Comparison of Pregnancy Outcomes in Thyroid Antibody-Positive Women with Different Fertilization Methods
Kang Yi-fan,
Gao Qing-zhuo,
Yin Zhao-fang,
Wang Zhi-hong,
Liang Hui-zhi,
Yang Yuan,
Yang Pan,
Duan Xia
Issue:
Volume 9, Issue 2, June 2023
Pages:
35-41
Received:
2 September 2022
Accepted:
24 March 2023
Published:
11 April 2023
Abstract: Objective To compare the pregnancy outcomes of thyroid antibody (ATA) positive women treated by different fertilization methods during in vitro fertilization-embryo transfer. Methods A total of 204 female patients with normal thyroid function and positive ATA in the reproductive Medicine Center of the First Hospital of Shanxi Medical University from January 2020 to January 2022 were selected. According to different fertilization methods, they were divided into IVF group and ICSI group, including 115 IVF cycles and 89 ICSI cycles. The general data, clinical indicators after ovulation induction, fertilization, embryo status, and pregnancy outcome of the two groups were compared. Results There were no significant differences in age, BMI, bE2, FSH, FT3, FT4, AFC, Gn dosage, Gn stimulation time, E2 on HCG day, P on HCG day, intrauterine thickness on HCG day, number of retrieved oocytes and average number of embryos transferred between the two groups (P>0.05). The fertilization rate of the ICSI group was higher than that of IVF group within the group, while the high-quality embryo rate was significantly lower than that of the IVF group, with statistical significance (P<0.05). There were significant differences in sperm motility and sperm density between the two groups (P<0.05), and there was no significant difference between sperm volume and normal morphology rate (P>0.05). There were no significant differences in embryo implantation rate, biochemical pregnancy rate, clinical pregnancy rate, early abortion rate and live birth rate between the two groups (P>0.05). Logistic regression analysis showed that the method of assisted pregnancy and semen quality were not independent factors affecting high-quality embryo (P>0.05). In IVF group, TGAb was negatively correlated with fertilization rate (r=-0.202, P<0.05); and in ICSI group, TPOAb was negatively correlated with high quality embryo rate (r=-0.349, P<0.05). Conclusion Thyroid autoimmunity (TAI) in infertile women undergoing assisted reproductive technology (ART), the semen quality should be considered as the priority criteria for ATA. ICSI should not be recommended as routine fertilization.
Abstract: Objective To compare the pregnancy outcomes of thyroid antibody (ATA) positive women treated by different fertilization methods during in vitro fertilization-embryo transfer. Methods A total of 204 female patients with normal thyroid function and positive ATA in the reproductive Medicine Center of the First Hospital of Shanxi Medical University fro...
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Serological Status of Hepatitis B Virus Among Pregnant Women in the Mifi District (West Cameroon)
Juliana Vinciane Ntchimou Tochie,
Pascal Blaise Well a Well a Koul,
Esther Voundi-Voundi,
Claire Astrid Dikosso,
Christine Moubitang Matomba,
Marius Mbiandjeu Tchoumke,
Romaric de Manfouo Tuono,
Pierre Rene Fotsing Kwetche
Issue:
Volume 9, Issue 2, June 2023
Pages:
42-46
Received:
8 March 2023
Accepted:
28 March 2023
Published:
11 April 2023
Abstract: Introduction: Mother-to-child transmission is a major route of hepatitis B virus (HBV) transmission, particularly in highly endemic areas. The aim of our work was to determine the extent of HBV serological markers in pregnant women in the Mifi district (West Cameroon). Method: We conducted a descriptive cross-sectional study over a period of two months from 01 August to 02 October 2022. For the search for serological markers, we used immuno-chromatographic tests [HBV 5-in-1 Hepatitis B Virus markers Rapid Test Panel (serum/plasma), China, 2022] and enzyme-linked immunosorbent assays [Hepatitis B Virus surface Antigen (HBsAg) ELISA Test Kit, lot: HBSG37310B, China, 2022], both of which are from HIGHTOP. The markers investigated by the immuno-chromatographic tests were HBsAg, HBsAb, HBeAg, HBeAb, and HBcAb. Logistic regression analysis was performed to determine the degree of association with HBsAg carriage at the 5% significance level. Results: A total of 109 pregnant women were enrolled in the present study, the mean age was 26.89 ± 6 years with a range of 16 to 42 years. The following serological profiles were obtained in 27 (24.77%) participants and distributed as follows 19% (5/27) of the pregnant women were surface antigen positive (AgHbs +; AcHbc +); 37% (10/27) had been in contact with the virus in the past and were cured (AcHbs +; AcHbc +), 7% (2/27) had been vaccinated against hepatitis B virus (AgHBs -; Ac Hbs +; Ac anti Hbc -) and 37% (10/27) were in contact with the virus (AcHbc +). Logistic regression analyses revealed no association between socio-demographic variables and HBsAg carriage. Conclusion: In sum, the present work resulted in a prevalence of HBsAg of 4.59% (5/50); with an estimated marker positivity of 11% (12/50); 22.94% (25/50); 7.34% (8/50) and 0% for HBsAg, cAbAg, HBeAg and HBeAg respectively. Furthermore, no socio-demographic variables showed an association with HBsAg carriage.
