Mechanical, Mucoadhesive and Biocompatibility Behavior of Hydrogel Films: A Slow Anticancer Drug Delivery System

Baljit Singh; Arindam Sharma; A. Dhiman; S. Kumar

doi:doi:10.11648/j.ajpst.20150101.11

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Mechanical, Mucoadhesive and Biocompatibility Behavior of Hydrogel Films: A Slow Anticancer Drug Delivery System

Baljit Singh, Arindam Sharma, A. Dhiman, S. Kumar

Published in American Journal of Polymer Science and Technology (Volume 1, Issue 1)

Received: 28 July 2015 Accepted: 1 September 2015 Published: 2 September 2015

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Abstract

Systemic administration of anticancer drugs is associated with a number of side effects. Therefore, it needs some targeted drug delivery system to deliver the drug which would ensure relief from side effects along with the direct delivery of drug to the site of action in a controlled manner. Keeping in view the importance of mucoadhesive polymers in site specific drug delivery, in the present work, an attempt has been made to prepare, polysaccharide gum, PVA and AAm based mucoadhesive polymeric films for use as slow, site specific drug delivery system for oral cancer drug 5-flurouracil. Characterizations of polymers have been carried out by SEMs, EDAX, FTIR, TGA/DTA/DTG, XRD and swelling studies. The in vitro release dynamics of drug and some important biomedical properties of hydrogel films (like blood compatibility, mucoadhesion, tensile strength, relaxation, resilience and bursting strength) have also been studied. The values of maximum detachment force (F_max) and work of adhesion (W_ad) of) polymeric films have been observed (1.026±0.175 N) and (0.073±0.010 N mm) respectively. The release of drug in simulated saliva fluid occurred through Fickian diffusion mechanism and polymer films have been observed to be biocompatible nature.

Published in	American Journal of Polymer Science and Technology (Volume 1, Issue 1)
DOI	10.11648/j.ajpst.20150101.11
Page(s)	1-8
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Polymers Matrix, Mucoadhesive, Hydrogels, Drug Delivery, Anticancer, Biocompatibility

References

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APA Style

Baljit Singh, Arindam Sharma, A. Dhiman, S. Kumar. (2015). Mechanical, Mucoadhesive and Biocompatibility Behavior of Hydrogel Films: A Slow Anticancer Drug Delivery System. American Journal of Polymer Science and Technology, 1(1), 1-8. https://doi.org/10.11648/j.ajpst.20150101.11

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ACS Style

Baljit Singh; Arindam Sharma; A. Dhiman; S. Kumar. Mechanical, Mucoadhesive and Biocompatibility Behavior of Hydrogel Films: A Slow Anticancer Drug Delivery System. Am. J. Polym. Sci. Technol. 2015, 1(1), 1-8. doi: 10.11648/j.ajpst.20150101.11

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AMA Style

Baljit Singh, Arindam Sharma, A. Dhiman, S. Kumar. Mechanical, Mucoadhesive and Biocompatibility Behavior of Hydrogel Films: A Slow Anticancer Drug Delivery System. Am J Polym Sci Technol. 2015;1(1):1-8. doi: 10.11648/j.ajpst.20150101.11

