Relationship Between FKBP5 Polymorphisms at Rs1334894, Rs9394309, and Rs6912833 Loci, and Dyslipidemia in Pediatric Nephrotic Syndrome

Shuting Peng; Fang Yang; Zhiqiang Guo; Ding Liu

doi:doi:10.11648/j.ajp.20230902.13

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Relationship Between FKBP5 Polymorphisms at Rs1334894, Rs9394309, and Rs6912833 Loci, and Dyslipidemia in Pediatric Nephrotic Syndrome

Shuting Peng, Fang Yang, Zhiqiang Guo, Ding Liu

Published in American Journal of Pediatrics (Volume 9, Issue 2)

Received: 9 April 2023 Accepted: 26 April 2023 Published: 10 May 2023

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Abstract

Background: This study aimed to investigate the relationship between rs1334894, rs9394309, and rs6912833 polymorphisms in FKBP5 and hyperlipidemia in nephrotic syndrome (NS). Methods: The case group included 74 children with primary NS, while the control group included 76 healthy children. Polymerase chain reaction and gene sequencing were used to detect polymorphisms at the rs1334894, rs9394309, and rs6912833 loci of FKBP5, in children with NS. Clinical data of total cholesterol (CHOL), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and plasma albumin were collected. Correlations between FKBP5 polymorphisms and serum lipid levels were analyzed during the active period of the disease. Results: A significant difference in LDL levels between the AA and TA genotypes was observed at the rs6912833 locus of FKBP5 in the case group, but no statistical difference in CHOL, TG, and HDL levels between these genotypes was found. No statistically significant differences in LDL levels between the AA and TA genotypes, and among the steroid-sensitive, -dependent, and -resistant groups were noted. Moreover, no statistically significant differences in the CHOL, TG, HDL, and LDL levels were observed between TT and TC genotypes at the rs1334894 locus. Conclusion: The AA genotype at the rs6912833 locus of FKBP5 may be correlated with plasma lipid levels (LDL) in PNS patients.

Published in	American Journal of Pediatrics (Volume 9, Issue 2)
DOI	10.11648/j.ajp.20230902.13
Page(s)	68-74
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Primary Nephrotic Syndrome, FKBP5, Dyslipidemia, Gene Polymorphism

References

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APA Style

Shuting Peng, Fang Yang, Zhiqiang Guo, Ding Liu. (2023). Relationship Between FKBP5 Polymorphisms at Rs1334894, Rs9394309, and Rs6912833 Loci, and Dyslipidemia in Pediatric Nephrotic Syndrome. American Journal of Pediatrics, 9(2), 68-74. https://doi.org/10.11648/j.ajp.20230902.13

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ACS Style

Shuting Peng; Fang Yang; Zhiqiang Guo; Ding Liu. Relationship Between FKBP5 Polymorphisms at Rs1334894, Rs9394309, and Rs6912833 Loci, and Dyslipidemia in Pediatric Nephrotic Syndrome. Am. J. Pediatr. 2023, 9(2), 68-74. doi: 10.11648/j.ajp.20230902.13

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AMA Style

Shuting Peng, Fang Yang, Zhiqiang Guo, Ding Liu. Relationship Between FKBP5 Polymorphisms at Rs1334894, Rs9394309, and Rs6912833 Loci, and Dyslipidemia in Pediatric Nephrotic Syndrome. Am J Pediatr. 2023;9(2):68-74. doi: 10.11648/j.ajp.20230902.13

