Abstract: Systemic administration of anticancer drugs is associated with a number of side effects. Therefore, it needs some targeted drug delivery system to deliver the drug which would ensure relief from side effects along with the direct delivery of drug to the site of action in a controlled manner. Keeping in view the importance of mucoadhesive polymers in site specific drug delivery, in the present work, an attempt has been made to prepare, polysaccharide gum, PVA and AAm based mucoadhesive polymeric films for use as slow, site specific drug delivery system for oral cancer drug 5-flurouracil. Characterizations of polymers have been carried out by SEMs, EDAX, FTIR, TGA/DTA/DTG, XRD and swelling studies. The in vitro release dynamics of drug and some important biomedical properties of hydrogel films (like blood compatibility, mucoadhesion, tensile strength, relaxation, resilience and bursting strength) have also been studied. The values of maximum detachment force (Fmax) and work of adhesion (Wad) of) polymeric films have been observed (1.026±0.175 N) and (0.073±0.010 N mm) respectively. The release of drug in simulated saliva fluid occurred through Fickian diffusion mechanism and polymer films have been observed to be biocompatible nature.Abstract: Systemic administration of anticancer drugs is associated with a number of side effects. Therefore, it needs some targeted drug delivery system to deliver the drug which would ensure relief from side effects along with the direct delivery of drug to the site of action in a controlled manner. Keeping in view the importance of mucoadhesive polymers i...Show More
Abstract: Poly (acrylamide/maleic acid/gelatin) P(AAm/MA/G) hydrogels have been prepared by gamma radiation and their adsorption for chromium ion from aqueous solutions have been investigated. The structural of the hydrogels was monitored by FTIR. The swelling behavior of the hydrogels has been investigated in distilled water and different pH's values at ambient temperature. The P(AAm) hydrogel showed fair pH-dependent swelling whereas P(AAm/MA) and P(AAm/MA/G) hydrogels exhibit a higher swelling by increasing the pH. The chromium ion solutions have been exposed to gamma radiation for precipitation. The results showed that the precipitation (%) decrease by increasing the initial chromium ions concentration. The possibility of using different hydrogels for the uptake of irradiated chromium ion solutions was investigated. The P(AAm/MA) hydrogel showed higher chromium ion uptake compared to that by P(AAm) and P(AAm/MA/G). The adsorption studies show that, the chromium uptake is pH dependent. Lowering of the chromium ion concentration has been achieved after the treatment of chromium ion solution by gamma radiation followed by adsorption onto hydrogels.Abstract: Poly (acrylamide/maleic acid/gelatin) P(AAm/MA/G) hydrogels have been prepared by gamma radiation and their adsorption for chromium ion from aqueous solutions have been investigated. The structural of the hydrogels was monitored by FTIR. The swelling behavior of the hydrogels has been investigated in distilled water and different pH's values at amb...Show More
