Diabetes Insipidus (DI) is rare, with an estimated incidence of 1 in 25,000 cases; less than 10% of cases are hereditary. CDI accounts for over 90% of DI cases and can appear at any age, depending on the cause. There is no indication that hereditary CDI causes are frequent. Central diabetes insipidus (CDI) is uncommon in neonates, particularly in very low-birth-weight newborns, and the great majority of cases are caused by disorders such as ischemia damage or bleeding brain injury. CDI is caused by a deficiency of antidiuretic hormone (ADH) as a result of posterior pituitary and/or hypothalamus dysfunction. We report a case of female, premature newborn, delivered in Sultan Qaboos Hospital in Salalah at 28 weeks gestational age, with a very low birth weight of 1001 grams. She also suffered polyuria and hypernatremia. The baby had hypernatremia and polyuria and low urine specific gravidity at the same time. Baby was early identified with central diabetes insipidus, we failed to control hypernatremia by fluid compensation but the case was effectively treated and controlled with oral desmopressin. Conclusion: Oral Desmopressin is effective and safe in the treatment of CDI but therapy necessitates frequent monitoring of hydration status, polyuria, serum sodium, and dosage calibration as needed.
| Published in | American Journal of Pediatrics (Volume 9, Issue 3) |
| DOI | 10.11648/j.ajp.20230903.13 |
| Page(s) | 118-121 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Central Diabetes Insipidus, Desmopressin, Sultan Qaboos Hospital, Salalah
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APA Style
Allam Fayez Mahmoud Abuhamda. (2023). Central Diabetes Insipidus (CDI) in Very Low Birth Weight Neonate: Case Report. American Journal of Pediatrics, 9(3), 118-121. https://doi.org/10.11648/j.ajp.20230903.13
ACS Style
Allam Fayez Mahmoud Abuhamda. Central Diabetes Insipidus (CDI) in Very Low Birth Weight Neonate: Case Report. Am. J. Pediatr. 2023, 9(3), 118-121. doi: 10.11648/j.ajp.20230903.13
AMA Style
Allam Fayez Mahmoud Abuhamda. Central Diabetes Insipidus (CDI) in Very Low Birth Weight Neonate: Case Report. Am J Pediatr. 2023;9(3):118-121. doi: 10.11648/j.ajp.20230903.13
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Download@article{10.11648/j.ajp.20230903.13,
author = {Allam Fayez Mahmoud Abuhamda},
title = {Central Diabetes Insipidus (CDI) in Very Low Birth Weight Neonate: Case Report},
journal = {American Journal of Pediatrics},
volume = {9},
number = {3},
pages = {118-121},
doi = {10.11648/j.ajp.20230903.13},
url = {https://doi.org/10.11648/j.ajp.20230903.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20230903.13},
abstract = {Diabetes Insipidus (DI) is rare, with an estimated incidence of 1 in 25,000 cases; less than 10% of cases are hereditary. CDI accounts for over 90% of DI cases and can appear at any age, depending on the cause. There is no indication that hereditary CDI causes are frequent. Central diabetes insipidus (CDI) is uncommon in neonates, particularly in very low-birth-weight newborns, and the great majority of cases are caused by disorders such as ischemia damage or bleeding brain injury. CDI is caused by a deficiency of antidiuretic hormone (ADH) as a result of posterior pituitary and/or hypothalamus dysfunction. We report a case of female, premature newborn, delivered in Sultan Qaboos Hospital in Salalah at 28 weeks gestational age, with a very low birth weight of 1001 grams. She also suffered polyuria and hypernatremia. The baby had hypernatremia and polyuria and low urine specific gravidity at the same time. Baby was early identified with central diabetes insipidus, we failed to control hypernatremia by fluid compensation but the case was effectively treated and controlled with oral desmopressin. Conclusion: Oral Desmopressin is effective and safe in the treatment of CDI but therapy necessitates frequent monitoring of hydration status, polyuria, serum sodium, and dosage calibration as needed.},
year = {2023}
}
TY - JOUR T1 - Central Diabetes Insipidus (CDI) in Very Low Birth Weight Neonate: Case Report AU - Allam Fayez Mahmoud Abuhamda Y1 - 2023/07/11 PY - 2023 N1 - https://doi.org/10.11648/j.ajp.20230903.13 DO - 10.11648/j.ajp.20230903.13 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 118 EP - 121 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20230903.13 AB - Diabetes Insipidus (DI) is rare, with an estimated incidence of 1 in 25,000 cases; less than 10% of cases are hereditary. CDI accounts for over 90% of DI cases and can appear at any age, depending on the cause. There is no indication that hereditary CDI causes are frequent. Central diabetes insipidus (CDI) is uncommon in neonates, particularly in very low-birth-weight newborns, and the great majority of cases are caused by disorders such as ischemia damage or bleeding brain injury. CDI is caused by a deficiency of antidiuretic hormone (ADH) as a result of posterior pituitary and/or hypothalamus dysfunction. We report a case of female, premature newborn, delivered in Sultan Qaboos Hospital in Salalah at 28 weeks gestational age, with a very low birth weight of 1001 grams. She also suffered polyuria and hypernatremia. The baby had hypernatremia and polyuria and low urine specific gravidity at the same time. Baby was early identified with central diabetes insipidus, we failed to control hypernatremia by fluid compensation but the case was effectively treated and controlled with oral desmopressin. Conclusion: Oral Desmopressin is effective and safe in the treatment of CDI but therapy necessitates frequent monitoring of hydration status, polyuria, serum sodium, and dosage calibration as needed. VL - 9 IS - 3 ER -
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