Introduction: Retinopathy of prematurity (ROP) is an eye condition that affects the blood vessels of the retina in preterm infants. For the majority of children, retinopathy of prematurity occurs in a mild to moderate form and spontaneously regresses; however, more severe types of ROP can result in blindness in one or both eyes. Retinopathy of prematurity is often correlated with preterm delivery, however the risk for its emergence is a result of the interacting effects of other variables. This study seeks to identify the risk factors for ROP in neonates treated at the Prof. DR. I. G. N. G. Ngoerah Hospital in Denpasar, Bali. Material and methods: This study was retrospective study with design of case control study that conducted from Januari 2020 until January 2022. Samples of this study is neonates born prematurely undergone screening for ROP at Prof. DR. I. G. N. G. Ngoerah Hopital during study period. Results: The total sample of the study was 60 subjects, consisting of 30 subjects with ROP and 30 subjects without ROP. Multivariate analysis with logistic regression shows that gestational age < 32 weeks (OR 29.14; 95% CI 2.87 – 295.80), length of oxygen supplementation 14 days (OR 9.83; 95% CI 1.53 – 63.03), and severe infection (OR 12.17; 95% CI 1.05 – 141.69) was statistically significant for the occurrence of retinopathy of prematurity. Conclusion: The evaluation of risk factors that impacted the development of active ROP indicated statistically significant effects for gestational age, severe infection, and oxygen treatment duration. In order to avoid childhood blindness, timely screening and appropriate treatment are crucial.
Published in | American Journal of Pediatrics (Volume 8, Issue 4) |
DOI | 10.11648/j.ajp.20220804.14 |
Page(s) | 213-217 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Retinopathy of Prematurity, Risk Factor, Neonate
[1] | Huang Hai, Chen Yi, Hicks M, Yi Yanm Zhang QS, Chow CB, Cheung Po Y. Early Risk Factors for Retinopathy of Prematurity in Very and Extremely Preterm Chinese Neonates. Front. Pediatr. 2020; 8: 1-7. |
[2] | Halimic JA, Zvizdic D, Halilovic, Dodik Irena, Duvnjak S. Risk Factor for Retinopathy in Premature born Children. Med Arch. 2018; 69 (6): 409-13. |
[3] | Subramanian KNS. Retinopathy of Prematurity in Pediatrics: Cardiac Disease and Critical Care Medicine. 2021. |
[4] | Dani Carlo, Coviello Caterina, Panin F, Frosini S, Costa S, Purcaro V, Lepore D, Vento G. Incidence and risk factors of retinopathy of prematurity in Italian cohort of preterm infants. Italian Journal of Pediatrics. 2021: 47: 64; 1-6. |
[5] | Tan Wei, Li Bingyan, Wang Zicong, Zou Jingling, Jia Yang, Yoshida S, Zhou Yedi. Novel Potential Biomarkers for Retinopathy of Prematurity. Front. Pediatr. 2022; 9: 1-10. |
[6] | Wang J, Ju Rong, Chen Y, Zhang Lei, Hu Junjie, Wu Yu, Dong Wentao, Zhong Jie, Yi Zang. Automated retinopathy of prematurity screening using deep neural networks. EBio Medicine. 2018: 35; 361-68. |
[7] | Freitas A. M, Morschbacher R, Thorell M, Rhoden E. L. Incidence and risk factor for retinopathy of prematurity: a retrospective cohort study. Int J Retin Vitr. 2018: 4; 20: 1-8. |
[8] | Yau G. S. K, Lee J, Tam V. T, Liu C. C. L, Yip S, Cheng E, Chu B. C. Y, Yuen C. Y. F. Incidence and Risk Factors of Retinopathy of Prematurity From 2 Neonatal Intensive Care Units in a Hong Kong Chinese Population. Asia-Pacific Journal of Ophthalmology. 2016: 5; 3: 185-9. |
[9] | Wang X, Tang K, Chen L, Cheng S, Xu H. Association between sepsis and retinopathy of prematurity: a systematic review and meta-analysis. BMJ. 2019; 9: 1-9. |
[10] | Lee J, Dammann O. Perinatal infection, inflammation, and retinopathy of prematurity. Fetal and Neonatal med. 2012; 17: 26-29. |
[11] | Das P. K, Hossain M, Shirin M, Halim S, Paul S, Hossain A. H. M. Effect of supplemental oxygen on development of retinopathy of prematurity. MedPulse International Journal of Pediatrics. 2020; 15: 11-16. |
[12] | Chan-Ling T, Gock B, Stone J. The effect of oxygen on vasoformative cell division. Evidence that ’physiological hypoxia’ is the stimulus for normal retinal vasculogenesis. Invest Ophthalmol Vis Sci. 1995; 36 (7): 1201–14. |
[13] | Fleck BW, McIntosh N. Pathogenesis of retinopathy of prematurity and possible preventive strategies [review]. Early Hum Dev 2008; 84 (2): 83–8. |
[14] | Hellstrom A, Engstrom E, Hard AL, et al. Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth. Pediatrics 2003; 112 (5): 1016–20. |
