Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein

Tomoki Chiba; Yoshiaki Ito; Hiroshi Asahara

doi:doi:10.11648/j.bs.20160203.11

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Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein

Tomoki Chiba, Yoshiaki Ito, Hiroshi Asahara

Published in Biomedical Sciences (Volume 2, Issue 3)

Received: 4 July 2016 Accepted: 22 July 2016 Published: 22 August 2016

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Abstract

Recent advanced studies have demonstrated that post-transcriptional gene regulation is involved in many aspects of biological processes and in the pathogenesis of various types of disorders, such as neurodegenerative diseases, autoimmune diseases, and cancer. In addition to transcriptional regulation, spatially and temporally regulated gene expression is achieved by the post-transcriptional control of transcribed RNAs, including through splicing, export, stability, localization, and translation. These processes are regulated by the formation of ribonucleoprotein complexes with RNA-binding proteins and small non-coding RNAs. Here, we will describe the findings obtained from studies on mice deficient for individual RNA-binding proteins and microRNAs involved in maintaining homeostasis or causing disease.

Published in	Biomedical Sciences (Volume 2, Issue 3)
DOI	10.11648/j.bs.20160203.11
Page(s)	16-23
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Post-Transcriptional Regulation, MicroRNA, RNA-Binding Protein, Knockout Mice

References

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Tomoki Chiba, Yoshiaki Ito, Hiroshi Asahara. (2016). Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein. Biomedical Sciences, 2(3), 16-23. https://doi.org/10.11648/j.bs.20160203.11

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Tomoki Chiba; Yoshiaki Ito; Hiroshi Asahara. Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein. Biomed. Sci. 2016, 2(3), 16-23. doi: 10.11648/j.bs.20160203.11

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AMA Style

Tomoki Chiba, Yoshiaki Ito, Hiroshi Asahara. Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein. Biomed Sci. 2016;2(3):16-23. doi: 10.11648/j.bs.20160203.11

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@article{10.11648/j.bs.20160203.11,
  author = {Tomoki Chiba and Yoshiaki Ito and Hiroshi Asahara},
  title = {Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein},
  journal = {Biomedical Sciences},
  volume = {2},
  number = {3},
  pages = {16-23},
  doi = {10.11648/j.bs.20160203.11},
  url = {https://doi.org/10.11648/j.bs.20160203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20160203.11},
  abstract = {Recent advanced studies have demonstrated that post-transcriptional gene regulation is involved in many aspects of biological processes and in the pathogenesis of various types of disorders, such as neurodegenerative diseases, autoimmune diseases, and cancer. In addition to transcriptional regulation, spatially and temporally regulated gene expression is achieved by the post-transcriptional control of transcribed RNAs, including through splicing, export, stability, localization, and translation. These processes are regulated by the formation of ribonucleoprotein complexes with RNA-binding proteins and small non-coding RNAs. Here, we will describe the findings obtained from studies on mice deficient for individual RNA-binding proteins and microRNAs involved in maintaining homeostasis or causing disease.},
 year = {2016}
}

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TY  - JOUR
T1  - Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein
AU  - Tomoki Chiba
AU  - Yoshiaki Ito
AU  - Hiroshi Asahara
Y1  - 2016/08/22
PY  - 2016
N1  - https://doi.org/10.11648/j.bs.20160203.11
DO  - 10.11648/j.bs.20160203.11
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 16
EP  - 23
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20160203.11
AB  - Recent advanced studies have demonstrated that post-transcriptional gene regulation is involved in many aspects of biological processes and in the pathogenesis of various types of disorders, such as neurodegenerative diseases, autoimmune diseases, and cancer. In addition to transcriptional regulation, spatially and temporally regulated gene expression is achieved by the post-transcriptional control of transcribed RNAs, including through splicing, export, stability, localization, and translation. These processes are regulated by the formation of ribonucleoprotein complexes with RNA-binding proteins and small non-coding RNAs. Here, we will describe the findings obtained from studies on mice deficient for individual RNA-binding proteins and microRNAs involved in maintaining homeostasis or causing disease.
VL  - 2
IS  - 3
ER  -

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Tomoki Chiba

Department of Systems BioMedicine, Graduate school of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Yoshiaki Ito

Department of Systems BioMedicine, Graduate school of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Hiroshi Asahara

Department of Systems BioMedicine, Graduate school of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

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Tomoki Chiba, Yoshiaki Ito, Hiroshi Asahara. (2016). Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein. Biomedical Sciences, 2(3), 16-23. https://doi.org/10.11648/j.bs.20160203.11

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ACS Style

Tomoki Chiba; Yoshiaki Ito; Hiroshi Asahara. Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein. Biomed. Sci. 2016, 2(3), 16-23. doi: 10.11648/j.bs.20160203.11

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AMA Style

Tomoki Chiba, Yoshiaki Ito, Hiroshi Asahara. Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein. Biomed Sci. 2016;2(3):16-23. doi: 10.11648/j.bs.20160203.11

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@article{10.11648/j.bs.20160203.11,
  author = {Tomoki Chiba and Yoshiaki Ito and Hiroshi Asahara},
  title = {Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein},
  journal = {Biomedical Sciences},
  volume = {2},
  number = {3},
  pages = {16-23},
  doi = {10.11648/j.bs.20160203.11},
  url = {https://doi.org/10.11648/j.bs.20160203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20160203.11},
  abstract = {Recent advanced studies have demonstrated that post-transcriptional gene regulation is involved in many aspects of biological processes and in the pathogenesis of various types of disorders, such as neurodegenerative diseases, autoimmune diseases, and cancer. In addition to transcriptional regulation, spatially and temporally regulated gene expression is achieved by the post-transcriptional control of transcribed RNAs, including through splicing, export, stability, localization, and translation. These processes are regulated by the formation of ribonucleoprotein complexes with RNA-binding proteins and small non-coding RNAs. Here, we will describe the findings obtained from studies on mice deficient for individual RNA-binding proteins and microRNAs involved in maintaining homeostasis or causing disease.},
 year = {2016}
}

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TY  - JOUR
T1  - Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein
AU  - Tomoki Chiba
AU  - Yoshiaki Ito
AU  - Hiroshi Asahara
Y1  - 2016/08/22
PY  - 2016
N1  - https://doi.org/10.11648/j.bs.20160203.11
DO  - 10.11648/j.bs.20160203.11
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 16
EP  - 23
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20160203.11
AB  - Recent advanced studies have demonstrated that post-transcriptional gene regulation is involved in many aspects of biological processes and in the pathogenesis of various types of disorders, such as neurodegenerative diseases, autoimmune diseases, and cancer. In addition to transcriptional regulation, spatially and temporally regulated gene expression is achieved by the post-transcriptional control of transcribed RNAs, including through splicing, export, stability, localization, and translation. These processes are regulated by the formation of ribonucleoprotein complexes with RNA-binding proteins and small non-coding RNAs. Here, we will describe the findings obtained from studies on mice deficient for individual RNA-binding proteins and microRNAs involved in maintaining homeostasis or causing disease.
VL  - 2
IS  - 3
ER  -

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