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@article{10.11648/j.ajpst.20150101.11,
  author = {Baljit Singh and Arindam Sharma and A. Dhiman and S. Kumar},
  title = {Mechanical, Mucoadhesive and Biocompatibility Behavior of Hydrogel Films: A Slow Anticancer Drug Delivery System},
  journal = {American Journal of Polymer Science and Technology},
  volume = {1},
  number = {1},
  pages = {1-8},
  doi = {10.11648/j.ajpst.20150101.11},
  url = {https://doi.org/10.11648/j.ajpst.20150101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpst.20150101.11},
  abstract = {Systemic administration of anticancer drugs is associated with a number of side effects. Therefore, it needs some targeted drug delivery system to deliver the drug which would ensure relief from side effects along with the direct delivery of drug to the site of action in a controlled manner. Keeping in view the importance of mucoadhesive polymers in site specific drug delivery, in the present work, an attempt has been made to prepare, polysaccharide gum, PVA and AAm based mucoadhesive polymeric films for use as slow, site specific drug delivery system for oral cancer drug 5-flurouracil. Characterizations of polymers have been carried out by SEMs, EDAX, FTIR, TGA/DTA/DTG, XRD and swelling studies. The in vitro release dynamics of drug and some important biomedical properties of hydrogel films (like blood compatibility, mucoadhesion, tensile strength, relaxation, resilience and bursting strength) have also been studied. The values of maximum detachment force (Fmax) and work of adhesion (Wad) of) polymeric films have been observed (1.026±0.175 N) and (0.073±0.010 N mm) respectively. The release of drug in simulated saliva fluid occurred through Fickian diffusion mechanism and polymer films have been observed to be biocompatible nature.},
 year = {2015}
}

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TY  - JOUR
T1  - Mechanical, Mucoadhesive and Biocompatibility Behavior of Hydrogel Films: A Slow Anticancer Drug Delivery System
AU  - Baljit Singh
AU  - Arindam Sharma
AU  - A. Dhiman
AU  - S. Kumar
Y1  - 2015/09/02
PY  - 2015
N1  - https://doi.org/10.11648/j.ajpst.20150101.11
DO  - 10.11648/j.ajpst.20150101.11
T2  - American Journal of Polymer Science and Technology
JF  - American Journal of Polymer Science and Technology
JO  - American Journal of Polymer Science and Technology
SP  - 1
EP  - 8
PB  - Science Publishing Group
SN  - 2575-5986
UR  - https://doi.org/10.11648/j.ajpst.20150101.11
AB  - Systemic administration of anticancer drugs is associated with a number of side effects. Therefore, it needs some targeted drug delivery system to deliver the drug which would ensure relief from side effects along with the direct delivery of drug to the site of action in a controlled manner. Keeping in view the importance of mucoadhesive polymers in site specific drug delivery, in the present work, an attempt has been made to prepare, polysaccharide gum, PVA and AAm based mucoadhesive polymeric films for use as slow, site specific drug delivery system for oral cancer drug 5-flurouracil. Characterizations of polymers have been carried out by SEMs, EDAX, FTIR, TGA/DTA/DTG, XRD and swelling studies. The in vitro release dynamics of drug and some important biomedical properties of hydrogel films (like blood compatibility, mucoadhesion, tensile strength, relaxation, resilience and bursting strength) have also been studied. The values of maximum detachment force (Fmax) and work of adhesion (Wad) of) polymeric films have been observed (1.026±0.175 N) and (0.073±0.010 N mm) respectively. The release of drug in simulated saliva fluid occurred through Fickian diffusion mechanism and polymer films have been observed to be biocompatible nature.
VL  - 1
IS  - 1
ER  -

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Author Information

Baljit Singh

Department of Chemistry, Himachal Pradesh University Shimla, Himachal Pradesh, India
Arindam Sharma

Resident, Department of Medicine, Indira Gandhi Medical College Shimla, Himachal Pradesh, India
A. Dhiman

Department of Chemistry, Himachal Pradesh University Shimla, Himachal Pradesh, India
S. Kumar

Department of Chemistry, Himachal Pradesh University Shimla, Himachal Pradesh, India

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APA Style

Baljit Singh, Arindam Sharma, A. Dhiman, S. Kumar. (2015). Mechanical, Mucoadhesive and Biocompatibility Behavior of Hydrogel Films: A Slow Anticancer Drug Delivery System. American Journal of Polymer Science and Technology, 1(1), 1-8. https://doi.org/10.11648/j.ajpst.20150101.11

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ACS Style

Baljit Singh; Arindam Sharma; A. Dhiman; S. Kumar. Mechanical, Mucoadhesive and Biocompatibility Behavior of Hydrogel Films: A Slow Anticancer Drug Delivery System. Am. J. Polym. Sci. Technol. 2015, 1(1), 1-8. doi: 10.11648/j.ajpst.20150101.11

