Investigation of Treatment Regimen of the Genital Warts Using Various Chemotherapeutic Agents

Arsalan Khan; Muhammad Jamil; Rida Naz; Ayesha Humayun; Safi Ullah; Ghulam Jelani

doi:doi:10.11648/j.bs.20200601.11

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Investigation of Treatment Regimen of the Genital Warts Using Various Chemotherapeutic Agents

Arsalan Khan, Muhammad Jamil, Rida Naz, Ayesha Humayun, Safi Ullah, Ghulam Jelani

Published in Biomedical Sciences (Volume 6, Issue 1)

Received: 28 October 2019 Accepted: 3 January 2020 Published: 21 January 2020

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Abstract

Genital warts are the most commonly sexually transmitted viral infection of human beings caused by Human Papillomavirus, infecting both male as well as female sexes. The disease is clinically characterized by the appearance of external warts on the genital organs viz penis, scrotum, vulva, anus and perineal area. The present study was designed for the investigation of chemotherapeutic agents for the successful treatment/removal of lesions of genital warts in terms of recovery of patients and clearance percentage of genital organs from the warts. For this purpose, a total of 12 patients infected with genital warts were selected and randomly distributed into four different groups, each group comprising 03 patients. Group A was treated using locally available wart removal preparation Dewart® (Verrugon, Milk Acid), Group B was treated using Podophyllotoxin 15-25%, procured from chemical suppliers, Group C was treated using locally available Duofilm™ (Salicylic Acid 16.7% w/v, Lactic Acid 16.6% w/v) and Group D served as negative control. The results of the current study revealed that the standard and most effective treatment of the genital warts is found to be Podophyllotoxin @15-25%, which showed 100% recovery of the patients and 100% clearance of their genital areas from the stubborn warts. However, Duofilm™ was also found effective, because all the patients were recovered and 80% warts were cleared off from their genitalia, but after few weeks, the lesions re-appeared in the patients treated with Duofilm™. Also the warts did not go off with the local brands of Dewart® nor spontaneously recovered.

Published in	Biomedical Sciences (Volume 6, Issue 1)
DOI	10.11648/j.bs.20200601.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Clearance Percentage, Dewart®, Duofilm™, Genital Warts, Podophyllotoxin

References

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[2]	Scheinfeld N, Lehman DS. An evidence-based review of medical and surgical treatments of genital warts. Dermatol Online J. 2006; 12 (3): 5.
[3]	Cates WJ. Estimates of the incidence and prevalence of sexually transmitted diseases in the United States. Sexually Trans Dis. 1999; 26 (4): 2–7.
[4]	Markowitz LE, Dunne EF, Saraiya M, Lawson HW, Chesson H, Hunger ER. Quadrivalent human Papillomavirus vaccine: Recommendations of the Advisory Committee on Immunization Practices (ACIP). Recommendations and Reports. 2007; 56 (2): 1–24.
[5]	Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, Snijders PJ, Peto J, Meijer CJ, Munoz N. Human Papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999; 189 (1): 12–19.
[6]	Valerie R, Rita Y, Patel V, Goldenberg G. Genital Warts A Comprehensive Review. J Clin Aesthet Dermatol. 2018; 5 (6): 25–36.
[7]	deVilliers EM. Human Papillomavirus: Introduction. Seminars in Cancer Biology, 1999; 9 (6): 377.
[8]	Sabeena S, Bhat P, Kamath V, Arunkumar G. Possible non‐sexual modes of transmission of human papilloma virus. J Obstet Gynec Res. 2017; 43 (3): 429–435.
[9]	Beutner KR, Wiley DJ, Douglas JM, Tyring SK, Fife K, Trofatter K, Stone KM. Genital warts and their treatment. Clin Infec Dis. 1999; 28 (1): 37–56.
[10]	Munoz N, Bosch FX, Sanjose S, Herrero R, Castellsague X, Shah KV. Epidemiological Classification of human Papillomavirus types associated with cervical cancer. The New England J Med. 2003; 348 (6): 518-527.
[11]	Batteiger BE. External genital warts. Best Pract. Med. 2000; 9 (10): 312-314.
[12]	Yanofsky VR, Patel RV, Goldenberg G. Genital Warts: A Comprehensive Review. J Clinic Aesthetic Dermatol. 2012; 5 (6): 25-36.
[13]	Charles M, Kodner MD, Nasraty S. Management of genital warts. J American Family Physician, 2004; 70 (12): 2335-2342.
[14]	Wiley DJ, Douglas J, Beutner K, Cox T, Fife K, Moscicki AB, Fukumoto L. External Genital Warts: Diagnosis, Treatment and Prevention. J Clinic Infect Dis. 2002; 35 (2): 210-224.
[15]	Reinholz M, Benjamin M, Engelshofen C, Heppt MV, Hirai Y, Ruzicka T, Berking CV, Braunmühl TV. Successful Treatment of Genital Warts with Ingenol Mebutate Monitored with Optical Coherence Tomography and Reflectance Confocal Microscopy. Annals Dermatol. 2019; 31 (4): 434-436.
[16]	Moore RA, Edwards JE, Hopwood J, Hicks D. Imiquimod for the treatment of genital warts: A quantitative systematic review. BMC Infect Dis. 200; 1 (3): 1-9.

