Objective To compare the pregnancy outcomes of thyroid antibody (ATA) positive women treated by different fertilization methods during in vitro fertilization-embryo transfer. Methods A total of 204 female patients with normal thyroid function and positive ATA in the reproductive Medicine Center of the First Hospital of Shanxi Medical University from January 2020 to January 2022 were selected. According to different fertilization methods, they were divided into IVF group and ICSI group, including 115 IVF cycles and 89 ICSI cycles. The general data, clinical indicators after ovulation induction, fertilization, embryo status, and pregnancy outcome of the two groups were compared. Results There were no significant differences in age, BMI, bE2, FSH, FT3, FT4, AFC, Gn dosage, Gn stimulation time, E2 on HCG day, P on HCG day, intrauterine thickness on HCG day, number of retrieved oocytes and average number of embryos transferred between the two groups (P>0.05). The fertilization rate of the ICSI group was higher than that of IVF group within the group, while the high-quality embryo rate was significantly lower than that of the IVF group, with statistical significance (P<0.05). There were significant differences in sperm motility and sperm density between the two groups (P<0.05), and there was no significant difference between sperm volume and normal morphology rate (P>0.05). There were no significant differences in embryo implantation rate, biochemical pregnancy rate, clinical pregnancy rate, early abortion rate and live birth rate between the two groups (P>0.05). Logistic regression analysis showed that the method of assisted pregnancy and semen quality were not independent factors affecting high-quality embryo (P>0.05). In IVF group, TGAb was negatively correlated with fertilization rate (r=-0.202, P<0.05); and in ICSI group, TPOAb was negatively correlated with high quality embryo rate (r=-0.349, P<0.05). Conclusion Thyroid autoimmunity (TAI) in infertile women undergoing assisted reproductive technology (ART), the semen quality should be considered as the priority criteria for ATA. ICSI should not be recommended as routine fertilization.
| Published in | Biomedical Sciences (Volume 9, Issue 2) |
| DOI | 10.11648/j.bs.20230902.11 |
| Page(s) | 35-41 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Thyroid Antibodies, Thyroid Autoimmunity, Different Fertilization Methods, Pregnancy Outcomes
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APA Style
Kang Yi-fan, Gao Qing-zhuo, Yin Zhao-fang, Wang Zhi-hong, Liang Hui-zhi, et al. (2023). Comparison of Pregnancy Outcomes in Thyroid Antibody-Positive Women with Different Fertilization Methods. Biomedical Sciences, 9(2), 35-41. https://doi.org/10.11648/j.bs.20230902.11
ACS Style
Kang Yi-fan; Gao Qing-zhuo; Yin Zhao-fang; Wang Zhi-hong; Liang Hui-zhi, et al. Comparison of Pregnancy Outcomes in Thyroid Antibody-Positive Women with Different Fertilization Methods. Biomed. Sci. 2023, 9(2), 35-41. doi: 10.11648/j.bs.20230902.11
AMA Style
Kang Yi-fan, Gao Qing-zhuo, Yin Zhao-fang, Wang Zhi-hong, Liang Hui-zhi, et al. Comparison of Pregnancy Outcomes in Thyroid Antibody-Positive Women with Different Fertilization Methods. Biomed Sci. 2023;9(2):35-41. doi: 10.11648/j.bs.20230902.11
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author = {Kang Yi-fan and Gao Qing-zhuo and Yin Zhao-fang and Wang Zhi-hong and Liang Hui-zhi and Yang Yuan and Yang Pan and Duan Xia},
title = {Comparison of Pregnancy Outcomes in Thyroid Antibody-Positive Women with Different Fertilization Methods},
journal = {Biomedical Sciences},
volume = {9},
number = {2},
pages = {35-41},
doi = {10.11648/j.bs.20230902.11},
url = {https://doi.org/10.11648/j.bs.20230902.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20230902.11},
