Investigation of Treatment Regimen of the Genital Warts Using Various Chemotherapeutic Agents
Arsalan Khan,
Muhammad Jamil,
Rida Naz,
Ayesha Humayun,
Safi Ullah,
Ghulam Jelani
Issue:
Volume 6, Issue 1, March 2020
Pages:
1-4
Received:
28 October 2019
Accepted:
3 January 2020
Published:
21 January 2020
Abstract: Genital warts are the most commonly sexually transmitted viral infection of human beings caused by Human Papillomavirus, infecting both male as well as female sexes. The disease is clinically characterized by the appearance of external warts on the genital organs viz penis, scrotum, vulva, anus and perineal area. The present study was designed for the investigation of chemotherapeutic agents for the successful treatment/removal of lesions of genital warts in terms of recovery of patients and clearance percentage of genital organs from the warts. For this purpose, a total of 12 patients infected with genital warts were selected and randomly distributed into four different groups, each group comprising 03 patients. Group A was treated using locally available wart removal preparation Dewart® (Verrugon, Milk Acid), Group B was treated using Podophyllotoxin 15-25%, procured from chemical suppliers, Group C was treated using locally available Duofilm™ (Salicylic Acid 16.7% w/v, Lactic Acid 16.6% w/v) and Group D served as negative control. The results of the current study revealed that the standard and most effective treatment of the genital warts is found to be Podophyllotoxin @15-25%, which showed 100% recovery of the patients and 100% clearance of their genital areas from the stubborn warts. However, Duofilm™ was also found effective, because all the patients were recovered and 80% warts were cleared off from their genitalia, but after few weeks, the lesions re-appeared in the patients treated with Duofilm™. Also the warts did not go off with the local brands of Dewart® nor spontaneously recovered.
Abstract: Genital warts are the most commonly sexually transmitted viral infection of human beings caused by Human Papillomavirus, infecting both male as well as female sexes. The disease is clinically characterized by the appearance of external warts on the genital organs viz penis, scrotum, vulva, anus and perineal area. The present study was designed for ...
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Versatile Regulator or Integrator RNA-binding Protein TLS/FUS Works for Phase Separation on Regulation of the Human Genome - In Relation to Liposarcoma and ALS
Issue:
Volume 6, Issue 1, March 2020
Pages:
5-16
Received:
21 January 2020
Accepted:
7 February 2020
Published:
18 February 2020
Abstract: This review article aims at comprehensive understanding of biological functions of RNA-binding proteins (RBPs) and cognate RNAs. For showing the divergent and dispersed aspects of RBP functions of the human genome in living cells, RBP TLS/FUS is chosen for these topics. Recent discovery of TLS as a phase transition or phase separation inducer presents previously unprecedented models regarding phase separation and enhancer functions in the genome. Trends in research altered up to interests or desire of scientists. Research activities of TLS/FUS have been dramatically drifted across over the last century. TLS was identified as a fusion gene product of TLS-CHOP of liposarcoma in 1993. Before announcement of the human genome draft, there were compelling desires to hunt novel genes. Gene cloning from libraries was one of prevalent activities at that time. Next wave came with describing TLS as a causative gene for familial amyotrophic lateral sclerosis (ALS). Investigation of lethal neurodegenerative disease, ALS has social impact. Elucidation of onset of ALS has progressed rapidly. Latest discovery with TLS is its solute for phase separation and phase transition into aggregation. The phase separation and resultant aggregation are pointed out in relation to the onset of ALS. Then, people rush to search for tide of TLS to phase separation in link to cause for ALS. Analysis of the phase separation could provide a novel outline for long distant regulation of gene in the genome. In this review article, the author focuses emerging trendy targets of a versatile molecule TLS and discuss scientific needs behind these orientation for a specific molecule in biological sciences.
Abstract: This review article aims at comprehensive understanding of biological functions of RNA-binding proteins (RBPs) and cognate RNAs. For showing the divergent and dispersed aspects of RBP functions of the human genome in living cells, RBP TLS/FUS is chosen for these topics. Recent discovery of TLS as a phase transition or phase separation inducer prese...
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