Objective: Early diagnosis of Persistent pulmonary hypertension of newborn is a challenge in developing countries. This study aimed to observe the association of Red Cell Distribution Width (RDW) in this critical condition of neonates. Method: This retrospective study was performed in Neonatology department of United Hospital Limited, Dhaka, over 5 years (2013 to 2017) where all PPHN cases were enrolled and compared with neonates without having PPHN. Pre-formed questionnaire was used to collect data. Baseline complete blood count was reviewed in all cases to see the mean Red Cell Distribution Width (RDW). Risk factors for developing persistent pulmonary hypertension was analyzed and cut off value of RDW was observed using Receiver-operating characteristics (ROC) curve. Result: A total of 157 cases were found with PPHN having male predominance (66%). Important risk factors for PPHN were maternal pregnancy induced hypertension and asthma. Respiratory Distress Syndrome and Meconium Aspiration Syndrome were strongly associated with PPHN. RDW was found higher in PPHN neonates than those in the control group (p <0.05). The cutoff point of RDW predictive of PPHN was 17.05 (with 85% sensitivity). Conclusion: Red Cell Distribution Width is an early predictor of persistent pulmonary hypertension of Newborn.
| Published in | American Journal of Pediatrics (Volume 8, Issue 4) |
| DOI | 10.11648/j.ajp.20220804.18 |
| Page(s) | 239-243 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Persistent Fetal Circulation, RDW, Predictor, PPHN, Bangladesh
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APA Style
Nargis Ara Begum, Sharmin Afroze, Abrar Wahab, Runa Laila, Shahnaz Parvin Siddiqua, et al. (2022). Red Cell Distribution Width (RDW) - An Early Predictor of Persistent Pulmonary Hypertension of Newborn (PPHN): A Comparative Study in Dhaka, Bangladesh. American Journal of Pediatrics, 8(4), 239-243. https://doi.org/10.11648/j.ajp.20220804.18
ACS Style
Nargis Ara Begum; Sharmin Afroze; Abrar Wahab; Runa Laila; Shahnaz Parvin Siddiqua, et al. Red Cell Distribution Width (RDW) - An Early Predictor of Persistent Pulmonary Hypertension of Newborn (PPHN): A Comparative Study in Dhaka, Bangladesh. Am. J. Pediatr. 2022, 8(4), 239-243. doi: 10.11648/j.ajp.20220804.18
AMA Style
Nargis Ara Begum, Sharmin Afroze, Abrar Wahab, Runa Laila, Shahnaz Parvin Siddiqua, et al. Red Cell Distribution Width (RDW) - An Early Predictor of Persistent Pulmonary Hypertension of Newborn (PPHN): A Comparative Study in Dhaka, Bangladesh. Am J Pediatr. 2022;8(4):239-243. doi: 10.11648/j.ajp.20220804.18
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Download@article{10.11648/j.ajp.20220804.18,
author = {Nargis Ara Begum and Sharmin Afroze and Abrar Wahab and Runa Laila and Shahnaz Parvin Siddiqua and Nurun Nahar Begum and Sabrina Khondoker Nila},
title = {Red Cell Distribution Width (RDW) - An Early Predictor of Persistent Pulmonary Hypertension of Newborn (PPHN): A Comparative Study in Dhaka, Bangladesh},
journal = {American Journal of Pediatrics},
volume = {8},
number = {4},
pages = {239-243},
doi = {10.11648/j.ajp.20220804.18},
url = {https://doi.org/10.11648/j.ajp.20220804.18},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220804.18},
abstract = {Objective: Early diagnosis of Persistent pulmonary hypertension of newborn is a challenge in developing countries. This study aimed to observe the association of Red Cell Distribution Width (RDW) in this critical condition of neonates. Method: This retrospective study was performed in Neonatology department of United Hospital Limited, Dhaka, over 5 years (2013 to 2017) where all PPHN cases were enrolled and compared with neonates without having PPHN. Pre-formed questionnaire was used to collect data. Baseline complete blood count was reviewed in all cases to see the mean Red Cell Distribution Width (RDW). Risk factors for developing persistent pulmonary hypertension was analyzed and cut off value of RDW was observed using Receiver-operating characteristics (ROC) curve. Result: A total of 157 cases were found with PPHN having male predominance (66%). Important risk factors for PPHN were maternal pregnancy induced hypertension and asthma. Respiratory Distress Syndrome and Meconium Aspiration Syndrome were strongly associated with PPHN. RDW was found higher in PPHN neonates than those in the control group (p <0.05). The cutoff point of RDW predictive of PPHN was 17.05 (with 85% sensitivity). Conclusion: Red Cell Distribution Width is an early predictor of persistent pulmonary hypertension of Newborn.},
year = {2022}
}
TY - JOUR T1 - Red Cell Distribution Width (RDW) - An Early Predictor of Persistent Pulmonary Hypertension of Newborn (PPHN): A Comparative Study in Dhaka, Bangladesh AU - Nargis Ara Begum AU - Sharmin Afroze AU - Abrar Wahab AU - Runa Laila AU - Shahnaz Parvin Siddiqua AU - Nurun Nahar Begum AU - Sabrina Khondoker Nila Y1 - 2022/11/10 PY - 2022 N1 - https://doi.org/10.11648/j.ajp.20220804.18 DO - 10.11648/j.ajp.20220804.18 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 239 EP - 243 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20220804.18 AB - Objective: Early diagnosis of Persistent pulmonary hypertension of newborn is a challenge in developing countries. This study aimed to observe the association of Red Cell Distribution Width (RDW) in this critical condition of neonates. Method: This retrospective study was performed in Neonatology department of United Hospital Limited, Dhaka, over 5 years (2013 to 2017) where all PPHN cases were enrolled and compared with neonates without having PPHN. Pre-formed questionnaire was used to collect data. Baseline complete blood count was reviewed in all cases to see the mean Red Cell Distribution Width (RDW). Risk factors for developing persistent pulmonary hypertension was analyzed and cut off value of RDW was observed using Receiver-operating characteristics (ROC) curve. Result: A total of 157 cases were found with PPHN having male predominance (66%). Important risk factors for PPHN were maternal pregnancy induced hypertension and asthma. Respiratory Distress Syndrome and Meconium Aspiration Syndrome were strongly associated with PPHN. RDW was found higher in PPHN neonates than those in the control group (p <0.05). The cutoff point of RDW predictive of PPHN was 17.05 (with 85% sensitivity). Conclusion: Red Cell Distribution Width is an early predictor of persistent pulmonary hypertension of Newborn. VL - 8 IS - 4 ER -
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