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APA Style

Arsalan Khan, Muhammad Jamil, Rida Naz, Ayesha Humayun, Safi Ullah, et al. (2020). Investigation of Treatment Regimen of the Genital Warts Using Various Chemotherapeutic Agents. Biomedical Sciences, 6(1), 1-4. https://doi.org/10.11648/j.bs.20200601.11

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ACS Style

Arsalan Khan; Muhammad Jamil; Rida Naz; Ayesha Humayun; Safi Ullah, et al. Investigation of Treatment Regimen of the Genital Warts Using Various Chemotherapeutic Agents. Biomed. Sci. 2020, 6(1), 1-4. doi: 10.11648/j.bs.20200601.11

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AMA Style

Arsalan Khan, Muhammad Jamil, Rida Naz, Ayesha Humayun, Safi Ullah, et al. Investigation of Treatment Regimen of the Genital Warts Using Various Chemotherapeutic Agents. Biomed Sci. 2020;6(1):1-4. doi: 10.11648/j.bs.20200601.11

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@article{10.11648/j.bs.20200601.11,
  author = {Arsalan Khan and Muhammad Jamil and Rida Naz and Ayesha Humayun and Safi Ullah and Ghulam Jelani},
  title = {Investigation of Treatment Regimen of the Genital Warts Using Various Chemotherapeutic Agents},
  journal = {Biomedical Sciences},
  volume = {6},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.bs.20200601.11},
  url = {https://doi.org/10.11648/j.bs.20200601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20200601.11},
  abstract = {Genital warts are the most commonly sexually transmitted viral infection of human beings caused by Human Papillomavirus, infecting both male as well as female sexes. The disease is clinically characterized by the appearance of external warts on the genital organs viz penis, scrotum, vulva, anus and perineal area. The present study was designed for the investigation of chemotherapeutic agents for the successful treatment/removal of lesions of genital warts in terms of recovery of patients and clearance percentage of genital organs from the warts. For this purpose, a total of 12 patients infected with genital warts were selected and randomly distributed into four different groups, each group comprising 03 patients. Group A was treated using locally available wart removal preparation Dewart® (Verrugon, Milk Acid), Group B was treated using Podophyllotoxin 15-25%, procured from chemical suppliers, Group C was treated using locally available Duofilm™ (Salicylic Acid 16.7% w/v, Lactic Acid 16.6% w/v) and Group D served as negative control. The results of the current study revealed that the standard and most effective treatment of the genital warts is found to be Podophyllotoxin @15-25%, which showed 100% recovery of the patients and 100% clearance of their genital areas from the stubborn warts. However, Duofilm™ was also found effective, because all the patients were recovered and 80% warts were cleared off from their genitalia, but after few weeks, the lesions re-appeared in the patients treated with Duofilm™. Also the warts did not go off with the local brands of Dewart® nor spontaneously recovered.},
 year = {2020}
}