Abstract: Introduction: Mother-to-child transmission is a major route of hepatitis B virus (HBV) transmission, particularly in highly endemic areas. The aim of our work was to determine the extent of HBV serological markers in pregnant women in the Mifi district (West Cameroon). Method: We conducted a descriptive cross-sectional study over a period of two mo...
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Serological Status of Viral Hepatitis B and Associated Factors Among Sex Workers in Douala (Littoral-Cameroon)
Dikosso Claire Astrid,
Voundi-Voundi Esther,
Well a Well a Koul Pascal Blaise,
Moubitang Matomba Christine,
Ntchimou Tochie Juliana Vinciane,
Mbiandjeu Tchoumke Marius,
Romaric De Manfouo Tuono,
Fotsing Kwetche Pierre Rene
Issue:
Volume 9, Issue 2, June 2023
Pages:
47-52
Received:
17 April 2023
Accepted:
28 April 2023
Published:
17 May 2023
Abstract: Introduction: Viral Hepatitis B (VHB) is a real concern for international organisations in general and the Cameroonian authorities in particular; our work aimed to determine the serological status of VHB as well as the associated factors among female sex workers (FSWs) in the city of Douala. Method: We conducted a descriptive cross-sectional study over a period of two months from 01 August to 02 October 2022. For the detection of serological markers, we used immuno-chromatographic tests [HBV 5-in-1 Hepatitis B Virus markers Rapid Test Panel (batch number; China, 2022)] and enzyme-linked immunosorbent assays [Hepatitis B Virus surface Antigen (HBsAg) ELISA Test Kit, batch number: HBSG37310B, China, 2022], both of HIGHTOP brand. The markers investigated by the immuno-chromatographic tests were HBsAg, HBsAb, HBeAg, HBeAb, and cHbAb. Logistic regression analysis was performed to determine the degree of association with HBsAg carriage at the 5% significance level. Results: A total of 87 participants were included in the present work, with a mean age of 29.66 ± 6.24 years, ranging from 18 to 43 years; furthermore, the serological profiles obtained in these TS were distributed as follows: 1% (1/87) of the participants were infected with the presence of viral activity; 7% (6/87) were infected with the absence of viral activity; 19% (17/87) had received a vaccine; 13% (11/87) had been in contact with the virus; 7% (6/87) had been in contact with the virus in the past and were cured; and 53% (46/87) were not infected; However, univariate regression analyses showed that primary education (OR= 0.042; 95% CI = 0.002-0.973; P=0.048); secondary education (OR= 0.034; 95% CI = 0.003-0.459; P=0.011); barmaid activity (OR= 0.030; 95% CI = 0.002-0.495; P=0.014) and shopkeeper activity (OR= 0.056; 95% CI = 0.003-0.923; P=0.044) were significantly associated with HBsAg carriage Conclusion: The present study shows that a variety of serological profiles of HBV were found among SWs in the city of Douala; however, the implementation of large-scale sensitization campaigns (via the media, social networks, and within schools) and expanded vaccination programmes against HBV throughout the country would help reduce its prevalence.
Abstract: Introduction: Viral Hepatitis B (VHB) is a real concern for international organisations in general and the Cameroonian authorities in particular; our work aimed to determine the serological status of VHB as well as the associated factors among female sex workers (FSWs) in the city of Douala. Method: We conducted a descriptive cross-sectional study ...
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