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@article{10.11648/j.ajp.20230902.13,
  author = {Shuting Peng and Fang Yang and Zhiqiang Guo and Ding Liu},
  title = {Relationship Between FKBP5 Polymorphisms at Rs1334894, Rs9394309, and Rs6912833 Loci, and Dyslipidemia in Pediatric Nephrotic Syndrome},
  journal = {American Journal of Pediatrics},
  volume = {9},
  number = {2},
  pages = {68-74},
  doi = {10.11648/j.ajp.20230902.13},
  url = {https://doi.org/10.11648/j.ajp.20230902.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20230902.13},
  abstract = {Background: This study aimed to investigate the relationship between rs1334894, rs9394309, and rs6912833 polymorphisms in FKBP5 and hyperlipidemia in nephrotic syndrome (NS). Methods: The case group included 74 children with primary NS, while the control group included 76 healthy children. Polymerase chain reaction and gene sequencing were used to detect polymorphisms at the rs1334894, rs9394309, and rs6912833 loci of FKBP5, in children with NS. Clinical data of total cholesterol (CHOL), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and plasma albumin were collected. Correlations between FKBP5 polymorphisms and serum lipid levels were analyzed during the active period of the disease. Results: A significant difference in LDL levels between the AA and TA genotypes was observed at the rs6912833 locus of FKBP5 in the case group, but no statistical difference in CHOL, TG, and HDL levels between these genotypes was found. No statistically significant differences in LDL levels between the AA and TA genotypes, and among the steroid-sensitive, -dependent, and -resistant groups were noted. Moreover, no statistically significant differences in the CHOL, TG, HDL, and LDL levels were observed between TT and TC genotypes at the rs1334894 locus. Conclusion: The AA genotype at the rs6912833 locus of FKBP5 may be correlated with plasma lipid levels (LDL) in PNS patients.},
 year = {2023}
}

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TY  - JOUR
T1  - Relationship Between FKBP5 Polymorphisms at Rs1334894, Rs9394309, and Rs6912833 Loci, and Dyslipidemia in Pediatric Nephrotic Syndrome
AU  - Shuting Peng
AU  - Fang Yang
AU  - Zhiqiang Guo
AU  - Ding Liu
Y1  - 2023/05/10
PY  - 2023
N1  - https://doi.org/10.11648/j.ajp.20230902.13
DO  - 10.11648/j.ajp.20230902.13
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 68
EP  - 74
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20230902.13
AB  - Background: This study aimed to investigate the relationship between rs1334894, rs9394309, and rs6912833 polymorphisms in FKBP5 and hyperlipidemia in nephrotic syndrome (NS). Methods: The case group included 74 children with primary NS, while the control group included 76 healthy children. Polymerase chain reaction and gene sequencing were used to detect polymorphisms at the rs1334894, rs9394309, and rs6912833 loci of FKBP5, in children with NS. Clinical data of total cholesterol (CHOL), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and plasma albumin were collected. Correlations between FKBP5 polymorphisms and serum lipid levels were analyzed during the active period of the disease. Results: A significant difference in LDL levels between the AA and TA genotypes was observed at the rs6912833 locus of FKBP5 in the case group, but no statistical difference in CHOL, TG, and HDL levels between these genotypes was found. No statistically significant differences in LDL levels between the AA and TA genotypes, and among the steroid-sensitive, -dependent, and -resistant groups were noted. Moreover, no statistically significant differences in the CHOL, TG, HDL, and LDL levels were observed between TT and TC genotypes at the rs1334894 locus. Conclusion: The AA genotype at the rs6912833 locus of FKBP5 may be correlated with plasma lipid levels (LDL) in PNS patients.
VL  - 9
IS  - 2
ER  -

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Author Information

Shuting Peng

Department of Pediatrics, First Affiliated Hospital of Jinan University, Guangzhou, China
Fang Yang

Department of Pediatrics, First Affiliated Hospital of Jinan University, Guangzhou, China
Zhiqiang Guo

Department of Pediatrics, First Affiliated Hospital of Jinan University, Guangzhou, China
Ding Liu

Department of Pediatrics, First Affiliated Hospital of Jinan University, Guangzhou, China

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APA Style

Shuting Peng, Fang Yang, Zhiqiang Guo, Ding Liu. (2023). Relationship Between FKBP5 Polymorphisms at Rs1334894, Rs9394309, and Rs6912833 Loci, and Dyslipidemia in Pediatric Nephrotic Syndrome. American Journal of Pediatrics, 9(2), 68-74. https://doi.org/10.11648/j.ajp.20230902.13

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ACS Style

Shuting Peng; Fang Yang; Zhiqiang Guo; Ding Liu. Relationship Between FKBP5 Polymorphisms at Rs1334894, Rs9394309, and Rs6912833 Loci, and Dyslipidemia in Pediatric Nephrotic Syndrome. Am. J. Pediatr. 2023, 9(2), 68-74. doi: 10.11648/j.ajp.20230902.13