[15] | Hellstrom A, Perruzzi C, Ju M, et al. Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity. Proc Natl Acad Sci U S A 2001; 98 (10): 5804–8. |
APA Style
Dewa Ayu Angga Rainingsih, Made Sukmawati, I Made Kardana, I Wayan Dharma Artana, Putu Junara Putra, et al. (2022). Risk Factor Associated with Retinopathy of Prematurity in Denpasar Tertiary Hospital. American Journal of Pediatrics, 8(4), 213-217. https://doi.org/10.11648/j.ajp.20220804.14
ACS Style
Dewa Ayu Angga Rainingsih; Made Sukmawati; I Made Kardana; I Wayan Dharma Artana; Putu Junara Putra, et al. Risk Factor Associated with Retinopathy of Prematurity in Denpasar Tertiary Hospital. Am. J. Pediatr. 2022, 8(4), 213-217. doi: 10.11648/j.ajp.20220804.14
@article{10.11648/j.ajp.20220804.14, author = {Dewa Ayu Angga Rainingsih and Made Sukmawati and I Made Kardana and I Wayan Dharma Artana and Putu Junara Putra and Putu Mas Vina Paramitha Cempaka}, title = {Risk Factor Associated with Retinopathy of Prematurity in Denpasar Tertiary Hospital}, journal = {American Journal of Pediatrics}, volume = {8}, number = {4}, pages = {213-217}, doi = {10.11648/j.ajp.20220804.14}, url = {https://doi.org/10.11648/j.ajp.20220804.14}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220804.14}, abstract = {Introduction: Retinopathy of prematurity (ROP) is an eye condition that affects the blood vessels of the retina in preterm infants. For the majority of children, retinopathy of prematurity occurs in a mild to moderate form and spontaneously regresses; however, more severe types of ROP can result in blindness in one or both eyes. Retinopathy of prematurity is often correlated with preterm delivery, however the risk for its emergence is a result of the interacting effects of other variables. This study seeks to identify the risk factors for ROP in neonates treated at the Prof. DR. I. G. N. G. Ngoerah Hospital in Denpasar, Bali. Material and methods: This study was retrospective study with design of case control study that conducted from Januari 2020 until January 2022. Samples of this study is neonates born prematurely undergone screening for ROP at Prof. DR. I. G. N. G. Ngoerah Hopital during study period. Results: The total sample of the study was 60 subjects, consisting of 30 subjects with ROP and 30 subjects without ROP. Multivariate analysis with logistic regression shows that gestational age Conclusion: The evaluation of risk factors that impacted the development of active ROP indicated statistically significant effects for gestational age, severe infection, and oxygen treatment duration. In order to avoid childhood blindness, timely screening and appropriate treatment are crucial.}, year = {2022} }
TY - JOUR T1 - Risk Factor Associated with Retinopathy of Prematurity in Denpasar Tertiary Hospital AU - Dewa Ayu Angga Rainingsih AU - Made Sukmawati AU - I Made Kardana AU - I Wayan Dharma Artana AU - Putu Junara Putra AU - Putu Mas Vina Paramitha Cempaka Y1 - 2022/10/18 PY - 2022 N1 - https://doi.org/10.11648/j.ajp.20220804.14 DO - 10.11648/j.ajp.20220804.14 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 213 EP - 217 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20220804.14 AB - Introduction: Retinopathy of prematurity (ROP) is an eye condition that affects the blood vessels of the retina in preterm infants. For the majority of children, retinopathy of prematurity occurs in a mild to moderate form and spontaneously regresses; however, more severe types of ROP can result in blindness in one or both eyes. Retinopathy of prematurity is often correlated with preterm delivery, however the risk for its emergence is a result of the interacting effects of other variables. This study seeks to identify the risk factors for ROP in neonates treated at the Prof. DR. I. G. N. G. Ngoerah Hospital in Denpasar, Bali. Material and methods: This study was retrospective study with design of case control study that conducted from Januari 2020 until January 2022. Samples of this study is neonates born prematurely undergone screening for ROP at Prof. DR. I. G. N. G. Ngoerah Hopital during study period. Results: The total sample of the study was 60 subjects, consisting of 30 subjects with ROP and 30 subjects without ROP. Multivariate analysis with logistic regression shows that gestational age Conclusion: The evaluation of risk factors that impacted the development of active ROP indicated statistically significant effects for gestational age, severe infection, and oxygen treatment duration. In order to avoid childhood blindness, timely screening and appropriate treatment are crucial. VL - 8 IS - 4 ER -