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TY  - JOUR
T1  - Investigation of Treatment Regimen of the Genital Warts Using Various Chemotherapeutic Agents
AU  - Arsalan Khan
AU  - Muhammad Jamil
AU  - Rida Naz
AU  - Ayesha Humayun
AU  - Safi Ullah
AU  - Ghulam Jelani
Y1  - 2020/01/21
PY  - 2020
N1  - https://doi.org/10.11648/j.bs.20200601.11
DO  - 10.11648/j.bs.20200601.11
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20200601.11
AB  - Genital warts are the most commonly sexually transmitted viral infection of human beings caused by Human Papillomavirus, infecting both male as well as female sexes. The disease is clinically characterized by the appearance of external warts on the genital organs viz penis, scrotum, vulva, anus and perineal area. The present study was designed for the investigation of chemotherapeutic agents for the successful treatment/removal of lesions of genital warts in terms of recovery of patients and clearance percentage of genital organs from the warts. For this purpose, a total of 12 patients infected with genital warts were selected and randomly distributed into four different groups, each group comprising 03 patients. Group A was treated using locally available wart removal preparation Dewart® (Verrugon, Milk Acid), Group B was treated using Podophyllotoxin 15-25%, procured from chemical suppliers, Group C was treated using locally available Duofilm™ (Salicylic Acid 16.7% w/v, Lactic Acid 16.6% w/v) and Group D served as negative control. The results of the current study revealed that the standard and most effective treatment of the genital warts is found to be Podophyllotoxin @15-25%, which showed 100% recovery of the patients and 100% clearance of their genital areas from the stubborn warts. However, Duofilm™ was also found effective, because all the patients were recovered and 80% warts were cleared off from their genitalia, but after few weeks, the lesions re-appeared in the patients treated with Duofilm™. Also the warts did not go off with the local brands of Dewart® nor spontaneously recovered.
VL  - 6
IS  - 1
ER  -

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Author Information

Arsalan Khan

Livestock Research & Development Station, Paharpur, Dera Ismail Khan, Pakistan
Muhammad Jamil

Arid Zone Research Centre, Pakistan Agriculture Research Council, Dera Ismail Khan, Pakistan
Rida Naz

District Headquarter Teaching Hospital, Dera Ismail Khan, Pakistan
Ayesha Humayun

Department of Clinical Studies, Faculty of Veterinary and Animal Sciences, Arid Agriculture University, Rawalpindi, Pakistan
Safi Ullah

Livestock Research & Development Station, Paharpur, Dera Ismail Khan, Pakistan
Ghulam Jelani

Department of Veterinary and Animal Sciences, University of Agriculture, Dera Ismail Khan, Pakistan

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APA Style

Arsalan Khan, Muhammad Jamil, Rida Naz, Ayesha Humayun, Safi Ullah, et al. (2020). Investigation of Treatment Regimen of the Genital Warts Using Various Chemotherapeutic Agents. Biomedical Sciences, 6(1), 1-4. https://doi.org/10.11648/j.bs.20200601.11

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ACS Style

Arsalan Khan; Muhammad Jamil; Rida Naz; Ayesha Humayun; Safi Ullah, et al. Investigation of Treatment Regimen of the Genital Warts Using Various Chemotherapeutic Agents. Biomed. Sci. 2020, 6(1), 1-4. doi: 10.11648/j.bs.20200601.11

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AMA Style

Arsalan Khan, Muhammad Jamil, Rida Naz, Ayesha Humayun, Safi Ullah, et al. Investigation of Treatment Regimen of the Genital Warts Using Various Chemotherapeutic Agents. Biomed Sci. 2020;6(1):1-4. doi: 10.11648/j.bs.20200601.11