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AMA Style

Shuting Peng, Fang Yang, Zhiqiang Guo, Ding Liu. Relationship Between FKBP5 Polymorphisms at Rs1334894, Rs9394309, and Rs6912833 Loci, and Dyslipidemia in Pediatric Nephrotic Syndrome. Am J Pediatr. 2023;9(2):68-74. doi: 10.11648/j.ajp.20230902.13

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@article{10.11648/j.ajp.20230902.13,
  author = {Shuting Peng and Fang Yang and Zhiqiang Guo and Ding Liu},
  title = {Relationship Between FKBP5 Polymorphisms at Rs1334894, Rs9394309, and Rs6912833 Loci, and Dyslipidemia in Pediatric Nephrotic Syndrome},
  journal = {American Journal of Pediatrics},
  volume = {9},
  number = {2},
  pages = {68-74},
  doi = {10.11648/j.ajp.20230902.13},
  url = {https://doi.org/10.11648/j.ajp.20230902.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20230902.13},
  abstract = {Background: This study aimed to investigate the relationship between rs1334894, rs9394309, and rs6912833 polymorphisms in FKBP5 and hyperlipidemia in nephrotic syndrome (NS). Methods: The case group included 74 children with primary NS, while the control group included 76 healthy children. Polymerase chain reaction and gene sequencing were used to detect polymorphisms at the rs1334894, rs9394309, and rs6912833 loci of FKBP5, in children with NS. Clinical data of total cholesterol (CHOL), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and plasma albumin were collected. Correlations between FKBP5 polymorphisms and serum lipid levels were analyzed during the active period of the disease. Results: A significant difference in LDL levels between the AA and TA genotypes was observed at the rs6912833 locus of FKBP5 in the case group, but no statistical difference in CHOL, TG, and HDL levels between these genotypes was found. No statistically significant differences in LDL levels between the AA and TA genotypes, and among the steroid-sensitive, -dependent, and -resistant groups were noted. Moreover, no statistically significant differences in the CHOL, TG, HDL, and LDL levels were observed between TT and TC genotypes at the rs1334894 locus. Conclusion: The AA genotype at the rs6912833 locus of FKBP5 may be correlated with plasma lipid levels (LDL) in PNS patients.},
 year = {2023}
}

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TY  - JOUR
T1  - Relationship Between FKBP5 Polymorphisms at Rs1334894, Rs9394309, and Rs6912833 Loci, and Dyslipidemia in Pediatric Nephrotic Syndrome
AU  - Shuting Peng
AU  - Fang Yang
AU  - Zhiqiang Guo
AU  - Ding Liu
Y1  - 2023/05/10
PY  - 2023
N1  - https://doi.org/10.11648/j.ajp.20230902.13
DO  - 10.11648/j.ajp.20230902.13
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 68
EP  - 74
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20230902.13
AB  - Background: This study aimed to investigate the relationship between rs1334894, rs9394309, and rs6912833 polymorphisms in FKBP5 and hyperlipidemia in nephrotic syndrome (NS). Methods: The case group included 74 children with primary NS, while the control group included 76 healthy children. Polymerase chain reaction and gene sequencing were used to detect polymorphisms at the rs1334894, rs9394309, and rs6912833 loci of FKBP5, in children with NS. Clinical data of total cholesterol (CHOL), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and plasma albumin were collected. Correlations between FKBP5 polymorphisms and serum lipid levels were analyzed during the active period of the disease. Results: A significant difference in LDL levels between the AA and TA genotypes was observed at the rs6912833 locus of FKBP5 in the case group, but no statistical difference in CHOL, TG, and HDL levels between these genotypes was found. No statistically significant differences in LDL levels between the AA and TA genotypes, and among the steroid-sensitive, -dependent, and -resistant groups were noted. Moreover, no statistically significant differences in the CHOL, TG, HDL, and LDL levels were observed between TT and TC genotypes at the rs1334894 locus. Conclusion: The AA genotype at the rs6912833 locus of FKBP5 may be correlated with plasma lipid levels (LDL) in PNS patients.
VL  - 9
IS  - 2
ER  -

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