; 101: 126. |
| [15] | Başpınar EÖ, Dayan S, Bekçibaşı M, Tekin R, Ayaz C, Deveci Ö, et al. Comparison of culture and PCR methods in the diagnosis of bacterial meningitis. Brazilian J Microbiol. 2017; 48 (2): 232–6. |
| [16] | Adil SM, Hodges SE, Charalambous LT, Kiyani M, Liu B, Lee HJ, et al. Paediatric bacterial meningitis in the USA: Outcomes and healthcare resource utilization of nosocomial versus community-acquired infection. J Med Microbiol. 2020; 70 (1). |
| [17] | Dinçer E, Dalgıç Karabulut N. Ventriculo-Peritoneal Shunt Infections in a Tertiary Center, 3 Years Experience. Trends Pediatr. 2021; 2 (1): 28–34. |
| [18] | Van Sorge NM, Doran KS. Defense at the border: the blood-brain barrier versus bacterial foreigners. Futur Microbiol. 2012; 7 (3): 383–94. |
| [19] | Noguchi T, Nagao M, Yamamoto M, Matsumura Y, Kitano T, Takaori-Kondo A, et al. Staphylococcus epidermidis meningitis in the absence of a neurosurgical device secondary to catheter-related bloodstream infection: a case report and review of the literature. |
| [20] | Göker T, Aşık RZ, Yılmaz MB, Çelik İ, Tekiner A. Sphingomonas paucimobilis: A rare infectious agent found in cerebrospinal fluid. J Korean Neurosurg Soc. 2017; 60 (4): 481–3. |
| [21] | Mehmood H, Khan N, Ullah S, Ullah A, Marwat A. A rare case of Sphingomonas paucimobilis meningitis in the absence of cerebrospinal fluid pleocytosis. J Investig Med High Impact Case Reports. 2018; 6: 1–3. |
| [22] | Sırmatel F, Behzadi E, Karabay O, Özensoy A. Nosocomial Infections and Cases of Sphingomonas Paucimobilis. Meandros Med Dent J. 2019; 20 (2): 164–70. |
| [23] | Zainel A, Mitchell H, Sadarangani M. Bacterial meningitis in children: Neurological complications, associated risk factors, and prevention. Microorganisms. 2021; 9 (3): 1–12. |
| [24] | Thomas V, Ahmed R, Qasim S. Cerebro spinal fluid analysis in childhood bacterial meningitis. Oman Med J [Internet]. 2008 Jan; 23 (1): 32–3. |
APA Style
Dewi Sutriani Mahalini, Putu Pradnyanita Mustika, I Gusti Ngurah Made Suwarba. (2022). Microorganism and Antibiotik Sensitivity Pattern of Children Bacterial Meningitis in Denpasar Tertiary Hospital 2019-2020. American Journal of Pediatrics, 8(2), 146-151. https://doi.org/10.11648/j.ajp.20220802.27
ACS Style
Dewi Sutriani Mahalini; Putu Pradnyanita Mustika; I Gusti Ngurah Made Suwarba. Microorganism and Antibiotik Sensitivity Pattern of Children Bacterial Meningitis in Denpasar Tertiary Hospital 2019-2020. Am. J. Pediatr. 2022, 8(2), 146-151. doi: 10.11648/j.ajp.20220802.27
AMA Style
Dewi Sutriani Mahalini, Putu Pradnyanita Mustika, I Gusti Ngurah Made Suwarba. Microorganism and Antibiotik Sensitivity Pattern of Children Bacterial Meningitis in Denpasar Tertiary Hospital 2019-2020. Am J Pediatr. 2022;8(2):146-151. doi: 10.11648/j.ajp.20220802.27
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Download@article{10.11648/j.ajp.20220802.27,
author = {Dewi Sutriani Mahalini and Putu Pradnyanita Mustika and I Gusti Ngurah Made Suwarba},
title = {Microorganism and Antibiotik Sensitivity Pattern of Children Bacterial Meningitis in Denpasar Tertiary Hospital 2019-2020},
journal = {American Journal of Pediatrics},
volume = {8},
number = {2},
pages = {146-151},
doi = {10.11648/j.ajp.20220802.27},
url = {https://doi.org/10.11648/j.ajp.20220802.27},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220802.27},