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AMA Style

Baljit Singh, Arindam Sharma, A. Dhiman, S. Kumar. Mechanical, Mucoadhesive and Biocompatibility Behavior of Hydrogel Films: A Slow Anticancer Drug Delivery System. Am J Polym Sci Technol. 2015;1(1):1-8. doi: 10.11648/j.ajpst.20150101.11

Copy | Download

@article{10.11648/j.ajpst.20150101.11,
  author = {Baljit Singh and Arindam Sharma and A. Dhiman and S. Kumar},
  title = {Mechanical, Mucoadhesive and Biocompatibility Behavior of Hydrogel Films: A Slow Anticancer Drug Delivery System},
  journal = {American Journal of Polymer Science and Technology},
  volume = {1},
  number = {1},
  pages = {1-8},
  doi = {10.11648/j.ajpst.20150101.11},
  url = {https://doi.org/10.11648/j.ajpst.20150101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpst.20150101.11},
  abstract = {Systemic administration of anticancer drugs is associated with a number of side effects. Therefore, it needs some targeted drug delivery system to deliver the drug which would ensure relief from side effects along with the direct delivery of drug to the site of action in a controlled manner. Keeping in view the importance of mucoadhesive polymers in site specific drug delivery, in the present work, an attempt has been made to prepare, polysaccharide gum, PVA and AAm based mucoadhesive polymeric films for use as slow, site specific drug delivery system for oral cancer drug 5-flurouracil. Characterizations of polymers have been carried out by SEMs, EDAX, FTIR, TGA/DTA/DTG, XRD and swelling studies. The in vitro release dynamics of drug and some important biomedical properties of hydrogel films (like blood compatibility, mucoadhesion, tensile strength, relaxation, resilience and bursting strength) have also been studied. The values of maximum detachment force (Fmax) and work of adhesion (Wad) of) polymeric films have been observed (1.026±0.175 N) and (0.073±0.010 N mm) respectively. The release of drug in simulated saliva fluid occurred through Fickian diffusion mechanism and polymer films have been observed to be biocompatible nature.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Mechanical, Mucoadhesive and Biocompatibility Behavior of Hydrogel Films: A Slow Anticancer Drug Delivery System
AU  - Baljit Singh
AU  - Arindam Sharma
AU  - A. Dhiman
AU  - S. Kumar
Y1  - 2015/09/02
PY  - 2015
N1  - https://doi.org/10.11648/j.ajpst.20150101.11
DO  - 10.11648/j.ajpst.20150101.11
T2  - American Journal of Polymer Science and Technology
JF  - American Journal of Polymer Science and Technology
JO  - American Journal of Polymer Science and Technology
SP  - 1
EP  - 8
PB  - Science Publishing Group
SN  - 2575-5986
UR  - https://doi.org/10.11648/j.ajpst.20150101.11
AB  - Systemic administration of anticancer drugs is associated with a number of side effects. Therefore, it needs some targeted drug delivery system to deliver the drug which would ensure relief from side effects along with the direct delivery of drug to the site of action in a controlled manner. Keeping in view the importance of mucoadhesive polymers in site specific drug delivery, in the present work, an attempt has been made to prepare, polysaccharide gum, PVA and AAm based mucoadhesive polymeric films for use as slow, site specific drug delivery system for oral cancer drug 5-flurouracil. Characterizations of polymers have been carried out by SEMs, EDAX, FTIR, TGA/DTA/DTG, XRD and swelling studies. The in vitro release dynamics of drug and some important biomedical properties of hydrogel films (like blood compatibility, mucoadhesion, tensile strength, relaxation, resilience and bursting strength) have also been studied. The values of maximum detachment force (Fmax) and work of adhesion (Wad) of) polymeric films have been observed (1.026±0.175 N) and (0.073±0.010 N mm) respectively. The release of drug in simulated saliva fluid occurred through Fickian diffusion mechanism and polymer films have been observed to be biocompatible nature.
VL  - 1
IS  - 1
ER  -

Copy | Download