abstract = {Objective To compare the pregnancy outcomes of thyroid antibody (ATA) positive women treated by different fertilization methods during in vitro fertilization-embryo transfer. Methods A total of 204 female patients with normal thyroid function and positive ATA in the reproductive Medicine Center of the First Hospital of Shanxi Medical University from January 2020 to January 2022 were selected. According to different fertilization methods, they were divided into IVF group and ICSI group, including 115 IVF cycles and 89 ICSI cycles. The general data, clinical indicators after ovulation induction, fertilization, embryo status, and pregnancy outcome of the two groups were compared. Results There were no significant differences in age, BMI, bE2, FSH, FT3, FT4, AFC, Gn dosage, Gn stimulation time, E2 on HCG day, P on HCG day, intrauterine thickness on HCG day, number of retrieved oocytes and average number of embryos transferred between the two groups (P>0.05). The fertilization rate of the ICSI group was higher than that of IVF group within the group, while the high-quality embryo rate was significantly lower than that of the IVF group, with statistical significance (P0.05). There were no significant differences in embryo implantation rate, biochemical pregnancy rate, clinical pregnancy rate, early abortion rate and live birth rate between the two groups (P>0.05). Logistic regression analysis showed that the method of assisted pregnancy and semen quality were not independent factors affecting high-quality embryo (P>0.05). In IVF group, TGAb was negatively correlated with fertilization rate (r=-0.202, PConclusion Thyroid autoimmunity (TAI) in infertile women undergoing assisted reproductive technology (ART), the semen quality should be considered as the priority criteria for ATA. ICSI should not be recommended as routine fertilization.},
year = {2023}
}
TY - JOUR T1 - Comparison of Pregnancy Outcomes in Thyroid Antibody-Positive Women with Different Fertilization Methods AU - Kang Yi-fan AU - Gao Qing-zhuo AU - Yin Zhao-fang AU - Wang Zhi-hong AU - Liang Hui-zhi AU - Yang Yuan AU - Yang Pan AU - Duan Xia Y1 - 2023/04/11 PY - 2023 N1 - https://doi.org/10.11648/j.bs.20230902.11 DO - 10.11648/j.bs.20230902.11 T2 - Biomedical Sciences JF - Biomedical Sciences JO - Biomedical Sciences SP - 35 EP - 41 PB - Science Publishing Group SN - 2575-3932 UR - https://doi.org/10.11648/j.bs.20230902.11 AB - Objective To compare the pregnancy outcomes of thyroid antibody (ATA) positive women treated by different fertilization methods during in vitro fertilization-embryo transfer. Methods A total of 204 female patients with normal thyroid function and positive ATA in the reproductive Medicine Center of the First Hospital of Shanxi Medical University from January 2020 to January 2022 were selected. According to different fertilization methods, they were divided into IVF group and ICSI group, including 115 IVF cycles and 89 ICSI cycles. The general data, clinical indicators after ovulation induction, fertilization, embryo status, and pregnancy outcome of the two groups were compared. Results There were no significant differences in age, BMI, bE2, FSH, FT3, FT4, AFC, Gn dosage, Gn stimulation time, E2 on HCG day, P on HCG day, intrauterine thickness on HCG day, number of retrieved oocytes and average number of embryos transferred between the two groups (P>0.05). The fertilization rate of the ICSI group was higher than that of IVF group within the group, while the high-quality embryo rate was significantly lower than that of the IVF group, with statistical significance (P0.05). There were no significant differences in embryo implantation rate, biochemical pregnancy rate, clinical pregnancy rate, early abortion rate and live birth rate between the two groups (P>0.05). Logistic regression analysis showed that the method of assisted pregnancy and semen quality were not independent factors affecting high-quality embryo (P>0.05). In IVF group, TGAb was negatively correlated with fertilization rate (r=-0.202, PConclusion Thyroid autoimmunity (TAI) in infertile women undergoing assisted reproductive technology (ART), the semen quality should be considered as the priority criteria for ATA. ICSI should not be recommended as routine fertilization. VL - 9 IS - 2 ER -
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