abstract = {Introduction: Bacterial meningitis is a severe acute infection of the central nervous system that caused by bacteria. The antibiotic should be given immediately. An appropriate antibiotic may reduce the morbidity and mortality caused by bacterial meningitis. This study aims to evaluate the bacterial pattern and antibiotic sensitivity in children bacterial meningitis at tertiary hospital in Denpasar. Material and methods: This retrospective descriptive study was using a cross-sectional design that involved pediatric patients aged 1 month-18 years old with suspected bacterial meningitis who underwent a lumbar puncture at Sanglah Hospital from January 2019 to December 2020. The diagnosis of bacterial meningitis was made based on cerebrospinal fluid culture and antibiotic sensitivity test. Samples were taken by consecutive sampling method and would be excluded if the medical record was incomplete. Results: There were ninety five pediatric patients treated with suspected meningitis. Thirty-three subjects had positive cerebrospinal fluid culture results with eight of them were contaminants. The proportion of bacterial meningitis was 26.3%. Bacterial meningitis was more common in children younger less than two years old (72%) compare with older children. The most gram-positive bacteria were Staphylococcus sp. while for gram-negative was Acinetobacter sp. and Sphingomonas paucimobilis. Vancomycin had a high sensitivity (92.8%) for gram-positive therapy, while for gram-negative it was cephalosporin drug which is ceftriaxone and cefepime (63.6%). Conclusion: Ceftriaxone as the main choice of empiric therapy still has high sensitivity to gram-negative bacteria but low sensitivity to gram-positive bacteria.},
year = {2022}
}
TY - JOUR T1 - Microorganism and Antibiotik Sensitivity Pattern of Children Bacterial Meningitis in Denpasar Tertiary Hospital 2019-2020 AU - Dewi Sutriani Mahalini AU - Putu Pradnyanita Mustika AU - I Gusti Ngurah Made Suwarba Y1 - 2022/06/27 PY - 2022 N1 - https://doi.org/10.11648/j.ajp.20220802.27 DO - 10.11648/j.ajp.20220802.27 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 146 EP - 151 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20220802.27 AB - Introduction: Bacterial meningitis is a severe acute infection of the central nervous system that caused by bacteria. The antibiotic should be given immediately. An appropriate antibiotic may reduce the morbidity and mortality caused by bacterial meningitis. This study aims to evaluate the bacterial pattern and antibiotic sensitivity in children bacterial meningitis at tertiary hospital in Denpasar. Material and methods: This retrospective descriptive study was using a cross-sectional design that involved pediatric patients aged 1 month-18 years old with suspected bacterial meningitis who underwent a lumbar puncture at Sanglah Hospital from January 2019 to December 2020. The diagnosis of bacterial meningitis was made based on cerebrospinal fluid culture and antibiotic sensitivity test. Samples were taken by consecutive sampling method and would be excluded if the medical record was incomplete. Results: There were ninety five pediatric patients treated with suspected meningitis. Thirty-three subjects had positive cerebrospinal fluid culture results with eight of them were contaminants. The proportion of bacterial meningitis was 26.3%. Bacterial meningitis was more common in children younger less than two years old (72%) compare with older children. The most gram-positive bacteria were Staphylococcus sp. while for gram-negative was Acinetobacter sp. and Sphingomonas paucimobilis. Vancomycin had a high sensitivity (92.8%) for gram-positive therapy, while for gram-negative it was cephalosporin drug which is ceftriaxone and cefepime (63.6%). Conclusion: Ceftriaxone as the main choice of empiric therapy still has high sensitivity to gram-negative bacteria but low sensitivity to gram-positive bacteria. VL - 8 IS - 2 ER -
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