Copy | Download

@article{10.11648/j.bs.20200601.11,
  author = {Arsalan Khan and Muhammad Jamil and Rida Naz and Ayesha Humayun and Safi Ullah and Ghulam Jelani},
  title = {Investigation of Treatment Regimen of the Genital Warts Using Various Chemotherapeutic Agents},
  journal = {Biomedical Sciences},
  volume = {6},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.bs.20200601.11},
  url = {https://doi.org/10.11648/j.bs.20200601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20200601.11},
  abstract = {Genital warts are the most commonly sexually transmitted viral infection of human beings caused by Human Papillomavirus, infecting both male as well as female sexes. The disease is clinically characterized by the appearance of external warts on the genital organs viz penis, scrotum, vulva, anus and perineal area. The present study was designed for the investigation of chemotherapeutic agents for the successful treatment/removal of lesions of genital warts in terms of recovery of patients and clearance percentage of genital organs from the warts. For this purpose, a total of 12 patients infected with genital warts were selected and randomly distributed into four different groups, each group comprising 03 patients. Group A was treated using locally available wart removal preparation Dewart® (Verrugon, Milk Acid), Group B was treated using Podophyllotoxin 15-25%, procured from chemical suppliers, Group C was treated using locally available Duofilm™ (Salicylic Acid 16.7% w/v, Lactic Acid 16.6% w/v) and Group D served as negative control. The results of the current study revealed that the standard and most effective treatment of the genital warts is found to be Podophyllotoxin @15-25%, which showed 100% recovery of the patients and 100% clearance of their genital areas from the stubborn warts. However, Duofilm™ was also found effective, because all the patients were recovered and 80% warts were cleared off from their genitalia, but after few weeks, the lesions re-appeared in the patients treated with Duofilm™. Also the warts did not go off with the local brands of Dewart® nor spontaneously recovered.},
 year = {2020}
}

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TY  - JOUR
T1  - Investigation of Treatment Regimen of the Genital Warts Using Various Chemotherapeutic Agents
AU  - Arsalan Khan
AU  - Muhammad Jamil
AU  - Rida Naz
AU  - Ayesha Humayun
AU  - Safi Ullah
AU  - Ghulam Jelani
Y1  - 2020/01/21
PY  - 2020
N1  - https://doi.org/10.11648/j.bs.20200601.11
DO  - 10.11648/j.bs.20200601.11
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20200601.11
AB  - Genital warts are the most commonly sexually transmitted viral infection of human beings caused by Human Papillomavirus, infecting both male as well as female sexes. The disease is clinically characterized by the appearance of external warts on the genital organs viz penis, scrotum, vulva, anus and perineal area. The present study was designed for the investigation of chemotherapeutic agents for the successful treatment/removal of lesions of genital warts in terms of recovery of patients and clearance percentage of genital organs from the warts. For this purpose, a total of 12 patients infected with genital warts were selected and randomly distributed into four different groups, each group comprising 03 patients. Group A was treated using locally available wart removal preparation Dewart® (Verrugon, Milk Acid), Group B was treated using Podophyllotoxin 15-25%, procured from chemical suppliers, Group C was treated using locally available Duofilm™ (Salicylic Acid 16.7% w/v, Lactic Acid 16.6% w/v) and Group D served as negative control. The results of the current study revealed that the standard and most effective treatment of the genital warts is found to be Podophyllotoxin @15-25%, which showed 100% recovery of the patients and 100% clearance of their genital areas from the stubborn warts. However, Duofilm™ was also found effective, because all the patients were recovered and 80% warts were cleared off from their genitalia, but after few weeks, the lesions re-appeared in the patients treated with Duofilm™. Also the warts did not go off with the local brands of Dewart® nor spontaneously recovered.
VL  - 6
IS  - 1
ER  -

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